DESC:FIELD OF THE INVENTION
The present invention relates to the field of agrochemical compositions for crop protection. More specifically, the invention pertains to a synergistic fungicidal composition comprising mandipropamid in combination with at least one additional fungicide selected from the strobilurin class, cymoxanil, or propineb. The invention further relates to the process for preparing such synergistic compositions and their application in the prevention and control of plant pathogenic fungi on seeds, foliage, and other parts of plants at various growth stages, thereby contributing to improved crop health and enhanced agricultural yield.
BACKGROUND OF THE INVENTION
Crop protection is the practice of protecting the crop yields from pests, weeds, plant diseases, and other organisms that damage agricultural crops, which is critical from early stages of crop development. Preventing pests and diseases in the entire crop cycle, i.e., from root development to maturing crops, leads to increased crop quality and yield. The control of plant diseases caused by fungi is extremely important in achieving high crop efficiency. Plant diseases cause significant damage to vegetables, fields, cereal, fruit and other crops, leading to reduction in productivity, yield and quality of the crops. Fungicides help to minimize this damage by controlling plant pathogenic fungi. The use of two or more appropriate active ingredient combinations in specific dose ratios leads to synergism in crop protection. In addition to this, often highly destructive plant diseases can be difficult to control and may develop resistance to commercial fungicides. Many products are commercially available for these purposes, but there is still a continues need to develop new fungicidal combinations which are more effective, less costly, less toxic, environmentally safer and have different sites of action.
The biggest challenge in the field of crop protection is to reduce the dosage rate of active ingredients to diminish or circumvent environmental or toxicological effects without compromising on effective crop protection against pathogenic fungi, in addition to long lasting and broad-spectrum protection from plant diseases. Another challenge is to reduce the excessive application of solo chemical compounds or insecticides which invariably help in rapid selection of pathogenic fungi and aid in developing natural or adapted resistance against the active compound in question.
Therefore, it is indeed necessary to use the fungicidal combination in lower doses, fast acting with the different mode of action that can provide long lasting control against broad spectrum of pathogenic fungi and check the resistance development in fungi. The composition should have high synergistic action, no cross resistance to existing fungicides, avoid excess loading of the toxicant to the environment and negligible impact to environmental safety. Thus, there is a need for synergistic fungicidal combinations which could be physico-compatible formulations in the form of storage stability, safe packaging and ready to use formulations.
Mandipropamid is a systemic fungicide belonging to the mandelamide class. It works by inhibiting cellulose synthase, disrupting cell wall formation in target fungi, and is classified under FRAC Group 40. It is primarily used to control oomycete pathogens such as Phytophthora and Pythium, which cause diseases like downy mildew and late blight in crops such as grapes, potatoes, tomatoes, cucurbits, and onions. Mandipropamid offers translaminar activity, rainfastness, and high selectivity, making it effective at low doses with minimal impact on non-target organisms.
Strobilurins are a class of broad-spectrum fungicides derived from natural compounds produced by the wood-decay fungus Strobilurus tenacellus. They work by inhibiting mitochondrial respiration in fungal cells, specifically targeting the Qo site of cytochrome bc1 complex (complex III), which disrupts energy production and leads to fungal death. Classified under FRAC Group 11, strobilurins are effective against a wide range of fungal pathogens causing diseases like rusts, powdery mildew, and leaf spots in crops such as cereals, fruits, vegetables, and soybeans
Cymoxanil is a systemic and contact fungicide belonging to the cyanoacetamide-oxime chemical group. It acts by inhibiting nucleic acid synthesis in the pathogen, stopping spore germination and mycelial growth at early infection stages. It is primarily used to control oomycete fungi, such as Phytophthora and Peronospora species. Cymoxanil is classified under FRAC Code 27. It is particularly effective against diseases like late blight in potatoes and tomatoes and downy mildew in grapes and cucurbits. It has curative properties to broaden its spectrum and improve efficacy.
Propineb is a broad-spectrum protective (contact) fungicide belonging to the dithiocarbamate chemical group. It works by interfering with multiple enzymes containing sulfhydryl groups, thereby inhibiting vital metabolic processes in fungal cells. Propineb provides a multi-site mode of action, which reduces the risk of resistance development and is classified under FRAC Group M3. It is used to control a wide range of fungal diseases such as early blight, late blight, downy mildew, leaf spots, and scabs in crops like potatoes, tomatoes, grapes, apples, and cucurbits. It forms a protective film on the plant surface, preventing spore germination and fungal penetration.
Although each of the above fungicides is effective against specific fungal targets, their standalone use is often insufficient to achieve comprehensive disease control under diverse agronomic and environmental conditions. Moreover, the overreliance on single-site fungicides such as mandipropamid, strobilurins or others has been associated with the rapid development of fungicide-resistant fungal strains.
