DESC:DESCRIPTION:
Field of the invention:
[0001] The present disclosure generally relates to the technical field of biotechnology and tissue engineering, and in specific relates to biodegradable scaffolds with exceptional biocompatibility, sustainability, and versatility for tissue regeneration.
Background of the invention:
[0002] Traditionally, synthetic materials such as polylactic acid (PLA) and polyglycolic acid (PGA) have been the most widely used materials for tissue engineering scaffolds. These materials are biocompatible, meaning that they do not cause an adverse reaction in the body. However, they are also primarily derived from petrochemical sources, which raises concerns about their sustainability. Additionally, the degradation byproducts of these materials can elicit undesirable tissue responses, such as inflammation.
[0003] Petrochemical resources are non-renewable and their extraction and processing can be harmful to the environment. For example, the production of PLA and PGA requires the use of fossil fuels and generates greenhouse gases. Additionally, these materials are often difficult to recycle and can end up in landfills, where they can take hundreds of years to decompose. PLA and PGA degrade into lactic acid and glycolic acid, respectively. These acids are generally considered to be safe, but they can cause inflammation and other tissue damage if they are released in high concentrations. This is especially a concern for people with sensitive immune systems or pre-existing medical conditions.
[0004] In addition to the sustainability and biocompatibility concerns, synthetic materials often have other limitations that make them less than ideal for tissue engineering applications. For example, they can be difficult to process into complex shapes and architectures. Additionally, they may not provide the same level of mechanical support and bioactivity as natural materials.
[0005] Most biodegradable scaffolds currently used are made from synthetic polymers derived from petrochemical resources, which are non-renewable and environmentally harmful. This lack of sustainability is not in line with current eco-friendly trends. Additionally, some synthetic materials used in previous scaffolds can cause immune responses or adverse reactions when implanted in the human body, limiting their suitability for certain medical applications. Natural fiber-based scaffolds are often weaker than synthetic scaffolds, making them unsuitable for load-bearing applications or tissues that need strong support.
[0006] Additionally, manufacturing and scaling up production of existing biodegradable scaffolds can be difficult and expensive, which limits their use in healthcare and other industries. The degradation by-products of some existing synthetic materials can be harmful to the environment, and these materials may have limited versatility, making them less adaptable for various tissue engineering applications. This restricts their potential use in a wide range of medical treatments.
[0007] Therefore, there is a need for biodegradable scaffolds with exceptional biocompatibility, sustainability, and versatility for tissue regeneration. A biodegradable scaffold is also needed that promotes tissue integration and minimizes the risk of immune responses or adverse reactions, hence the biodegradable scaffolds exhibits biocompatibility. There is also need for a hemp fiber based scaffold that exhibits high strength and durability. There is also a need for a scaffold that is adaptable to various tissue engineering applications, from bone and cartilage regeneration to wound healing and organ replacement.
Objectives of the invention:
[0008] The primary objective of the invention is to develop biodegradable scaffolds with exceptional biocompatibility, sustainability, and versatility for tissue regeneration.
[0009] The other objective of the invention is to provide biodegradable scaffolds that promotes tissue integration and minimizes the risk of immune responses or adverse reactions, hence the biodegradable scaffolds exhibits biocompatibility.
[0010] Another objective of the invention is to develop a hemp fibers based scaffold that provide robust support structures for cell and tissue growth, enabling the regeneration of functional and resilient tissues, hence have high strength and durability.
[0011] The other objective of the invention is to develop fibre based biodegradable scaffolds that is a rapidly renewable and eco-friendly resource, aligning with sustainability goals in healthcare and materials science.
[0012] Yet another objective of the invention is to provide a manufacturing process that is scalable, making hemp fibers based scaffolds cost-effective and accessible for widespread use.
[0013] Further objective of the invention is to provide a scaffold that is adaptable to various tissue engineering applications, from bone and cartilage regeneration to wound healing and organ replacement.
Summary of the invention:
[0014] The present disclosure proposes a method for producing a fibre based biodegradable scaffold for tissue regeneration. The following presents a simplified summary in order to provide a basic understanding of some aspects of the claimed subject matter. This summary is not an extensive overview. It is not intended to identify key/critical elements or to delineate the scope of the claimed subject matter. Its sole purpose is to present some concepts in a simplified form as a prelude to the more detailed description that is presented later.
[0015] In order to overcome the above deficiencies of the prior art, the present disclosure is to solve the technical problem to provide biodegradable scaffolds with exceptional biocompatibility, sustainability, and versatility for tissue regeneration.
