DESC:FIELD OF THE INVENTION:
The present invention relates to a fungicidal compositions comprising a) Compound A 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide or its agrochemically acceptable salts, esters and derivatives; b) Compound B is selected from at least one triazole fungicide from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole; c) Compound C is selected from at least one more insecticide selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron; d) one or more inactive excipients. The present invention further relates to process of preparing said composition along with at least one or more inactive excipients and formulation thereof.

BACKGROUND OF THE INVENTION:
Combination of fungicides and insecticide are used to broaden the spectrum of control of insect–pests and fungi, to improve the pest control with synergistic effect, to mitigate the effect of biotic and abiotic stress on crop plants, to reduce dosage, thereby reducing environmental impact, decrease chances of resistance development and to enhance residual control so lesser the number of sprays for crop protections and minimizing the pesticidal load in ecosystem. The combination of fungicides and insecticides at times demonstrate an additive or synergistic effect that results in an improved control on the insect-pests and fungi.
Fungicides and insecticides in combination are used widely and very frequently in commercial agriculture and have enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in term of economic advantage as well as ease of farming activities.
There are many combinations of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide along with other fungicides and insecticide known in the prior art for the control of insect-fungi.
For example, CN109287636A relates to a 3-(difluoromethyl)-1-methyl-N-(3', 4', 5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide and cyproconazole-containing bactericidal composition and application thereof. The 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide and cyproconazole-containing bactericidal composition is composed of effective active components of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide and cyproconazole at a weight ratio of 1:50-50:1. The 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide and cyproconazole-containing bactericidal composition can be prepared into agriculturally allowable wettable powder, water dispersible granule, suspension agent, suspension emulsion, microemulsion, microcapsule suspension, microcapsule suspension-suspension, and dispersible oil suspension.
CN108541711A relates to a bactericidal composition containing mefentrifluconazole and 3-(difluoromethyl)-1-methyl-N-(3', 4', 5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide. The bactericidal composition is characterized by containing active ingredients of mefentrifluconazole and 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide, the mass ratio of mefentrifluconazole to3-(difluoromethyl)-1-methyl-N-(3',4', 5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide is 1:50 to 50:1, of the mass of the composition. Mefentrifluconazole and 3-(difluoromethyl)-1-methyl-N-(3',4', 5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide are compounded in a certain proportion.
CN103109844A relates to a 3-(difluoromethyl)-1-methyl-N-(3', 4', 5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide and flusilazole pesticide composition. The composition comprises commonly used additives, 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide and flusilazole, wherein the mass ratio of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamideto flusilazole is 5: 1 to 1: 15, preferably, the ratio is 3: 1 to 1: 7 and the pesticide composition is applicable to the prevention and control of crop diseases caused by fungal pathogens, especially powdery mildew, rust disease and gray mold.
202121037709 relates to a pesticidal composition comprising elemental sulphur in the range of 30% w/w to 90% w/w of the total composition; 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide present in the range of 0.01% to 25% w/w of the total composition; and prothioconazole present in the range of 1% to 20% w/w of the total composition and at least one agrochemically acceptable excipient, wherein the composition has a particle size range of 0.1 to 50 microns.
There is however a need for improvement of these combinations. Multiple active combinations used over a long period of time have resulted in resistance. With the onset of resistance to certain fungi, there is a need in the art for a combination of insecticides that decreases chances of resistance and improves the spectrum of control over fungi, insect and pest.
However still there is a need for a composition comprises 3-(difluoromethyl)-1-methyl-N-(3', 4', 5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide; atleast one triazole fungicides selected from list or mixture thereof; and an insecticide selected from a list. The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the fungicides actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism. However, most active fungicide compounds that are used as fungicides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating fungicide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved compositions of fungicides and insecticides for the control of fungi, insect and pests. Another object of the present invention is to provide a method and a composition for controlling fungi, insect and pests.
Yet another object of the present invention is to provide improved compositions of fungicides and insecticides that promote plant health and to increase plant or crop yield.
Another object of the present invention is to provide a fungicidal formulation that gives broad spectrum control of fungi, insect and pests in one shot application.
Further object of the present invention is to provide a fungicidal formulation that gives residual control i.e. longer duration of control.
Another object of the present invention is to provide a fungicidal formulation which prevents or causes delayed development of resistance to fungi against fungicides with a specific site/ mode of action.
Further object of the present invention is to provide a fungicidal formulation that gives synergistic control; i.e. grams of active ingredients required are less to achieve desired level of control.
Another object of the present invention is to provide a fungicidal formulation that gives immediate protection to crops.
Further object of the present invention is to provide a fungicidal formulation that has improved rain-fastness properties.
Another object of the present invention is to provide a fungicidal formulation with environment-friendly formulations; i.e. formulations are without organic solvent as carrier.
Yet another object of the present invention is to provide a fungicidal formulation that is safe to the crops.
Still another object of the present invention is to provide a process for preparing a stable and non-phytotoxic formulation.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
The present invention have found that the novel fungicidal composition of 3-(difluoromethyl)-1-methyl-N-(3', 4', 5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide; Atleast one triazole fungicides selected from the given list; and an insecticides. The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof as described herein which can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION
The main aspect of the present invention is to a fungicidal composition comprising a) Compound A 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide or its agrochemically acceptable salts, esters and derivatives; b) Compound B is selected from at least one triazole fungicide selected from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole; c) Compound C is selected from at least one more insecticide selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron and d) one or more inactive excipients.
In further aspect the present invention relates to the fungicidal composition comprising a) Compound A is in an amount of 1% to 30% w/w of the composition; b) Compound B is in an amount of 1% to 30% w/w of the composition; and c) Compound C is in an amount of 0.5% to 30% w/w of the composition.
The formulated composition of the present invention in addition amounts of active ingredients further comprises inactive formulation excipients including but not limited to wetting agents, wetting-spreading-penetrating agent, dispersant or dispersing agent, anti-freezing agent, emulsifying agent, anti-foam agent, preservatives, solvents, co-solvents, preservative, stabilizer, diluent, carriers, suspension aid or suspending agent, thickener, and buffering agent.
As per one embodiment formulation for the agrochemical composition is selected from Suspension concentrate (SC), Suspo-emulsion (SE), Wettable granule/Water dispersible granule (WG/WDG). The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is completely free from organic solvents.
Further aspect of the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against insect-pests damage by applying to the plant propagation material a composition comprising a pesticidal composition defined in the first aspect.
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.

