DESC:4. DESCRIPTION
Technical Field of the invention
The present invention relates to the field of advanced herbal dermatology More Specifically, a phytosomal gel formulation utilizing plant extracts for improved acne 5 treatment.
Background of the invention
The treatment of acne, a prevalent skin condition, has historically relied on synthetic 10 compounds and conventional formulations. However, these approaches often exhibit limitations in terms of efficacy, potential side effects, and patient compliance. There is a growing demand for alternative and natural solutions that can provide comprehensive and safe acne relief.
15
This invention stems from the need to overcome these limitations and presents a groundbreaking approach in the field of dermatology. By harnessing the synergistic potential of plant extracts known for their antibacterial and anti-inflammatory properties, this phytosomal gel formulation offers a promising avenue for addressing acne-related concerns. 20
The innovative aspect lies in the utilization of phytosomes, which are specialized nano-formulations that enhance the bioavailability of polar plant extracts. Through a meticulously designed process, the active constituents of the chosen plant materials are encapsulated within phytosomes, resulting in improved permeability through lipid 25 membranes. This leads to better absorption of the therapeutic agents, thereby enhancing the overall efficacy of the acne treatment.
3
Moreover, the careful selection of plant extracts, each with its distinct beneficial properties, contributes to a holistic and comprehensive approach to acne relief. The formulation not only targets the microbial aspects but also addresses inflammation and promotes skin health. By encapsulating these extracts within a gel base, the invention ensures controlled and sustained release of the active compounds, prolonging their 5 therapeutic impact.
In essence, this invention represents a significant leap in the advancement of herbal dermatology. It offers a natural and effective solution for individuals seeking a safer and more potent alternative for managing acne. The utilization of phytosomal 10 technology, coupled with the specific selection of plant extracts, paves the way for a new era in acne treatment, catering to both the immediate and long-term needs of individuals dealing with this skin condition.
Brief Summary of the invention 15
The following presents a simplified summary of the disclosure to provide a basic understanding to the reader. This summary is not an extensive overview of the disclosure, and it does not identify key/critical elements of the invention or delineate the scope of the invention. Its sole purpose is to present some concepts disclosed herein 20 in a simplified form as a prelude to the more detailed description that is presented later.
One of the primary objectives of the invention is to develop a phytosomal gel formulation that significantly improves the efficacy of acne treatment. By encapsulating potent plant extracts within phytosomes, the formulation aims to enhance 25 the bioavailability of active compounds, allowing for deeper penetration into the skin and targeting acne-related concerns more effectively.
4
Another objective of the invention is to provide a natural and holistic solution for acne management. By utilizing carefully selected plant extracts with known antibacterial and anti-inflammatory properties, the invention seeks to address multiple aspects of acne, including microbial activity and skin inflammation, while promoting overall skin health. 5
According to an aspect of the present invention, the advanced phytosomal technology to encapsulate plant extracts within lipid complexes. This enhances the permeability of polar plant compounds through lipid membranes, resulting in improved absorption and prolonged release of therapeutic agents. This contributes to the formulation's increased 10 efficacy and sustained impact.
In accordance with the aspect of the present invention, careful selection of specific plant extracts, the formulation offers a comprehensive approach to acne relief. Each chosen extract brings unique properties that collectively address various facets of acne, 15 such as bacterial growth inhibition, inflammation reduction, and overall skin rejuvenation. The comprehensive strategy sets the invention apart from traditional acne treatments.
Further objects, features, and advantages of the invention will be readily apparent from 20 the following description of the preferred embodiments thereof, taken in conjunction with the accompanying drawings.
Detailed Description of the invention
25
It is to be understood that the present disclosure is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the drawings. The present disclosure is capable of other embodiments and of being practiced or of being carried out in various ways. In
5
addition, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting.
The use of “including”, “comprising” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as 5 additional items. The terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items.
The present invention pertains to a groundbreaking phytosomal gel formulation designed to provide comprehensive relief from acne. Acne, a prevalent skin condition 10 characterized by inflammation, bacterial overgrowth, and sebum production, often presents challenges in conventional treatment approaches. This invention represents a novel and advanced solution that harnesses the therapeutic potential of plant extracts using state-of-the-art drug delivery strategies.
15
Phytosomal Technology:
Central to this invention is the utilization of phytosomal technology, a cutting-edge drug delivery method. Phytosomes are lipid-based complexes formed by the interaction of plant extracts with compatible lipid materials. In this formulation, the chosen plant extracts are carefully encapsulated within phytosomes to enhance their bioavailability 20 and permeability. This technology addresses the challenge posed by the polarity of active compounds, which often hinders their efficient penetration through the lipid-rich skin barrier
Plant Material Selection and Extraction: 25
The invention incorporates a strategic selection of plant materials renowned for their antibacterial, anti-inflammatory, and skin-soothing properties. The selected plant materials, including achyranthes aspera, amaranthus spinosus, pomegranate, Green tea, and others, undergo a meticulous extraction process. The plants are shade-dried,
6
powdered, and subjected to soxhlet extraction using ethanol. The resulting extracts are then processed to remove solvent residue under vacuum, yielding concentrated and potent plant extracts.
