DESC:FORM 2
THE PATENTS ACT 1970
(39 of 1970)
&
The Patents Rules, 2003
COMPLETE SPECIFICATION
(See section 10 and rule 13)
1. TITLE OF THE INVENTION: “A SYNERGISTIC TERNARY INSECTICIDAL COMPOSITION”
2. APPLICANT:
(a) Name : RAJDHANI PETROCHEMICALS PRIVATE LIMITED
(b) Nationality : INDIAN
(c) Address : 6, LALITA COMPLEX, RASALA ROAD, NAVRANGPURA, AHMEDABAD-380009 Gujarat, India
PROVISIONAL
The following specification describes the invention. þCOMPLETE
The following specification particularly describes the invention and the manner in which it is to be performed.

FIELD OF INVENTION
The present invention relates to a synergistic ternary insecticidal composition. More specifically, the present invention relates to an insecticidal composition comprising 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide, (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] pentacosa- 10, 14, 16, 22-tetraene] -2'-one, and at least one compound selected from the group of insecticide; and a process of preparing said composition. The present invention further relates to an insecticidal composition that provides effective and synergistic control on broad spectrum of insect-pests and mites with one shot application by increasing plant vigor and yield of treated plants by providing residual control and increment in tolerance against insect-pets and mites.

BACKGROUND OF THE INVENTION
In recent years due to long-term use of chemical insecticides, insect pests and mites are more and more resistant to insecticides. At the same time, frequent application of insecticides has increased the burden on farmers and increased environmental pollution. In the process of agricultural production, plant diseases and pests damage the roots, stems, leaves and other parts of plants, as well as fruit, seeds, tubers and other reproductive organs, so that the crop yield sharply reduces, and the quality drops seriously. Therefore, a new composition of high-efficiency, low-toxicity and environmental-friendly insecticides has become a mainstream direction in the field of insecticides research.
Further, people often increase the amount of insecticides used to kill pests, resulting in serious insecticides residue and exceeds the standard, causing great harm to human food safety. The reduction in effectiveness of insecticides due to the development of resistance is one of the forces that drives the discovery and development of new insecticides. The challenge of growing enough food to feed the world’s expanding population has driven the need to improve crop yield and quality through the control of a wide range of insect pests.
IN201831025712 patents relates to the combination comprising at least one insecticidal diamide compound, dinotefuran, and at least third insecticidal compound. The said patent application was found to be synergistic in the control of a broad spectrum of insect-pests.
IN201727026472 patent relates to the synergistic insecticidal composition comprising spinosad, abamectin or bifenthrin and at least one selected from a group of insecticides. The said patent is related to a method to prevent, control and/or treat insect infestations in plants and plant parts and/or surrounding.
This above mentioned inventions features with the repeated use of a large number of existing pesticides and the improper application of pesticides by some farmers, there is a relatively large resistance to the existing common pesticides, and the difficulty of chemical control becomes increasingly greater. Long-term use of the same single agent for pest control is highly prone to the insecticidal resistance. Combination of insecticides can greatly delay the production of insecticide resistance, improve control efficiency, expand insecticidal spectrum, and reduce the use of chemicals and environmental pollution. The active ingredients known from the literature have certain disadvantages such as insufficient control efficacy, restriction of its use due to the appearance of drug-resistant insects or pests, phytotoxicity and contamination to plants, or toxicity to human beings, fishes and the like.
In order to overcome and delay the formation and development of plant pest resistance, it is necessary to avoid using the same insecticide, but to rotate or mix it with other insecticide.
Therefore, it is necessary to develop a composition that can solve the problem of resistance of insecticides used alone. Insecticides play an important role in agricultural production and are an important guarantee for high quality and stable yield of crops. The present inventors have surprisingly developed an effective insecticidal combination which ameliorates the aforesaid shortcomings of the prior art.

OBJECT OF THE INVENTION
The principal object of the present invention is to provide an a synergistic ternary insecticidal composition.
Another object of the present invention is to provide a synergistic ternary insecticidal composition comprising bioactive amounts of 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide, (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] pentacosa- 10, 14, 16, 22-tetra ene] -2'-one, at least one insecticide and agrochemically acceptable excipients; and method of preparation thereof.
Further object of the present invention is to provide insecticidal composition demonstrating high efficacy.
Yet another object of the present invention is to provide insecticidal composition for controlling the harmful pests in plants and to provide complete protection to crop plants against insect-pests and mites.
Still another object of the present invention is to provide insecticidal composition which increases yield of treated plants.
Further object of the present invention is to provide insecticidal composition to delay resistance development and effective control of hard to kill and resistant insect-pests and mites.
Yet another object of the present invention is to provide residual control i.e. longer duration of control with immediate crop protection.
Another object of the present invention is to provide a method of preparing a stable and non-phytotoxic formulation which improves overall health, yield and vigor of the treated plant.
Further object of the present invention is to provide insecticidal composition which increase plant vigor, is tolerant against insect-pests and mites and is environmentally safe.

SUMMARY OF THE INVENTION
The present invention provides a synergistic ternary insecticidal composition comprising bioactive amounts of (A) 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide; (B) (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] pentacosa- 10, 14, 16, 22-tetraene] -2'-one; (C) at least one compound selected from the group of insecticides; and agrochemically acceptable excipients.
The formulation for an insecticidal composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Wettable granule/Water dispersible granule (WG/WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).
The process for preparing the present insecticidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
The present invention is formulated to control harmful insect pests and mites in plants demonstrating high efficacy and providing resistance management or to delay resistance development through engaging multiple modes of action. Further, the insecticidal composition is effective on crops which have been rendered tolerant to herbicides or class of herbicides. Moreover, it also showcases its synergistic efficacy on the crops rendering resistant towards harmful insects by genetic engineering methods. Therefore, the insecticidal composition results in an increase in plant tolerance against insect-pests and mites, abiotic stress and improve overall health and vigor of the treated plant making it environment friendly and demonstrating high efficacy.

DETAILED DESCRIPTION OF THE INVENTION
Before explaining the present invention in detail, it is to be understood that the invention is not limited in its application to the details of the parts illustrated. The invention is capable of other embodiments, as described above and of being practiced or carried out in a variety of ways. It is to be understood that the phraseology and terminology employed herein is for the purpose of description and not to limitation. The invention may have various embodiments and they may be performed as described in the following pages of the provisional specification.
The terms and words used in the following description are not limited to the bibliographical meanings, but, are merely used by the inventors to enable a clear and consistent understanding of the invention. Accordingly, it should be apparent to those skilled in the art that the following description of exemplary embodiments of the present invention are provided for illustration purpose only and not for the purpose of limiting the scope of the invention.
It is to be understood that the singular forms "a," "an," and "the" include plural reference unless the context clearly dictates otherwise.
Features that are described and/or illustrated with respect to one embodiment may be used in the same way or in a similar way in one or more other embodiments and/or in combination with or instead of the features of the other embodiments.
It should be emphasized that the term "comprises/comprising" when used in this specification is taken to specify the presence of stated features, steps or components but does not preclude the presence or addition of one or more other features, steps, components or groups thereof.
The term 'plants' as used herein, refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage and fruits. The term "plant" is to be understood as including wild type plants and plants, which have been modified by either conventional breeding, or mutagenesis or genetic engineering, or by a combination thereof.
The term "crop" refers to both, growing and harvested crops.
The term "insects" as used herein, includes all organisms in the class "Insecta."
The term "animal pest" includes arthropods, gastropods, and nematodes. Preferred animal pests according to the invention are arthropods, preferably insects and arachnids, in particular insects. Insects, which are of particular relevance for crops, are typically referred to as crop insect pests.
The term "insecticidal" as used herein, refers to the ability of an insecticide to increase mortality or inhibit growth rate of insects.
To "control" or "controlling" pests means to inhibit, through a toxic effect, the ability of pests to survive, grow, feed, and/or reproduce, or to limit pest related damage or loss in crop plants. To "control" pests may or may not mean killing the pests, although it preferably means killing the pests.
The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased.
"Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals).
"Increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the composition according to the invention.
The present invention provides an insecticidal composition comprising
1. Compound A – 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluorobenzamide,
2. Compound B – (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] penta cosa- 10, 14, 16, 22-tetra ene] -2'-one,
3. Compound C – at least one compound selected from group of insecticides with the following mass percentage of the composition:

Sr. No. Ingredient Concentration range (w/w %)
1. Compound A 1 to 20
2. Compound B 0.5 to 20
3. Compound C 1 to 50

Compound A is Broflanilide, 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl) - 6 - (trifluoromethyl) phenyl] - 2 -fluoro benzamide is a polycyclic, bisamide organohalogen insecticide.

It is mainly focused for controlling vegetable, rice, soyabean, cotton, corn and non-crop Lepidoptera, Coleoptera pests and health pests such as termites, mosquitoes and cockroaches. The agent has a high larvicidal activity against spodopteralitura and is suitable for controlling human, animal and is environmental safety.
Compound B is Abamectin, (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] penta cosa- 10, 14, 16, 22-tetra ene] -2'-one, which act as macrolide antibiotic having unique mechanism of action which can simultaneously stimulate the release of ?-aminobutyric acid, an inhibitory neurotransmitter, which activates chloride channels. It controls motile stages of mites, leaf miners, suckers, colorado beetles, etc on ornamentals, cotton, citrus fruit, pome fruit, nut crops, vegetables, potatoes and other crops. Moreover, acts on multiple targets in pests such as nematodes and arthropods providing broad spectrum high efficiency and low toxic insecticidal activity.

Compound C is a wide-spectrum insecticide effective against a broad spectrum of pests. It is mainly used in the control of lepidopteran pests, thrips, whiteflies, leaf miners, beetles and mites on crops such as fruit trees, vegetables, soybeans, cotton and tea trees and other crops.

Insecticide(s) for Compound C is selected from but not limited to,

C1 bifenthrin, (2-methyl-3-phenylphenyl)methyl (1R,3R)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate,

C2 hexythiazox, (4S,5S)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide,

C3 indoxacarb, methyl (4aS)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate,

C4 lambda cyhalothrin, [(R)-cyano-(3-phenoxyphenyl)methyl] (1S,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate,

C5 fipronil, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile,

C6 etoxazole, 4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole,

C7 chlorfenapyr, 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile,

C8 fenpyroximate, tert-butyl 4-[[(E)-(1,3-dimethyl-5-phenoxypyrazol-4-yl)methylideneamino]oxymethyl]benzoate,

C9 cyenopyrafen, [(E)-2-(4-tert-butylphenyl)-2-cyano-1-(2,4,5-trimethylpyrazol-3-yl)ethenyl] 2,2-dimethylpropanoate,

C10 pyrifluquinazon, 1-acetyl-6-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-3-(pyridin-3-ylmethylamino)-4H-quinazolin-2-one.

C11 afidopyropen, [(1S,2S,5S,6R,7R,9S,10S,18R)-5-(cyclopropane carbonyloxy) -9, 18 - dihydroxy-2,6,10-trimethyl- 16 – oxo – 14 - pyridin-3-yl-11,15 – dioxatetracyclo [8.8.0.02,7.012,17] octadeca – 12 (17), 13-dien-6-yl] methylcyclopropanecarboxylate,

C12 flonicamid, N-(cyanomethyl) - 4- (trifluoromethyl) pyridine – 3 –carboxamide,

C13 emamectin benzoate, (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E ,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12' [(2R,4S,5S,6S) -4-methoxy-5-[(2S,4S,5S,6S)-4-methoxy-6-methyl-5-(methylamino)oxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydro pyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one,

C14 methoxyfenozide, N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide,

C15 novaluron, N-[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoro methoxy)ethoxy] phenyl]carbamoyl]-2,6-difluorobenzamide,

C16 spinosad, (1S,2S,5R,7S,9S,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethyl amino)-6-methyloxan-2-yl]oxy-19-ethyl-4,14-dimethyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9] docosa-3,11-diene-13,21-dione,

C17 acetamiprid, N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methyl ethanimidamide,

C18 clothianidin, 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine,

C19 thiamethoxam, (NE)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene]nitramide,

C20 dinotefuran, 2-methyl-1-nitro-3-(oxolan-3-ylmethyl)guanidine,

C21 fenpropathrin, [cyano-(3-phenoxyphenyl)methyl] 2,2,3,3-tetramethylcyclopropane-1-carboxylate,

C22 phenthoate, ethyl 2-dimethoxyphosphinothioylsulfanyl-2-phenyl acetate,

C23 phosalone, 6-chloro-3-(diethoxyphosphinothioylsulfanylmethyl)-1,3-benzoxazol-2-one,

C24 profenofos, 4-bromo-2-chloro-1-[ethoxy(propylsulfanyl)phosphoryl] oxybenzene,

