DESC:4.DESCRIPTION
Technical Field of the Invention
The invention relates to a Nutraceutical Composition. More particularly, it relates to a 5 herbal extract-infused chocolate formulation for natural menstrual relief.
Background of the Invention
The drawbacks of present medications for menstrual relief include potential side 10 effects, limited efficacy, lack of personalization, and a preference for natural alternatives. These drawbacks create a need for a safer, more effective, and holistic approach to address menstrual-related symptoms. The present invention, an herbal extract-infused chocolate formulation, aims to overcome these disadvantages in the following ways: 15
1.Side Effects: Many pharmaceutical medications used for menstrual relief canhave adverse effects on the body. These side effects may range from milddiscomfort to more severe complications. In contrast, the herbal extract-infusedchocolate formulation utilizes natural herbal extracts known for their safety20 profile and minimal side effects, offering a safer alternative for women seekingrelief without the risks associated with conventional medications.
2.Limited Efficacy: Some medications may not provide satisfactory relief for allsymptoms experienced during menstruation. The herbal extracts used in the25 present invention have been selected based on their historical use and scientificevidence supporting their efficacy in addressing a wide range of menstrualsymptoms. The combination of these standardized herbal extracts in thechocolate formulation offers a comprehensive solution to alleviate multiple
3
symptoms, providing more effective relief compared to single-targeted medications.
3. Lack of Personalization: Conventional medications for menstrual relief often follow a one-size-fits-all approach, without considering the unique needs and 5 variations in symptoms experienced by different women. The herbal extract-infused chocolate formulation allows for a personalized approach as it incorporates a blend of herbal extracts known for their diverse actions on the body. This personalized approach accounts for variations in symptoms and provides a more tailored and effective solution to meet individual needs. 10
4. Preference for Natural Alternatives: Many women are increasingly seeking natural alternatives to pharmaceutical drugs due to concerns about synthetic chemicals and their potential long-term effects. The herbal extract-infused chocolate formulation aligns with this preference by utilizing plant-based 15 extracts known for their holistic and natural properties. It provides a natural and gentle approach to menstrual relief, catering to the growing demand for safer and more sustainable options.
Overall, the present invention overcomes the drawbacks of present medications for 20 menstrual relief by offering a herbal extract-infused chocolate formulation that is safe, effective, personalized, and aligns with the preference for natural alternatives. By combining carefully selected herbal extracts in a palatable chocolate base, the formulation provides a comprehensive solution to address multiple symptoms associated with menstruation, enhancing women's well-being and quality of life during 25 their menstrual cycle.
4
Objectives of the Invention
The objectives of the present invention are as follows:
1. To provide a natural and holistic solution for alleviating multiple symptoms associated with menstruation. 5
2. To develop a herbal extract-infused chocolate formulation that combines the therapeutic benefits of standardized herbal extracts with the enjoyable experience of consuming chocolate.
3. To create a formulation that effectively regulates mood swings and improves emotional well-being during menstruation by targeting dopamine receptors, 10 serotonin receptors, and GABA receptors.
4. To inhibit PROSTAGLANDIN production, maintain estrogen levels, and exhibit anti-inflammatory properties, thereby reducing hot flushes, cramps, and pains associated with menstruation.
5. To enhance the bioavailability and absorption of active compounds through the 15 synergistic combination of herbal extracts and dark cocoa.
6. To provide a standardized formulation that ensures consistent potency and efficacy across different batches, ensuring reproducible therapeutic effects.
7. To develop a formulation that is convenient, palatable, and compliant, increasing its acceptability among women and promoting adherence to 20 treatment.
8. To offer a natural alternative to traditional medications for menstrual relief, minimizing potential side effects and promoting overall well-being.
9. To provide a comprehensive solution that addresses various menstrual-related symptoms, including mood swings, hot flushes, cramps, and pains, in a single 25 formulation.
10. To improve the quality of life for women during menstruation by offering a safe, effective, and enjoyable method of managing menstrual health.
5
Brief Summary of the Invention
The following presents a simplified summary of the disclosure in order to provide a basic understanding to the reader. This summary is not an extensive overview of the disclosure, and it does not identify key/critical elements of the invention or delineate 5 the scope of the invention. Its sole purpose is to present some concepts disclosed herein in a simplified form as a prelude to the more detailed description that is presented later.
The present invention is an herbal extract-infused chocolate formulation designed to provide natural relief for various symptoms associated with menstruation. It combines 10 a blend of standardized herbal extracts, including Liquorice, Flax seed, Ashoka, Brahmi, Grape seeds, Jatamansi, Onion, and Ginger, with sugar and dark cocoa. The formulation offers a comprehensive solution for alleviating mood swings, hot flushes, cramps, and pains, while maintaining estrogen levels during menstruation.
