DESC:FIELD OF THE INVENTION:
The present invention relates to aerosol spray formulation and, more particularly to crackling foam-based aerosol spray formulation for relieving muscular cramps and the pain associated with them.

BACKGROUND OF THE INVENTION:
A sudden, unexpected tightening of one or more muscles is commonly referred to as a muscle cramp or spasm. Spasms in the muscles are typical. Smooth muscle spasm and inflammation are caused by the body's production of prostaglandins and other hormones in several medical conditions. Muscle fatigue, excessive high-intensity exercise, stress, electrolyte imbalance, and dehydration etc. are all potential causes of muscle spasms. During a muscle cramp, a single muscle, a group of muscles, or one or more of the muscle fibers will contract involuntarily, painfully, and continuously.
Now a days, there exist numerous over-the-counter medications that offer temporary or restricted relief for these frequent symptoms. NSAIDs, or non-steroidal anti-inflammatory drugs, comprise a significant portion of these oral medications that are used as general-purpose pain relievers. Examples of such medications include aspirin, ibuprofen, and acetaminophen, as well as numerous other synthetic compounds that have similar effects. Gastritis, accompanied by nausea, dizziness, and sleepiness, as well as kidney and liver damage, are the most frequent adverse effects associated with them.
Topical painkillers, often known as analgesics, are often used to relieve pain by rubbing, spraying, or applying patches to the skin over sore muscles or joints. Counterirritants, including menthol, methyl salicylate, and other medications used, may cause redness, warmth, or irritation where the medication is applied.
Lidocaine and benzocaine are widely used local anaesthetics in pain-relief sprays, but they come with notable risks and limitations. Many individuals are allergic to one or both of these ingredients, leading to skin reactions such as rashes, itching, or swelling at the application site. Excessive lidocaine application or absorption through broken skin can result in severe side effects, including seizures, heart arrhythmias, dizziness, and even loss of consciousness. Benzocaine poses a significant risk of methemoglobinemia, particularly in young children, making it unsuitable for paediatric use. It may also cause localized irritation and is generally less effective for deeper tissue pain.
Similarly, NSAID-based topical sprays or creams, while applied to the skin and associated with lower systemic absorption compared to oral medications, still pose potential risks. Their use during pregnancy is generally discouraged unless specifically recommended by a healthcare provider, as systemic absorption could pose risks to the foetus. These limitations highlight the need for safer, more universally accessible alternatives for pain relief.
The United States Patent US9717757B1 to Gasque, Jr., Samuel N. discloses a composition and method of topical application of the composition to treat and prevent muscle cramping, muscle pain, and swelling in and around muscle tissue. The composition contains a combination of active ingredients, including an anti-inflammatory agent, a cell-growth-promoting agent, and an immune system-enhancing agent. This may be associated with the typical adverse effects of using NSAIDs, including nausea, dizziness, and skin irritation in addition to gastritis.
The Czech Patent CZ287277B6 to Russell Julian Paul discloses an aerosol spray formulation containing water, dimethoxymethane, an alcoholic auxiliary solvent, and dimethyl ether. The formulation provides a cooling effect and targets pain relief for conditions such as rheumatic pain, sports injuries, and muscular discomfort. Though effective for ailments like sprains, back pain, and arthritis, the formulation poses risks, including respiratory irritation, dizziness, headaches, nausea and toxicity.
Thus, there is a need for a completely herbal, fast-acting topical formulation to relieve pain associated with muscular spasms. Further, there is a need for a composition that is easy to prepare and use and has no adverse effects on the body.

