DESC:FIELD OF INVENTION
[001] The present invention is related to hair serum formulations comprising higher amounts of mineral oil. Further the invention relates to the process of preparation of hair serum formulations comprising higher amounts of mineral oil.

BACKGROUND OF THE INVENTION
[002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[003] Hair have long been associated with beauty of a person and therefore hair serums are used for detangling of hair fibres, which helps in cuticle alignment and improvement in hair shine.
[004] Conventionally, three types of hair serums are available- silicone base serums (Mixture of volatile silicones and silicone polymers), oil based silicone and emulsion based serums.
[005] Available hair serum in the market are generally designed with silicone polymers. Almost 90-95% of serum is made up with volatile silicones like cyclomethicones. Hair serum also contains silicone polymers like dimethiconol, dimethicone, Amodimethicone, etc., which gives conditioning benefits to the hair. These polymers are also responsible for consistency of the hair serum, which is critical parameter for consumer experience.
[006] Volatile silicones are solubiliser for Silicone polymers and gives non-sticky, light formulation. It also adds up to transient conditioning and shine. Since, most of the silicone in hair serum is volatile, it gives limited period of benefit in terms of shine and manageability.
[007] Replacement of volatile silicones with non-volatile hydrophobic material like vegetable oil, mineral oils would help in improvement in hair shine. However, compatibility of silicone polymers with mineral oil or any other vegetable oil is a challenge.
[008] Additionally, mineral oil reduces consistency of the hair serum and makes hair limp, which changes consumer experience.
[009] FR3110851A1 discloses in particular an anhydrous cosmetic composition comprising: i) at least 30% by weight, relative to the total weight of the composition, of one or more branched alkanes having from 8 to 16 carbon atoms; ii) a or more dimethiconols; iii) one or more amino silicones; iv) one or more silicones other than dimethiconols ii) and amino silicones iii); and v) optionally one or more non-silicone fatty substances having a melting point less than or equal to 25 ° C different from the branched alkanes.
[0010] FR3094639A1 discloses a cosmetic composition comprising a branched alkane and a combination of specific silicones The present invention relates to a cosmetic composition, preferably anhydrous, comprising: a) one or more branched alkanes having from 8 to 16 carbon atoms; b) one or more dimethiconol; c) one or more silicones, other than dimethiconols, having a viscosity at 25 ° C of less than 200.10-6 m2/s; and) one or more silicones, other than dimethiconols, having a viscosity at 25 ° C greater than or equal to 200.10-6 m2/s; preferably with a weight ratio of the total amount of silicone (s) c) relative to the total amount of silicone (s) d) ranging from 0.5 to 5. A subject of this invention is also a cosmetic treatment process using this composition, as well as the use of the latter for conditioning keratin fibers.
[0011] CN110072515A relates to a hair conditioning composition comprising a non-volatile oil and a volatile oil, wherein the non-volatile oil comprises a high molecular weight non-volatile silicone oil having a weight average molecular weight of 700,000 to 1,500,000 g/mol. The hair conditioning composition of the present invention allows for a reduction in the content of the non-volatile oil and exhibits a light and refreshing feeling while exhibiting an excellent hair conditioning effect and improved persistence.
[0012] EP2747748B1 Present invention relates to a substantially non-aqueous composition for hair for conditioning hair. Accordingly, present invention is a substantially non-aqueous composition for hair comprising one or more alkyl methicone, one or more volatile organic solvent and one or more volatile isoalkane with the condition that the composition comprises not more than 5% by weight, water, calculated to the total composition. [EP2550956A1]
[0013] Conventionally, hair serums are designed with 4 to 8% of Silicone polymers, which are responsible for hair conditioning as well as to give necessary consistency to the product. Currently, market hair serums are available with 10-12% of mineral oil without big alteration in sensorial experience.
[0014] To add higher amount of mineral oil in the serum, compatibility with silicone polymer is challenge.
[0015] There is, therefore, an unmet need to develop transparent hair serum without changing sensorial experience.