DETAILED DESCRIPTION OF THE INVENTION:
The present invention is a fungicidal composition comprising a) Compound A 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide or its agrochemically acceptable salts, esters and derivatives; b) Compound B is selected from at least one triazole fungicide from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole. c) Compound C is selected from at least one more insecticide selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron; and d) one or more inactive excipients.
Compound A: 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4 carboxamide is a pyrazole-carboxamide fungicide used on a large variety of commercial crops. 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide Molecular formula is C18H12F5N3O.
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide stunts fungus growth by inhibiting the succinate dehydrogenase (SQR) enzyme. Application of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide helps prevent many wilts and other fungal infections from taking hold. As with other systemic pesticides that have a long chemical half-life, there are concerns about keeping 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide out of the groundwater, especially when combined with pyraclostrobin. There is also concern that some fungi may develop resistance to 4-(2, 3-dichloro-4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide.
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamideis also succinate dehydrogenase inhibitor (SDHI). It interferes with a number of key fungal life functions, including spore germination, germ tube growth, appresoria formation and mycelium growth. Specifically it interferes with the production of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, which in turn interferes with the tricarboxylic cycle and mitochondrial electron transport. SDHIs are not specific to fungi, they inhibit SDH, the CII of the mitochondrial respiratory chain. As a result, they act on all organisms that have mitochondria.
An embodiment of the present invention results in a synergistic action. The combination of the present invention allows for a broad spectrum of insect pest and fungi control and has surprisingly improved plant vigour and yield. Also providing residual control, i.e. longer duration of control and thereby reducing the number of applications. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The fungicidal composition of specific active ingredient has the special advantage of being highly active against insect, pests and fungi. The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of pest control and has surprisingly improved plant vigour and yield. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The fungicidal composition has very advantageous fungicidal properties for protecting cultivated plants against fungi, insect and pests. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the fungi, insect and pests that occur on plants or parts of plants of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such fungi, insect and pests .
The fungicidal compositions of fungicide are used to protect the crops and plants from fungi, insect and pests. the crops on which the present compositions used, include GMO (Genetically Modified Organism) and Non GMO traits, hybrids and conventional varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Groundnut/Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Red gram (Cajanus cajan), French bean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilli (Capsicum annum), Bell pepper (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Black Pepper (Piper nigrum), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).
Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO-, ACCase- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available.
Crops are also to be understood as being those which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt maize (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and also Bt potatoes (resistant to Colorado beetle). Examples of Bt maize are the Bt 176 maize hybrids of (Syngenta Seeds). The Bt toxin is a protein that is formed naturally by Bacillus thuringiensis soil bacteria. Examples of toxins, or transgenic plants able to synthesise such toxins, are described in EP-A-451 878, EP-A-374 753, WO 93/07278, WO 95/34656, WO 03/052073 and EP-A-427 529. Examples of transgenic plants comprising one or more genes that code for an insecticidal resistance and express one or more toxins are maize, cotton, potatoes. Plant crops or seed material thereof can be both resistant to herbicides and, at the same time, resistant to insect feeding (“stacked” transgenic events). For example, seed can have the ability to express an insecticidal Cry3 protein while at the same time being tolerant to glyphosate.
Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod and ornamental plants such as flowers or bushes.
The fungicidal combination of the present invention used to control the insects-pests and fungi.
The major insect-pests are belongs to the order Hemiptera, for example, rice leafhopper/green leaf hopper (GLH) Nephotettix nigropictus, rice brown plant hopper (BPH) Nilaparvata lugen, rice backed plant hopper (WBPH) Sogatella furcifera , Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, aphid Aphis gossypii, jassid Amrasca biguttula biguttla, mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp.; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, sugarcane early shoot borer Chilo infuscatellus tobacco budworm Heliothis virescens, tomato fruit worm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, fall armyworm Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza nivella, Tryporyza incertulas, Tuta absoluta.
The order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci, Thrips parvispinus and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp.; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp.
The major plant parasitic mites are from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Chilli yellow mite-Polyphagotarsonemus latus, Tarsonemus spp., Red spider mite-Tetranychus urticae, Tetranychus cinnabarinus.
The compositions can be employed for controlling diseases caused by phytopathogenic fungi belongs to Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes.Examples which may be mentioned, but not by limitation, are some pathogens of fungal diseases which come under the above generic terms:
Diseases caused by pathogens causing powdery mildew such as, for example, Blumeria species such as, for example, Blumeria graminis; Podosphaera species such as, for example, Podosphaera leucotricha; Oidium species such as, for example Oidium mangiferae, Sphaerotheca species such as, for example, Sphaerotheca fuliginea; Uncinula species such as, for example, Uncinula necator; Leveillula species such as, for example Leveillula taurica, Erysiphe species such as for example Erysiphe polygoni, diseases caused by pathogens of rust diseases such as, for example, Gymnosporangium species such as, for example, Gymnosporangium sabinae, Hemileia species such as, for example, Hemileia vastatrix; Phakopsora species such as, for example, Phakopsora pachyrhizi and Phakopsora meibomiae; Puccinia species such as, for example, Puccinia graminis, Puccinia recondita or Puccinia triticina, Puccinia striiformis; Uromyces species such as, for example, Uromyces phaseoli; diseases caused by pathogens of smut diseases such as, for example, Sporisorium species such as , for example, Sporisorium scitamineum; Ustilago species such as, for example Ustilago maydis, Tilletia species such as for example Tilletia tritici, Ustilaginoidea species such as , for example Ustilaginoidea virens, diseases caused by pathogens of ergot diseases such as, for example Claviceps species, Claviceps purpurea; diseases caused by pathogens from the group of the Oomycetes such as, for example, Bremia species such as, for example, Bremia lactucae; Peronospora species such as, for example, Peronospora pisi or P. brassicae; Phytophthora species such as, for example, Phytophthora infestans; Plasmopara species such as, for example, Plasmopara viticola; Pseudoperonospora species such as, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis; Pythium species such as, for example, Pythium ultimum; leaf spot diseases and leaf wilt caused by, for example, Alternaria species such as, for example, Alternaria solani, Alternaria alternata, Alternaria porii; Cercospora species such as, for example, Cercospora arachidicola; Cladiosporum species such as, for example, Cladiosporium cucumerinum; Cochliobolus species such as, for example, Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium);
Colletotrichum species such as, for example, Colletotrichum capsici; Cycloconium species such as, for example, Cycloconium oleaginum; Diaporthe species such as, for example, Diaporthe citri;
Elsinoe species such as, for example, Elsinoe fawcettii; Gloeosporium species such as, for example, Gloeosporium laeticolor; Glomerella species such as, for example, Glomerella cingulata; Guignardia species such as, for example, Guignardia bidwelli; Leptosphaeria species such as, for example, Leptosphaeria maculans; Magnaporthe species such as, for example, Magnaporthe grisea;
Mycosphaerella species such as, for example, Mycosphaerella graminicola; Phaeosphaeria species such as, for example, Phaeosphaeria nodorum; Pyrenophora species such as, for example, Pyrenophora teres;
Ramularia species such as, for example, Ramularia collo-cygni; Rhynchosporium species such as, for example, Rhynchosporium secalis; Septoria species such as, for example, Septoria apii; Typhula species such as, for example, Typhula incarnata; Venturia species such as, for example, Venturia inaequalis; root and stalk diseases, caused by, for example, Corticium species such as, for example, Corticium graminearum; Fusarium species such as, for example, Fusarium oxysporum;
Gaeumannomyces species such as, for example, Gaeumannomyces graminis; Rhizoctonia species such as, for example, Rhizoctonia solani; Tapesia species such as, for example, Tapesia acuformis;
Thielaviopsis species such as for example, Thielaviopsis basicola; ear and panicle diseases (including maize cobs), caused by, for example, Alternaria species such as, for example, Alternaria spp.;
Aspergillus species such as, for example, Aspergillus flavus; Cladosporium species such as, for example, Cladosporium spp.; Claviceps species such as, for example, Claviceps purpurea;
Fusarium species such as, for example, Fusarium culmorum; Gibberella species such as, for example, Gibberella zeae; Monographella species such as, for example, Monographella nivalis; diseases caused by smuts such as, for example, Sphacelotheca species such as, for example, Sphacelotheca reiliana; Tilletia species such as, for example, Tilletia caries; Urocystis species such as, for example, Urocystis occulta; Ustilago species such as, for example, Ustilago nuda; fruit rot caused by, for example, Aspergillus species such as, for example, Aspergillus flavus; Botrytis species such as, for example, Botrytis cinerea; Penicillium species such as, for example, Penicillium expansum; Sclerotinia species such as, for example, Sclerotinia sclerotiorum; Verticilium species such as, for example, Verticilium alboatrum; seed- and soil-borne rots and wilts, and seedling diseases, caused by, for example, Fusarium species such as, for example, Fusarium culmorum; Phytophthora species such as, for example, Phytophthora cactorum; Pythium species such as, for example, Pythium ultimum; Rhizoctonia species such as, for example, Rhizoctonia solani; Sclerotium species such as, for example, Sclerotium rolfsii; cankers, galls and witches' broom diseases, caused by, for example, Nectria species such as, for example, Nectria galligena; wilts caused by, for example, Monilinia species such as, for example, Monilinia laxa; deformations of leaves, flowers and fruits, caused by, for example, Taphrina species such as, for example, Taphrina deformans; degenerative diseases of woody species, caused by, for example, Esca species such as, for example, Phaemoniella clamydospora; flower and seed diseases, caused by, for example, Botrytis species such as, for example, Botrytis cinerea; diseases of plant tubers caused by, for example, Rhizoctonia species such as, for example, Rhizoctonia solani; diseases caused by bacterial pathogens such as, for example, Xanthomonas species such as, for example, Xanthomonas campestris pv. oryzae; Pseudomonas species such as, for example, Pseudomonas syringae pv. lachrymans; Erwinia species such as, for example, Erwinia amylovora.
In an especially embodiment of the invention, the yield of the treated plant is increased.
In another embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.
Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall Fresh Weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.
A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.
The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).
Another indicator for the condition of the plant is the "quality" of a plant and/or its products.
In an especially preferred embodiment of the invention, the quality of the treated plant is increased.
In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.
Further embodiment of the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product: increased nutrient content, increased protein content, increased content of fatty acids, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher process ability of the harvested products.
Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means (1.) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fungicidal and insecticidal action which directly destroys the microorganisms or fungi/insects, but rather by a stimulation of the plants' own defensive reactions against said stress factors.
Formulation of the present invention is selected from Suspension concentrate (SC), Suspo-emulsion (SE), Wettable granule/Water dispersible granule (WG/WDG).
Further fungicidal composition comprising a) Compound A 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide or its agrochemically acceptable salts, esters and derivatives; b) Compound B is selected from at least one triazole fungicide from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole. c) Compound C is selected from at least one more insecticide selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron; and d) one or more inactive excipients.
Further embodiment of the present invention relates to the fungicidal composition comprising a) Compound A is 1% to 30% w/w of the composition; b) compound B is 1% to 30% w/w of the composition; and c) Compound C is 0.5% to 30% w/w of the composition.