[0016] According to an aspect, the invention provides a method for preparing fibre based biodegradable scaffolds. First, long, high-quality hemp fibers are extracted from harvested hemp stems. Next, the extracted fibers are refined by removing impurities and improving their quality through mechanical and chemical treatments to obtain refined fibers. Next, a scaffold is formed by layering and binding the refined fibers together using biocompatible adhesives or electro-spinning. Later, the scaffold is subjected to rigorous quality control measures to ensure consistency and biocompatibility.
[0017] In one embodiment, the proposed method combines existing techniques for hemp fiber extraction, refinement, and scaffold formation in a unique way. The use of biocompatible adhesives or electro-spinning to bind the fibers together is a novel aspect of the claim. Further, the use of biocompatible adhesives or electro-spinning allows for the creation of scaffolds with a wider range of properties and architectures. Additionally, the rigorous quality control measures ensure that the scaffolds are consistent and biocompatible, making them suitable for use in biomedical applications. Furthermore, the method claim has industrial applicability because it can be used to produce hemp fiber scaffolds for a variety of applications, including tissue engineering, wound healing, and drug delivery.
[0018] Further, objects and advantages of the present invention will be apparent from a study of the following portion of the specification, the claims, and the attached drawings.
Detailed description of drawings:
[0019] The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate an embodiment of the invention, and, together with the description, explain the principles of the invention.
[0020] FIG. 1 illustrates a flow chart for a method for preparing fibre based biodegradable scaffolds, in accordance to an exemplary embodiment of the invention.
Detailed invention disclosure:
[0021] Various embodiments of the present invention will be described in reference to the accompanying drawings. Wherever possible, same or similar reference numerals are used in the drawings and the description to refer to the same or like parts or steps.
[0022] The present disclosure has been made with a view towards solving the problem with the prior art described above, and it is an object of the present invention to provide biodegradable scaffolds with exceptional biocompatibility, sustainability, and versatility for tissue regeneration.
[0023] According to an exemplary embodiment of the invention, FIG. 1 refers to a flow chart 100 for a method for preparing fibre based biodegradable scaffolds. At step 102, long, high-quality hemp fibers are extracted from harvested hemp stems. At step 104, the extracted hemp fibers are refined by removing impurities and improving their quality through mechanical and chemical treatments to obtain refined fibers. In specific, hemp fibers are extracted and refined using mechanical and chemical processes to produce high-quality hemp fibers.
[0024] At step 106, a scaffold is formed by layering and binding the refined fibers together using biocompatible adhesives or electro-spinning. At step 108, the scaffold is subjected to rigorous quality control measures to ensure consistency and biocompatibility. In specific, the refined fibers are then used to construct a porous three-dimensional scaffold that mimics the natural extracellular matrix. When the scaffold is implanted in a body, the scaffold provides a framework for cells to adhere, proliferate, and differentiate, promoting tissue growth.
[0025] In one embodiment, the proposed method combines existing techniques for hemp fiber extraction, refinement, and scaffold formation in a unique way. The use of biocompatible adhesives or electro-spinning to bind the fibers together is a novel aspect of the claim. Further, the use of biocompatible adhesives or electro-spinning allows for the creation of scaffolds with a wider range of properties and architectures. Additionally, the rigorous quality control measures ensure that the scaffolds are consistent and biocompatible, making them suitable for use in biomedical applications. Furthermore, the method claim has industrial applicability because it can be used to produce hemp fiber scaffolds for a variety of applications, including tissue engineering, wound healing, and drug delivery. In one embodiment, the scaffold is designed with a porous structure to facilitate nutrient exchange and cell migration. The scaffold is constructed using layers of hemp fibers bound together to create a robust yet biodegradable framework.
[0026] In one embodiment, the hemp fiber-based scaffolds represent a significant advancement in the field of tissue engineering. The hemp fiber-based scaffolds offer a number of advantages over traditional synthetic materials, including sustainability, biocompatibility, strength, durability, scalability, and versatility. Hemp fiber-based scaffolds have the potential to revolutionize the way to repair and regenerate damaged tissues.
[0027] The hemp fiber-based scaffolds are made of hemp. Hemp is a rapidly renewable and sustainable resource, addressing the limitations of non-renewable petrochemical-based materials and aligning with eco-conscious objectives. Hemp fibers have demonstrated remarkable biocompatibility, reducing the risk of immune responses or adverse reactions, overcoming concerns associated with some existing materials. Hemp fibers are renowned for their strength and durability, making the hemp fiber-based scaffold suitable for load-bearing applications and a wide range of tissue types, addressing the mechanical strength limitations of other natural fiber-based scaffolds. Hemp cultivation and processing are well-established and scalable industries, offering a cost-effective and readily available source material for scaffold production, addressing manufacturing challenges faced by existing materials. Hemp fibers naturally biodegrade, and their by-products have a lower environmental impact compared to some synthetic materials, minimizing concerns related to environmental consequences.