OBJECTS OF THE INVENTION
[0016] The primary objective of the present invention is to provide a hair serum formulation comprising higher amounts of mineral oil.
[0017] Another objective of the present disclosure is to provide a method of preparation of hair serum formulation comprising higher amounts of mineral oil.
[0018] Another objective of the present disclosure is to provide a hair serum formulation that provides improvement in shine of the hair fibres.
[0019] Another objective of the present disclosure is to provide a hair serum formulation that promotes detangling of hair fibres, helps in cuticle alignment and improvement in hair shine.

SUMMARY
[0020] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in Detailed Description section. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.
[0021] According to one aspect of the present disclosure a hair serum formulation is provided. The formulation comprises
(a) 10-50 % v/v Mineral oil;
(b) 2-5 % v/v Silicone Polymers;
(c) 41-58 % v/v solubilizer;
(d) 0.01-2 % v/v pharmaceutically acceptable excipients.
[0022] In some embodiments, the mineral oil is selected from C13-14 Isoparaffin, C10-13 Isoparaffin, C11-13 Isoalkane, Isohexadecane, Mineral Oil, LLP, HLP, Isododecane, C13-15 alkane, Undecane (and) Tridecane, Coco-Caprylate/Caprate, C15-19 Alkane or combinations thereof.
[0023] In some embodiments, the alternatives of mineral oil is an alcohol selected from a group of Octyldodecanol, Cyclohexanol, Hexanol, Isoamyl Alcohol or combinations thereof.
[0024] In some embodiments, the alternatives of mineral oil is an ester selected from C12-15 Alkyl Benzoate, Caprylic/Capric triglyceride, Isopropyl Myristate, Isopropyl Palmitate, Octylpalmitate, Isodecyl Neopentanoate or combinations thereof.
[0025] In some embodiments, the alternatives of mineral oil is a vegetable oils selected from Almond Oil, Castor oil, Coconut Oil, Jojoba Oil, Sesame Oil, Sunflower Oil, Olive Oil, Mustard Oil, Rice Bran Oil, Wheat germ oil, Walnut Oil, argan Oil, Macadamia oil, Avocado Oil, Canola Oil, Corn Oil, Cottonseed oil, Grape Seed oil, Lemon oil, Linseed oil, orange oil, palm oil, Soyabean oil or combinations thereof.
[0026] In some embodiments, the silicone polymer is selected from a group comprising Dimethicone or Dimethiconol or Dimethiconol or Amodimethicone or combinations thereof.
[0027] In some embodiments, the silicone polymer is a silicone gum selected from a group comprising polydimethyl siloxane gums, dimethicone, polydimethylsiloxane gums.hydroxyl, cross linked siloxanes, silicone elastomers, organic substituted siloxane gums, resin reinforced siloxanes, and cross linked siloxane polymers, monomethyl, dimethyl, monophenyl, diphenyl, methylphenyl, monovinyl, and methylvinyl chlorosilanes, together with tetrachlorosilane.
[0028] In some embodiments, the Dimethicone is a mixture selected from the following:
Dimethicone (and) Dimethiconol (and) Trisiloxane (and) Isododecane;
Dimethicone (and) Isododecane(and) Dimethiconol;
Dimethicone (and) C11-13 Isoalkane (and) Dimethiconol;
Dimethicone (and) Dimethiconol. Dimethicone (and) Isododecane;
Dimethicone (and) Phenyl trimethicone.
[0029] In some embodiments, the silicone polymer is selected from Propoxytetramethyl Piperidinyl Dimethicone, Propoxytetramethyl Piperidinyl Dimethicone or combinations thereof.
[0030] In some embodiments, the solubilizer is selected from Linear or branched or Cyclic Alkane or Siloxane.
[0031] In some embodiments, the solubilizer is selected from Common cyclic siloxane structures, hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6), Cyclopentasiloxane, Cyclohexasiloxane (and) Cyclopentasiloxane or combination thereof.
[0032] In some embodiments, the solubilizer is a Volatile silicones which can be linear or cyclic.
[0033] In some embodiments, the linear silicone is selected from Disiloxane, Trisiloxane, Dimethicone, linear polydimethyl siloxanes or combinations thereof.
[0034] In some embodiments, the pharmaceutically acceptable excipient is selected from an antioxidant, surfactant, nourishing agent, perfume or combinations thereof.
[0035] In some embodiments, the formulation comprises the following:
Cyclopentasiloxane 49.38
Dimethicone 2.5
Dimethiconol 2.1
Paraffinum Liquidum 45.00
Isopropyl myristate 1.0
Prunus amygdalus dulcis oil 0.01
Tocopheryl Acetate 0.01