Compound A Compound B Compound C
Composition 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide Atleast one triazole fungicide At least one or more insecticides
% Ratio (w/w) 1% to 30% w/w 1% to 30% w/w 0.5% to 30% w/w
Further embodiment of the present invention in addition amounts of active ingredients further comprises inactive formulation excipients including but not limited to wetting agents, wetting-spreading-penetrating agent, dispersant or dispersing agent, anti-freezing agent, emulsifying agent, anti-foam agent, preservatives, solvents, co-solvents, preservative, stabilizer, diluent, carriers, suspension aid or suspending agent, thickener, and buffering agent.
Super- wetting- spreading- penetrating agent for the Suspension Concentrate (SC) formulation is selected from trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or mixture thereof is present in the amount of 1% to 5% w/w.
Dispersing agent for the Suspension Concentrate (SC) formulation is selected from Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate. EO/PO based copolymer, Ethylene-propylene oxide block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide or mixture thereof is present in the amount of 0.5% to 20% w/w.
Suspending agent for the Suspension Concentrate (SC) formulation is selected from and not limited to aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or mixture thereof is present in the amount of 0.1% to 5% w/w.
Antifoaming agent for the Suspension Concentrate (SC) formulation is selected from and not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane and a mixture thereof is present in the amount of 0.25% to 2% w/w.
Anti-freezing agent for the Suspension Concentrate (SC) formulation is selected from and not limited to ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate, heptahydrate, sodium chloride and a mixture thereof is present in the amount of 1% to 10 %w/w.
Preservatives for the Suspension Concentrate (SC) formulation is selected from and not limited to 1, 2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1, 3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one and a mixture thereof.
Thickeners for the Suspension Concentrate (SC) formulation is selected from and not limited to xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum and a mixture thereof.
Solvent for the Suspension Concentrate (SC) formulation is selected from aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, alkylated vegetable oil such as methyl soyate, mineral oil, demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, glycerine, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropylether, dioxane, tetrahydrofuran and a mixture thereof.
Dispersing agent for the Water dispersible granules (WG) formulation is selected from Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate, modified Sodium lignosulphonate. EO/PO based copolymer, modified polyacrylate copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and a mixture thereof is present in the amount of 1% to 20% w/w.
Wetting agent for the Water dispersible granules (WG) formulation is selected from ethylene oxide/propylene oxide (EO/PO) block copolymer, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol and a mixture thereof is present in the amount of 1% to 10% w/w.
Antifoaming agent for the Water dispersible granules (WG) formulation is selected from and not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane and a mixture thereof is present in the amount of 0.5 % to 2% w/w.
Carrier for the water dispersible granules (WG) formulation is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers and a mixture thereof .
Emulsifier for the Suspension Emulsion (SE) formulation is selected from castor oil ethoxylate with 36 EO, tristyrylphenol ethoxylate, castor oil ethylene oxide adduct, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, Polyarylphenyl anionic ether sulfate ammonium salt, calcium dodecyl benzenesulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethoxylated alkylamines, octylphenol ethoxylate, ethoxylated alkyl phenols, ethoxylated sorbitol oleates, polyoxyethylene sorbitan monolaurate, Iso-C12 alkyl benzene sulfonate calcium salt (Phenyl sulphonate CA) and a mixture thereof is present in the amount of 0.5 % to 10% w/w.
Solvent for the Suspension Emulsion (SE) formulation is selected from aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, alkylated vegetable oil such as methyl soyate, mineral oil, demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, glycerine, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropylether, dioxane, tetrahydrofuran and a mixture thereof .
Dispersing agent for the Suspension Concentrate (SC) formulation is selected from Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate. EO/PO based copolymer, acrylic graft copolymer , phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, butyl Polyalkylene Oxide block copolymer , tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and a mixture thereof is present in the amount of 1% to 10% w/w.
Antifoaming agent for the Suspension Emulsion (SE) is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, and tallow based fatty acids and a mixture thereof.
Anti-freezing agent for the Suspension Emulsion (SE) is selected from ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, and polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride and a mixture thereof.
Preservatives for the Suspension Emulsion (SE) formulation is selected from and not limited to 1, 2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1, 3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one and a mixture thereof.
Thickeners for the Suspension Emulsion (SE) formulation is selected from and not limited to xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum and a mixture thereof.
The fungicidal composition comprising of a) Compound A 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide or its agro chemically acceptable salts, esters and derivatives present in an amount of 1% to 30% w/w of the composition; b) Compound B is selected from at least one triazole fungicide from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole is present in an amount of 1% to 30% ; and c) insecticide compound C is selected from at least one more insecticide selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron is present in an amount of 0.5% to 30% w/w; d) One or more inactive excipients of the composition shows :
• Synergistic control (grams of active ingredients required less to achieve desired level of control).
• Broad spectrum control of fungal diseases and insect-pests (caterpillars, sucking pests, mites) with one shot application.
• Residual control i.e., longer duration of control with immediate crop protection.
• Delay in development of resistance and effective control of difficult to manage diseases and hard to kill insect-pests.
• Increase in yield of treated plants (vegetables, cereals, pulses, oilseeds, fiber crop, sugar crops, tuber crops, fruit crops, flowers, ornamentals etc.)
• Increase in yield due to protection against diseases and insect-pests.
• Increase in yield due to a greater number of tillers, more branches and sub branches, a greater number of flowers, a greater number of fruits.
• Increase plant vigor.
• Increase tolerance to abiotic stress.