SUMMARY OF THE INVENTION:
The present invention discloses a crackling foam-based aerosol spray formulation. The crackling foam-based aerosol spray formulation includes 0.1 to 5 % w/w of a wintergreen oil, 0.1 to 3 % w/w of a plant flower extract, 0.2 to 2 % w/w of a cinnamon bark oil extract, 0.5 to 3 % w/w of a ginger oil extract, 0.5 to 5 % w/w of a mineral supplement, 1 to 15 % w/w of a solvent, 0.5 to 2 % w/w of a fragrance/perfume, 15 to 35 % w/w of a propellant, 1 to 7 % w/w of an emulsifier, 1 to 7 % w/w of a moisturizer and 50 to 60 % w/w of purified water.
The plant flower extract is selected from clove, menthol crystal and mint flower (pudina ka phool). The mineral supplement is selected from magnesium sulfate, sodium chloride and magnesium chloride. The solvent is selected from isopropyl alcohol, diethylene glycol monoethyl ether, ethyl alcohol, methylated spirit and dimethyl sulfonamide.
Further, the fragrance agent is selected from breezing wood, mint and clove and the propellant is selected from liquefied petroleum gas and liquid nitrogen gas. Further, the emulsifier is selected from hydrogenated castor oil, PEG 100, fatty acid emulsifier, polysorbate 80 and cetyl alcohol, and the moisturizer is selected from propylene glycol, glycerin, isopropyl myristate, propanediol and soyabean oil.
The present invention also discloses a process of preparation of the crackling foam-based aerosol spray formulation. The process of preparation of the crackling foam-based aerosol spray formulation includes
a first phase of adding 0.5 to 5 % w/w of mineral supplement and 1 to 7 % w/w of moisturizer in 50 to 60 % w/w purified water in the main manufacturing tank sequentially and stirring continuously at 50 to 100 rpm for 10 to 30 minutes at 15 to 25?,
a second phase of adding 0.1 to 5 % w/w of wintergreen oil, 0.1 to 3 % w/w of plant flower extract, 0.2 to 2 % w/w of cinnamon bark oil extract and 0.5 to 3 % w/w of ginger oil extract in 1 to 15 % w/w of solvent in the separate tank and mixing the solution at 50 to 150 RPM for 25 to 45 minutes at 15 to 25?,
a third phase of transferring the mixture prepared in the second phase to the main manufacturing tank, a fourth phase of mixing 0.5 to 2 % w/w of fragrance agent and 1 to 7 % w/w of emulsifier in the main tank and stirring the mixture for 25 to 45 minutes at 15 to 25? to form a hazy liquid, and
a fifth phase of packaging the formulation into the container or spray bottles including quality control analysis of the hazy liquid obtained in fourth phase followed by filling the hazy liquid in a spray pump bottle charged with 15 to 35 % w/w propellant and sealing the container or spray pump bottles.