[0036] In some embodiments, the formulation comprises the following:
Cyclopentasiloxane 45.67
Dimethicone 2.5
Dimethiconol 2.55
Parafinnum Liquidum 49.17
Cocos nucifera Oil 0.1
Tocopheryl Acetate 0.01

[0037] In some embodiments, the formulation comprises the following:
Cyclopentasiloxane 45.49
Dimethicone 2
Dimethiconol 2.4
Parafinnum Liquidum 50
Cocos nucifera Oil 0.1
Tocopheryl Acetate 0.01

[0038] According to one aspect of the present disclosure a process of preparation of hair serum formulation comprising higher amounts of mineral oil is disclosed. Said process comprises the following steps:
a. Mixing required amount of solubilizer and Silicone Polymer;
b. Mixture is mixed for 4-5 hrs to form homogenous solution that is free of lumps;
c. Adding Mineral oil and pharmaceutically acceptable excipients to above mixture slowly to form homogenous clear uniform solution of hair serum formulation.
[0039] Various objects, features, aspects and advantages of the present disclosure will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like features.

BRIEF DESCRIPTION OF THE DRAWINGS
[0040] The accompanying drawing(s) are included to provide a further understanding of the present disclosure and are incorporated in and constitute a part of this specification. The drawings illustrate exemplary embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure. The diagrams are for illustration only, which thus is not a limitation of the present disclosure.
[0041] FIG. 1 illustrates the compatibility of Silicones and Mineral Oil:
[0042] FIG. 2 illustrates that inclusion of mineral oil also decreases viscosity of final formulation significantly.
[0043] FIG. 3 illustrates the impact of Mineral Oil on sensory.
[0044] FIG. 4 illustrates Boxplot of hair shine of hair swatches of Treated and Untreated hair swatches.
[0045] FIG. 5 illustrates statistics of hair shine (GU) of hair swatches of Treated and Untreated hair swatches.
[0046] FIG. 6 illustrates Boxplot of Combing force (gf) for treated and untreated hair swatches.
[0047] FIG. 7 illustrates Statistics of combing force (gf) for treated and untreated hair swatches.
[0048] FIG. 8 illustrates Boxplot of peak load (gf) for treated and untreated hair swatches
[0049] FIG. 9 illustrates Statistics of Peak load (gf) for treated and untreated hair swatch
[0050] FIG. 10 illustrates SEM Image of cuticals (a) After product application (b) Before product application