The process for preparing the present novel fungicidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
Example 1: Composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5%+Tolfenpyrad 12.5% SC
Chemical composition content (% w/w)
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 6.25
Difenoconazole a.i. 5.00
Tolfenpyrad a.i. 12.50
Methylated seed oil, polyalkyleneoxide modified trisiloxane (super wetting-spreading-penetrating agent) 3.00
Ethylene-propylene oxide block copolymer (dispersing agent ) 5.00
Sodium naphthalene sulphonate formaldehyde condensates (dispersing agent ) 1.00
Aluminum magnesium silicate (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.30
Sodium benzoate (preservative) 0.20
Polypropylene glycol (anti freezing agent) 5.00
Xanthan gum (thickener) 0.20
Diluent water (solvent) 61.05
Total 100.00
a.i. (active ingredient) on 100% purity basis
Storage Stability: 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5%+Tolfenpyrad 12.5% SC
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 5.94 to 6.875 6.65 6.44 6.65
Difenoconazole a.i. 4.75 to 5.5 5.40 5.32 5.40
Tolfenpyrad a.i. 11.88 to 13.125 13.00 12.85 13.00
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide suspensibility (%) 80 98.70 98.15 98.60
Difenoconazole suspensibility (%) 80 98.60 98.25 98.50
Tolfenpyrad suspensibility (%) 80 98.50 98.20 98.35
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.40 98.10 98.20
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months
Parameters Specification Initial 1 month 6 month 12 month
Fluxapyroxad a.i. 5.94 to 6.875 6.65 6.65 6.58 6.52
Difenoconazole a.i. 4.75 to 5.5 5.40 5.40 5.28 5.24
Tolfenpyrad a.i. 11.88 to 13.125 13.00 13.00 12.86 12.75
Fluxapyroxad suspensibility (%) 80 98.70 98.70 98.60 98.50
Difenoconazole suspensibility (%) 80 98.60 98.60 98.50 98.40
Tolfenpyrad suspensibility (%) 80 98.50 98.50 98.35 98.30
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 nil nil nil nil

The composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5%+Tolfenpyrad 12.5% SC meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).

Procedure: Manufacturing process for 100 kg batch of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5%+Tolfenpyrad 12.5% SC

Step 1: Preparation of 2% Gum Solution: Charge Xanthan gum (2.0 kg) and Sodium benzoate (2.0 kg) into 96.0 kg water and homogenize. It should be made 12-18 hour prior to use.
Step 2: Charge DM water (51.05 kg) and 1, 2-propylene glycol (5 kg) into designated vessel and ix thoroughly.
Step 3: Add Sodium naphthalene sulphonate formaldehyde condensates (1 kg), Ethylene-propylene oxide block copolymer (5 kg) and Aluminum magnesium silicate (0.5 kg) into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Then add 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide technical (6.25 kg), Difenoconazole technical (5 kg) and Tolfenpyrad technical (12.5 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5: Before grinding half the quantity of Polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6: Add remaining Polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7: Finally add 10.0 kg of 2% Xanthum gum solution and 3 kg of Methylated seed oil, polyalkyleneoxide modified trisiloxane to this formulation and homogenized for 30 minutes.
Step 8: Now send this final formulation to QC for quality check.