DESCRIPTION OF THE INVENTION:
The present invention relates to a crackling foam-based aerosol spray formulation for relieving muscular cramps and the pain associated with them. The present invention also relates to a process of preparation of the crackling foam-based aerosol spray formulation.
References in the specification to "one embodiment" or "an embodiment" means that a particular feature, structure, characteristic, or function described in connection with the embodiment is included in at least one embodiment of the invention. The appearances of the phrase “in one embodiment” in various places in the specification are not necessarily all referring to the same embodiment.
References in the specification to “preferred embodiment” means that a particular feature, structure, characteristic, or function described in detail thereby omitting known constructions and functions for clear description of the present invention.
The foregoing description of specific embodiments of the present invention has been presented for purposes of illustration and description. They are not intended to be exhaustive or to limit the present invention to the precise forms disclosed and obviously many modifications and variations are possible in light of the above teaching.
In one aspect, the present invention discloses a crackling foam-based aerosol spray formulation.
In another aspect, the present invention discloses a process of preparation of the crackling foam-based aerosol spray formulation.
In accordance with a preferred embodiment, the crackling foam-based aerosol spray formulation of the present invention includes:
a) 0.1 to 5 % w/w of a wintergreen oil,
b) 0.1 to 3 % w/w of a plant flower extract,
c) 0.2 to 2 % w/w of a cinnamon bark oil extract,
d) 0.5 to 3 % w/w of a ginger oil extract,
e) 0.5 to 5 % w/w of a mineral supplement,
f) 1 to 15 % w/w of a solvent,
g) 0.5 to 2 % w/w of a fragrance/perfume,
h) 15 to 35 % w/w of a propellant,
i) 1 to 7 % w/w of an emulsifier,
j) 1 to 7 % w/w of a moisturizer, and
k) 50 to 60 % w/w of a purified water.
In accordance with this preferred embodiment, the plant flower extract is selected from clove, menthol crystal, mint flower (pudina ka phool), and the like. The plant oils/extracts obtained from different parts of the plant include active pain-relieving constituents. These plant parts or extracts/oils are procured from commercially available sources.
In accordance with the preferred embodiment, the mineral supplement is selected from magnesium sulfate, sodium chloride, magnesium chloride and the like. The mineral supplement acts as an electrolyte replenisher that aids in pain relief. The solvent is selected from isopropyl alcohol, diethylene glycol monoethyl ether, ethyl alcohol, methylated spirit, dimethyl sulfonamide and the like. The fragrance agent or perfume is selected from breezing wood, mint, clove and the like. The propellant is selected from liquefied petroleum gas, liquid nitrogen gas and the like. The propellants in aerosol systems create pressure inside the can to expel contents through the valve resulting in controlled and even spraying.
In accordance with the preferred embodiment, the emulsifier is selected from hydrogenated castor oil, PEG 100, fatty acid emulsifier, polysorbate 80, cetyl alcohol, and the like. Emulsifiers in sprays stabilize and blend immiscible ingredients like oil and water, ensuring a smooth, consistent spray and preventing component separation for even application. The moisturizer in the formulation is selected from propylene glycol, glycerin, isopropyl myristate, propanediol, soyabean oil and the like. The purified water is selected from distilled water, reverse osmosis water, deionized water and the like.
All materials used herein are commercially purchased or prepared from commercially purchased materials as described herein.
Now, a preferred process for the preparation of the crackling foam-based aerosol spray formulation in accordance with the present invention is described.
The process of the present invention includes a plurality of phases, including a first phase of adding mineral supplement and moisturizer in purified water, a second phase of adding plant extracts or oils in solvents, a third phase of transferring the mixture in the main tank, a fourth phase of mixing perfume and emulsifier, and a fifth phase of packaging the formulation into the container.
In the process, the first phase includes adding a predefined amount of mineral supplement and moisturizer in a predefined amount of purified water in the main manufacturing tank. Mineral supplements and moisturizer are added separately and sequentially to the purified water in the main tank by stirring continuously at a predefined RPM for a predefined time at a predefined temperature.
In accordance with the preferred embodiment, the mineral supplement is selected from magnesium sulfate, sodium chloride, magnesium chloride and the like and the moisturizer is selected from propylene glycol, glycerin, isopropyl myristate, propanediol, soyabean oil and the like.