Formulation Development: 5
The invention's formulation development involves the creation of phytosomes by combining the concentrated plant extracts with compatible lipid material, such as Soya lecithin and cholesterol. Various ratios of plant extracts and lipid material are explored to optimize the phytosomal formulation. The resulting phytosome complexes are obtained through a carefully orchestrated process involving solvent evaporation, 10 refluxing, and sonication. These thin-film phytosome complexes are then dried and sieved to achieve a stable powder form.
S. No.
Contents
1.
Carbopol 934
2.
Propylene glycol
3.
Polyethylene glycol
4.
Distilled water
Gel Formulation: 15
The optimized phytosome complexes are integrated into a gel base to create a user-friendly and effective topical application. The gel base consists of Carbopol 934, which acts as a gelling agent, and additional components such as propylene glycol and polyethylene glycol for humectant and skin-conditioning effects. The incorporation of phytosomes into the gel base is achieved through thorough mechanical stirring to 20 ensure uniform dispersion and consistency.
7
S. No.
Plant extracts
Part used
1.
Achyranthes aspera
Aerial parts extract
2.
Amaranthus spinosus
Aerial parts extract
3.
Alternanthera ficoidea
Aerial parts extract
4.
Pupalia lappacea
Aerial parts extract
5.
Areca catechu
Seeds extract
6.
Terminalia chebula
Fruit extract
7.
Camellia sinensis extract
Leaves extract
8.
Punica granatum
Fruit peel extract
9.
Berberis aristata
Root extract
10.
Curcuma longa
Rhizome essential oil
Comprehensive Acne Relief:
The resulting phytosomal gel formulation represents a breakthrough in acne treatment. The encapsulated plant extracts with enhanced bioavailability enable deeper penetration into the skin layers, targeting microbial growth and inflammation. The 5 holistic approach of using multiple plant extracts addresses various aspects of acne, including bacterial inhibition, reduction of skin redness, and promotion of skin health.
In conclusion, the invention's phytosomal gel formulation introduces an innovative and advanced approach to acne relief. By combining the benefits of phytosomal technology 10 with carefully selected plant extracts, the formulation offers enhanced bioavailability, sustained release, and comprehensive acne management.
15
8
,CLAIMS:5. Claims
We claim,
1. A phytosomal gel composition for acne relief, comprising;
a. a lipid-based phytosome complex encapsulateplant extracts obtained from a group consisting of: 5
aspera, amaranthus spinosus, alternanthera ficoidea, pupalia lappacea, areca catechu, terminalia chebula, pomegranate, green tea, and berberis aristata;
b. a gel base comprising Carbopol 934, propylene glycol, polyethylene glycol, and water; 10
c. wherein said lipid-based phytosome complex is dispersed uniformly within said gel base, providing enhanced bioavailability and targeted delivery of active compounds for comprehensive acne relief.
2. A method of preparing a phytosomal gel composition for acne relief, 15 comprising the steps of:
a. obtaining plant extracts from a group consisting of Achyranthes aspera, Amaranthus spinosus, Alternanthera ficoidea, Pupalia lappacea, Areca catechu, Terminalia chebula, Pomegranate, green tea, and Berberis aristata;
b. formulating a lipid-based phytosome complex by encapsulating said plant 20 extracts within lipid material using solvent evaporation, refluxing, and sonication;
c. integrating said lipid-based phytosome complex into a gel base comprising Carbopol 934, propylene glycol, polyethylene glycol, and water;
d. stirring said lipid-based phytosome complex into said gel base to achieve a 25 uniform dispersion, thereby creating a phytosomal gel composition suitable for topical application.
9
3. The method as claimed in claim 2, wherein the plant extracts are obtained through a process of shade drying, powdering, and subjecting to soxhlet extraction using ethanol.
4. The method as claimed in claim 2, wherein the lipid-based phytosome complex is 5 prepared by reacting the plant extracts with soy lecithin and cholesterol in various proportions, followed by solvent evaporation, refluxing, and sonication.
5. The method as claimed in claim 2, wherein the gel base comprises Carbopol 934 as a gelling agent, propylene glycol and polyethylene glycol as humectants and skin 10 conditioners, and water to achieve a stable and consistent phytosomal gel composition.
6. The method as claimed in claim 2, wherein the stirring of the lipid-based phytosome complex into the gel base is performed using a mechanical stirrer to ensure 15 thorough dispersion and uniform consistency of the phytosomal gel composition.
7. The method as claimed in claim 2, further comprising the step of drying the phytosomal gel composition under controlled conditions to attain stability and suitable texture for topical application. 20
8. The method as claimed in claim 2, wherein the phytosomal gel composition is packaged in a light-resistant amber-colored glass container and flushed with nitrogen to preserve its stability during storage.
25
9. The method as claimed in claim 2, wherein the topical application of the phytosomal gel composition involves gently massaging it onto the acne-affected skin until absorbed, allowing the encapsulated plant extracts to provide sustained and targeted relief.
30
10
6. DATE AND SIGNATURE
Dated this 05th day of August, 2023 Signature
5
(Mr. Srinivas Maddipati)
IN/PA 3124
Agent for Applicant
11