DETAILED DESCRIPTION OF THE INVENTION
[0051] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
[0052] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.
[0053] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0054] In some embodiments, numbers have been used for quantifying weights, percentages, ratios, and so forth, to describe and claim certain embodiments of the invention and are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
[0055] The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[0056] Unless the context requires otherwise, throughout the specification which follows, the word “comprise” and variations thereof, such as “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[0057] As used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[0058] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[0059] All methods described herein can be performed in a suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples or exemplary language (e.g., “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[0060] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified.
[0061] The description that follows, and the embodiments described therein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure.
[0062] It should also be appreciated that the present disclosure can be implemented in numerous ways, including as a system, a method or a device. In this specification, these implementations, or any other form that the invention may take, may be referred to as processes. In general, the order of the steps of the disclosed processes may be altered within the scope of the invention.
[0063] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[0064] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0065] The term "or", as used herein, is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.
[0066] Various terms are used herein to the extent a term used is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0067] In present invention the term “formulation” and “composition” are used interchangeably.
[0068] Conventionally, hair serums are designed with 4 to 8% of Silicone polymers, which are required to deliver hair conditioning benefits as well as to give necessary consistency to the product. Currently, market hair serums are available with 10-12% of mineral oil without big alteration in sensorial experience.
[0069] To add higher amount of mineral oil in the serum, compatibility with silicone polymer is challenge.
[0070] Compatibility of Silicones and Mineral Oil: As described in FIG. 1, Mineral oil and Volatile silicone are completely compatible with each other at every point in the phase diagram. However, Silicone polymer is having limited compatibility with Mineral oil. About 40% of mineral oil is compatible with silicone polymer system. Thus, the phase diagram is governed by compatibility of mineral oil with silicone polymers.
[0071] Impact of Mineral oil on Viscosity: as illustrated in FIG. 2, inclusion of mineral oil resulted in decrease in viscosity of final formulation significantly.
[0072] Impact of Mineral Oil on sensory: as illustrated in FIG. 3, it is possible to replace 50% of silicones with mineral oil, but there is significant drop in the consistency of the product and significant increase in hair limp.
[0073] In the present work, higher amounts (10-50%) of mineral oil has been added by replacing part of silicone polymers. The consistency of the product is adjusted by adding high molecular weight silicone polymers, which helps in increasing consistency of the product. These polymers also help to negate to limp sensory of the mineral oil. Synergy of silicone polymers along with mineral oil has been demonstrated to achieve superior hair conditioning benefit.
[0074] According to one aspect of the present disclosure a hair serum formulation is provided. The formulation comprises
(a) 10-50 % v/v Mineral oil;
(b) 2-5 % v/v Silicone Polymers;
(c) 41-58 % v/v solubilizer;
(d) 0.01-2 % v/v pharmaceutically acceptable excipients.

Proto Specific Ratio
BO 90-96% Cyclopentasiloxane + 4-10% Dimethiconol Gum
BO + L 40-80% Cyclopentasiloxane + 10-20% Dimethiconol Gum
+ 10-40% Mineral Oil
BO
+ Polymer
+L 40-50% Cyclopentasiloxane + 1-7% Dimethiconol Gum
+ 2-3% High Molecular weight Dimethicone
+ 10-50% LP