The second phase includes a first step of adding a predefined amount of plant extracts or oils in a predefined amount of solvent in the separate tank and a second step of mixing the solution at a predefined RPM for a predefined time and at a predefined temperature.
In accordance with the preferred embodiment, the plant extracts or oils are selected from wintergreen oil, cinnamon bark oil extract, ginger oil extract and plant flower extract selected from clove, menthol crystal, mint flower (pudina ka phool) and the like. The solvent is selected from isopropyl alcohol, diethylene glycol monoethyl ether, ethyl alcohol, methylated spirit, dimethyl sulfonamide and the like.
The third phase includes transferring the mixture prepared in the second phase to the main manufacturing tank.
The fourth phase includes a first step of mixing a predefined amount of fragrance agent or perfume and emulsifier in the main tank and a second step of stirring the mixture for a predefined time at a predefined temperature to form a hazy liquid.
In accordance with the preferred embodiment, the emulsifier is selected from hydrogenated castor oil, PEG 100, fatty acid emulsifier, polysorbate 80, cetyl alcohol, and the like and the fragrance agent is selected from breezing wood, mint, clove and the like.
The fifth phase of packaging the formulation into the container includes a first step of quality control analysis of the hazy liquid obtained in the fourth phase, a second step of filling the hazy liquid in a spray pump bottle charged with a predefined amount of propellant and a third step of sealing the container or spray pump bottles.
In the first step of the fifth phase, quality control analysis includes analysis of the liquid using IPQC Methods such as pH, viscosity, solubility, color and the like. In accordance with the preferred embodiment, the propellant is selected from liquefied petroleum gas, liquid nitrogen gas and the like. In the third step of the fifth phase, the bottles or containers are sealed by aerosol crimp sealing machine/ crimping machine. In accordance with the present invention, in the first phase of adding a predefined amount of mineral supplement and moisturizer in a predefined amount of purified water, the predefined amount of mineral supplement is 0.5 to 5 % w/w, the predefined amount of moisturizer is 1 to 7 % w/w and the predefined amount of purified water is 50 to 60 % w/w. The mineral supplement and moisturizer are added separately and sequentially to the purified water in the main tank by stirring continuously at the predefined RPM of 50 to 100 RPM for the predefined time of 10 to 30 minutes at the predefined temperature of 15 to 25?.
In the second phase of adding a predefined amount of plant extracts or oils in a predefined amount of solvent, the predefined amount of plant extracts or oils i.e., wintergreen oil is 0.1 to 5 % w/w, cinnamon bark oil extract is 0.2 to 2 % w/w, ginger oil extract is 0.5 to 3 % w/w, plant flower extract is 0.1 to 3 % w/w and the predefined amount of solvent is 1 to 15 % w/w. The solution obtained in the second phase is mixed at the predefined RPM of 50 to 150 RPM for the predefined time of 25 to 45 minutes and at the predefined temperature of 15 to 25?. Then, in the fourth phase of mixing the predefined amount of fragrance agent is 0.5 to 2 % w/w and the predefined amount of emulsifier 1 to 7 % w/w. The mixture obtained in the fourth phase is mixed by stirring for the predefined time of 25 to 45 minutes at the predefined temperature of 15 to 25? to form a hazy liquid Further, in the last phase i.e., the fifth phase of packaging the formulation into the container, the predefined amount of propellant is 15 to 35 % w/w.
The solution prepared by the method of the present invention is further tested for quality control. The formulation prepared by the process of the present invention is filled into an aluminum can or spray bottles. Next, a predefined amount of propellant is crimped and charged into the canister. Once the product is fully assembled, it undergoes rigorous testing for quality control.
In accordance with the present invention, the formulation of the present invention is packaged in a container or spray bottle made of Aluminum having dimensions 35 x 85 mm having 1" aluminum valve, an actuator having white with red insert and a cap made of polypropylene of 35 mm.
In accordance with the present invention, the aerosol spray formulation generates a crackling foam that swiftly disappears following application. By replenishing electrolytes and rehydrating the affected areas, it treats the underlying cause of cramps and eases the associated discomfort. This ensures quick and targeted action.
These and other embodiments will be apparent to those of skill in the art and others in view of the following detailed description of some embodiments. It should be understood, however, that this summary and the detailed description illustrate only some examples of various embodiments and are not intended to be limiting to the invention as claimed.