C25 quinalphos, diethoxy-quinoxalin-2-yloxy-sulfanylidene-?5-phosphane,

The present invention optionally comprises agrochemically acceptable excipients including, but not limited to, dispersing agents, anti-freezing agent, anti-foam agent, wetting agents, suspension aid and carriers, anti-microbial agent, thickener, colorants, quick coating agent or sticking agents (also referred to as “stickers” or “binders”), polymers, disintegrating agent, oil additive, buffering agent, and solvents.
However, those skilled in the art will appreciate that it is possible to utilize additional agrochemically acceptable excipients without departing from the scope of the present invention. The agrochemically acceptable excipients can be in the range from 0.1% to 99% of the total weight of the composition.
The amount of a composition according to the invention to be applied, will depend on various factors, such as the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for example spraying, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic disease control; in case of disease control the type of fungi to be controlled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a skilled agronomist.
The combination of the present invention is formulated in a manner which suits the specific application. The formulation is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension(OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion(SE), Soluble concentrate (SL), Water dispersible granule (WG or WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) for soil application includes controlled release granules (CR), Jambo balls or bags (bags in water soluble pouch).
More particularly, the composition is selected from Oil dispersion (OD), Suspo Emulsion (SE), Suspension Concentrate (SC), Suspo-emulsion (SE), Water Dispersible Granule/ Wettable Granule (WG/WDG), Wettable powder (WP) and a mixed formulation of capsule suspension CS and SC (ZC).
The inactive excipients used in various formulations are as follows:
A. Lists of inactive excipients used in Oil dispersion (OD) formulation:
The Oil Dispersion formulation (OD) of the present invention comprises agrochemically acceptable excipients including, but not limited to, wetting agent(s), wetting-spreading-penetrating agent(s), emulsifying agent(s), dispersing agent(s), stabilizer(s), antifoaming agent(s), antifreezing agent(s), solvent(s), and co-solvent(s).
The wetting agent of OD is selected from, but not limited to, ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyldiphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkylnaphthalene sulfonate or mixture thereof.
The wetting-spreading-penetrating agent of OD is selected from, but not limited to, Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
The emulsifying agent of OD is selected from, but not limited to,castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, polyoxyethylene sorbitan monolaurate or mixture thereof.
The dispersing agent of OD is selected from, but not limited to,alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide or mixture thereof.
The stabilizers of OD is selected from, but not limited to, hectorite clay, aluminium magnesium silicate, bentonite clay, silica, attapulgite clay or mixture thereof.
The antifoaming agent of OD is selected from, but not limited to,silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane or mixture thereof.
The anti-freezing agent of OD is selected from, but not limited to, ethylene glycol, propane diols, glycerine or the urea, glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride or mixture thereof.
The preservative of OD is selected from, but not limited to, 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or mixture thereof.
The solvent of OD is selected from, but not limited to, as solvent for the present formulation is selected from and not limited to vegetable oil (plant, seed or tree) or its alkylated or ethoxylated or esterified. The alkylated vegetable oil may be methylated vegetable oil or ethylated vegetable oil. The vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. The alkyl ester of vegetable oils includes methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils. Some of the examples are methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1-C3 amines, alkylamines or alkanolamines with C6–C18 carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols. The above oil based carrier/diluting agents may be used as solo or mixture of two or more if desired.
The co-solvent of OD is selected from, but not limited to, Cyclohexanone, Acetophenone, NMP, Dimethyl sulfoxide, Benzyl alcohol, Butanol, N-octanol, N-Propanol, 2-ethyl hexanol, Tetrahydro furfuryl alcohol, Isophorone, Fatty acid dimethyl amide, 2-hexylethyl lactate, Propylene carbonate or mixture thereof.
The rheology modifier of OD is selected from, but not limited to bentonite clay.
Manufacturing process for Oil dispersion (OD) formulation:
Part A-Preparation of the liquid premix (OD)
Step 1: The vegetable oil or solvent or both are charged into a vessel with an anchor stirrer.
Step 2: The emulsifier(s) and dispersing agent(s) are added under stirring condition until all the ingredients get completely dissolved.
Part B-Preparation of the slurry (OD)
Step 1: The liquid premix is charged into a second vessel which is equipped with a cooling and heating device of a high shear stirrer.
Step 2: The active ingredients are added and homogenized thoroughly. The mixture is pre-milled and a particle size distribution is achieved by the final milling, practiced along with a bead mill as required by the specification.
Part C-Preparation of the thickener gel (OD)
Step 1: The vegetable/plant/seed oil or solvent is charged to the vessel which is equipped with a high shear stirrer.
Step 2: The thickener(s) is/are gradually added throughout by mixing and maintaining high-shear. The stirring is continued until thoroughly mixed.
Step 3: The thickener activating agent(s) is/are added under stirring condition. Further, the gel is allowed to get swell whilst maintaining the mixing.
Part D-Preparation of the final formulation (OD)
Step 1: The thickener gel is added and the mixture is dispersed by using a high shear stirrer.
Step 2: The recommended wetting and spreading agent(s) or adjuvant(s) (silicone or non-silicone based) are finally added to this formulation and dispersed by using high shear stirrer.
Step 3: The finished formulation is checked with specification.
Step 4: The material is packed in its required package sizes when approved.
B. Lists of inactive excipients used in Suspension Concentrate (SC) formulation:
The Suspension Concentrate formulation (SC) of the present invention comprises agrochemically acceptable excipients including, but not limited to, wetting agent(s), wetting-spreading-penetrating agent(s), dispersing agent(s), suspending agent(s), antifoaming agent(s), antifreezing agent(s), preservative(s), thickener(s) and humectants(s).
The wetting agent of SC is selected from, but not limited to, ethylene oxide/propylene oxide (EO/PO) block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate.Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol or mixture thereof.
The wetting spreading-penetrating agent of SC is selected from, but not limited to, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or mixture thereof.
The dispersing agent of SC is selected from, but not limited to, Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide or mixture thereof.
The suspending agent of SC is selected from, but not limited to, aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or mixture thereof.
The antifoaming agent of SC is selected from, but not limited to, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids or mixture thereof.
The anti-freezing agent of SC is selected from, but not limited to, ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride or mixture thereof.
The preservatives of SC is selected from, but not limited to,1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or mixture thereof.
The thickeners of SC is selected from, but not limited to, xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum or mixture thereof.
The humectant of OD is selected from, but not limited to, urea, humic acid, glycerol, lactose or mixture thereof.
Manufacturing process for Suspension Concentrate (SC) formulation:
Step 1: Gel preparation: A required quantity of water is charged to a vessel which is equipped with a high shear stirrer whilst the agitation is initiated. A required amount of preservative(s) is/are added and mixed to form a homogenous mixture. A required amount of thickener(s) is/are added and mixed vigorously to achieve wetness.
Step 2: A required quantity of water is charged to a vessel which is equipped with a bulk agitator and a high shear homogenizer; initiated the agitation. Further, a required amount of an anti freezing agent(s) is/are added and mixed to achieve uniformity. Moreover, the antifoaming agent(s) is/are added whilst ensuring that it is well dispersed. The wetting and dispersing agent(s) is/are added and mixed to achieve uniformity whilst ensuring that the dispersing agent(s) is/are fully dispersed.
Step 3: The active ingredients are added and the agitation of the vessel contents are continued until all the compounds get dissolved. The pre-mix is milled through a colloid mill and subsequently through a dyno mill to meet the specified particle size.
Step 4: The remaining antifoaming agent(s) is/are added to this SC mill base to a vessel which is equipped with the bulk agitator and mixed to achieve uniformity. The required amount of 2% aqueous pre-gel and suspending agent(s) is/are added and the agitation is continued until the formulation is homogeneous and has reached the target viscosity.
Step 5: The final product is submitted for QC’s approval.
Step 6: The material is packed in its required package sizes when received approval.
C. Lists of inactive excipient used in Suspo Emulsion (SE) formulation [mixed formulation of SC+EC]:
The Suspo Emulsion formulation (SE) is a mixture of Suspension Concentrates (SC) and Emulsifiable Concentrate (EC). The Suspo Emulsion (SE) of the present invention comprises agrochemically acceptable excipients including, but not limited to, solvent(s), emulsifier(s), stabilizer(s), antifreezing agent(s), antifoaming agent(s), suspending agent(s), wetting agent(s), wetting spreading-penetrating agent(s), preservative(s), thickener(s), dispersing agent(s), buffering agent(s) and humectants(s). Since the excipients for SC are the same, only the excipients for SE are listed here.
The solvent of SE is selected from, but not limited to, water, water soluble alcohols and dihydroxy alcohol ethers. Water soluble alcohol or lower alcohol (1-4 carbon atoms) includes-methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol. Macromolecular alcohol includes polyethylene glycol, sorbitol, glucitol etc., dihydroxy alcohol ethers includes dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, di-propylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, di-propylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, di-propylene glycolphenyl ether, and the like. Any of the mentioned solvent can be used either alone or in combinations thereof.
Hyrdocarbons includes n-pentane, hexane(s), cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene(s), isophorone and ester solvents such as methyloleate, dimethylamide and morpholineamide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; alcohols including methanol; ethanol; iso-propanol; n-propanol; n-butanol; iso-butanol; and tert-butanol; Methyl L-lactate, 2-Ethylhexyl L-lactate, Ethyl L-lactate, n-Butyl L-lactate, Octyl phenol ethoxylates or mixture thereof.
The emulsifiers of SE is selected from, but not limited to,salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol (tristyrlphenol with 16 moles EO), tristyrylphenol-polyglycolether-phosphate, fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylether sulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxyethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol or mixture thereof.
The stabilizer of SE is selected from, but not limited to, butylated hydroxytoluene (BHT) and epoxidized soybean oil (ESBO), Epichlorhydrin or mixture thereof.
The anti-freezing of SE is selected from, but not limited to, ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride or mixture thereof.
The anti-foaming of SE is selected from, but not limited to, silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxanes or mixture thereof.
The suspending agent of SE is selected from, but not limited to, aluminum magnesium silicate, bentonite clay, silica, silicone dioxide, attapulgite clay or mixture thereof.
The wetting agent of SE is selected from, but not limited to, Ethylene oxide/propylene oxide block copolymer, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol, Sodium dioctyl sulfosuccinate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, alkyl diphenylsulfonates, sodium isopropyl naphthalene sulfonate, Alkyl naphthalene sulfonate, Octyl phenol ethoxylate, alkyl phenol ethoxylate or mixture thereof.
The wetting-spreading-penetrating agent of SE is selected from, but not limited to, Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, heptamethyl trisiloxane ethoxylate, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, may or may not be in modified form, may be liquid or powder form or mixture thereof.
The preservatives of SE is selected from, but not limited to, propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2- methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.
The thickeners of SE is selected from, but not limited to, Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and 15 seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenan; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixture thereof.
The dispersing agent of SE is selected from, but not limited to, can be a conventionally available for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylic polymers, acrylic graft copolymer, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. The examples of dispersing agents are alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium salt of alkyl naphthalene sulfonate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide or mixture thereof.
The buffering agent of SE is selected from, but not limited to, as used herein is selected from group consisting of calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide or mixture thereof.
The humectants of SE is selected from, but not limited to, urea, humic acid, glycerol, lactose or mixture thereof.
Manufacturing process for Suspo Emulsion (SE) formulation:
Step 1: Gel preparation: A required quantity of water is charged to a vessel which is equipped with a high shear stirrer whilst the agitation is initiated. The required amount of preservative(s) is/are added and mixed to achieve homogeneity. Further, a required amount of thickener(s) is/are added and mixed vigorously to achieve full wetness.
Step 2: Oil phase: The solvent(s) is/are charged into the vessel and then the active is slowly added and if required, it is heated for 50°C so that the active ingredients can be dissolved in the solvent and followed by addition of emulsifier(s).
Step 3: The agitation is initiated when a required quantity of water is charged to a vessel which is equipped with a bulk agitator and a high shear homogenizer. A required amount of anti freezing agent(s) is/are added and mixed to achieve a uniform mixture. The antifoaming agent(s) is/are added and ensured that it is well dispersed. The wetting and dispersing agent(s) is/are added and mixed to achieve uniform mixture and ensured that the dispersing agent is fully dispersed.
Step 4: The active ingredients are added in the vessel and agitated till entire compounds get dissolved. The pre-mix is milled through a colloid mill and subsequently through a dyno mill to achieve a specified particle size.
Step 5: The remaining antifoaming agent(s) is/are added in the mill base to a vessel which is equipped with bulk agitator and mixed to achieve uniformity.
Step 6: An addition of an oil phase in an aqueous phase is performed and stirred for 30 minutes by using homogenizer.
Step 7: A required amount of aqueous pre-gel and suspending agent(s) are added. A homogenous mixture and a target viscosity are achieved by continuous agitation.
Step 8: The final product is submitted for QC’s approval.
Step 9: The material is packed in its required package sizes when approved.
D. Lists of inactive excipients used in WG (Wettable Granule)/WDG (Water Dispersible Granule) formulation:
The wettable granule/ water dispersible granule formulation (WG/WDG) of the present invention comprises agrochemically acceptable excipients including, but not limited to, dispersing agent(s), wetting agent(s), antifoaming agent(s), carrier(s), disintegrating agent(s) and humectants(s).
The dispersing agent of WG is selected from, but not limited to, alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalenesulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt or mixture thereof.
The wetting agent of WG is selected from, but not limited to, sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutylnaphthalene sulphonic acid sodium salt, sodium di-isopropylnaphthalenesulphonate, sodium lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxaneheptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
The antifoaming agent of WG is selected from, but not limited to, polydimethylsiloxanes or mixture thereof.
The carrier of WG is selected from, but not limited to, china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay,bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers or mixture thereof.
The disintegrating agent of WG is selected from, but not limited to, citric acid, succinic acid or the sodium bicarbonate or mixture thereof.
The humectants of WG is selected from, but not limited to, urea, humic acid, glycerol, lactose or mixture thereof.
Manufacturing process for Wettable granule/ Water Dispersible Granule (WG/ WDG):
Step 1: An exact weight of active ingredients is considered and a required quantity of binder(s) and surfactant(s) is/are added in the blender and mixed to achieve a complete homogenization.
Step 2: The homogenized mixture is milled to achieve required wet sieve and post blended to attain homogeneity.
Step 3: The above described homogenous material is passed through an extruder for granulation to achieve granular of require size.
Step 4: The wet granules are transferred through fluidized bed drier to remove excess moisture.
Step 5: The wet granules are further transferred to vibro shifter and further graded using vibrator screens.
Step 6: The final material is collected from the vibro shifter into drum.
Step 7: The sample is sent to QC for an approval.
Step 8: The material is transferred into the different size of drums when received an approval from QC.
E. List of inactive excipients used in the ZC formulation [mixed formulation of CS+SC]:
The mixed formulation (ZC) is a mixture of Capsule Suspension (CS) and Suspension Concentrates (SC). The mixed formulation (ZC) of the present invention comprises agrochemically acceptable excipients including, but not limited to, wall forming material(s) 1, wall forming material(s) 2, dispersing agent(s), wetting agent(s), wetting-spreading-penetrating agent(s), solvent(s), thickner(s), suspending agent(s), antifoaming agent(s), antifreezing agent(s),preservative(s), emulsifier(s) and buffering agent(s). Since the excipients for SC are the same, only the excipients for CS are listed here.
The wall forming material 1 of ZC is selected from, but not limited to, Tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethenediisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form or mixture thereof.
The wall forming material 2 of ZC is selected from, but not limited to, Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4'-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4'-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone or mixture thereof.
The dispersing agent of ZC is selected from, but not limited to, Ethoxylated lignosulfonic acid salts, lignosulfonic acid salts, oxidized lignins, lignin salts, salts of styrenemaleic anhydride copolymers, polyvinyl alcohol, salts of partial esters of styrene-maleic anhydride copolymers, partial salts of polyacrylic acid and partial salts of polyacrylic acid terpolymers. the surfactant is lignosulfonate of calcium or sodium or mixtures thereof or a modified kraft lignin with a high sulfonic acid group, dibutylnaphthalenesulfonic acid ,fatty acids, alkyl- and alkylarylsulfonates, alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols and of fatty alcohol glycol ethers, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or of the naphthalenesulfonic acids with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctyl-, octyl- or nonylphenol, alkyl phenyl polyglycol ethers, tributyl phenyl polyglycol ethers, alkyl aryl polyether alcohols, is tridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulphite waste liquors, and proteins, denatured proteins, polysaccharides , ammonium salts of sulfonates, sulfates, phosphates or carboxylates, alkylarylsulfonates, diphenyl sulfonates, alpha-olefin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of condensed naphthalene, sulfonates of dodecyl- and tridecyl benzenes, sulfonates of naphthalene and alkylnaphthalenes, sulfosuccinates or sulfosuccinates, alkoxylates, N-alkylated fatty acid amides, amine oxides, esters or sugar-based surfactants, alkylphenols, amines (e.g. tallow amine), amides, aryl phenols, fatty acids or fatty acid esters which have been alkoxylated. Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide, polyethylene oxide and polypropylene oxide, polyacids or polybases or mixture thereof.
The wetting agent of ZC is selected from, but not limited to, Ethylene oxide/propylene oxide block copolymer, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol, Sodium dioctyl sulfosuccinate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, alkyl diphenylsulfonates, sodium isopropyl naphthalene sulfonate,Alkyl naphthalene sulfonate, Octyl phenol ethoxylate, alkyl phenol ethoxylate;
The wetting spreading penetrating agent of ZC is selected from, but not limited to, Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, may or may not be in modified form, may be liquid or powder form or mixture thereof.
The solvent of ZC is selected from, but not limited to, Hydrocarbon solvent such a aliphatic, cyclic and aromatic hydrocarbons (e.g. toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalene or their derivatives, mineral oil fractions of medium to high boiling point (such as kerosene, diesel oil, coal tar oils)); a vegetable oil such as corn oil, rapeseed oil; a fatty acid ester such as C1-C10-alkylester of a C10-C22-fatty acid; or, methyl- or ethyl esters of vegetable oils such as rapeseed oil methyl ester or corn oil methyl ester, acetophenone, 2-Heptanon , 3-heptanone, 2-hexanone, 5-methyl-2-hexanone, 5-methyl-3-heptanone, 3-methyl-2-hexanone, 4-methyl-2-hexanone, 2-methyl-3-hexanone, 4-methyl-3-hexanone, 5-methyl-3-hexanone, 3-ethyl-2-pentanone, 3,3-dimethyl-2-pentanone, 3,4-dimethyl-2-pentanone, 4,4-dimethyl-2-pentanone, 2,2-dimethyl-3-pentanone, 2,4-dimethyl-3-pentanone, 2-octanone, 2,5-dimethyl-3-hexanone, 2,2-dimethyl-3-hexanone, 3,3-dimethyl-2-hexanone, 3,4-dimethyl-2-hexanone, 4,4-dimethyl-3-hexanone, 3-ethyl-4-methyl-2-pentanone, 2-methyl-3-heptanone, 2-methyl-4-heptanone, 3-methyl-2-heptanone, 3-methyl-4-heptanone, 5-methyl-3-heptanone, 6-methyl-2-heptanone, 6-methyl-3-heptanone, 3-octanone, 4-octanone, 2,2,4-trimethyl-3-pentanone, 3-ethyl-3-methyl-2-pentanone, 5-methyl-2-heptanone, isoprene or mixture thereof.
The thickener of ZC is selected from, but not limited to, Xanthan gum, Carboxy methyl cellulose, Attapulgite clay, Bentonite clay or mixture thereof.
The suspending agent of ZC is selected from, but not limited to, Aluminium Magnesium Silicate, Bentonite clay, Silica, Attapulgite clay or mixture thereof.
The antifoaming agent of ZC is selected from, but not limited to, silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, Silicone antifoam emulsion, Dimethyl siloxane, Polydimethyl siloxane, Vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane or mixture thereof.
The antifreezing agent of ZC is selected from, but not limited to, ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol,p glycol), glycerine, urea, magnesium sulphateheptahydrate, sodium chloride or mixture thereof.
The preservative of CS is selected from, but not limited to, 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or mixture thereof.
The buffering agent of CS is selected from, but not limited to, Sodium hydroxide, potassium hydroxide, acetic acid, sulphuric acid, hydrochloric acid, ortho phosphoric acid, ammonium hydroxide or mixture thereof.
Manufacturing process for mixed formulation (ZC):
Step 1: Aqueous Phase - Charge water to a stainless-steel vessel equipped with a high speed stirrer. Under agitation, add the wetting agent, dispersing agent 1and dispersing agent 2 into the vessel. Now add 50% quantity of antifoam to avoid foam generation in this vessel.
Step 2: Organic Phase - Charge heavy aromatic hydrocarbons solvent into second stainless-steel reactor. Then, slowly add melted active ingredient into the reactor. Afterwards, the wall forming material 1 is/are charged to the reactor while mixing it. Cool the reactor contents to room temperature.
Step 3: Start the high shear disperser of aqueous phase and charge the ‘Organic Solution’ into the ‘Aqueous Phase Solution’ under gravity in specific rate so that required particle size can be achieved and continue to shear for 30 min. Then, start heating the reactor to around 50 °C and stir the formulation under slow rpm for 3-4 hours so that Polymerization reaction gets completed.
Step 4: Now add wall forming material 2 so that residual wall forming material 1 can be consumed and stir for 1 more hour at the same temperature and if required add half quantity of antifoam to remove foam generating due to CO2 during reaction.
Step 5: After the wall polymerization reaction, increase the agitator to high speed. Add the rest half quantity of antifoam to the formulation. Under slight vacuum, allow the mixture to de-gas for approximately 30 minutes to remove CO2 from the solution. Add the linear polysaccharide, preservative and in last freezing agent and mix for some minutes. Add buffering agent for pH adjustment and mix well.
Step 6: Final product is sent for QC approval.
Step 7: After approval, material is packed in required pack sizes.
EXAMPLES
The present invention has been described with reference to specific embodiment which is merely illustrative and not intended to limit the scope of the invention as defined in the present complete specification.
Biological Examples:
The synergistic pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) or tank mix of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:

The objective of the present studies was to study the synergism and benefits of present compositions.
Example 1: Bio efficacy against insect-pests infesting chilli crop.
Crop : Chilli
Number of Treatments: 17
Plot size : 50 sq.m. (m2)
Crop stage : 77 days after transplanting.
Water volume : 450 liter per hectare
Method of Application: Foliar spray with battery operated backpack sprayer.
Observation Methods:
Thrips (mixed infestation of Scirtothrips dorsalis and Thrips parvispinus): Count the number of live thrips by shaking the twigs on black piece of paper. Record the observations from 3 twigs per plant and 10 plants per plot on 7 and 14 DAA (days after application). Calculate thrips control (%) as observed control and apply Colby’s formula to calculate synergism.

Mite (Polyphagotarsonemus latus): Count the number of motile stages of mite per unit area using 10X pocket microscope. Record the observations from 5spots on randomly selected leaves (young growing leaves) per plant. Observe 10 plants per plot. Calculate mite control (%) as per formula given for thrips control.

Fruit borer (Helicoverpa armigera) larvae: Count the number of live larvae per plant. Record observations from 10 plants per plot, calculate larval control (%) by using given Formula.

Healthy Fruit count: Count the number of healthy marketable fruits per plant. Record the observations from 10 plants per plot and calculate increase (%) in healthy marketable fruits over UTC (untreated check).

Composition of Compound A 8% + Compound B 3% + Compound C5 32% WG [T4 of Ex. 1]

Chemical composition Function Content
(% w/w)
Compound A a.i. Compound A 8.00
Compound B a.i. Compound B 3.00
Compound C5 a.i. Compound C 32.00
Modified Sodium lignosulphonate Dispersing agent I 7.00
Modified polyacrylate copolymer Dispersing agent II 3.00
Sodium isopropyl naphthalene sulfonate Wetting agent 5.00
Polydimethylsiloxane Antifoaming Agent 1.00
Corn Starch Carrier 15.00
China clay Carrier 26.00
Total 100.00
Active ingredient on 100% purity basis

Storage Stability: Composition of Compound A 8% + Compound B 3% + Compound C5 32% WG [T4 of Ex.1]
Laboratory storage stability for 14 days [T4 of Ex. 1]
Parameters Specifications Initial At 54±2 °C At 0±2 °C
Compound A a.i. 7.60 to 8.80 8.25 8.11 8.25
Compound B a.i. 2.85 to 3.33 3.15 3.10 3.15
Compound C5 a.i. 30.40 to 33.60 32.50 32.24 32.5
Compound A suspensibility (%) 70 98.40 97.30 98.20
Compound B suspensibility (%) 70 98.20 97.50 98.20
Compound C5 suspensibility (%) 70 98.80 97.40 98.60
pH range (1% aq. Suspension) 5 to 9 7.50 7.60 7.50
Wettability Max 30 s 10 12 10
Wet Sieve(45 micron) Mini 98.5% 99.5 99.4 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.2 1.4
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months [T4 of Ex. 1]
Parameters Specifications Initial 1 month 6 months 12 months
Compound A a.i. 7.60 to 8.80 8.25 8.25 8.23 8.21
Compound B a.i. 2.85 to 3.33 3.15 3.15 3.14 3.10
Compound C5 a.i. 30.40 to 33.60 32.50 32.50 32.47 32.45
Compound A suspensibility (%) 70 98.40 98.40 98.40 98.30
Compound B suspensibility (%) 70 98.20 98.20 98.10 98.10
Compound C5 suspensibility (%) 70 98.80 98.80 98.80 98.70
pH range (1% aq. Suspension) 5 to 9 7.50 7.50 7.50 7.55
Wettability Max 30 s 10 10 10 11
Wet Sieve(45 micron) Mini 98.5% 99.5 99.5 99.5 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.4 1.4 1.3
Persistent foam ml (after 1 minute) max. 60 nil nil nil nil
The composition of Compound A 8% + Compound B 3% + Compound C5 32% WG meets all in-house specifications for storage stability studies in laboratory (at 54±2 °C & At 0±2 °C for 14 days) and room temperature (for 12 months)

Manufacturing process for 100 kg batch of Compound A 8% + Compound B 3% + Compound C5 32% WG [T4 of Ex. 1]

Step 1: Charged china clay (26 kg), corn starch (15 kg), polydimethylsiloxane antifoam (0.5 kg), sodium isopropyl naphthalene sulfonate (5 kg), modified polyacrylate copolymer (3 kg) and modified sodium lignosulphonate (7 kg) blend into a ribbon or premix blender and homogenization for 30 minutes.