Example 2: Composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Chlorantraniliprole 10% WG
Chemical composition content (% w/w)
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 15.00
Difenoconazole a.i. 10.00
Chlorantraniliprole a.i. 10.00
Modified Sodium lignosulphonate (dispersing agent ) 7.00
Modified polyacrylate copolymer (dispersing agent) 3.00
Sodium isopropyl naphthalene sulfonate (wetting agent) 5.00
Polydimethylsiloxane (Antifoaming Agent) 1.00
Corn Starch / Lactose monohydrate / Sodium sulphate anhydrous (carrier) 15.00
China clay 34.00
Total 100.00
a.i. (active ingredient) on 100% purity basis

Storage Stability: 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Chlorantraniliprole 10% WG
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 14.25 to 15.75 15.66 15.54 15.65
Difenoconazole a.i. 9.50 to 10.5 10.44 10.32 10.42
Chlorantraniliprole a.i. 9.50 to 10.5 10.45 10.35 10.44
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide suspensibility (%) 70 98.50 97.20 98.10
Difenoconazole suspensibility (%) 70 98.40 97.50 98.30
Chlorantraniliprole suspensibility (%) 70 98.40 97.40 98.20
pH range (1% aq. Suspension) 5 to 9 7.40 7.50 7.40
Wettability Max 30 s 9 11 9
Wet Sieve(45 micron) Mini 98.5% 99.6 99.5 99.6
Bulk Density 0.45-0.85 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.2 1.4
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months
Parameters Specifications Initial 1 month 6 month 12 month
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 14.25 to 15.75 15.66 15.66 15.62 15.54
Difenoconazole a.i. 9.50 to 10.5 10.44 10.43 10.42 10.41
Chlorantraniliprole a.i. 9.50 to 10.5 10.45 10.45 10.43 10.35
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide suspensibility (%) 70 98.50 98.50 97.80 97.10
Difenoconazole suspensibility (%) 70 98.40 98.40 97.60 97.40
Chlorantraniliprole suspensibility (%) 70 98.40 98.40 97.80 97.30
pH range (1% aq. Suspension) 5 to 9 7.40 7.40 7.40 7.50
Wettability Max 30 s 9 9 10 11
Wet Sieve(45 micron) Mini 98.5% 99.6 99.6 99.5 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.4 1.4 1.3
Persistent foam ml (after 1 minute) max. 60 nil nil nil nil

The composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Chlorantraniliprole 10% WG meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Procedure: Manufacturing process for 100 kg batch of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Chlorantraniliprole 10% WG
Step 1: Step 1 Charge the 34 kg China clay, 15.0 kg Corn starch, 0.5 kg silicone antifoam, 5 kg of Sodium isopropyl naphthalene sulfonate, 3 kg Modified polyacrylate copolymer and 7.0 kg of Modified Sodium lignosulphonate blend into a ribbon or premix blender and homogenization for 30 minutes.
Step 2: Now charge 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide technical (15 kg), Difenoconazole technical (10 kg) and Chlorantraniliprole technical (10 kg) and again homogenize for 30 minutes and now this Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 3: Finely grinded powder is mixed with 15 kg of water having 0.5 kg silicone antifoam to form extrudable dough.
Step 4: Dough is passed through extruder to get granules of required size.
Step 5 : Wet granules are passed through Fluidized bed drier to remove 15 kg extra water added and further graded using vibrating screens.
Step 6: Final product is sent for QC approval.
Step 7: After approval material is packed in required pack sizes.

Example 3: Composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Epoxiconazole 6%+Triflumezopyrim 2.5% SE
Chemical composition content (% w/w)
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 7.50
Epoxiconazole a.i. 6.00
Triflumezopyrim a.i. 2.50
Polyarylphenyl anionic ether sulfate, ammonium salt (Emulsifier) 1.50
Aromatic solvent C-9 (solvent ) 15.00
Acrylic graft copolymer (dispersing agent ) 3.00
Butyl Polyalkylene Oxide block copolymer (dispersing agent ) 4.50
Aluminum magnesium silicate (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.20
1,2-benzisothiazolin-3(2H)-one (preservative) 0.15
Polypropylene glycol (anti freezing agent) 5.00
Xanthan gum (thickner) 0.15
Diluent water (solvent) 54.00
Total 100.00
a.i. (active ingredient) on 100% purity basis

Storage stability-3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Epoxiconazole 6%+Triflumezopyrim 2.5% SE

Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 7.13 to 8.25 8.15 8.02 8.14
Epoxiconazole a.i. 5.70 to 6.6 6.55 6.35 6.55
Triflumezopyrim a.i. 2.38 to 2.75 2.72 2.60 2.72
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide suspensibility (%) 80 97.50 96.00 97.20
Epoxiconazole suspensibility (%) 80 98.20 97.20 97.80
Triflumezopyrim suspensibility (%) 80 98.80 97.00 98.20
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.00 7.10
Pourability (%) 95 98.20 98.20 97.80
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 550 560 560
Particle size (micron) D50<3, D90<10 2.1,8.2 2.2,8.5 2.1,8.2
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months
Parameters Specification Initial 1 month 6 month 12 month
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide a.i. 7.13 to 8.25 8.15 8.15 8.12 8.00
Epoxiconazole a.i. 5.70 to 6.6 6.55 6.55 6.45 6.30
Triflumezopyrim a.i. 2.38 to 2.75 2.72 2.72 2.65 2.60
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide suspensibility (%) 80 97.50 97.50 97.20 96.00
Epoxiconazole suspensibility (%) 80 98.20 98.00 97.60 97.00
Triflumezopyrim suspensibility (%) 80 98.80 98.60 98.20 96.80
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.10 7.10 7.08
Pourability (%) 95 98.20 98.20 98.20 98.20
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 550 550 550 555
Particle size (micron) D50<3, D90<10 2.1,8.2 2.1,8.2 2.1,8.2 2.1,8.2
Persistent foam in ml (after 1 minute) max. 60 nil nil nil nil

The composition of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Epoxiconazole 6%+Triflumezopyrim 2.5% SE meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Procedure: Manufacturing process for 100 kg batch of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Epoxiconazole 6%+Triflumezopyrim 2.5% SE
Step 1: Preparation of 2% Gum solution: Charge Xanthan gum (2 kg) and 1, 2-benzisothiazoline-3-one (2 kg) into 96 kg water and homogenizeand should be made 12-18 hour prior to use. .
Step 2: EC premix-Add 15.0 kg of Aromatic solvent into other vessel having slow stirring. Now add Epoxiconazole technical (6 kg) and 4.5 kg of Butyl Polyalkylene Oxide block copolymer and mix properly for 30-45 minutes
Step 3: Charge 44.0 kg of DM water and 5 kg of 1,2-propylene glycol into designated vessel and mix thoroughly
Step 4: Add 0.5 kg of Aluminum magnesium silicate, 3.0 kg of Acrylic graft copolymer, 1.50 kg of Polyarylphenyl anionic ether sulfate, ammonium salt and 0.10 kg of Polydimethylsiloxane into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 5: Then add 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide technical (7.5 kg) and Triflumezopyrim technical (2.5 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 6: Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 7: Add remaining 0.10 kg of Polydimethyl siloxane antifoam was added after grinding process completes and before sampling for in process analysis.

Step 8: Now mix EC premix to this milled slurry under slow stirring and homogenize for 30-45 minutes
Step 9: Finally add 7.5 kg of 2% gum solution to this formulation and send to QC for quality check.

Biological Examples:
The pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) or tank mix of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:

The objective of the present studies was to study the synergism and benefits. The various compositions comprising 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide, at least one triazole fungicide and one more insecticide were evaluated on various crops.