EXAMPLES:
Only a few examples and implementations are disclosed. Variations, modifications, and enhancements to the described examples and implementations and other implementations can be made based on what is disclosed.
Examples are set forth herein below and are illustrative of different amounts and types of reactants and reaction conditions that can be utilized in practicing the disclosure. It will be apparent, however, that the disclosure can be practiced with other amounts and types of reactants and reaction conditions than those used in the examples, and the resulting devices various different properties and uses in accordance with the disclosure above and as pointed out hereinafter.

Example 1: Crackling Foam-Based Aerosol Spray Formulation
The crackling foam-based aerosol spray formulation, including plant oils or extracts, solvents, propellants, emulsifiers, and moisturizers was as provided below:
Table No. 1: Crackling foam-based aerosol spray formulation
Sr No Active Ingredients %w/w For 75g
1 Wintergreen Oil 0.5 0.375
2 Lavang/Clove Oil 1 0.75
3 Cinnamon Oil 0.5 0.375
4 Mint Flower Extract 1 0.75
5 Ginger Oil Extract 1 0.75
6 Magnesium Sulfate 1 0.75
7 Isopropyl alcohol 4.5 3.375
8 Fragrance Breezing Wood 1 0.75
9 Liquid Petroleum Gas 25 18.75
10 Hydrogenated Castor Oil 5.5 4.125
11 Glycerine 5 3.75
12 Purified Water 54 40.5
Example 2: Process of Preparation of Crackling Foam-Based Aerosol Spray Formulation
1. 1 % w/w of magnesium sulfate and 5 % w/w of glycerine were added in a 54 % w/w of purified water in the main manufacturing tank and stirred continuously at 50 to 100 rpm for 10 to 30 minutes at 15 to 25?.
2. Further, 0.5 % w/w of wintergreen oil, 1 % w/w of mint flower extract, 1 % w/w of lavang/clove oil, 0.5 % w/w of cinnamon oil and 1 % w/w of ginger oil extract were added in 4.5 % w/w of isopropyl alcohol in the separate tank and the solution formed was mixed at 50 to 150 RPM for 25 to 45 minutes at 15 to 25?.
3. The mixture prepared in the second step was transferred to the main manufacturing tank.
4. Then, 1 % w/w of fragrance breezing wood and 5.5 % w/w of hydrogenated castor oil was added in the main tank and the mixture was stirred for 25 to 45 minutes at 15 to 25? to form a hazy liquid.
5. This hazy liquid formed in the above step was subjected to quality control analysis and then filled in a spray pump bottle or container charged with 25 % w/w of liquid petroleum gas.
6. Finally, the container or spray pump bottles were sealed.
7. The aerosol spray formulation generated a crackling foam that swiftly disappeared following application and treated the cramps and eased the associated discomfort.
Example 3: Clinical Assessment of Crackling Foam-Based Aerosol Spray in Muscle Cramps
The clinical study was undertaken to evaluate the effectiveness of a crackling foam-based aerosol spray in relieving muscle cramps. A total of 30 patients, aged 14 to 60 years, were enrolled in the study. The impact of crackling foam-based aerosol spray was assessed based on parameters, including cramp frequency, intensity and duration of acute cramps, onset of relief, and residual muscle soreness. Additionally, the Global Patient Satisfaction Scale (GPSS) was measured on a 0-5 scale to gauge overall user satisfaction with the spray.

Example 3.1: Effect of crackling foam-based aerosol spray on frequency of cramps
The effect of crackling foam-based aerosol spray was assessed on the frequency of cramps after the application of aerosol spray prior to physical exertion for a period of 15 days. The results of the assessment were tabulated in Table no. 2
Table No. 2: Effect on frequency of cramps after application of crackling foam-based aerosol spray prior to physical exertion for 15 days
Mean No. of Episodes
No. of Subjects Before Application After Application % Reduction
Frequency of cramps

5 3 1 66.66
9 2 0.7 65
17 1 0.3 70
Mean = 67.22

Result: The effect of the crackling foam-based aerosol spray on the frequency of cramp was evaluated over 15 days of use before physical exertion. The mean frequency of cramps was calculated before and after application, revealing a 67% reduction in the number of cramp episodes compared to previous experiences.