Step 2: Charged compound A technical (8 kg), compound B technical (3 kg) and compound C5 technical (32 kg) and again homogenize for 30 minutes and now this pre-blended material was then grinded through jet mill/ air classifier mills. Finely grinded material was blended in post blender till it becomes homogeneous (approx. 1.5 hr).

Step 3: Finely grinded powder was mixed with water (15 kg) having polydimethylsiloxane antifoam (1 kg) to form extrudable dough.

Step 4: Dough was passed through extruder to get granules of required size.

Step 5: Wet granules was passed throughf bed drier to remove extra water (15 kg) added and further graded using vibrating screens.

Step 6: Final product was sent for QC approval.

Step 7: After approval material was packed in required pack sizes.

Table 1: Treatment details [Ex.1]
S.No. Treatment compositions gram actives per hectare
T1 Compound A 5% + Compound B 1.8% + Compound C5 12% SC 25+9+60
T2 Compound A 5% + Compound B 1.8% + Compound C5 12% SE 25+9+60
T3 Compound A 4%+ Compound B 1.5% + Compound C5 16% OD 20+7.5+80
T4 Compound A 8% + Compound B 3% + Compound C5 32% WG 20+7.5+80
T5 Compound A 5% + Compound C5 12% SC 25+60
T6 Compound A 4% + Compound C5 16% OD 20+80
T7 Compound B 1.8% + Compound C5 12% SC 9+60
T8 Compound B 1.5% + Compound C5 16% OD 7.5+80
T9 Compound A 5% + Compound B 1.8% SC 25+9
T10 Compound A 8% + Compound B 3% WG 20+7.5
T11 Compound A 30% SC 25
T12 Compound A 30% SC 20
T13 Bbamectin 1.9% EC 9
T14 Compound B 1.9% EC 7.5
T15 Compound C5 5% SC 60
T16 Compound C5 5% SC 80
T17 Untreated Check (UTC) -

T1 to T4 are present compositions, whereas T5 to T10 are known formulations.

Table 2a: Thrips control in chilli crop [Ex. 1]
S.
No. Thrips control (%) at 7 DAA Thrips control (%) at 14 DAA
Observed Expected Colby's ratio Synergism (Y/N) Observed Expected Colby's ratio Synergism (Y/N)
T1 100.0 95.3 1.05 Y 99.6 89.2 1.12 Y
T2 100.0 95.3 1.05 Y 99.4 89.2 1.11 Y
T3 100.0 94.6 1.06 Y 99.3 87.5 1.13 Y
T4 100.0 94.6 1.06 Y 99.1 87.5 1.13 Y
T5 87.8 88.8 0.99 N 75.3 80.1 0.94 N
T6 88.2 89.0 0.99 N 74.8 80.0 0.94 N
T7 78.6 79.1 0.99 N 62.8 65.3 0.96 N
T8 80.4 81.8 0.98 N 62.6 67.5 0.93 N
T9 89.6 90.4 0.99 N 80.2 83.0 0.97 N
T10 84.7 85.6 0.99 N 74.5 76.1 0.98 N
T11 77.3 - - 68.8 - -
T12 70.5 - - 61.6 - -
T13 57.8 - - 45.6 - -
T14 51.2 - - 37.8 - -
T15 50.5 - - 36.2 - -
T16 62.7 - - 47.8 - -
T17 0.0 - - 0.0 - -
Abbreviation: DAA-days after application, Y-yes, N-no.

All the present compositions (T1 to T4) show synergism in terms of thrips control and provide residual on 7 and 14 days, whereas known formulations (T5 to T10) do not provide residual control. All the present compositions (T1 to T4) show strong synergism as compared to known formulations (T5 to T10). Higher the Colby’s ratio means stronger the synergism.
Table 2b: Control of Fruit borer larvae and Chilly fruit yield.
Treatment Number Fruit borer larval control (%) at 7 DAA Number of healthy fruits per plant Increase (%) in fruits over UTC

T1 100.0 92.7 152.6
T2 100.0 92.5 152.0
T3 100.0 92.2 151.2
T4 100.0 91.8 150.1
T5 90.8 70.3 91.6
T6 90.3 68.8 87.5
T7 55.8 65.6 78.7
T8 59.5 66.4 80.9
T9 82.8 68.2 85.8
T10 78.8 69.1 88.3
T11 81.7 60.3 64.3
T12 77.8 59.8 62.9
T13 10.3 56.3 53.4
T14 6.8 55.6 51.5
T15 51.8 57.2 55.9
T16 57.4 58.1 58.3
T17 0.0 36.7 0.0

All the present compositions (T1 to T4) provide complete protection against fruit borer larvae and also produces higher number (>150%) of green chilly fruits per plant.
Conclusion: Among the various compositions as shown in Table 1 treatment number T1 to T4 are considered to be present inventive compositions which showed excellent synergism and effectiveness against thrips and fruit borer larval with 100% control at 7 DAA [days after application]. Particularly, the thrips control for T1 to T4 was > 99% at 14 DAA. Moreover, the colby’s ratio was found to be >1 which shows strong synergism, when compared with known combinations and market products.

Example 2 : Insect-pests control in Okra Crop.
Crop : Okra
Number of Treatments: 24
Plot size : 40 sq.m.
Crop age : 80 days after transplanting.
Water volume : 500 liter per hectare
Method of Application: Foliar spray with battery operated backpack sprayer.
Observation Methods:
Fruit borer (Helicoverpa armigera) larvae: Count the number of live larvae per plant. Record observations from 10 plants per plot; calculate larval control (%) by using given Formula.

Red spider mite (Tetranychus urticae): Count the number of motile stages of mite per unit area using 10X pocket microscope. Record the observations from 5 spots on randomly selected leaves (young growing leaves) per plant. Observe 10 plants per plot. Calculate mite control (%).

Composition of Compound A 4% + Compound B 1.8% + Compound C2 5% SE [T1 of Ex. 2]
Chemical composition Function content (% w/w)
Compound A a.i. Compound A 4.00
Compound B a.i. Compound B 1.80
Compound C2 a.i. Compound C 5.00
Polyarylphenyl anionic ether sulfate, ammonium salt Emulsifier-2 1.50
Aromatic solvent C-9 Solvent 7.50
1-methyl-2-pyrrolidinone Co-solvent 7.50
Acrylic graft copolymer Dispersing agent I 3.00
Butyl Polyalkylene Oxide block copolymer Dispersing agent II 4.50
Aluminum magnesium silicate Suspending agent 0.50
Polydimethylsiloxane Anti foaming agent 0.20
1,2-benzisothiazolin-3(2H)-one Preservative 0.15
Propylene glycol Anti freezing agent 5.00
Xanthan gum Thickner 0.15
Diluent water 59.20
Total 100.00
active ingredient on 100% purity basis

Storage stability: Compound A 4% + Compound B 1.8% + Compound C2 5% SE [T1 of Ex. 2]
Laboratory storage stability for 14 days [T2 of Ex. 2]
Parameters Specifications Initial At 54±2 °C At 0±2 °C
Compound A a.i. 3.80 to 4.4 4.30 4.14 4.3
Compound B a.i. 1.71 to 1.98 1.95 1.89 1.95
Compound C2 a.i. 475 to 5.25 5.25 5.15 5.25
Compound A suspensibility (%) 80 98.90 97.50 98.50
Compound B suspensibility (%) 80 99.00 97.90 98.60
Compound C2 suspensibility (%) 80 98.50 97.60 98.30
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.00 7.10
Pourability (%) 95 98.20 98.20 97.80
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62, 20 rpm 350-800 cps 550 560 560
Particle size (micron) D50<3, D90<10 2.1,8.2 2.2,8.5 2.1,8.2
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months [T1 of Ex. 2]
Parameters Specification Initial 1 month 6 months 12 months
Compound A a.i. 3.80 to 4.4 4.30 4.30 4.28 4.26
Compound B a.i. 1.71 to 1.98 1.95 1.95 1.93 1.91
Compound C2 a.i. 475 to 5.25 5.25 5.25 5.23 5.20
Compound A suspensibility (%) 80 98.90 98.70 98.70 98.50
Compound B suspensibility (%) 80 99.00 98.90 98.80 98.70
Compound C2 suspensibility (%) 80 98.50 98.40 98.40 98.40
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.10 7.10 7.08
Pourability (%) 95 98.20 98.20 98.20 98.20
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 550 550 550 555
Particle size (micron) D50<3, D90<10 2.1,8.2 2.1,8.2 2.1,8.2 2.1,8.2
Persistent foam in ml (after 1 minute) max. 60 nil nil nil Nil
The composition of Compound A 4% + Compound B 1.8% + Compound C2 5% SE meets all in-house specifications for storage stability studies in laboratory (at 54±2 °C & At 0±2 °C for 14 days) and room temperature (for 12 months)

Manufacturing process for 100 kg batch of Compound A 4% + Compound B 1.8% + Compound C2 5% SE [T1 of Ex. 2]

Step 1: Preparation of 2% gum solution: Charge xanthan gum (2 kg) and 1,2-benzisothiazoline-3-one (2 kg) into water (96 kg) and homogenized for 12 to 18 hours prior to use.

Step 2: EC premix- Added aromatic solvent (7.5 kg), 1-methyl-2-pyrrolidinone (7.5 kg) into other vessel having slow stirring. Compound A technical (4 kg), compound C2 technical (5 kg) and 4.5 kg of butyl polyalkylene oxide block copolymer were also added and mixed properly for 30 to 45 minutes.

Step 3: Charged DM water (51.7 kg) and propylene glycol (5 kg) into designated vessel and mixed thoroughly.

Step 4: Added aluminum magnesium silicate (0.5 kg), acrylic graft copolymer (3 kg), polyarylphenyl anionic ether sulfate, ammonium salt (1.5 kg) and polydimethylsiloxane (0.1 kg) into the vessel having water and homogenized the contents for 45 to 60 minutes using high shear homogenizer.

Step 5: Then added compound B technical (1.8 kg) to this premix slowly and homogenized to get uniform slurry ready for grinding.

Step 6: Before grinding half the quantity of antifoam was added and then material was subjected to grinding in dyno mill till desired particle size is achieved.

Step 7: Remaining polydimethyl siloxane antifoam (0.1 kg) was added after grinding process completes and before sampling for in process analysis.

Step 8: EC premix was mixed to this milled slurry under slow stirring and homogenized for 30 to 45 minutes.

Step 9: Finally added 2% gum solution (7.5 kg) to this formulation and sent it to QC for quality check.
Table 3: Treatment details [Ex. 2]
S.No. Treatment compositions gram actives per hectare
T1 Compound A 4% + Compound B 1.8% + Compound C2 5% SE 20+9+25
T2 Compound A 4% + Compound B 1.8% + Compound C6 5% SC 20+9+25
T3 Compound A 4% + Compound B 1.8% + Compound C7 10% SC 20+9+50
T4 Compound A 4% + Compound B 1.8% + Compound C8 5% SC 20+9+25
T5 Compound A 4% + Compound B 1.8% + Compound C9 18% SC 20+9+90
T6 Compound A 4% + Compound C2 5% SE 20+25
T7 Compound A 4% + Compound C6 5% SC 20+25
T8 Compound A 4% + Compound C7 10% SC 20+50
T9 Compound A 4% + Compound C8 5% SC 20+25
T10 Compound A 4% + Compound C9 18% SC 20+90
T11 Compound B 1.8% + Compound C2 5% SE 9+25
T12 Compound B 1.8% + Compound C6 5% SC 9+25
T13 Compound B 1.8% + Compound C7 10% SC 9+50
T14 Compound B 1.8% + Compound C8 5% SC 9+25
T15 Compound B 1.8% + Compound C9 18% SC 9+90
T16 Compound A 4% + Compound B 1.8% SE 20+9
T17 Compound A 30% SC 20
T18 Compound B 1.9% EC 9
T19 Compound C2 5.45% w/w (5% w/v) EC 25
T20 Compound C6 10% SC 25
T21 Compound C7 10% SC 50
T22 Compound C8 5% SC 25
T23 Compound C9 30% SC 90
T24 Untreated Check (UTC) -