15
The standardized herbal extracts are obtained through an extraction process using suitable solvents, ensuring the enrichment of target molecules such as Glabridin, Glycyrrhizin, SDG, Matairesinol, Icaiside, Bacopaside I, Bacoside A3, Bacopasaponin C, Resveratrol, Desoxo-narchinol A, Cycloallin, and Gingerols. These herbal extracts exhibit superior binding affinities to target receptors, including dopamine receptors, 20 serotonin receptors, and GABA receptors, regulating mood swings and improving emotional well-being.
Furthermore, the formulation inhibits PROSTAGLANDIN production, exhibits anti-inflammatory properties, and maintains estrogen levels, reducing hot flushes, cramps, 25 and pains associated with menstruation. The herbal extracts and dark cocoa also contribute to the formulation's antioxidant properties, providing additional health benefits and supporting overall well-being.
6
The herbal extract-infused chocolate formulation is prepared by mixing the herbal extract powders with a pre-melted chocolate base, ensuring homogeneity and consistent dosage. The combination of herbal extracts and chocolate synergistically enhances the absorption and bioavailability of the active compounds, allowing for more efficient delivery of the therapeutic benefits. 5
Overall, the invention provides a safe, effective, and natural alternative to traditional medications for menstrual relief. It addresses the limitations of current treatments by offering a personalized approach, minimizing side effects, and aligning with the preference for natural alternatives. The herbal extract-infused chocolate formulation 10 offers women a convenient and enjoyable way to improve their menstrual health, providing comprehensive relief and enhancing their overall well-being.
Further objects, features, and advantages of the invention will be readily apparent from the following description of the preferred embodiments thereof, taken in conjunction 15 with the accompanying drawings.
Brief Description of the Drawings
The invention will be further understood from the following detailed description of a 20 preferred embodiment taken in conjunction with an appended drawing, in which:
Fig. 1 illustrates in silico results docking study results compared with the synthetic marketed drugs in accordance to an exemplary embodiment of the present invention.
25
Detailed Description of the Invention
The use of “including”, “comprising” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as
7
additional items. The terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items. Further, the use of terms “first”, “second”, and “third”, and the like, herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another.
5
The present invention provides an herbal extract-infused chocolate formulation for natural menstrual relief. The formulation comprises a blend of standardized herbal extracts, including Liquorice (Glycyrrhiza glabra), Flax seed (Linum usitatissimum), Ashoka (Saraca asoca), Brahmi (Bacopa monnieri), Grape seeds (Vitis vinifera), Jatamansi (Nardostachys jatamansi), Onion (Allium cepa), and Ginger (Zingiber 10 officinalis), combined with sugar and dark cocoa (Theobroma cacao). This unique blend of herbal extracts and chocolate offers a comprehensive solution for alleviating multiple symptoms associated with menstruation.
Table 1. Formula 15
Ingredients
Percentage
Liquorice (Glycyrrhiza glabra)
6.25
Flax seed (Linum usitatissimum)
2.50
Ashoka (Saraca asoca)
1.25
Brahmi (Bacopa monnieri)
1.50
Grape seeds (Vitis vinifera)
1.00
Jatamansi (Nardostachys jatamansi)
1.88
Onion (Allium cepa)
2.50
Ginger (Zingiber officinalis)
0.63
8
Sugar
15.00
Dark cocoa (Theobroma cacao)
67.50
TOTAL
100.00
The standardized herbal extracts are obtained through an extraction process using suitable solvents for each plant. This ensures the enrichment of target molecules such as Glabridin, Glycyrrhizin, Secoisolariciresinol diglucoside (SDG), Matairesinol, Icaiside, Bacopaside I, Bacoside A3, Bacopasaponin C, Resveratrol, Desoxo-narchinol 5 A, Cycloallin, and Gingerols. The use of specific extraction solvents allows for the extraction of desired compounds from each plant, maximizing their presence in the formulation.