Example 3.2: Effect of crackling foam-based aerosol spray on intensity of acute cramps
The effect of crackling foam-based aerosol spray was assessed on the intensity of acute cramps. The results are tabulated in Table no. 3.
Table No. 3: Effect of crackling foam-based aerosol spray on intensity of acute cramps

Intensity of Cramp Pain on VAS Scale (0-10 cm) Before Application (No. of subjects) 1 min After Application (No. of subjects)
No cramp pain 0 cm 0 26
Mild cramp pain 1 to 3 cm 0 3
Moderate cramp pain 4 to 6 cm 0 1
Severe cramp pain 7 to 9 cm 2 0
Extremely severe cramp pain 10 cm 28 0

Result: The effect of the crackling foam-based aerosol spray on the intensity of acute cramps was assessed before and after application. Before application, 93% of subjects reported experiencing extremely severe cramp pain. After applying the spray, 86% of subjects reported complete pain relief, while 10% experienced only mild pain.

Example 3.3: Effect of crackling foam-based aerosol spray on duration of acute cramps
The effect of crackling foam-based aerosol spray was assessed on the duration of acute cramps and the results were tabulated in Table no. 4.
Table No. 4: Effect of crackling foam-based aerosol spray on duration of acute cramps
Duration of Cramp Episode Previous Experience After Application
11 to 15 min 3 0
10 to 5 min 7 0
4 to 2 min 15 5
1 min 5 25
0 min 0 0

Result: The effect of the crackling foam-based aerosol spray on the duration of acute cramps was assessed before and after application. Before application, 83% of subjects experienced cramps lasting between 2 to 4 minutes. After using the spray, 83% of subjects reported a significant reduction in cramp duration to less than 1 minute, while only 17% continued to experience cramps lasting between 2 to 4 minutes.
Example 3.4: Effect of crackling foam-based aerosol spray on time of onset of relief in acute cramps
The effect of crackling foam-based aerosol spray was assessed on the time of onset of relief in acute cramps. The results were tabulated in Table no. 5.
Table No. 5: Effect of crackling foam-based aerosol spray on time of onset of relief in acute cramps
Onset of Relief of Cramp Previous Experience After Application
0 to 30 Seconds 0 14
30 seconds to 1 min 0 11
2 to 4 min 15 5
5 to 7 min 11 0
10 min 4 0

Result: The effect of the crackling foam-based aerosol spray on the onset of relief from acute cramps was assessed before and after application. Without the spray, 100% of subjects experienced relief onset after 2 to 4 minutes. But after applying the spray, 83% of subjects reported relief in less than 1 minute, while the remaining subjects experienced relief within 2 to 4 minutes.
Example 3.5: Effect of crackling foam-based aerosol spray in residual soreness in acute cramps
The effect of crackling foam-based aerosol spray was assessed to determine the residual muscle soreness, with results displayed in Table no. 6.
Table No. 6: Effect of crackling foam-based aerosol spray in residual soreness in acute cramps
Residual Soreness on VAS Scale Previous Experience After Application
0 cm 0 3
1 to 3 cm 2 26
4 to 6 cm 7 1
7 to 9 cm 8 0
10 cm 13 0

Result: The effect of the crackling foam-based aerosol spray on the acute cramps was assessed before and after application. It was observed that the residual soreness in muscles was significantly reduced after the application of crackling foam-based aerosol spray.
Example 3.7: Overall Global Patient Satisfaction Scale (GPSS) after use of Cramp Relief Spray on Scale (0-5)
The Global Patient Satisfaction Scale (GPSS) was measured on a 0-5 scale to gauge overall user satisfaction with the spray and the observations were depicted in Table no. 7.
Table No. 7: Global Patient Satisfaction Scale (GPSS)
Scale (0-5) GPSS after use of Cramp Relief Spray
Not Satisfied at all: 0 0
Average: 1 0
Moderate: 2 0
Good: 3 3
Excellent: 4 4
Exceptional: 5 23