To address these limitations, synergistic combinations of fungicides with different mechanisms of action are gaining importance. Such combinations not only broaden the spectrum of disease control, but also delay the onset of resistance, and enhance the overall efficacy of the formulation.
The present invention relates to a novel fungicidal composition comprising mandipropamid and at least one more fungicide selected from strobilurin class, cymoxanil, and propineb in a water dispersible granule (WDG/WG) or wettable Powder (WP) or suspension concentrates (SC) formulation which offers a synergistic effect against a broad range of phytopathogens. This composition combines the systemic and broad-spectrum activity of its individual components to deliver enhanced protection, prolonged residual activity, and improved field performance. Furthermore, the combination is designed to provide storage stability, and ease of handling, which are essential for practical field applications.
OBJECTS OF THE INVENTION
The primary objective of the invention is to provide synergistic binary fungicidal composition.
Another objective of the present invention is to provide a synergistic composition comprising mandipropamid and at least one morefungicide selected from strobilurin class, cymoxanil, and propineb with at least one agriculturally acceptable excipient.
Another objective of the present invention is to provide a fungicidal composition with enhanced efficacy and crop yield without phytotoxicity.
Another objective of the present invention is to provide a process for the preparation of synergistic fungicidal composition.
Another objective of the present invention is to provide a synergistic composition with broad spectrum control of fungi.
The above and other objectives of the present invention are achieved according to the following embodiments of the present invention. However, the disclosed embodiments are exemplary based on the preferred and best mode of the invention and not limit the scope of the present invention.
SUMMARY OF THE INVENTION
The present invention aims to provide a synergistic fungicidal composition comprising mandipropamid and at least one more fungicide selected from strobilurin class, cymoxanil, and propineb with at least one agriculturally acceptable excipient and the process of preparation thereof.
In another aspect, the present invention provides a process for preparing the synergistic composition comprising mandipropamid and at least one more fungicide selected from strobilurin class, cymoxanil, and propineb with at least one agriculturally acceptable excipient.
In accordance with one aspect of the present invention, there is provided a synergistic composition for crop protection management comprising of a) mandipropamid in an amount in the range of 1-40% by weight, b) at least one more fungicide selected from strobilurin class, cymoxanil, and propineb in an amount in the range of 1-80% by weight, and c) agriculturally acceptable excipient in an amount in the range of 0.01-80% by weight.
In another aspect, the synergistic composition of the present invention may be formulated as Water dispersible granules (WDG/WG) or wettable Powder (WP) or Suspension concentrates (SC).
In another aspect of the present invention, the synergistic composition comprises one or more inactive excipients selected from the group comprising of a carrier(s), surfactant(s), binder(s), disintegrating agent(s), dispersants or dispersing agent(s), wetting agent(s), pH modifier(s), thickener(s), biocide(s), preservative(s), anti-freezing agent(s), antifoaming agent (s), solvents, water soluble polymers, and/or stabilizer(s) or a combination thereof.
In accordance with one aspect of the present invention, there is provided a synergistic composition for crop protection management comprising of a) mandipropamid in an amount in the range of 1-40% by weight, b) at least one more fungicide selected from strobilurin class, cymoxanil, and propineb in an amount in the range of 1-80% by weight, and c) agriculturally acceptable excipient in an amount in the range of 0.01-80% by weight, wherein the resultant composition is non-toxic, efficient Water dispersible granules (WDG/WG) or wettable Powder (WP) or Suspension concentrates (SC) formulation.
These and other objectives and embodiments of the invention will become more fully apparent when the following detailed description is read with the accompanying study details and examples. However, both the foregoing summary of the invention and the following detailed description of it represent one potential experiment and embodiment and are not restrictive of the invention or other alternate embodiments of the invention.
DETAILED DESCRIPTION OF THE INVENTION
The present specification refers to a synergistic fungicidal composition and the process for the preparation for crop protection.
The definitions provided herein below for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit, the scope of the present invention disclosed in the present disclosure.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Other process and materials similar, or equivalent, to those described herein may be used in the practice of the present invention.
As used herein, the terms “comprises”, “comprising”, “includes”, “including”, “has”, “having”, “contains”, “containing”, “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method.
The term “combination” can be replaced with the words “mixture” or “composition” or "formulation" defined or refers to as combining two or more active ingredients formulated in desired formulations.
The term “pesticide” as used in this specification refers to a substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest or weeds which causes damage to the crop. Herbicides, insecticides, and fungicides are mainly used as pesticides which control weeds and insect pests and disease-causing pathogens, respectively that eventually lead to high yield of crops.
The term “Fungicide” also called Antimycotic, as used in this specification refers to a type of chemical compound or substance specifically designed to protect crops and kill or inhibit the growth of fungi and their spores that cause economic damage to crop, ornamental plants or endanger the health of domestic animals or humans.