Example 1: Synergistic action of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide+triazole fungicide+tolfenpyrad.
Crop : Chilli
Location : Umreth, Gujarat
Number of Treatments: 22
Plot size : 6 m x 5 m
Crop stage : 75 days after transplanting.
Method of application: foliar spray with battery operated backpack sprayer
Water volume : 430 liter per hectare
Observation Methods:
Powdery mildew (caused by Leveillula Taurica):
The severity of powdery mildew was scored at 10 days after spray. The disease severity of powdery mildew was recorded on 10 plants and 10 leaves on lower, middle and upper leaves by using 0-9 disease rating scale and expressed as Percent Disease Index (PDI).


Powdery mildew of chilli disease rating scale:

Score Description
0 No symptoms of powdery mildew
1 Small scattered powdery mildew specks covering 1% or less leaf area
3 Small powdery lesions covering 1-10% of leaf area
5 Powdery lesions enlarged covering 11-25% of leaf area
7 Powdery lesions coalesce to form big patches covering 26-50% of leaf area
9 Big powdery patches covering 51% or more of leaf area and defoliation

Thrips (Scirtothrips dorsalis): Count the number of live thrips by shaking the twigs on black piece of paper. Record the observations from 3 twigs per plant and 10 plants per plot on 7th DAA (days after application). Calculate thrips control (%) as observed control and apply Colby’s formula to calculate synergism.

Fruit count: Count the number of healthy fruits per plant. Record the observations from 10 plants per plot and calculate increase (%) in healthy fruits over UTC (untreated check).
Crop vigor: Crop vigor recorded by visual observation considering rapid growth, plant canopy, leaf and fruit color, number of branches, flowers, fruits, leaves. Crop vigour rating given from 1 to 10 scale, 1 means normal poor growth with stunted plants with less number of leaves, flowers, fruits, branches, whereas 10 means excellent vigor with very large plant canopy, higher number of leaves, flowers, fruits, branches.

Table 1: Treatment details
S. No. Treatments gram actives per hectare
T1 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5%+Tolfenpyrad 12.5% SC 37.5+30+75
T2 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Prothioconazole 5%+Tolfenpyrad 12.5% WG 37.5+30+75
T3 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 5%+Tebuconazole 10%+Tolfenpyrad 10% EC 30+60+60
T4 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 5%+Propiconazole 10%+Tolfenpyrad 10% EC 30+60+60
T5 Difenoconazole 5%+Tolfenpyrad 12.5% SC 30+75
T6 Prothioconazole 5%+Tolfenpyrad 12.5% WG 30+75
T7 Tebuconazole 10%+Tolfenpyrad 10% EC 60+60
T8 Propiconazole 10%+Tolfenpyrad 10% EC 60+60
T9 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Difenoconazole 5% SC 37.5+30+75
T10 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Prothioconazole 5% WG 37.5+30+75
T11 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 5%+Tebuconazole 10% EC 30+60+60
T12 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 5%+Propiconazole 10% EC 30+60+60
T13 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6.25%+Tolfenpyrad 12.5% SC 37.5+30+75
T14 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 5%+Tolfenpyrad 10% EC 30+60+60
T15 fluxpyroxad 33.3% FS 37.5
T16 fluxpyroxad 33.3% FS 30
T17 Tolfenpyrad 15% EC 75
T18 Tolfenpyrad 15% EC 60
T19 difenoconazole 25% EC 30
T20 prothioconazole 25% EC 30
T21 tebuconazole 25% WG 60
T22 propiconazole 25% EC 60
T23 Untreated Check (UTC) -
T1 to T4-present compositions, T5 to T14-binary mixtures.

Table 2: Synergistic control of powdery mildew and Thrips control in chilli crop
S. No. Powdery mildew control (%) Thrips control (%) No. of fruits per plant Crop vigor rating
Observed Expected Colby's ratio Observed Expected Colby's ratio
T1 98.4 88.0 1.12 86.4 79.1 1.09 61.7 8.0
T2 95.2 87.0 1.09 84.2 78.8 1.07 59.5 7.8
T3 93.6 82.9 1.13 80.6 62.8 1.28 60.3 7.6
T4 90.2 81.3 1.11 81.4 63.4 1.28 58.3 7.4
T5 78.4 77.0 1.02 78.4 77.6 1.01 48.4 5.6
T6 76.2 75.1 1.01 78.2 77.4 1.01 47.6 5.0
T7 72.8 71.4 1.02 62.4 61.0 1.02 46.9 4.6
T8 70.0 68.7 1.02 62.2 61.6 1.01 45.3 4.6
T9 74.8 72.2 1.04 15.8 14.3 1.11 43.1 5.2
T10 72.6 69.9 1.04 14.6 13.1 1.11 41.7 5.0
T11 70.0 67.5 1.04 12.4 11.1 1.12 41.4 4.8
T12 68.6 64.4 1.07 13.8 12.4 1.11 39.7 4.2
T13 80.2 77.4 1.04 78.6 77.2 1.02 43.5 4.0
T14 71.2 68.5 1.04 62.4 60.1 1.04 45.3 4.6
T15 47.8 - - 6.4 - - 34.7 3
T16 40.2 - - 4.6 - - 37.3 3.4
T17 56.8 - - 75.6 - - 37.1 3.0
T18 47.4 - - 58.2 - - 40.3 3.4
T19 46.8 - - 8.4 - - 35.6 3.6
T20 42.4 - - 7.2 - - 34.4 3.2
T21 45.6 - - 6.8 - - 35.1 3.0
T22 40.4 - - 8.2 - - 33.2 3.0
T23 0.0 - - 0.0 - - 23.8 2.4

All the present compositions (T1 to T4) provide synergistic control of powdery mildew disease and thrips control as compared to all known binary mixtures (T5 to T14) and market products (T15 to T22). All the present compositions (T1 to T4) show strong synergism (higher the colby’s ratio) with higher crop vigor rating.

Example 2: Synergistic action of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide+triazole fungicide+triflumezopyrim.
Crop : Rice
Location : Rajim, Chhattishgarh
Number of Treatments: 24
Plot size : 7 m x 6 m
Crop stage : 52 days after transplanting.
Method of application: foliar spray with battery operated backpack sprayer
Water volume : 460 liter per hectare
Observation Methods:
Sheath blight (caused by Rhizoctonia solani) control (%):
Observations was recorded on disease severity in each treatment before and at 10 days after spray. The observations of severity of sheath blight disease were recorded using 0-9 grade (SES,IRRI 1996). Twenty randomly selected hills were scored as per scale. The percent disease index (PDI) of plants was calculated by the following formula.


Sheath blight disease grading (0-9 scale):
Grade Symptoms
0 No incidence
1 Less than 1% sheath area infected
3 1-5% sheath area infected
5 6-25% sheath area infected
7 26-50% sheath area infected
9 51-100% sheath area infected

Brown Plant Hopper (BPH) control:
Count the number of live hoppers per hill, record observations from 20 hills per plot. Calculate mean number of BPH per hill and percent control.