BO refers to Solubilizer, BO +L refers to Solubilizer + Mineral Oil and BO +Polymer +L refers to Solubilizer + High Molecular Weight Dimethicone.
[0075] It would be apparent to a person skilled in the art that broad ratio of active components can be derived from Phase diagram (FIG. 1).
[0076] In some embodiments the mineral oil is selected from petrolatum origin, alkane & Isoalkane, of chain length C9-C15, and mineral oil of Chain length C20.
[0077] The mineral oil is present in the hair care composition in the range of 0.01 v % to 99.0 v %. In preferred embodiments, the mineral oil is present in the hair care composition in the range of 10 v/v % to 50 v/v %. In more preferred embodiments, 50 v/v % mineral oil is present in the hair care composition.
[0078] In some embodiments, the mineral oil is selected from C13-14 Isoparaffin, C10-13 Isoparaffin, C11-13 Isoalkane, Isohexadecane, Mineral Oil, LLP, HLP, Isododecane, C13-15 alkane, Undecane (and) Tridecane, Coco-Caprylate/Caprate, C15-19 Alkane or combinations thereof.
[0079] In some embodiments, alternatives of mineral oil may be used. Alternatives of mineral oil are selected from alcohols, esters, vegetable oils or combinations thereof.
[0080] In some embodiments, the alternatives of mineral oil is an alcohol selected from a group of Octyldodecanol, Cyclohexanol, Hexanol, Isoamyl Alcohol or combinations thereof.
[0081] In some embodiments, the alternatives of mineral oil is an ester selected from C12-15 Alkyl Benzoate, Caprylic/Capric triglyceride, Isopropyl Myristate, Isopropyl Palmitate, Octylpalmitate, Isodecyl Neopentanoate or combinations thereof.
[0082] In some embodiments, the alternatives of mineral oil is a vegetable oils selected from Almond Oil, Castor oil, Coconut Oil, Jojoba Oil, Sesame Oil, Sunflower Oil, Olive Oil, Mustard Oil, Rice Bran Oil, Wheat germ oil, Walnut Oil, argan Oil, Macadamia oil, Avocado Oil, Canola Oil, Corn Oil, Cottonseed oil, Grape Seed oil, Lemon oil, Linseed oil, orange oil, palm oil, Soyabean oil or combinations thereof.
[0083] In some embodiments, the silicone polymer is selected from a group comprising Dimethicone or Dimethiconol or Dimethiconol or Amodimethicone or combinations thereof.
[0084] In some embodiments, the viscosity is of these polymer ranges from 4000cps to 500000cps.
[0085] In some embodiments, the concentration of silicone Polymer is from 1% to 10%. In preferred embodiments, the silicone Polymer is present in the hair care composition in the range of 1% to 5% v/v %. In more preferred embodiments, 2.1-2.5 v/v % silicone Polymer is present in the hair care composition.
[0086] In some embodiments the Silicone polymer is selected from Polydimethyl siloxane gums which have, viscosities of at least about 100,000 centistoke (CSTK) and up to about 300,000,000 CSTK and, preferably from about 1,000,000 CSTK to about 20,000,000 CSTK.
[0087] In some embodiments, the silicone polymer is a silicone gum selected from a group comprising polydimethyl siloxane gums, dimethicone, polydimethylsiloxane gums.hydroxyl, cross linked siloxanes, silicone elastomers, organic substituted siloxane gums, resin reinforced siloxanes, and cross linked siloxane polymers, monomethyl, dimethyl, monophenyl, diphenyl, methylphenyl, monovinyl, and methylvinyl chlorosilanes, together with tetrachlorosilane.
[0088] In some embodiments the Silicone gums are selected from siloxanes which have been sparingly crosslinked but are still soluble in solvents such as cyclomethicone. Precursors for the rigid material can be any high molecular weight polydimethyl siloxanes, polydimethyl siloxanes containing vinyl groups and other siloxanes, PEG 10 Dimethicone.
[0089] In some embodiments, the Dimethicone is a mixture selected from the following:
Dimethicone (and) Dimethiconol (and) Trisiloxane (and) Isododecane;
Dimethicone(and) Isododecane(and) Dimethiconol;
Dimethicone (and) C11-13 Isoalkane (and) Dimethiconol;
Dimethicone (and) Dimethiconol. Dimethicone (and) Isododecane;
Dimethicone (and) Phenyl trimethicone.
[0090] In some embodiments, the silicone polymer is selected from Propoxytetramethyl Piperidinyl Dimethicone, Propoxytetramethyl Piperidinyl Dimethicone or combinations thereof.
[0091] In some embodiments the Solubilizer is selected from Linear or branched or Cyclic Alkane or Siloxane having Vapour pressure within 0.005 KPa to 0.15 KPa (at 25 OC), more preferably within 0.007 KPa to 0.11 KPa, such as Cyclopentasiloxane, C10-C13 N-Alkane, Isohexadecane or combinations thereof.
[0092] In some embodiments, the viscosities of solubilizer are less than 10 centipoise (cP) at 25° C.
[0093] In some embodiments, the solubilizer is selected from Common cyclic siloxane structures, hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6), Cyclopentasiloxane, Cyclohexasiloxane (and) Cyclopentasiloxane or combination thereof.
[0094] In some embodiments, the solubilizer is a Volatile silicones which can be linear or cyclic.
[0095] In some embodiments, the linear silicone is selected from Disiloxane, Trisiloxane, Dimethicone, linear polydimethyl siloxanes or combinations thereof.
[0096] In some embodiments, the linear silicone is have viscosities of less than about 5cP at 25° C.
[0097] In some embodiments, the linear silicone contain from about 3 to about 9 silicone atoms and have the general formula:
(CH3)3 SiO[Si (CH3)2O]n Si (CH3)3
wherein n=1-7.
[0098] In some embodiments, the silicones of the above-described types are widely available e.g., from Dow Corning as 344, 345 and 200 fluids; Union Carbide as Silicone 7202 and 7158; and Stauffer Chemical as SWS-03314.
[0099] In some embodiments, the concentration of solubilizer is from 40% to 60%. In preferred embodiments, the solubilizer is present in the hair care composition in the range of 41% to 58% v/v %. In more preferred embodiments, 46-48 v/v % of solubilizer is present in the hair care composition.
[00100] In some embodiments, the pharmaceutically acceptable excipients include but not limited to antioxidants, surfactants, perfumes, nourishing agents, and combinations thereof.
[00101] In some embodiments, the antioxidant is selected from ascorbic acid, erythorbic acid, Tocopheryl Acetate etc.
[00102] In some embodiments, the formulation may comprise oil soluble/miscible fragrance or perfume.
[00103] In some embodiments, the nourishing agents are selected from Almond Oil, Castor oil, Coconut Oil, Jojoba Oil, Sesame Oil, Sunflower Oil, Olive Oil, Mustard Oil, Rice Bran Oil, Wheat germ oil, Walnut Oil, argan Oil, Macadamia oil, Avocado Oil, Canola Oil, Corn Oil, Cottonseed oil, Grape Seed oil, Lemon oil, Linseed oil, orange oil, palm oil, Soyabean oil or combinations thereof.
[00104] According to one aspect of the present disclosure a process of preparation of hair serum formulation comprising higher amounts of mineral oil is disclosed. Said process comprises the following steps:
a. Mix required amount of solubilizer, Silicone Polymer and pharmaceutically acceptable carriers;
b. Mixture is mixed for 4-5 hrs to form homogenous solution that is free of lumps.
c. Adding mineral oil and pharmaceutically acceptable excipients to above mixture slowly to form homogenous clear uniform solution hair serum formulation.
[00105] Example 1:
a. Required amount of cyclopentasiloxane and dimethicone were mixed in a vessel.
b. Dimethiconol gum was added in the above mixture and mixed for 4-5 hrs to form homogenous solution.
c. Paraffinum Liquidum was slowly added to above to form homogenous clear uniform solution.
The core of the invention is in the blending of oils in right proportions and correct sequence