T1 to T5 are present compositions, whereas T6 to T16 are known compositions and T17 to T23 are market products.
Table 4: Control of Fruit borer larvae and Red spider mite in okra crop [Ex. 2]
S.No. Fruit borer larval control (%) on 7 DAA Red spider mite control (%) on 7 DAA
Observed Expected Colby's ratio Synergism (Y/N) Observed Expected Colby's ratio Synergism (Y/N)
T1 95.2 83.6 1.14 Y 96.2 90.9 1.06 Y
T2 91.6 82.9 1.10 Y 93.5 89.8 1.04 Y
T3 98.8 90.5 1.09 Y 94.2 89.1 1.06 Y
T4 90.7 82.5 1.10 Y 94.2 89.6 1.05 Y
T5 91.3 82.3 1.11 Y 95.8 90.9 1.05 Y
T6 80.6 81.6 0.99 N 73.2 72.9 1.00 Y
T7 78.8 80.8 0.98 N 70.4 69.8 1.01 Y
T8 88.3 89.3 0.99 N 68.3 67.5 1.01 Y
T9 78.9 80.3 0.98 N 69.2 68.9 1.00 Y
T10 78.4 80.1 0.98 N 74.5 73.0 1.02 Y
T11 22.7 23.8 0.95 N 90.2 89.0 1.01 Y
T12 19.5 20.5 0.95 N 88.7 87.7 1.01 Y
T13 54.6 55.8 0.98 N 87.4 86.8 1.01 Y
T14 17.5 18.8 0.93 N 88.2 87.4 1.01 Y
T15 16.9 17.8 0.95 N 90.6 89.0 1.02 Y
T16 78.6 80.9 0.97 N 73.1 72.2 1.01 Y
T17 78.5 - - - 17.4 - - -
T18 11.2 - - - 66.4 - - -
T19 14.2 - - - 67.2 - - -
T20 10.5 - - - 63.4 - - -
T21 50.2 - - - 60.6 - - -
T22 8.6 - - - 62.4 - - -
T23 7.4 - - - 67.3 - - -
T24 0.0 - - - 0.0 - - -

All present compositions (T1 to T5) provide synergistic control of fruit borer larvae and red spider mite on 7 DAA in okra crop.
Conclusion: Among the various compositions as shown in Table 3, T1 to T5 are the present compositions which showed excellent synergism in terms of fruit borer larvae and red spider mite in okra crop at 7 DAA. Further, (T3) showed 98.8% control followed by (T1) 95.2% control against fruit borer larvae at 7 DAA. At last, the colby’s ratio observed was >1 which means strong synergism, when compared with known combinations and market products.

Example 3: Pod borer larval control in red gram
Crop : Red gram
Treatments : 23
Crop age : 120 days after sowing.
Spray water volume : 500 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Pod borer (Helicoverpa armigera) larval control (%): Count the number of live larvae per plant. Record observations from 10 plants per plot on 14 days after application.

Pod count: count the number of healthy pods of red gram per plant. Record the observations from 10 plants per plot.
Composition of Compound A 4% + Compound B 1.5% + Compound C3 12% OD [T3 of Ex. 3]
Chemical composition Function content (% w/w)
Compound A a.i. Compound A 4.00
Compound B a.i. Compound B 1.50
Compound C3 a.i. Compound C 12.00
Polyoxyethylene sorbitol hexaoleate Oil Emulsifier 10.00
Salts of polyolefin condensates Non-Aqueous dispersant 2.50
Ethoxylated sorbitan ester Co-Emulsifier 8.50
Bentonite clay Rheology modifier 1.50
Styrene acrylic polymer Aqueous dispersant 1.50
Methylated seed oil Oil continuous phase 58.50
Total 100.00
active ingredient on 100% purity basis
Storage Stability: Compound A 4% + Compound B 1.5% + Compound C3 12% OD [T3 of Ex. 3]
Laboratory storage stability for 14 days [T3 of Ex. 3]
Parameters Specifications Initial At 54±2 °C At 0±2 °C
Compound A a.i. 3.80 to 4.4 4.30 4.14 4.3
Compound B a.i. 1.425 to 1.65 1.62 1.55 1.62
Compound C3 a.i. 11.40 to 12.60 12.50 12.30 12.50
Compound A suspensibility (%) 80 98.90 98.10 98.80
Compound B suspensibility (%) 80 99.00 98.50 98.90
Compound C3 suspensibility (%) 80 98.80 98.10 98.80
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 7.05 6.90
Pourability (%) 95 98.20 98.10 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03
Viscosity at spindle no.62,20 rpm 350-800 cps 510 520 510
Particle size (micron) D50<3, D90<10 2.1,8.0 2.1,8.2 2.1,8.1
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months [T3 of Ex. 3]
Parameters Specifications Initial 1 month 6 months 12 months
Compound A a.i. 3.80 to 4.4 4.30 4.30 4.28 4.26
Compound B a.i. 1.425 to 1.65 1.62 1.62 1.61 1.58
Compound C3 a.i. 11.40 to 12.60 12.50 12.50 12.47 12.45
Compound A suspensibility (%) 80 98.90 98.90 98.80 98.80
Compound B suspensibility (%) 80 99.00 98.90 98.90 98.80
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 6.90 6.90 6.95
Pourability (%) 95 98.20 98.20 98.20 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03 1.03
Viscosity at spindle no. 62, 20 rpm 350-800 cps 510 510 510 515
Particle size (micron) D50<3, D90<10 2.1,8.0 2.1,8.1 2.1,8.1 2.1,8.1
Persistent foam in ml (after 1 minute) max. 60 nil nil nil Nil
The composition of Compound A 4% + Compound B 1.5% + Compound C3 12% OD meets all in-house specifications for storage stability studies in laboratory (at 54±2 °C & At 0±2 °C for 14 days) and room temperature (for 12 months)

Manufacturing Process for 100 kg batch of Compound A 4% + Compound B 1.5% + Compound C3 12% OD [T3 of Ex. 3]

Step 1: Preparation of 15% bentonite clay solution: Added precipitated bentonite clay (15 kg) into methylated seed oil (85 kg) and homogenized till it gets completely dissolved. It must be kept for 12 to 18 hours prior to use.

Step 2: OD Premix: Charged methylated seed oil (48.5 kg) into a designated vessel for OD production.

Step 3: Polyoxyethylene sorbitol hexaoleate (10 kg), styrene acrylic polymer (1.5 kg), ethoxylated sorbitan ester (8.5 kg), salts of polyolefin condensates (2.5 kg) and polydimethyl siloxane (0.15 kg) were added and the contents were homogenized the contents for 45 to 60 minutes using high shear homogenizer.

Step 4: Added compound A technical (4 kg), compound B technical (1.5 kg) and compound C3 technical (12 kg), into this premix and homogenized for 30 to 45 minutes.

Step 5: Remaining silicon antifoam (0.15 kg) and 15% bentonite clay solution (10 kg) were added after milling to avoid foaming.

Step 6: Sent this final formulation to QC for quality check.

Table 5: Treatment details [Ex. 3]
S.No. Treatment compositions gram actives per hectare
T1 Compound A 4% + Compound B 1.5% + Compound C13 2% SC 20+7.5+10
T2 Compound A 4% + Compound B 1.5% + Compound C14 30% WG 20+7.5+150
T3 Compound A 4% + Compound B 1.5% + Compound C3 12% OD 20+7.5+60
T4 Compound A 4% + Compound B 1.5% + Compound C15 12% SE 20+7.5+60
T5 Compound A 4% + Compound B 1.5% + Compound C16 10% SC 20+7.5+50
T6 Compound A 4% + Compound C13 2% SC 20+10
T7 Compound A 4% + Compound C14 30% WG 20+150
T8 Compound A 4% + Compound C3 12% OD 20+60
T9 Compound A 4% + Compound C15 12% SE 20+60
T10 Compound A 4% + Compound C16 10% SC 20+50
T11 Compound B 1.5% + Compound C13 2% SC 7.5+10
T12 Compound B 1.5% + Compound C14 30% WG 7.5+150
T13 Compound B 1.5% + Compound C3 12% OD 7.5+60
T14 Compound B 1.5% + Compound C15 12% SE 7.5+60
T15 Compound B 1.5% + Compound C16 10% SC 7.5+50
T16 Compound A 30% SC 20
T17 Compound B 1.9% EC 7.5
T18 Compound C13 5% SG 10
T19 Compound C14 24% SC 150
T20 Compound C3 15% SC 60
T21 Compound C15 10% EC 60
T22 Compound C16 45% SC 50
T23 Untreated Check (UTC) -

T1 to T5 are present compositions, whereas T6 to T15 are known compositions and T15 to T22 are market products.
Table 6: Pod borer larval control and pod yield in red gram [Ex. 3]
S.No. Pod borer larval control (%) at 14 DAA Number of healthy pods per plant Increase (%) in healthy pods over UTC
Observed Expected Colby's ratio Synergism (Y/N)
T1 100.0 87.6 1.14 Y 287.1 116.4
T2 98.8 88.7 1.11 Y 285.3 115.0
T3 100.0 91.6 1.09 Y 289.7 118.3
T4 98.2 89.5 1.10 Y 286.5 115.9
T5 100.0 90.8 1.10 Y 288.3 117.3
T6 85.2 86.2 0.99 N 255.3 92.4
T7 84.6 87.4 0.97 N 252.4 90.2
T8 88.7 90.6 0.98 N 257.3 93.9
T9 86.2 88.3 0.98 N 251.7 89.7
T10 87.7 89.8 0.98 N 256.8 93.5
T11 56.7 60.8 0.93 N 243.8 83.7
T12 62.8 64.3 0.98 N 241.3 81.8
T13 70.4 73.5 0.96 N 246.4 85.7
T14 65.6 67.0 0.98 N 240.7 81.4
T15 70.2 71.1 0.99 N 244.8 84.5
T16 68.3 - - - 216.7 63.3
T17 10.2 - - - 186.2 40.3
T18 56.4 - - - 213.2 60.7
T19 60.3 - - - 208.7 57.3
T20 70.5 - - - 215.8 62.6
T21 63.2 - - - 210.5 58.6
T22 67.8 - - - 216.2 62.9
T23 0.0 - - - 132.7 0.0

All the present compositions (T1 to T5) provide synergistic and residual control of pod borer larvae and also yielded higher number of healthy pods per plant as compared to all known compositions.
Conclusion: Among the various compositions as shown in Table 5, T1 to T5 are the present composition which showed excellent synergism and effectiveness against pod borer larvae control and reduced pod damage in red gram. Further, T1, T3 and T5 showed 100% control followed by T2 (98.8%) and T4 (98.2%) at 14 DAA. At last, the Colby’s ratio observed was >1 which means strong synergism.

Further, the numbers of healthy pods per plant for T1 to T5 were more 285. In particular, (T3) showed 289.7 followed by (T5) 288.3, (T1) 287.1, (T4) 286.5, (T2) 285.3 number of healthy pod per plant. At last, (T3) showed 118.3% followed by (T5) 117.3%, (T1) 116.4%, (T4) 115.9%, (T2) 115% increase in healthy fruits over UTC [untreated check] from which it can be concluded that the present composition T1-T4 showcased effectiveness and synergism in red gram crop as compared to known compositions and market products.

Example 4: Flea beetle control in cabbage crop.
Crop : Cabbage
Treatments : 9
Crop age : 75 days after transplanting.
Spray water volume : 400 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Flea beetle control (%): Count the number of live beetles per plant, record the observations from 10 plants per plot. Calculate flea beetle control (%) as observed control and apply Colby’s formula to calculate synergism.
I. Composition of Compound A 4% + Compound B 1.44% + Compound C4 3% ZC [T1 of Ex. 4]
Chemical composition Function content
(% w/w)
Compound A a.i. Compound A 4.00
Compound B a.i. Compound B 1.44
Compound C4 a.i. Compound C 3.00
Mixture of heavy aromatic hydrocarbons Solvent 10.00
4,4'-diphenylmethane diisocyanate Wall forming material 0.25
Diethylene triamine wall forming material 0.15
Alkylbenzene sulfonate calcium salts Emulsifier-I 0.12
Tristyrylphenol polyethoxyester phosphate Emulsifier-II 3.50
Acrylic graft copolymer Dispersing agent I 2.50
Sodium naphthalene sulphonate formaldehyde condensate Dispersing agent II 0.16
Attapulgite clay Suspending agent 1.50
Polydimethylsiloxane Anti foaming agent 0.30
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Polypropylene glycol Anti freezing agent 5.00
Xanthan gum thickner 0.20
Diluent water 67.68
Total 100.00
active ingredient on 100% purity basis

Manufacturing process for 100 kg batch of Compound A 4% + Compound B 1.44% + Lambda cyhalothrin 3% ZC [T1 of Ex 4]

Step 1: Preparation of 2% gum solution: Charged xanthan gum (2 kg) and 1,2-benzisothiazoline-3-one (2 kg) into water (96 kg) and homogenized for 12 to 18 hours prior to use.

Step 2: Preparation of CS premix- Mixture of heavy aromatic hydrocarbon (10 kg) was added into other vessel having slow stirring. Added compound C4 technical (1.44 kg), alkylbenzene sulfonate calcium salts (0.12 kg) and 4,4'-diphenylmethane diisocyanate (0.25 kg) and mix them properly for 30 to 45 minutes. This premix was mixed with DM water (15 kg) and sodium naphthalene sulphonate formaldehyde condensate (0.16 kg) under high stirring and then added diethylene triamine (0.15 kg) and stirred at 50 °C for 3 hours and finally 2% gum solution were added (2 kg).

