Composition For Enhancing Intra Cellular Nitric Oxide Generation

Abstract: The present invention discloses a pharmaceutical composition comprising 1-{3-[9-methoxy-7-(2-methoxyphenyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-4-carbonyl]phenyl}imidazolidin-2-one ; N-tert-butyl-2-{N-[(furan-2-yl)methyl]-2-[5-(4-methylphenyl)-2H-1,2,3,4-tetrazol-2-yl]acetamido}-2-(4-hydroxyphenyl)acetamide ; 3-[2-(2-{[(6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(4hydroxyphenyl) methyl]amino}-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamido]benzoic acid; 2-oxo-2-(1H-pyrrol-2-yl)ethyl 2-[(4-fluorophenyl)methoxy]benzoate ; and 5-(3-{[(3-bromo-4-hydroxy-5 methoxyphenyl) methylidene]amino}-2 (butylimino)- 2,3-dihydro-1,3-thiazol-4-yl)-2-hydroxybenzamide.The components are small molecule antagonists that increase the intracellular nitric oxide level by inhibiting the interaction between Nitric oxide synthase interacting proteins and inducible Nitric oxide synthase.

Patent Information

Application #

Filing Date

28 November 2024

Publication Number

10/2025

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

INSTITUTE OF LIFE SCIENCES

(An Autonomous Institute of the Department of Bio Technology, Govt. of India) Nalco Square, Bhubaneswar – 751203, Odisha, India

TRANSLATIONAL HEALTH SCIENCES AND TECHNOLOGY INSTITUTE (THSTI)

NCR Biotech Science Cluster 3rd Milestone, Faridabad - Gurgaon Rd, Expressway, Faridabad – 121001, Haryana, India

Inventors

1. B.Ravindran

Institute of Life Sciences, Nalco Square, Bhubaneswar-751203, Odisha, India

2. Diwakar Kumar Singh

Institute of Life Sciences, Nalco Square, Bhubaneswar-751203, Odisha, India

3. Shailendra Asthana

Translational Health Sciences and Technology Institute (THSTI), Faridabad-121001, Haryana, India

4. Sagar Gaikwad

Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Route 1045, Galveston, 77555-1045, Texas, USA

5. Dileep Vasudevan

Institute of Life Sciences, Nalco Square, Bhubaneswar-751203, Odisha, India

6. Narottam Acharya

Institute of Life Sciences, Nalco Square, Bhubaneswar-751203, Odisha, India

Specification

Description:PLEASE SEE THE ATTACHMENT , Claims:PLEASE SEE THE ATTACHMENT

Documents

Application Documents

#	Name	Date
1	202432093349-STATEMENT OF UNDERTAKING (FORM 3) [28-11-2024(online)].pdf	2024-11-28
3	202432093349-Sequence Listing in txt [28-11-2024(online)].txt	2024-11-28
4	202432093349-Sequence Listing in PDF [28-11-2024(online)].pdf	2024-11-28
5	202432093349-REQUEST FOR EXAMINATION (FORM-18) [28-11-2024(online)].pdf	2024-11-28
6	202432093349-PROOF OF RIGHT [28-11-2024(online)].pdf	2024-11-28
7	202432093349-FORM FOR SMALL ENTITY(FORM-28) [28-11-2024(online)].pdf	2024-11-28
8	202432093349-FORM 18 [28-11-2024(online)].pdf	2024-11-28
9	202432093349-FORM 1 [28-11-2024(online)].pdf	2024-11-28
10	202432093349-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [28-11-2024(online)].pdf	2024-11-28
11	202432093349-EVIDENCE FOR REGISTRATION UNDER SSI [28-11-2024(online)].pdf	2024-11-28
12	202432093349-EDUCATIONAL INSTITUTION(S) [28-11-2024(online)].pdf	2024-11-28
13	202432093349-DRAWINGS [28-11-2024(online)].pdf	2024-11-28
14	202432093349-DECLARATION OF INVENTORSHIP (FORM 5) [28-11-2024(online)].pdf	2024-11-28
15	202432093349-COMPLETE SPECIFICATION [28-11-2024(online)].pdf	2024-11-28
16	202432093349-FORM-26 [21-02-2025(online)].pdf	2025-02-21
17	202432093349-FORM 3 [27-05-2025(online)].pdf	2025-05-27