Composition 1:
Sr. No. INCI Name Composition % v/v
1 Cyclopentasiloxane 49.38
2 Dimethicone 2.5
3 Dimethiconol 2.1
4 Paraffinum Liquidum 45.00
5 Isopropyl myristate 1.0
6 Prunus amygdalus dulcis oil 0.01
7 Tocopheryl Acetate 0.01

Composition 2:
Sr. No INCI Name Composition % v/v
1 Cyclopentasiloxane 45.67
2 Dimethicone 2.5
3 Dimethiconol 2.55
4 Parafinnum Liquidum 49.17
5 Cocos nucifera Oil 0.1
6 Tocopheryl Acetate 0.01

Composition 3:
Sr. No Composition Composition % v/v
1 Cyclopentasiloxane 45.49
2 Dimethicone 2
3 Dimethiconol 2.4
4 Parafinnum Liquidum 50
5 Cocos nucifera Oil 0.1
6 Tocopheryl Acetate 0.01

Proto Details Viscosity
volatile silicones (BO) 95% Cyclopentasiloxane +
4.5% Dimethiconol Gum 150-200cps
volatile silicones (BO)
+ Mineral Oil (L) 46% Cyclopentasiloxane +
1% Dimethiconol Gum +
50% Mineral Oil 70-80 cps
volatile silicones
+ Mineral Oil+
High molecular weight Polymer 45% Cyclopentasiloxan +
3% Dimethiconol Gum +
2.5% High Molecular weight Dimethicone
+ 50% LP 160-200cps
volatile silicones
+ Mineral Oil+
High molecular weight Polymer 45% Cyclopentasiloxan +
1.5% Dimethiconol Gum +
2.5% High Molecular weight Dimethicone + 80% LP 100 cps