Result: On studying the effect of crackling foam-based aerosol spray on the muscle cramps in subjects, it was observed that 76% of subjects rated their experience as exceptional (GPSS scale of 5), 13% reported excellent results (GPSS scale of 4), and 10% recorded good results (GPSS scale of 3).
Advantageously, the crackling foam-based aerosol spray formulation of the present invention is a fast-acting foam that eases post-cramp discomfort and quickly absorbs to relieve muscle cramps and spasms. The crackling foam-based aerosol spray formulation of the present invention replenishes electrolytes in the impacted areas and facilitates healing and targets the root cause of cramping. The formulation of the present invention is safe to use regularly, non-greasy, and made of natural substances. Furthermore, the formulation has a mild, non-overpowering scent.
The embodiments were chosen and described in order to best explain the principles of the present invention and its practical application, to thereby enable others, skilled in the art to best utilize the present invention and various embodiments with various modifications as are suited to the particular use contemplated.
It is understood that various omission and substitutions of equivalents are contemplated as circumstance may suggest or render expedient, but such are intended to cover the application or implementation without departing from the scope of the present invention.
,CLAIMS:We claim:
1. A crackling foam-based aerosol spray formulation comprising:
a) 0.1 to 5 % w/w of a wintergreen oil;
b) 0.1 to 3 % w/w of a plant flower extract;
c) 0.2 to 2 % w/w of a cinnamon bark oil extract;
d) 0.5 to 3 % w/w of a ginger oil extract;
e) 0.5 to 5 % w/w of a mineral supplement;
f) 1 to 15 % w/w of a solvent;
g) 0.5 to 2 % w/w of a fragrance/perfume;
h) 15 to 35 % w/w of a propellant;
i) 1 to 7 % w/w of an emulsifier;
j) 1 to 7 % w/w of a moisturizer; and
k) 50 to 60 % w/w of purified water.
2. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the plant flower extract being selected from clove, menthol crystal and mint flower (pudina ka phool).
3. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the mineral supplement being selected from magnesium sulfate, sodium chloride and magnesium chloride.
4. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the solvent being selected from isopropyl alcohol, diethylene glycol monoethyl ether, ethyl alcohol, methylated spirit and dimethyl sulfonamide.
5. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the fragrance being selected from breezing wood, mint and clove.
6. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the propellant being selected from liquefied petroleum gas and liquid nitrogen gas.
7. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the emulsifier being selected from hydrogenated castor oil, PEG 100, fatty acid emulsifier, polysorbate 80 and cetyl alcohol.
8. The crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the moisturizer being selected from propylene glycol, glycerin, isopropyl myristate, propanediol and soyabean oil.
9. A process of preparation of the crackling foam-based aerosol spray formulation as claimed in claim 1, wherein the process including the steps of:
a) a first phase of adding 0.5 to 5 % w/w of mineral supplement and 1 to 7 % w/w of moisturizer in 50 to 60 % w/w purified water in the main manufacturing tank sequentially and stirring continuously at 50 to 100 RPM for 10 to 30 minutes at 15 to 25?;
b) a second phase of adding 0.1 to 5 % w/w of wintergreen oil, 0.1 to 3 % w/w of plant flower extract, 0.2 to 2 % w/w of cinnamon bark oil extract and 0.5 to 3 % w/w of ginger oil extract in 1 to 15 % w/w of solvent in the separate tank and mixing the solution at 50 to 150 RPM for 25 to 45 minutes at 15 to 25?;
c) a third phase of transferring the mixture prepared in the second phase to the main manufacturing tank;
d) a fourth phase of mixing 0.5 to 2 % w/w of fragrance agent and 1 to 7 % w/w of emulsifier in the main tank and stirring the mixture for 25 to 45 minutes at 15 to 25? to form a hazy liquid;
e) a fifth phase of packaging the formulation into the container or spray bottles, including quality control analysis of the hazy liquid obtained in the fourth phase, followed by filling the hazy liquid in a spray pump bottle charged with 15 to 35 % w/w propellant and sealing the container or spray pump bottles.

Dated this 8th day of March 2024.

For, MIDASCARE PHARMACEUTICALS PVT LTD,

Mahurkar Anand Gopalkrishna
IN/PA-1862
(Agent for Applicant)