Productive tiller: Count the number of productive tillers from 1 sq.m. Spot, record observations from 10 spots per plot before harvesting and calculate mean number of productive tillers per 1 sq.m.

Table 3: Treatment details
S. No. Treatments gram actives per hectare
T1 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl) pyrazole-4-carboxamide 6%+Tebuconazole 10%+Triflumezopyrim 2.5% SC 60+100+25
T2 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Propiconazole 10%+Triflumezopyrim 2.5% SE 60+100+25
T3 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Difenoconazole 6%+Triflumezopyrim 2.5% SC 60+60+25
T4 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Epoxiconazole 7.5%+Triflumezopyrim 2.5% SE 60+75+25
T5 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Prothioconazole 7.5%+Triflumezopyrim 2.5% SE 60+75+25
T6 Tebuconazole 10%+Triflumezopyrim 2.5% SC 100+25
T7 Propiconazole 10%+Triflumezopyrim 2.5% SE 100+25
T8 Difenoconazole 6%+Triflumezopyrim 2.5% SC 60+25
T9 Epoxiconazole 7.5%+Triflumezopyrim 2.5% SE 75+25
T10 Prothioconazole 7.5%+Triflumezopyrim 2.5% SE 75+25
T11 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Tebuconazole 10% SC 60+100
T12 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Propiconazole 10% SE 60+100
T13 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Difenoconazole 6% SC 60+60
T14 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Epoxiconazole 7.5% SE 60+75
T15 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 6%+Prothioconazole 7.5% SE 60+75
T16 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 33.33% FS + Triflumezopyrim 10% SC 60+25
T17 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 33.33% FS 60
T18 triflumezopyrim 10% SC 25
T19 tebuconazole 25% EC 100
T20 propiconazole 25% EC 100
T21 difenoconazole 25% EC 60
T22 epoxiconazole 25% EC 75
T23 prothioconazole 25% EC 75
T24 Untreated Check (UTC) -
T1 to T5-present compositions, T6 to T16-binary mixtures

Table 4: Synergistic control of sheath blight disease and Brown plant hopper (BPH) in rice crop
S. No. Sheath blight control (%) BPH control (%) productive tillers
Observed Expected Colby's ratio control observed control expected Colby's ratio
T1 100.0 96.0 1.04 94.6 76.6 1.23 299.5
T2 100.0 95.9 1.04 95.4 76.8 1.24 300.7
T3 100.0 96.0 1.04 95.0 76.7 1.24 301.3
T4 100.0 95.8 1.04 97.4 77.1 1.26 302.7
T5 100.0 95.7 1.05 96.8 77.0 1.26 301.9
T6 71.4 69.6 1.03 77.4 75.4 1.03 267.5
T7 70.8 69.3 1.02 76.2 75.7 1.01 268.1
T8 70.2 69.8 1.01 76.8 75.5 1.02 270.3
T9 70.6 68.4 1.03 77.4 76.0 1.02 267.5
T10 68.8 67.3 1.02 76.8 75.8 1.01 269.8
T11 95.8 95.5 1.00 15.8 14.7 1.07 261.5
T12 96.2 95.5 1.01 16.2 15.5 1.05 260.8
T13 96.0 95.6 1.00 15.6 14.9 1.05 263.4
T14 95.8 95.4 1.00 17.2 16.6 1.04 262.4
T15 96.0 95.2 1.01 17.0 16.0 1.06 262.7
T16 89.4 88.1 1.01 75.4 73.9 1.02 260.5
T17 86.8 - - 4.8 - - 236.7
T18 10.2 - - 72.6 - - 238.4
T19 66.2 - - 10.4 - - 234.7
T20 65.8 - - 11.2 - - 235.9
T21 66.4 - - 10.6 - - 239.2
T22 64.8 - - 12.4 - - 233.4
T23 63.6 - - 11.8 - - 236.5
T24 0.0 - - 0.0 - - 220.8

All the present compositions (T1 to T5) provides synergistic control of sheath blight disease and rice BPH, and also produces higher number of productive tillers as compared to binary mixtures (T6 to T16).

Example 3: Synergistic control of Flower rots disease in marigold.
Crop : Marigold
Location : Umreth, Gujarat
Treatments : 9
Crop age : 67 days after transplanting.
Spray water volume : 420 liter per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Flower rot (Alternaria spp.) incidence (%): Count the number of diseases flower and healthy flowers per plant. Record the observations from 10 plants per plot.
Table 5: Treatment details
S. No. Treatments Dose (g.a.i./hectare)
T1 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Difenoconazole 5%+Fluxametamide 5% EC 60+40+40
T2 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Difenoconazole 5%+Isocycloseram 7.5% SC 60+40+60
T3 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 12%+Difenoconazole 8%+Broflanilide 5% SC 60+40+25
T4 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 33.3% FS 60
T5 difenoconazole 25% EC 40
T6 fluxametamide 10% EC 40
T7 isocycloseram 20% SC 60
T8 broflanilide 30% SC 25
T9 Untreated Check (UTC) -
T1 to T3-present compositions

Table 6: Control of flower rot diseases
S. No. Flower rot disease control (%) Number of flowers per plant Increase (%) in flowers over T9
Observed Expected Colby's ratio
T1 98.4 92.7 1.06 38.5 142.1
T2 98.8 92.4 1.07 38.1 139.6
T3 100.0 92.5 1.08 39.7 149.7
T4 79.4 - - 26.2 64.8
T5 60.2 - - 21.6 35.8
T6 11.2 - - 23.8 49.7
T7 7.8 - - 22.5 41.5
T8 8.4 - - 24.3 52.8
T9 0.0 - - 15.9 0.0

All the present compositions (T1, T2 and T3) provides synergistic control of flower rot disease and produces higher number of healthy flowers per plant.

Example 5: Synergistic control of early blight disease in tomato crop.
Crop : Tomato
Location : Rajnandgaon, Chhattisgarh
Treatments : 9
Crop age : 68 days after transplanting.
Spray water volume : 500 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Early blight (caused by Alternaria solani) control:
The disease severity was recorded on 10 plants and 10 leaves on lower, middle and upper leaves by using 0-9 disease rating scale and expressed as Percent Disease Index (PDI).
Table 7: Synergistic control of tomato early blight disease
Treatments Dose (g.a.i./hectare) Early blight disease control (%)
Observed Expected Colby's ratio
T1-3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Chlorantraniliprole 10% WG 60+40+40 94.8 87.6 1.08
T2-3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 15%+Difenoconazole 10%+Cyantraniliprole 15% WG 60+40+60 95.2 87.8 1.08
T3-3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 7.5%+Difenoconazole 5%+Tetraniliprole 5% SC 60+40+40 91.2 87.5 1.04
T4-3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide 33.3% FS 60 72.8 - -
T5-difenoconazole 25% EC 40 52.8 - -
T6-chlorantraniliprole 35% WG 40 3.6 - -
T7-cyantraniliprole 10% OD 60 5.2 - -
T8-tetraniliprole 20% SC 25 2.4 - -
T9-Untreated Check (UTC) - 0.0 - -

All the present compositions (T1, T2 and T3) provide synergistic control of early blight disease of tomato.