[00106] Example 2: Hair swatches of length about 20 cm were weighed and divided into following groups:
a) Untreated Hair
b) Treated with Solubilizer (BO)
c) Treated with Solubilizer + Mineral oil (BO+L)
d) Treaded with Solubilizer + Silicone Polymer + Mineral Oil (BO +Polymer+ L)
All hair swatches were cleaned thoroughly with 15% of SLES solution (10% of wt. of Hair swatch) to remove particulate impurities and dried with hair dryer (cool & dry). Finally, this hair swatches were processed for further treatment for Smoothness, Detangling and Shine study.
1. Hair Shine:
Hair Sample Preparation: The study was conducted in vitro using hair tress and the products benefits were compared versus an untreated hair. Increase in Hair shine with product application was compared versus untreated hair using Glossmeter- GL 200. The analysis was done at 25 ? temperature, 50-60% RH and in the absence of light to avoid interference. Six measurements were performed, two in each region of the swatches split into three regions, i.e., roof, middle and tip.
Software used for statistical analysis: Minitab 20 software. 2 sample t Test performed for the means of values of treated & untreated sets at the 0.01 level of significance
Table No. 1. Result of hair shine improvement.
Parameter Untreated BO+Polymer +L BO+L BO
Mean Of Glossmeter Units (GU) 1.84 4.12 4.17 4.15

FIG. 4 illustrates Boxplot of hair shine of hair swatches of Treated and Untreated hair swatches.
FIG. 5 illustrates statistics of hair shine (GU) of hair swatches of Treated and Untreated hair swatches.
2. Hair Smoothness: Plateau load value (Combing Force) was measured using Diastron instrument and UV win software. Data was recorded for untreated and treated swatches
Table 2: Result of Smoothness Study
Parameter Smoothness
Untreated BO+Polymer +L BO +L BO
Mean combing force (gf) 34.58 13.05 1 3.28 1 3.32

FIG. 6 illustrates Boxplot of Combing force (gf) for treated and untreated hair swatches.
FIG. 7 illustrates Statistics of combing force (gf) for treated and untreated hair swatches.
3. Hair Detangling: Peak load value was measured using Diastron instrument and UV win software. Data was recorded for untreated and treated swatches

Table 3: Result of Detangling Study
Parameter Detangling
Untreated BO BO +L BO +Polymer +L
Peak load force (gf) 42.3 12.6 12.9 12.5
Statistical Significance compared to untreated - p<0.001

FIG. 8 illustrates Boxplot of peak load (gf) for treated and untreated hair swatches.
FIG. 9 illustrates Statistics of Peak load (gf) for treated and untreated hair swatch.
The surprising effects of the hair formulation vane be observed from the above table. As it would be apparent to a person skilled in the art, best results are obtained when Cyclopentasiloxan + Dimethiconol Gum + High Molecular weight Dimethicone + LP (BO +Polymer+L are used together.
[00107] The foregoing examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.

ADVANTAGES OF THE INVENTION
[00108] The present disclosure provide a hair serum formulation comprising higher amounts of mineral oil.
[00109] The present disclosure provide a method of preparation of hair serum formulation comprising higher amounts of mineral oil.
[00110] The present disclosure provide a hair serum formulation that provides improvement in shine of the hair fibres.
[00111] The present disclosure provide a hair serum formulation that promotes detangling of hair fibres, helps in cuticle alignment and improvement in hair shine.
[00112] Although the present invention has been described with reference to preferred embodiments, it is submitted that various modifications can be made to the exemplary embodiments without departing from the spirit and scope of the invention.
,CLAIMS:1. A hair serum formulation comprising the following:
(a) 10-50 % v/v Mineral oil;
(b) 2-5 % v/v Silicone Polymers;
(c) 41-58 % v/v solubilizer;
(d) 0.01-1 % v/v pharmaceutically acceptable excipients.

2. The formulation as claimed in claim 1, wherein the mineral oil is selected from C13-14 Isoparaffin, C10-13 Isoparaffin, C11-13 Isoalkane, Isohexadecane, LLP, HLP, Isododecane, C13-15 alkane, Undecane (and) Tridecane, Coco-Caprylate/Caprate, C15-19 Alkane or combinations thereof.

3. The formulation as claimed in claim 1, wherein the alternatives of mineral oil is an alcohol selected from a group of Octyldodecanol, Cyclohexanol, Hexanol, Isoamyl Alcohol or combinations thereof.

4. The formulation as claimed in claim 1, wherein the alternatives of mineral oil is an ester selected from C12-15 Alkyl Benzoate, Caprylic/Capric triglyceride, Isopropyl Myristate, Isopropyl Palmitate, Octylpalmitate, Isodecyl Neopentanoate or combinations thereof.