Table 2. List of compounds of interest in the selected plant with appropriate 10 solvent
Plant
Molecule of interest
Extraction solvent
Glycyrrhiza
Glabridin, Glycyrrhizin
Hydro alcoholic
Flax seed
Secoisolariciresinol diglucoside (SDG), Matairesinol
Water
Ashoka
Icaiside
Water
Brahmi
bacopaside I
(Pseudojujubogenin)
bacoside A3
(Ebelin lactone)
Bacopasaponin C
(Bacogenin A1)
Hydroalcoholic
Grapes
Reservetrol
Hydroalcoholic
9
Jatamansi
Desoxo-narchinol A
Alcoholic
Onion
Cyclo allin
Alcoholic
Ginger
Gingerols
Alcoholic
The formulation is prepared by mixing the herbal extract powders obtained from the standardized extracts with a pre-melted chocolate base. This ensures homogeneity and consistent dosage throughout the product. The chocolate base acts as a palatable and convenient delivery system for the herbal extracts, making the formulation enjoyable 5 and easy to consume.
RESULTS:
To evaluate the potential efficacy of the herbal extract-infused chocolate formulation, in silico docking studies were conducted. The docking scores were compared with 10 synthetic marketed drugs, as shown in Table 3.
Molecule target screening and docking score:
Our product “Aparajitha” in silico docking study results compared with the synthetic marketed drugs (Red coloured) 15
Table 3. In silico results
Dopamine receptor
APARAJITA
Jujubogenin
-11.1
Bacopasaponin C
-10.8
Anti-depressants
Venalafexine
-6.9
Escitalopram
-8.3
Serotonin receptor
APARAJITA
Jujubogenin
-11
10
Bacopasaponin C
-10
Anti-depressants
Venalafexine
-7.8
Escitalopram
-8.5
GABA
APARAJITA
Jujubogenin
-9.5
Bacopasaponin C
-10.2
Anti-depressants
Venalafexine
-8.5
Escitalopram
-8.9
COX-2_CRAMPS
APARAJITA
Glabridin
-10.2
Glycyrrhizin
-12.2
SDG
-9.5
Bacopasaponin C
-11.1
NSAIDS
Ibuprofen
-7.6
Asprin
-6.9
Referring to Fig’s, Figure 1 shows a graphical representation of the molecular docking results obtained from the in silico studies. It illustrates the binding of herbal extracts to their respective target receptors. The receptors are depicted as three-dimensional 5 protein structures, and the herbal extracts are represented as colored molecules. The docking scores are indicated by the strength of the binding interactions between the herbal extracts and the receptors.
11
The in silico docking studies provide valuable insights into the potential mechanisms of action of the herbal extract-infused chocolate formulation. The results indicate that the herbal extracts in the formulation demonstrate favorable docking scores, comparable to or better than the synthetic marketed drugs.
5
The docking scores demonstrate the affinity of the herbal extracts for specific target receptors involved in regulating mood swings, serotonin levels, GABA activity, and prostaglandin production. The herbal extracts in the formulation, such as APARAJITA and Bacopasaponin C, exhibit strong binding affinities to the dopamine receptors, serotonin receptors, and GABA receptors. This suggests the potential of the 10 formulation to regulate mood swings, improve emotional well-being, and alleviate associated symptoms during menstruation.
Furthermore, the herbal extracts, including Glabridin, Glycyrrhizin, and Bacopasaponin C, show significant binding interactions with the COX-2_CRAMPS 15 receptor. This indicates their potential to inhibit prostaglandin production, maintain estrogen levels, and exhibit anti-inflammatory properties, thereby reducing hot flushes, cramps, and pains associated with menstruation.
The combination of herbal extracts and chocolate in the formulation synergistically 20 enhances the absorption and bioavailability of the active compounds, allowing for more efficient delivery of the therapeutic benefits. Additionally, the presence of the herbal extracts and the dark cocoa contributes to the formulation's antioxidant properties, providing additional health benefits and supporting overall well-being.
25
Advantages of the present invention:
1. Natural Alternative: Aparajita offers a natural alternative to pain medications, anti-depressants, and estradiol for women with menstrual-related symptoms. It
12
provides a holistic approach to menstrual health by harnessing the power of herbal extracts.
2. Reduced Dependence on Allopathic Medications: By incorporating a unique blend of herbal extracts with proven clinical efficacy, Aparajita reduces the 5 dependence on allopathic medications. This helps minimize the potential side effects associated with conventional pharmaceuticals.
3. Comprehensive Solution: Aparajita provides a multi-purpose solution for menstrual health. It addresses various symptoms such as mood swings, hot 10 flushes, cramps, and pains, offering comprehensive relief during the menstrual cycle.
4. Estrogen Level Maintenance: Aparajita supports hormonal balance by maintaining estrogen levels. This contributes to overall menstrual well-being 15 and helps alleviate related symptoms.