[0028] The hemp fiber-based scaffold is versatile and adaptable for various tissue engineering applications, from bone and cartilage regeneration to wound healing. Hemp fiber-based scaffolds can be tailored to meet the specific needs of different tissue engineering applications. For example, the pore size and architecture of the scaffold can be controlled to promote the growth of specific cell types. The hemp fiber-based scaffolds are relatively inexpensive to produce, making them a cost-effective option for tissue engineering applications.
[0029] In another embodiment, the scaffold has a porous three-dimensional structure of a natural extracellular matrix, promoting cell adhesion, proliferation, and differentiation. The biocompatible adhesives comprise at least one of fibrin, collagen, or chitosan, or hyaluronic acid, or biodegradable synthetic polymers. The electro-spinning utilizes a solution of the refined hemp fibers dissolved in a biocompatible solvent.
[0030] Numerous advantages of the present disclosure may be apparent from the discussion above. In accordance with the present disclosure, biodegradable scaffolds is disclosed with exceptional biocompatibility, sustainability, and versatility for tissue regeneration.
[0031] The proposed biodegradable scaffolds promotes tissue integration and minimizes the risk of immune responses or adverse reactions, hence the biodegradable scaffolds exhibits biocompatibility. The proposed hemp fibers based scaffold provides robust support structures for cell and tissue growth, enabling the regeneration of functional and resilient tissues, hence have high strength and durability. The proposed fibre based biodegradable scaffolds is a rapidly renewable and eco-friendly resource, aligning with sustainability goals in healthcare and materials science. The proposed manufacturing process is scalable, making hemp fibers based scaffolds cost-effective and accessible for widespread use. The proposed scaffold is adaptable to various tissue engineering applications, from bone and cartilage regeneration to wound healing and organ replacement.
[0032] The hemp fiber-based scaffolds represent a significant technical advancement in tissue engineering by introducing hemp fibers as the core material. The hemp fiber-based scaffolds reduces reliance on petrochemical-based materials and also aligns with global sustainability goals. The hemp fiber-based scaffold is an eco-friendly alternative, addressing the pressing need for environmentally responsible healthcare solutions.
[0033] The hemp fiber-based scaffolds’ superior biocompatibility sets it apart from existing materials. The hemp fiber-based scaffolds have compatibility with the human body reduces the risk of adverse reactions, immune responses, or rejection, making it a safer and more reliable choice for a wide range of tissue engineering applications. The hemp fiber-based scaffold is both versatile and scalable. The hemp fiber-based scaffold’s adaptability for various tissue types and the scalability of hemp cultivation and processing contribute to its economic significance. The hemp fiber-based scaffold offers cost-effective solutions for tissue regeneration, potentially reducing medical expenses and enhancing patient outcomes.
[0034] Hemp fibers inherent strength and durability provide a technical advantage, enabling the scaffold to support load-bearing applications effectively. This robustness expands its potential use in diverse medical treatments, contributing to its technical advancement. The use of hemp fibers as a sustainable and scalable source material can lead to reduced manufacturing costs compared to some synthetic alternatives. This economic advantage makes the Hemp Fusion scaffold an attractive choice for healthcare providers and industries seeking cost-effective solutions.
[0035] It will readily be apparent that numerous modifications and alterations can be made to the processes described in the foregoing examples without departing from the principles underlying the invention, and all such modifications and alterations are intended to be embraced by this application.
,CLAIMS:CLAIMS
I/We claim
1. A method for producing a fibre based biodegradable scaffold for tissue regeneration, comprising:
extracting long, high-quality hemp fibers from harvested hemp stems;
refining the extracted hemp fibers by removing impurities and improving quality of the extracted hemp fibers through mechanical and chemical treatments, thereby obtaining refined fibers;
forming a fibre based biodegradable scaffold by layering and binding the refined fibers together using biocompatible adhesives or electro-spinning; and
subjecting the formed fibre based biodegradable scaffold to rigorous quality control measures to ensure consistency and biocompatibility,
whereby, the fibre based biodegradable scaffold is used in tissue regeneration applications, such as bone regeneration, skin regeneration, or cartilage repair.
2. The method as claimed in claim 1, wherein the scaffold has a porous three-dimensional structure of a natural extracellular matrix, promoting cell adhesion, proliferation, and differentiation.
3. The method as claimed in claim 1, wherein the biocompatible adhesives comprise at least one of fibrin, collagen, or chitosan, or hyaluronic acid, or biodegradable synthetic polymers.
4. The method as claimed in claim 1, wherein the electro-spinning utilizes a solution of the refined hemp fibers dissolved in a biocompatible solvent.