The innovative compositions of 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide+triazole fungicide+ insecticide show synergism in terms of insect-pests and diseases control and also produces more fruits, flowers and grains, increases spectrum of control, reduces number of pesticidal applications under field conditions.
,CLAIMS:I/We Claims:
1. A fungicidal composition comprises;
a. compound A is 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide

or its agrochemically acceptable salts esters and derivatives;
b. compound B is selected from Cyproconazole, Difenoconazole, Diniconazole, Epoxiconazole, Etaconazole, Fenbuconazole, Fluquinconazole, Flusilazole, Frutriafol, Hexaconazole, Imibenconazole, Ipconazole, Mefentrifluconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Prothioconazole, Simconazole, Tebuconazole, Tetraconazole, Triticonazole;
c. compound C is selected from Tolfenpyrad, Fluxametamide, Isocycloseram, Broflanilide, Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Tetraniliprole, Pioxaniliprole, Methoxyfenozide, Chromafenozide, Tebufenozide, Triflumezopyrim, Emamectin benzoate, Indoxacarb, Novaluron;
d. one or more inactive excipients.

2. The fungicidal composition as claimed in claim 1, wherein a) compound A is present in the range of 1% to 30% w/w; b) compound B is present in the range of 1% to 30% w/w; and c) compound C is present in the range of 0.5% to 30% w/w.

3. The fungicidal composition claimed in claim 1, wherein one or more inactive excipients is selected from wetting agents, wetting-spreading-penetrating agent, dispersant or dispersing agent, anti-freezing agent, emulsifying agent, anti-foam agent, preservatives, solvents, co-solvents, preservative, stabilizer, diluent, carriers, suspension aid or suspending agent, thickener, and buffering agent.

4. The fungicidal composition claimed in claim 1, wherein formulations selected from Suspension concentrate (SC), Suspo-emulsion (SE), Wettable granule/Water dispersible granule (WG/WDG).

5. The fungicidal composition claimed in claim 4, wherein the Suspension concentrate(SC) formulation comprises:
a. compound A present in an amount of 1% to 30% w/w;
b. compound B present in an amount of 1% to 30% w/w;
c. compound C present in amount of 0.5 % to 30% w/w;
d. super wetting- spreading-penetrating agent present in an amount of 1% to 5% w/w;
e. dispersing agent present in an amount of 0.5% to 20% w/w;
f. suspending agent present in an amount of 0.1% to 5% w/w;
g. antifoaming agent present in an amount of 0.25% to 2% w/w;
h. anti-freezing agent present in amount of 1% to 10% w/w;

6. The fungicidal composition claimed in claim 5, wherein the Super wetting- spreading-pentrating agent for the Suspension concentrate (SC) formulation is selected from trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or mixture thereof.

7. The fungicidal composition in claim 5, wherein dispersing agent for Suspension Concentrate (SC) formulation is selected from Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate. EO/PO based copolymer, Ethylene-propylene oxide block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide or mixture thereof.

8. The fungicidal composition claimed in claim 5, wherein Suspending agent for Suspension Concentrate (SC) formulation is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or a combination thereof.

9. The fungicidal composition claimed in claim 5, wherein Antifoaming agent is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, and vegetable oil based antifoam, tallow based fatty acids or a combination thereof.

10. The fungicidal composition claimed in claim 5, wherein Anti-freezing agent selected from siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, magnesium stearate or a combination thereof.

11. The fungicidal composition claimed in claim 4, wherein the Water dispersible granules (WG) formulation comprises:
a. compound A present in an amount of 1% to 30% w/w;
b. compound B present in an amount of 1% to 30% w/w;
c. compound C present in amount of 0.5% to 30% w/w;
d. dispersing agent present in an amount of 0.5% to 20% w/w;
e. wetting agent present in an amount of 1% to 10% w/w;
f. antifoaming agent present in an amount of 0.5% to 2% w/w;

12. The fungicidal composition in claim 11, wherein dispersing agent for Water dispersible granules (WG) formulation is selected from Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate, modified Sodium lignosulphonate. EO/PO based copolymer, modified polyacrylate copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and a mixture thereof.

13. The fungicidal composition in claim 11, wherein wetting agent for Water dispersible granules (WG) formulation is selected from ethylene oxide/propylene oxide (EO/PO) block copolymer, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol and a mixture thereof.

14. The fungicidal composition claimed in claim 11, wherein Antifoaming agent for Water dispersible granules (WG) formulation is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, and vegetable oil based antifoam, tallow based fatty acids or a combination thereof.

15. The fungicidal composition claimed in claim 4, wherein the Suspension Emulsion (SE) formulation comprises:
a. compound A present in an amount of 1% to 30% w/w;
b. compound B present in an amount of 1% to 30% w/w;
c. compound C present in amount of 0.5% to 30% w/w;
d. emulsifier present in an amount of 0.5% to 10% w/w;
e. dispersing agent is present in an amount of 1% to 10 % w/w;
f. suspending agent is present in the amount of 0.25% to 2%w/w; and
g. solvent is present in a sufficient amount.

16. The fungicidal composition in claim 15, wherein Emulsifier for Suspension Emulsion (SE) formulation is selected from castor oil ethoxylate with 36 EO, tristyrylphenol ethoxylate, castor oil ethylene oxide adduct, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, Polyarylphenyl anionic ether sulfate ammonium salt, calcium dodecyl benzenesulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethoxylated alkylamines, octylphenol ethoxylate, ethoxylated alkyl phenols, ethoxylated sorbitol oleates, polyoxyethylene sorbitan monolaurate, Iso-C12 alkyl benzene sulfonate calcium salt (Phenyl sulphonate CA) and a mixture thereof.

17. The fungicidal composition in claim 15, wherein Solvent for the present Suspension Emulsion (SE) formulation is selected from aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, alkylated vegetable oil such as methyl soyate, mineral oil, demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, glycerine, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropylether, dioxane, tetrahydrofuran and a mixture thereof.

18. The fungicidal composition in claim 15, wherein Dispersing agent for Suspension Emulsion (SE) formulation is selected Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, and sodium polycarboxylate. EO/PO based copolymer, acrylic graft copolymer , phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, butyl Polyalkylene Oxide block copolymer , tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and a mixture thereof.

19. The fungicidal composition in claim 15, wherein Suspending agent for Suspension Emulsion (SE) formulation is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or a combination thereof.

Dated this 21st of September 2024