Step 3: Charged DM water (42.72 kg) and 1,2-propylene glycol (5 kg) into designated vessel and mix thoroughly.

Step 4: Added attapulgite clay (1.5 kg), acrylic graft copolymer (2.5 kg), tristyrylphenol polyethoxyester phosphate (3.5 kg) and polydimethylsiloxane (0.15 kg) into the vessel having water and homogenise the contents for 45 to 60 minutes using high shear homogeniser.

Step 5: Then added compound B technical (1.44 kg) and compound A technical (4 kg) to this premix slowly and homogenized to get uniform slurry ready for grinding.

Step 6: Before grinding half the quantity of antifoam (0.15 kg of polydimethylsiloxane) was added and then material was subjected to grinding in dyno mill till desired particle size is achieved.
Step 7: Remaining polydimethyl siloxane (0.15 kg) was added after grinding process completes and before sampling for in process analysis.

Step 8: CS premix was mixed to this milled slurry under slow stirring and homogenize for 30 to 45 minutes.

Step 9: Finally added 10 kg of 2% gum solution to this formulation and sent to QC for quality check.

Storage stability: Compound A 4% + Compound B 1.44% + Compound C4 3% ZC [T1 of Ex. 4]
Laboratory storage stability for 14 days [T1 of Ex. 4]
Parameters Specifications Initial At 54±2 °C At 0±2 °C
Compound A a.i. 3.80 to 4.40 4.30 4.14 4.28
Compound B a.i. 1.37 to 1.58 1.52 1.49 1.52
Compound C4 a.i. 2.85 to 3.30 3.25 3.20 3.24
Compound A suspensibility (%) 80 98.90 97.50 98.50
Compound B suspensibility (%) 80 99.00 97.90 98.60
Compound C4 suspensibility (%) 80 98.50 97.60 98.30
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.00 7.10
Pourability (%) 95 98.20 98.20 97.80
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 550 560 560
Particle size (micron) D50<3, D90<10 2.1,8.2 2.2,8.5 2.1,8.2
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months [T1 of Ex. 4]
Parameters Specifications Initial 1 month 6 months 12 months
Compound A a.i. 3.80 to 4.4 4.30 4.30 4.28 4.28
Compound B a.i. 1.37 to 1.58 1.52 1.52 1.49 1.48
Compound C4 a.i. 3.80 to 4.4 3.25 3.25 3.24 3.22
Compound A suspensibility (%) 80 98.90 98.90 98.50 97.50
Compound B suspensibility (%) 80 99.00 99.00 98.60 97.90
Compound C4 suspensibility (%) 80 98.50 98.50 98.30 97.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.10 7.10 7.00
Pourability (%) 95 98.20 98.20 97.80 98.20
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 550 550 560 560
Particle size (micron) D50<3, D90<10 2.1,8.2 2.1,8.2 2.1,8.2 2.2,8.5
Persistent foam in ml (after 1 minute) max. 60 nil nil nil nil
The composition of Compound A 4% + Compound B 1.44% + Compound C4 3% ZC meets all in-house specifications for storage stability studies in laboratory (at 54±2 °C & At 0±2 °C for 14 days) and room temperature (for 12 months)

II. Composition of Compound A 2% + Compound B 0.72% + Compound C1 7.5% SC [T2 of Ex. 4]
Chemical composition Function Content (% w/w)
Compound A a.i. Compound A 2.00
Compound B a.i. Compound B 0.72
Compound C1 a.i. Compound C 7.50
Methylated seed oil, polyalkyleneoxide modified trisiloxane Super wetting-spreading penetrating agent 7.50
Ethylene-propylene oxide block copolymer Dispersing agent I 5.00
Sodium naphthalene sulphonate formaldehyde condensates Dispersing agent II 1.25
Aluminum magnesium silicate Suspending agent 0.50
Polydimethylsiloxane Anti foaming agent 0.30
1,2-Benzisothiazol-3(2H)-one Preservatives 0.20
Propylene glycol Anti freezing agent 5.00
Xanthan gum thickner 0.20
Diluent water 69.83
Total 100.00
a.i. (active ingredient) on 100% purity basis

Manufacturing process for 100 kg batch of Compound A 2% + Compound B 0.72% + Compound C1 7.5% SC [T2 of Ex 4]

Step 1: Preparation of 2% gum solution: Charged xanthan gum (2.0 kg) and 1, 2-benzisothiazol-3(2H)-one (2.0 kg) into water (96 kg) and homogenized. It should be prepared 12 to 18 hours prior to use.

Step 2: Charged DM water (59.83 kg) and propylene glycol (5 kg) into designated vessel and mixed thoroughly.

Step 3: Added sodium naphthalene sulphonates formaldehyde condensates (1.25 kg), ethylene-propylene oxide block copolymer (5.0 kg) and aluminum magnesium silicate (0.5 kg) into the vessel having water and homogenized the contents for 45 to 60 minutes using high shear homogenizer.

Step 4: Then addd compound A technical (2.0 kg), compound B technical (0.72 kg) and compound C1 technical (7.5 kg) to this premix slowly and homogenized to get uniform slurry ready for grinding.

Step 5: Before grinding half the quantity of polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in dyno mill till desired particle size is achieved.

Step 6: Remaining polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.

Step 7: Finally added 2% xanthan gum solution (10 kg) and methylated seed oil, polyalkyleneoxide modified trisiloxane (7.5 kg) to this formulation and homogenized for 30 minutes.
Step 8: Now sent this final formulation to QC for quality check.

Storage Stability: Compound A 2% + Compound B 0.72% + Compound C1 7.5% SC [T2 of Ex. 4]
Laboratory storage stability for 14 days [T2 of Ex. 4]
Parameters Specification Initial At 54±2 °C At 0±2 °C
Compound A a.i. 1.90 to 2.20 2.20 2.12 2.2
Compound B a.i. 0.684 to 0.792 0.76 0.74 0.76
Compound C1 a.i. 7.125 to 8.25 7.80 7.65 7.8
Compound A suspensibility (%) 80 98.60 98.10 98.50
Compound B suspensibility (%) 80 98.50 98.30 98.50
Compound C1 suspensibility (%) 80 98.70 98.20 98.45
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.20 98.00 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 nil nil nil

Room temperature storage stability up to 12 months [T2 of Ex. 4]
Parameters Specification Initial 1 month 6 months 12 months
Compound A a.i. 1.90 to 2.20 2.20 2.20 2.19 2.17
Compound B a.i. 0.684 to 0.792 0.76 0.76 0.75 0.75
Compound C1 a.i. 7.125 to 8.25 7.80 7.80 7.79 7.77
Compound A suspensibility (%) 80 98.60 98.50 98.50 98.40
Compound B suspensibility (%) 80 98.50 98.50 98.50 98.40
Compound C1 suspensibility (%) 80 98.70 98.70 98.60 98.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 nil nil nil Nil
The composition of Compound A 2% + Compound B 0.72% + Compound C1 7.5% SC meets all in house specifications for storage stability studies in laboratory (at 54±2 °C & At 0±2 °C for 14 days) and room temperature (for 12 months)

Table 7: Treatment details [Ex. 4]
S.No. Treatment compositions gram actives per hectare

T1 Compound A 4% + Compound B 1.44% + Compound C4 3% ZC 20+7.2+15
T2 Compound A 2% + Compound B 0.72%+ Compound C1 7.5% SC 20+7.2+75
T3 Compound A 4.44% + Compound B 1.6% + Compound C21 15% OD 20+7.2+67.5
T4 Compound A 20% SC 20
T5 Compound B 1.9% EC 7.2
T6 Compound C4 5% EC 15
T7 Compound C1 10% EC 75
T8 Compound C21 10% E 67.5
T9 Untreated Check (UTC) -

Table 8: Flea beetle control in cabbage crop [Ex. 4]
Treatment Numbers Flea beetle control (%) at 10 DAA
Observed Expected Colby's ratio Synergism (Y/N)
T1 97.8 88.9 1.10 Y
T2 99.5 89.6 1.11 Y
T3 98.3 88.4 1.11 Y
T4 52.8 - - -
T5 40.7 - - -
T6 60.3 - - -
T7 62.8 - - -
T8 58.6 - - -
T9 0.0 - - -

All the present compositions (T1 to T3) provide synergistic and residual control of flea beetle in cabbage crop.
Conclusion: Among the various compositions as shown in Table 7, T1 to T3 are the present compositions which show very good result in term of Flea beetle control in cabbage crop. In particular, T2 showed 99.5% control followed by T3 showing 98.3% and T1 showing 97.8% control in cabbage crop as compared to the known compositions and market products. At last, the Colby’s ratio observed was >1 which means strong synergism.

Example 5: Whitefly control in cucumber
Crop : Cucumber
Number of Treatments: 9
Plot size : 50 sq.m.
Crop age : 62 days after transplanting.
Water volume : 400 liter per hectare
Method of Application: Foliar spray with battery operated backpack sprayer.
Observation Methods:
Whitefly control (%): Count the number of live whiteflies per leaf, record observations from 50 leaves per plot and calculate % whitefly control. Calculate whitefly control (%) as observed control and apply Colby’s formula to calculate synergism.
Table 9: Treatment details [Ex. 5]
S.No. Treatment compositions gram actives per hectare

T1 Compound A 4% + Compound B 1.6% + Compound C10 20% WG 20+8+100
T2 Compound A 8% + Compound B 3.2% + Compound C11 20% OD 20+8+50
T3 Compound A 8% + Compound B 3.2% + Compound C12 20% WG 20+8+50
T4 Compound A 20% SC 20
T5 Compound B 1.9% EC 8
T6 Compound C10 20% WG 100
T7 Compound C11 10% DC 50
T8 Compound C12 50% WG 50
T9 Untreated Check (UTC) -

Table 10: Control of whitefly in cucumber [Ex. 5]
Treatment number Whitefly control (%) at 7 DAA
Observed Expected Colby's ratio Synergism (Y/N)
T1 99.2 87.2 1.14 Y
T2 96.4 83.2 1.16 Y
T3 90.4 77.3 1.17 Y
T4 18.6 - - -
T5 36.4 - - -
T6 75.2 - - -
T7 67.5 - - -
T8 56.2 - - -
T9 0.0 - - -

All present compositions (T1 to T3) provide synergistic control of whitefly in cucumber.
Conclusion: Among the various compositions as shown in Table 9, T1 to T3 are the present compositions which show excellent results in terms of sucking pest control in okra crop. In particular, at 7 DAA (T1) showed 99.2% followed by (T2) showed 96.4% control against whitefly control. At last, the colby’s ratio observed for the present invention was >1 which means strong synergism compared to market products.

Example 6 : Jassid control in brinjal crop
Crop : Brinjal
Treatments : 11
Crop age : 77 days after transplanting.
Spray water volume : 450 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Jassid control (%): Count the number of live jassid per leaf, record the observations from 3 leaves per plant and 10 plants per plot on 7 DAA. Calculate jassid control (%) as observed control and apply Colby’s formula to calculate synergism.
Table 11: Treatment details [Ex. 6]
S.NO. Treatment compositions gram actives per hectare

T1 Compound A 15% + Compound B 5% + Compound C17 20% WG 18+6+24
T2 Compound A 15% + Compound B 5% + Compound C18 30% WG 18+6+36
T3 Compound A 15%+ Compound B 5%+ Compound C19 30% WG 18+6+36
T4 Compound A 15%+ Compound B 5%+ Compound C20 20% WG 18+6+24
T5 Compound A 20% SC 18
T6 Compound B 1.9% EC 6
T7 Compound C17 20% SP 24
T8 Compound C18 50% WG 36
T9 Thiamethoxm 25% WG 36
T10 Compound C20 20% SG 24
T11 Untreated Check (UTC) -
Table 12: Jassid control in brinjal crop [Ex. 6]
Treatment Number Jassid control (%) at 7 DAA
Observed Expected Colby's ratio Synergism (Y/N)
T1 90.4 79.7 1.13 Y
T2 95.6 81.7 1.17 Y
T3 93.2 80.6 1.16 Y
T4 97.8 83.5 1.17 Y
T5 20.6 - - -
T6 41.3 - - -
T7 56.4 - - -
T8 60.8 - - -
T9 58.4 - - -
T10 64.5 - - -
T11 0.0 - - -

All the present compositions (T1 to T4) provide synergistic and residual control of jassid in brinjal crop.
Conclusion: Among the various compositions as shown in Table 11, T1 to T4 are the present composition which showed excellent synergism and effectiveness against jassid control in brinjal crop. Further, T4 showed 97.8% control followed by T2 (95.6%) and T3 (93.2%) at 7 DAA. At last, the Colby’s ratio observed was >1 which means strong synergism.

Example 7: DBM (Daimond back moth) larval control in cauliflower
Crop : Cauliflower
Treatments : 11
Crop age : 48 days after transplanting.
Spray water volume : 375 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Flea beetle control (%): Count the number of live larvae per plant, record the observations from 10 plants per plot. Calculate DBM larval control (%) as observed control and apply Colby’s formula to calculate synergism.