5. Enjoyable and Convenient: Aparajita satisfies women's chocolate cravings during their periods while delivering the natural benefits of the herbal extracts. It combines the pleasure of indulging in chocolate with the therapeutic 20 properties of the herbal blend, making it a convenient and enjoyable way to improve menstrual health.
In summary, Aparajita stands out as a natural and effective solution for women seeking relief from menstrual-related symptoms. By offering a holistic approach, reducing the 25 reliance on allopathic medications, and providing comprehensive benefits, it aims to enhance the well-being and quality of life during the menstrual cycle.
13
In conclusion, the herbal extract-infused chocolate formulation presented in this invention offers a natural and comprehensive solution for menstrual relief. The standardized herbal extracts, combined with the palatable chocolate base, provide a convenient and enjoyable delivery system for the active compounds. The in silico docking results suggest the potential of the formulation to regulate mood swings, 5 improve emotional well-being, inhibit prostaglandin production, and alleviate various symptoms associated with menstruation. These findings pave the way for further studies and potential applications of the herbal extract-infused chocolate formulation in the field of women's health and wellness.
10
15
20
25
14
,CLAIMS:5. CLAIMS
I/We Claim
1. An herbal extract-infused chocolate formulation for natural menstrual relief, comprising:
a blend of standardized herbal extracts including Liquorice (Glycyrrhiza 5 glabra) at 6.25%, Flax seed (Linum usitatissimum) at 2.50%, Ashoka (Saraca asoca) at 1.25%, Brahmi (Bacopa monnieri) at 1.50%, Grape seeds (Vitis vinifera) at 1.00%, Jatamansi (Nardostachys jatamansi) at 1.88%, Onion (Allium cepa) at 2.50%, and Ginger (Zingiber officinalis) at 0.63%, combined with sugar at 15.00% and dark cocoa (Theobroma 10 cacao) at 67.50%, wherein said formulation provides a comprehensive solution for alleviating multiple symptoms associated with menstruation.
2. The herbal extract-infused chocolate formulation of claim 1, wherein the 15 standardized herbal extracts are obtained through an extraction process using suitable solvents for each plant, ensuring the enrichment of target molecules known as Glabridin, Glycyrrhizin, SDG (Secoisolariciresinol diglucoside), Matairesinol, Icaiside, Bacopaside I (Pseudojujubogenin), Bacoside A3 (Ebelin lactone), Bacopasaponin C (Bacogenin A1), Resveratrol, Desoxo-narchinol A, 20 Cycloallin, and Gingerols.
3. The herbal extract-infused chocolate formulation of claim 1, wherein the formulation is prepared by combining the herbal extract powders obtained from the standardized extracts with a pre-melted chocolate base, ensuring 25 homogeneity and consistent dosage throughout the product.
4. The herbal extract-infused chocolate formulation of claim 1, wherein the synergistic blend of herbal extracts exhibits superior binding affinities to target
15
receptors, including dopamine receptors, serotonin receptors, and GABA receptors, thereby regulating mood swings and improving emotional well-being during menstruation.
5. The herbal extract-infused chocolate formulation of claim 1, wherein the herbal 5 extracts inhibit PROSTAGLANDIN production, maintain estrogen levels, and exhibit anti-inflammatory properties, thereby reducing hot flushes, cramps, and pains associated with menstruation.
6. The herbal extract-infused chocolate formulation of claim 1, wherein the herbal 10 extracts undergo a proprietary extraction and enrichment process, enhancing their potency, bioavailability, and therapeutic efficacy for menstrual relief.
7. The herbal extract-infused chocolate formulation of claim 1, wherein the chocolate base acts as a palatable and convenient delivery system for the herbal 15 extracts, ensuring ease of consumption and increasing the acceptability and compliance of the formulation among women.
8. The herbal extract-infused chocolate formulation of claim 1, wherein the combination of herbal extracts and chocolate synergistically enhances the 20 absorption and bioavailability of the active compounds, allowing for more efficient delivery of the therapeutic benefits.
9. The herbal extract-infused chocolate formulation of claim 1, wherein the formulation is standardized based on the concentrations of the herbal extracts, 25 ensuring consistent potency and efficacy across different batches and ensuring reproducible therapeutic effects.
16
10.The herbal extract-infused chocolate formulation of claim 1, wherein thepresence of the herbal extracts and the dark cocoa contribute to theformulation's antioxidant properties, providing additional health benefits andsupporting overall well-being.
5
6.DATE AND SIGNATURE
Dated this 5th day of August 2024
Signature
10
(Mr. Srinivas Maddipati)
IN/PA 3124
Agent for applicant
17