5. The formulation as claimed in claim 1, wherein the alternatives of mineral oil is a vegetable oils selected from Almond Oil, Castor oil, Coconut Oil, Jojoba Oil, Sesame Oil, Sunflower Oil, Olive Oil, Mustard Oil, Rice Bran Oil, Wheat germ oil, Walnut Oil, argan Oil, Macadamia oil, Avocado Oil, Canola Oil, Corn Oil, Cottonseed oil, Grape Seed oil, Lemon oil, Linseed oil, orange oil, palm oil, Soyabean oil or combinations thereof

6. The formulation as claimed in claim 1, wherein the silicone polymer is selected from a group comprising Dimethicone or Dimethiconol or Dimethiconol or Amodimethicone or combinations thereof.

7. The formulation as claimed in claim 1, wherein the silicone polymer is a silicone gum selected from a group comprising polydimethyl siloxane gums, dimethicon, polydimethylsiloxane gums.hydroxyl, cross linked siloxanes, silicone elastomers, organic substituted siloxane gums, resin reinforced siloxanes, and cross linked siloxane polymers, monomethyl, dimethyl, monophenyl, diphenyl, methylphenyl, monovinyl, and methylvinyl chlorosilanes, together with tetrachlorosilane.

8. The formulation as claimed in claim 1, wherein the Dimethicone is a mixture selected from the following:
Dimethicone (and) Dimethiconol (and) Trisiloxane (and) Isododecane;
Dimethicone(and) Isododecane(and) Dimethiconol;
Dimethicone (and) C11-13 Isoalkane (and) Dimethiconol;
Dimethicone (and) Dimethiconol. Dimethicone (and) Isododecane;
Dimethicone (and) Phenyl trimethicone.

9. The formulation as claimed in claim 1, wherein the silicone polymer is selected from Propoxytetramethyl Piperidinyl Dimethicone, Propoxytetramethyl Piperidinyl Dimethicone or combinations thereof.

10. The formulation as claimed in claim 1, wherein the solubilizer is selected from Linear or branched or Cyclic Alkane or Siloxane.

11. The formulation as claimed in claim 1, wherein the solubilizer is selected from Common cyclic siloxane structures, hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6), Cyclopentasiloxane, Cyclohexasiloxane (and) Cyclopentasiloxane or combination thereof.

12. The formulation as claimed in claim 1, wherein the solubilizer is a Volatile silicones which can be linear or cyclic.

13. The formulation as claimed in claim 1, wherein the linear silicone is selected from Disiloxane, Trisiloxane, Dimethicone, linear polydimethyl siloxanes or combinations thereof.

14. The formulation as claimed in claim 1, wherein the pharmaceutically acceptable excipient is selected from an antioxidant, surfactant, nourishing agent, perfume or combinations thereof.

15. The formulation as claimed in claim 1, wherein the formulation comprises the following:
Cyclopentasiloxane 49.38
Dimethicone 2.5
Dimethiconol 2.1
Paraffinum Liquidum 45.00
Isopropyl myristate 1.0
Prunus amygdalus dulcis oil 0.01
Tocopheryl Acetate 0.01

16. The formulation as claimed in claim 1, wherein the formulation comprises the following:
Cyclopentasiloxane 45.67
Dimethicone 2.5
Dimethiconol 2.55
Parafinnum Liquidum 49.17
Cocos nucifera Oil 0.1
Tocopheryl Acetate 0.01

17. The formulation as claimed in claim 1, wherein the formulation comprises the following:
Cyclopentasiloxane 45.49
Dimethicone 2
Dimethiconol 2.4
Parafinnum Liquidum 50
Cocos nucifera Oil 0.1
Tocopheryl Acetate 0.01

18. A process of preparation of hair serum formulation comprising higher amounts of mineral oil, wherein said process comprises the following steps:
a. Mixing required amount of solubilizer and Silicone Polymer;
b. Mixture is mixed for 4-5 hrs to form homogenous solution that is free of lumps;
c. Adding mineral oil and pharmaceutically acceptable excipients to above mixture slowly to form homogenous clear uniform solution hair serum formulation.