Table 13: Treatment details [Ex. 7]
S.No. Treatment compositions gram actives per hectare

T1 Compound A 2.4% + Compound B 0.8% + Compound C22 24% SE 15+5+150
T2 Compound A 2.4% + Compound B 0.8% + Compound C23 30% SE 15+5+187.5
T3 Compound A 2.4% + Compound B 0.8% + Compound C24 30% SE 15+5+187.5
T4 Compound A 2.4%+ Compound B 0.8%+ Compound C25 30% SE 15+5+187.5
T5 Compound A 20% SC 15
T6 Compound B 1.9% EC 5
T7 Compound C22 50% EC 150
T8 Compound C23 35% EC 187.5
T9 Compound C24 50% EC 187.5
T10 Compound C25 25% EC 187.5
T11 Untreated Check (UTC) -

Table 14: DBM larval control in cauliflower crop [Ex. 7]
S.No. DBM larval control (%) at 10 DAA
Observed Expected Colby's ratio Synergism (Y/N)
T1 92.8 87.7 1.06 Y
T2 94.6 89.3 1.06 Y
T3 98.6 90.3 1.09 Y
T4 97.3 90.0 1.08 Y
T5 72.6 - - -
T6 17.5 - - -
T7 45.8 - - -
T8 52.8 - - -
T9 57.3 - - -
T10 55.6 - - -
T11 0.0 - - -

All the present compositions (T1 to T4) provide synergistic and residual control of DBM larvae in cauliflower crops.
Conclusion: Among the various compositions as shown in Table 13, T1 to T4 are the present compositions which show very good result in term of DBM larval control in cauliflower. In particular, T3 showed 98.6% control followed by T4 showing 97.3% control in cauliflower crop as compared to the known compositions and market products. At last, the Colby’s ratio observed was >1 which means strong synergism.

The process for preparing the insecticidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
Application to the seeds is carried out before sowing, either directly on the seeds or after having pre-germinated the latter. Suitable application methods include inter alia soil treatment, seed treatment, in furrow application, and foliar application. Soil treatment methods include drenching the soil, drip irrigation (drip application onto the soil), dipping roots, tubers or bulbs, or soil injection. Seed treatment techniques include seed dressing, seed coating, seed dusting, seed soaking, and seed pelleting. In furrow applications typically include the steps of making a furrow in cultivated land, seeding the furrow with seeds, applying the insecticidally active composition to the furrow, and closing the furrow. Foliar application refers to the application of the insecticidally active composition to plant foliage, e.g. through spray equipment.
The rates of application vary within wide limits and depend on the nature of the soil, the method of application, the crop plant, the pest to be controlled, the prevailing climatic conditions, and other factors governed by the method of application, the time of application and the target crop.
The present invention is suitable for use in protecting crops, plants, plant propagation materials, such as seeds, or sailor water, in which the plants are growing, from attack or infestation by animal pests. Therefore, the present invention also relates to a plant protection method, which comprises contacting crops, plants, plant propagation materials, such as seeds, or soil or water, in which the plants are growing, to be protected from attack or infestation by animal pests, with an insecticidally effective amount of the present invention.
The present invention is also suitable for use in combating or controlling animal pests. Therefore, the present invention also relates to a method of combating or controlling animal pests, which comprises contacting the animal pests, their habitat, breeding ground, or food supply, or the crops, plants, plant propagation materials, such as seeds, or soil, or the area, material or environment in which the animal pests grow, with an insecticidally effective amount of the present invention.
The lists of crops on which the insecticidal compositionof the present invention is used include, but not limited to GMO (Genetically Modified Organism) and Non GMO traits, hybrids and conventional varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Groundnut/Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Red gram (Cajanus cajan), French bean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilli (Capsicum annum), Bell pepper (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Black Pepper (Piper nigrum), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).
Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO-, ACCase- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is Clearfield® summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® and LibertyLink®.
Crops are also to be understood as being those which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt maize (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and also Bt potatoes (resistant to Colorado beetle). Examples of Bt maize are the Bt 176 maize hybrids of NK® (Syngenta Seeds). The Bt toxin is a protein that is formed naturally by Bacillus thuringiensis soil bacteria. Examples of toxins, or transgenic plants able to synthesise such toxins, are described in EP-A-451 878, EP-A-374 753, WO 93/07278, WO 95/34656, WO 03/052073 and EP-A-427 529. Examples of transgenic plants comprising one or more genes that code for an insecticidal resistance and express one or more toxins are KnockOut® (maize), Yield Gard® (maize), NuCOTIN33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protexcta®. Plant crops or seed material thereof can be both resistant to herbicides and, at the same time, resistant to insect feeding (“stacked” transgenic events). For example, seed can have the ability to express an insecticidal Cry3 protein while at the same time being tolerant to glyphosate.
Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod, and ornamental plants such as flowers or bushes.
The present composition used to control following major insect-pests and plant parasitic mites infesting crop plants. The major insect-pests are belongs to the order Hemiptera, for example, rice leafhopper/green leaf hopper (GLH) Nephotettix nigropictus, rice brown plant hopper (BPH) Nilaparvata lugen, rice backed plant hopper (WBPH) Sogatella furcifera , Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, aphid Aphis gossypii, jassid Amrasca biguttula biguttla, mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp.; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, sugarcane early shoot borer Chilo infuscatellus tobacco budworm Heliothis virescens, tomato fruit worm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, fall armyworm Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza nivella, Tryporyza incertulas, Tuta absoluta.
From the order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci, Thrips parvispinus and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp.; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp.
The major plant parasitic mites are from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Chilli yellow mite-Polyphagotarsonemus latus, Tarsonemus spp., Red spider mite-Tetranychus urticae, Tetranychus cinnabarinus.
The present invention has been described with reference to specific embodiment which is merely illustrative and not intended to limit the scope of the invention as defined in the present provisional specification.
,CLAIMS:Claims
1. A synergistic ternary insecticidal composition comprising:

A) Compound A: 1 to 20 w/w% of 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluoro benzamide;
B) Compound B: 0.5 to 20 w/w% of (1'R ,2R ,3S, 4'S, 6S, 8'R ,10' E,12'S ,13'S, 14'E ,16'E ,20'R ,21'R,24'S) -2- [(2S)-butan-2-yl] -21', 24'- dihydroxy- 12'- [(2R,4S,5S,6S) -5- [(2S,4S,5S,6S) -5- hydroxyl -4- methoxy -6- methyloxan -2-yl] oxy-4-methoxy -6- methyloxan -2-yl] oxy-3,11',13',22'- tetramethyl spiro [2,3- dihydropyran- 6,6'- 3, 7, 19-trioxa tetracyclo [15.6.1.14,8.020,24] pentacosa- 10, 14, 16, 22-tetra ene] -2'-one;
C) Compound C: 1 to 50 w/w% of at least one compound selected from group of insecticides and agrochemically acceptable excipients.

2. A synergistic ternary insecticidal composition as claimed in claim 1, wherein insecticides for Compound C is selected from the group consisting of,
C1, (2-methyl-3-phenylphenyl)methyl (1R,3R)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate,
C2, (4S,5S)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thia zolidine-3-carboxamide,
C3, methyl(4aS)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy) phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate,
C4, [(R)-cyano-(3-phenoxyphenyl)methyl] (1S,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate,
C5, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethyl sulfinyl)pyrazole-3-carbonitrile,
C6, 4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole,

C7, 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile,
C8, tert-butyl-4-[[(E)-(1,3-dimethyl-5-phenoxypyrazol-4-yl)methyl ideneamino]oxymethyl]benzoate,
C9, [(E)-2-(4-tert-butylphenyl)-2-cyano-1-(2,4,5-trimethylpyrazol-3-yl)
ethenyl] 2,2-dimethylpropanoate,
C10, 1-acetyl-6-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-3-(pyridin-3-yl methylamino)-4H-quinazolin-2-one,
C11, [(1S,2S,5S,6R,7R,9S,10S,18R)-5-(cyclopropane carbonyloxy) -9, 18 - dihydroxy-2,6,10-trimethyl- 16 – oxo – 14 - pyridin-3-yl-11,15 – dioxatetracyclo [8.8.0.02,7.012,17] octadeca – 12 (17), 13-dien-6-yl] methylcyclopropanecarboxylate,
C12, N-(cyanomethyl) - 4- (trifluoromethyl) pyridine – 3 –carboxamide,
C13, (1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E ,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'[(2R,4S, 5S ,6S)-4-methoxy-5-[(2S,4S,5S,6S)-4-methoxy-6-methyl-5-(methylamino) oxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro [2,3 -dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24] pentacosa-10,14,16,22-tetraene]-2'-one,
C14, N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzo hydrazide,
C15, N-[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy] phenyl] carbamoyl]-2,6-difluorobenzamide,
C16, (1S,2S,5R,7S,9S,10S,14R,19S)-15-[(2R,5S,6R)-5-(dimethyl amino)-6-methyloxan-2-yl]oxy-19-ethyl-4,14-dimethyl-7-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetra cyclo[10.10.0.02,10.05,9] docosa-3,11-diene-13,21-dione,
C17, N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methyl ethanimidamide,
C18, 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine,

C19 thiamethoxam, (NE)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene]nitramide,
C20, 2-methyl-1-nitro-3-(oxolan-3-ylmethyl)guanidine,
C21, [cyano-(3-phenoxyphenyl)methyl] 2,2,3,3-tetramethylcyclopropane-1-carboxylate,
C22, ethyl 2-dimethoxyphosphinothioylsulfanyl-2-phenyl acetate,
C23, 6-chloro-3-(diethoxyphosphinothioylsulfanylmethyl)-1,3-benzoxazol-2-one,
C24, 4-bromo-2-chloro-1-[ethoxy (propylsulfanyl) phosphoryl] oxybenzene,
C25, diethoxy-quinoxalin-2-yloxy-sulfanylidene-?5-phosphane.

3. A synergistic ternary insecticidal composition as claimed in claim 1, wherein the agrochemically acceptable excipients are selected from the group consisting of wetting-spreading-penetrating agent(s), dispersing agent(s), suspending agent(s), anti freezing agent(s), thickener(s), preservative(s), emulsifier(s), anti foaming agent(s), buffering agent(s), rheology modifier(s), wetting agent(s), carrier(s) and solvent(s).

4. A synergistic ternary insecticidal composition as claimed in claim 1, wherein the composition is in the form of wettable granule/ water dispersible granule (WG/WDG), mixed formulation (ZC), suspension concentrate (SC), oil dispersion (OD) and suspo emulsion (SE).

5. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the dispersing agent for wettable granule (WG) is selected from alkylnaphthalene sulfonate sodium salt, alkylnaphthalene sulfonate, modified polyacrylate copolymer, sodium polycarboxylate, naphthalenesulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates, phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt and mixture thereof.

6. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the carrier for wettable granule (WG) is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates, silica gels, fertilizers, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea, natural products of vegetable, grain meals, flours, bark meals, wood meals, nutshell meals, cellulosic powders, synthetic polymeric materials, groundpowdered plastics, resins, bentonites, zeolites, titanium dioxide, iron oxides, hydroxides, aluminium oxides, hydroxides, organic materials such as bagasse, charcoal, synthetic organic polymers or mixture thereof.

7. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the wetting agent for wettable granule (WG) is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutylnaphthalene sulphonic acid sodium salt, sodium di-isopropylnaphthalenesulphonate, sodium isopropyl naphthalene sulphonate, sodium lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates, non-ionic, tridecyl alcohol ethoxylate, alkyl-alkaryl sulfonates, alkylbenzene sulfonates, alpha olefin sulfonate, alkyl naphthalene sulfonates, ethoxylated, non-ethoxylated alkyl, alkaryl carboxylates, alkyl, alkaryl phosphate esters, alkyl polysaccharide, di, mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl, di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate, C10-C16 alkyl benzene sulfonate, organosilicons surfactants, trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxaneheptamethyl, polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane and mixture thereof.

8. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifoaming agent for wettable granule (WG) is selected from polydimethylsiloxane.

9. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the emulsifier for mixed formulation (ZC) is selected from alkylbenzene sulfonate calcium salts, tristyrlphenol polyethoxyester phosphate and mixture thereof.

10. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the wall forming material for mixed formulation (ZC) is selected from tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethenediisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5- naphthylene diisocyanate, 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate, polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional isocyanate, a polyamine in polarized form, diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6- hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12- diamine, 1,3-phenylenediamine, 2,4-toluenediamine, 2,6-toluenediamine, 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 1,5- diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6- triaminonaphthalene, 2,4,4'-triaminodiphenyl ether, 3,4,5-triamino-1,2,4- triazole, 1,4,5 ,5,8-tetraminoanthraquinone or mixture thereof.

11. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the dispersing agent for mixed formulation (ZC) is selected from ethoxylated lignosulfonic acid salts, lignosulfonic acid salts, oxidized lignins, lignin salts, salts of styrenemaleic anhydride copolymers, polyvinyl alcohol, salts of partial esters of styrene-maleic anhydride copolymers, partial salts of polyacrylic acid, partial salts of polyacrylic acid terpolymers, lignosulfonate of calcium, sodium, a modified kraft lignin with a high sulfonic acid group , dibutylnaphthalenesulfonic acid, fatty acids, alkyl-alkylarylsulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, salts of sulfated hexa, heptadecanols, octadecanols, fatty alcohol glycol ethers, condensates of sulfonated naphthalene-its derivatives with formaldehyde, condensates of naphthalene, naphthalenesulfonic acids with phenol, naphthalenesulfonic acids with formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctyl, octyl- nonylphenol, alkyl phenyl polyglycol ethers, tributyl phenyl polyglycol ethers, alkyl aryl polyether alcohols, tridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulphite waste liquors, proteins, denatured proteins, polysaccharides, ammonium salts of sulfonates, sulfates, phosphates, carboxylates, alkylarylsulfonates, diphenyl sulfonates, alpha-olefin sulfonates, sulfonates of fatty acids, oils, sulfonates of ethoxylated alkylphenols, sulfonates of condensed naphthalene, sulfonates of dodecyl-tridecyl benzenes, sulfonates of naphthalene, alkylnaphthalenes, sulfosuccinates, alkoxylates, N-alkylated fatty acid amides, amine oxides, esters, sugar-based surfactants, alkylphenols, amines, tallow amine, amides, aryl phenols, fatty acids, fatty acid esters, alkoxylated ethylene oxide, propylene oxide, ethylene oxide, polyethylene oxide, polypropylene oxide, polyacids, polybases, sodium naphthalene sulphonate formaldehyde condensates, acrylic graft copolymer and mixture thereof.

12. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the solvent for mixed formulation (ZC) is selected from hydrocarbon solvent such as an aliphatic, cyclic, aromatic hydrocarbons, toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalene, their derivatives, mineral oil fractions of medium to high boiling point such as kerosene, diesel oil, coal tar oils, a vegetable oil such as corn oil, rapeseed oil, a fatty acid ester such as C1-C10-alkylester of a C10-C22-fatty acid, methyl-ethyl esters of vegetable oils such as rapeseed oil methyl ester, corn oil methyl ester, acetophenone, 2-heptanon, 3-heptanone, 2- hexanone, 5-methyl-2-hexanone , 5-methyl-3-heptanone, 3-methyl-2-hexanone, 4-methyl-2-hexanone, 2-methyl-3-hexanone, 4-methyl-3-hexanone, 5-methyl-3-hexanone, 3-ethyl-2-pentanone, 3,3-dimethyl-2-pentanone, 3,4-dimethyl-2-pentanone, 4,4-dimethyl-2-pentanone, 2,2-dimethyl-3-pentanone , 2,4-dimethyl-3-pentanone, 2-octanone, 2,5-dimethyl-3-hexanone, 2,2-dimethyl-3-hexanone, 3,3-dimethyl-2-hexanone, 3,4-dimethyl-2-hexanone, 4,4-dimethyl-3-hexanone, 3-ethyl-4-methyl-2-pentanone, 2-methyl-3-heptanone, 2-methyl-4-heptanone, 3-methyl-2-heptanone, 3-methyl-4-heptanone, 5-methyl-3-heptanone, 6-methyl-2-heptanone, 6-methyl-3-heptanone, 3-octanone, 4-octanone, 2,2,4-trimethyl-3-pentanone, 3-ethyl-3-methyl-2-pentanone, 5-methyl-2-heptanone, isoprene or mixture thereof.

13. A synergistic ternary insecticidal composition claimed in claim 3, wherein the thickner for mixed formulation (ZC) is selected from xanthan gum, carboxy methyl cellulose, attapulgite clay, bentonite clay and mixture thereof.

14. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the suspending agent for mixed formulation (ZC) is selected from bentonite clay, aluminium magnesium silicate, silica, attapulgite clay and mixture thereof.

15. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifoaming agent for mixed formulation (ZC) is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds, C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, Dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane and mixture thereof.

16. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifreezing agent for mixed formulation (ZC) is selected from ethylene glycol, propane diols, glycerine, urea, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, magnesium sulphateheptahydrate, sodium chloride and mixture thereof.

17. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the preservatives for mixed formulation (ZC) is selected from 1,2-benzisothiazolin-3(2H)-one, 1,2-benzisothiazolin, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium ophenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4- isothiazolin-3-one and mixture thereof.

18. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the wetting spreading-penetrating agent(s) for suspension concentrate (SC) is selected from methylated seed oil, polyakyleneoxide modified trisiloxane, trisiloxane ethoxylate, heptamethyl trisiloxane, modified polyalkyleneoxide, modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, liquid or powder form and mixture thereof.

19. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the dispersing agent(s) for suspension concentrate (SC) is selected from ethylene-propylene oxide block coplolymer, naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol etherphosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide, sodium naphthalene sulphonate formaldehyde condensates and mixture thereof.
20. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the suspending agent SC for suspension concentrate (SC) is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay and mixture thereof.

21. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifoaming agent for suspension concentrate (SC) is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethylsiloxane, vegetable oil based antifoam, tallow based fatty acids and mixture thereof.

22. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifreezing agent for suspension concentrate (SC) is selected from ethylene glycol, propane diols, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerin, urea, magnesium sulfate heptahydrate, sodiumchloride and mixture thereof.

23. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the preservatives for suspension concentrate (SC) is selected from is 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2- bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and mixture thereof.

24. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the thickner for suspension concentrate (SC) is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum and mixture thereof.

25. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the emulsifying agent for oil dispersion (OD) is selected from castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, polyoxyethylene sorbitan monolaurate, polyxyethylene sobitol hexaoleate, ethoxylated sorbiton ester and mixture thereof.

26. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the dispersing agent for oil dispersion (OD) is selected from alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural fatty ethoxylate alcohols, synthetic fatty ethoxylate alcohols, natural fatty acid alkoxylates, synthetic fatty acid alkoxylates, natural fatty alcohols alkoxylates, synthetic fatty alcohols alkoxylates, alkoxylated alcohols, nbutyl alcohol poly glycol ether, block copolymers, ethylene oxidepropylene oxide block copolymers, ethylene oxide-butylene oxide block copolymers, fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether15 phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide, salts of polyolefin condensates, styrene acrylic polymer and mixture thereof.

27. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the rheology modifier for oil dispersion (OD) is selected from bentonite clay.

28. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the solvent for oil dispersion (OD) is selected from vegetable oil its alkylated or ethoxylated or esterified form, the alkylated vegetable oil, methylated vegetable oil, ethylated vegetable oil, the vegetable oils, olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil, the alkyl ester of vegetable oils, methyl ester, ethyl ester, propyl ester, butyl ester of vegetable oils, methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil, aromatic solvents, isoparaffin, base solvent, fatty acid amides, C1-C3 amines, alkylamines, alkanolamines with C6-C18 carboxylic acids, fatty acids, alkyl esters of fatty acids, methyl oleate, ethyl oleate, methyl soyate, ethyl soyate, alkyl benzenes, alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides, diamides, dialkylene carbonates, ketones, alcohols, cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, N-octanol, N-propanol, 2-ethyl hexanol, tetrahydro furfuryl alcohol, isophorone, fatty acid dimethyl amide, 2-hexylethyl lactate, propylene carbonate, methylated seed oil and mixtures thereof.

29. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the emulsifier(s) for suspo emulsion (SE) is selected from salts of dodecylbenzene sulphonate, Ca-salts, amine salts, sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates, ester phosphates, non-ionic surfactants, alkoxylated alcohols, alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated castor oil, fatty acid esters, sorbitol, their ethoxylated derivatives, ethoxylated amines, condensates of glycerol, catanionic emulsifiers, cationic amine, alkylsulphonate, ether sulphonate, ether phosphate, alkoxylated alcohols, alkoxylated alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated tristyrylphenol tristyrlphenol with 16 moles EO, tristyrylphenol-polyglycoletherphosphate, fatty acid esters of sorbitol, ethoxylated derivatives thereof, ethoxylated amines, condensates of glycerol, sulfonated alkylbenzenes in the range C11-C16, salts thereof, alkylether sulphates, alkyletherphosphates, alkylphenoletherphosphates, salts of phosphate esters of ethoxylated tristyrylphenol, salts of sulphated ethers of ethoxylated tristyrylphenol, catanionic system, alkylsulphonate, alkylethersulphonate, ether sulphate, ether phosphate, alkyletherphosphate, nonylphenol polyethoxyethanols, castor oil polyglycol ethers, poly adducts of ethylene oxide, poly adducts of polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethano, polyarylphenyl anionic ether sulphate, ammonium salts and mixture thereof.

30. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the dispersing agent(s) for suspo emulsion (SE) is selected from butyl polyalkylene oxide block copolymer, polyesters, polyamides, polycarbonates, polyurea, polyurethanes, acrylic polymers, acrylic graft copolymer, styrene copolymers, butadiene copolymers, polysaccharides, starch, cellulose derivatives, vinylalcohol, vinylacetate, vinylpyrrolidone polymers, copolymers, polyethers, epoxy, phenolic, melamine resins, polyolefins, define copolymers, acrylate polymers, polymethacrylate, polyethyl methacrylate, polymethylmethacrylate, acrylate copoylmers, styrene-acrylic copolymers, polystyrene-co maleic anhydride, cellulosic polymers, ethyl cellulose, cellulose acetate, cellulose acetate butyrate, acetylated mono, di, triglycerides, polyvinylpyrrolidone, vinyl acetate polymer, vinyl acetate copolymers, polyalkylene glycol, styrene butadiene copolymers, polyorthoesters, alkyd resins, mixtures of two or more of these, polymers, biodegradable polymers, biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, polylactic acid-glycolic acidits copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, polynamyl methacrylate, wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, polyhydroxybutyrate, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium salt of alkyl naphthalene sulfonate, sodium lingo sulfonate, sodium ploycarboxylate, EO/PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6- tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycoletherphosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide and mixture thereof.

31. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the suspending agent for suspo emulsion (SE) is selected from aluminum magnesium silicate, bentonite clay, silica, silicone dioxide, attapulgite clay and mixture thereof.

32. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the antifoaming agent for suspo emulsion (SE) is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds, C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified and mixture thereof.

33. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the preservatives for suspo emulsion (SE) is selected from propionic acid its sodium salt, sorbic acid-its sodium salt, potassium salt, benzoic acid-its sodium salt, p-hydroxy benzoic acid sodium salt, methyl p-hydroxy benzoate, biocide, sodium benzoate, 1,2-benzisothiazoline(2H)- 3-one, 2 methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates and mixture thereof.

34. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the buffering agent for suspo emulsion (SE) is selected from calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalciumphosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase, magnesium hydroxide, citric acid and mixture thereof.

35. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the solvent for suspo emulsion (SE) is selected from water, water oluble alcohols and dihydroxy alcohol ethers, water soluble alcohol or lower alcohol -1 to 4 carbon atoms, methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, macromolecular alcohol, polyethylene glycol, sorbitol, glucitol, dihydroxy alcohol ethers, dihydroxy alcohol alkyl ether, dihydroxy alcohol aryl ethers, dihydroxy alcohol alkyl ether, ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, di-propylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, dihydroxy alcohol aryl ethers includes ethylene glycol phenyl ether, 5 diethylene glycol phenyl ether, propylene glycol phenyl ether, di-propylene glycolphenyl ether, aromatic solvent C-9, hyrdocarbons, n-pentane, hexanes, cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylenes, isophorone, ester solvents, methyloleate, dimethylamide, morpholineamide derivatives of C6-C16 fatty acids, mono-alkylene carbonates, ethylene carbonate, propylene carbonate, butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol, nbutanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons, aliphatic hydrocarbons, one or more dimethylamides, C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP), dimethylformamide (DMF), dimethylisosorbide (DMI), isophorone, acetophenone, 1,3- dimethyl-2-imidazolidonone, lactate esters, dimethyl, diethylcarbonates, alcohols including methanol, ethanol, iso-propanol, n-propanol, n-butanol, iso-butanol, tert-butanol, methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, octyl phenol ethoxylates or mixture thereof.

36. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the anti freezing agent for suspo emulsion (SE) is selected from ethylene glycol, propane diols, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride and mixture thereof.

37. A synergistic ternary insecticidal composition as claimed in claim 3, wherein the thickner for suspo emulsion (SE) is selected from thickening, gelling, and anti-settling agents generally fall into two categories is selected from, but not limited to, water-insoluble particulates and watersoluble polymers, clays, silicas, montmorillonite, bentonite, magnesium aluminum silicate, attapulgite, water-soluble polysaccharides, natural extracts of seeds, seaweeds, synthetic derivatives of cellulose, guar gum, locust bean gum, carrageenam, xanthan gum, alginates, methyl cellulose, sodium carboxymethyl cellulose (SCMC), hydroxyethyl cellulose (HEC), modified starches, polyacrylates, polyvinyl alcohol, polyethylene oxide or mixtures thereof.