The term “synergism” as used in this specification refers to the interaction between two or more active compounds or other factors to produce a combined effect or properties that is greater than the sum of their separate effects or properties. The present invention involves the mixture of two active ingredients which has increased efficacy and broad spectrum of weed control when compared to individual use and admixture of those components.
As used herein, the term “agriculturally acceptable excipients” or “excipients” or "additive(s)" or “agriculturally acceptable additives” or "auxiliaries" or "agriculturally acceptable carrier(s)" can be used interchangeably and refers to inert substances which are commonly used as diluent, to provide stability or to increase the activity profile of the composition or formulation with or without having agrochemical activity.
The expression of various quantities in the terms of “% w/w” means the percentage by weight, relative to the weight of the total composition unless otherwise specified.
The expression of various quantities in the terms of “g.a.i/ha” means the gram active ingredient per hectare. The term “g.a.i/ha” is similar to gm/ha.
The inventors of the present invention conducted extensive study and came up with suitable composition comprising effective amount of specific adjuvants.
As used herein, the term “mandipropamid” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of mandipropamid.
As used herein, the term “strobilurin” is selected from but not limited to the group comprising azoxystrobin, coumoxystrobin, dimoxystrobin enoxastrobin, fenaminstrobin, flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobin, metominostrobin, orysastrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, and trifloxystrobin encompasses its agro-chemically acceptable salt(s), derivative(s) or any other modified form.
As used herein, the term “cymoxanil” encompasses its agrochemically acceptable salt(s), derivative(s) or any other modified form of cymoxanil.
As used herein, the term “propineb” encompasses its agro-chemically acceptable salt(s), derivative(s) or any other modified form of propineb.
In one embodiment, the present invention provides a synergistic fungicidal composition comprising of mandipropamid and at least one more fungicide selected from strobilurin class, cymoxanil, and propineb.
According to the present embodiment, the present invention provides a synergistic fungicidal composition comprising mandipropamid and at least one more fungicide selected from strobilurin class, cymoxanil, and propineb and at least one inactive excipient.
According to a preferred embodiment, the present invention provides a fungicidal waterdispersible granule (WDG/WG) formulation comprising:
mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-30% by weight;
strobilurin or agrochemically acceptable salt(s) thereof is present in the range of 1-20% by weight; preferably in an amount in the range of 10-20% by weight; and
at least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
In another aspect, the strobilurin fungicide is selected from but not limited to the group comprising azoxystrobin, coumoxystrobin, dimoxystrobin enoxastrobin, fenaminstrobin, flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobin, metominostrobin, orysastrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, and trifloxystrobin; preferably azoxystrobin and trifloxystrobin.
In another aspect, the strobilurin fungicide particularly preferred is azoxystrobin.
In another aspect, the strobilurin fungicide particularly preferred is trifloxystrobin.
According to a preferred embodiment, the present invention provides a fungicidal water dispersible granules (WDG) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-30% by weight; furthermore, preferably in an amount in the range of 25% by weight;
Azoxystrobin or agrochemically acceptable salt(s) thereof is present in the range of 1-20% by weight; preferably in an amount in the range of 10-20% by weight; furthermore, preferably in an amount in the range of 18% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
According to a preferred embodiment, the present invention provides a fungicidal water dispersible granule (WDG/WG) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-30% by weight; furthermore, preferably in an amount in the range of 24.5% by weight;
Trifloxystrobin or agrochemically acceptable salt(s) thereof is present in the range of 1-20% by weight; preferably in an amount in the range of 10-20% by weight; furthermore, preferably in an amount in the range of 12% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
According to a preferred embodiment, the present invention provides a fungicidal wettable Powder (WP) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-30% by weight; furthermore, preferably in an amount in the range of 20% by weight;
Cymoxanil or agrochemically acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-30% by weight; furthermore, preferably in an amount in the range of 20% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
According to a preferred embodiment, the present invention provides a fungicidal suspension concentrates (SC) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight; preferably in an amount in the range of 10-20% by weight; furthermore, preferably in an amount in the range of 10% by weight;
Propineb or agrochemically acceptable salt(s) thereof is present in the range of 1-80% by weight; preferably in an amount in the range of 40-70% by weight; furthermore, preferably in an amount in the range of 65% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
According to an embodiment of the present invention, agrochemically acceptable excipients are selected from the group comprising wetting agent(s), emulsifier(s), colorant(s), surfactant(s), thickener(s)/binder(s), antifreeze agent(s), anti-foaming agent(s), antioxidant(s), solvent(s)/carrier, preservative(s), glidant(s), anticaking agent(s), pH regulating agent(s), buffering agent(s), filler(s), formulation aid(s), disintegrant(s), or combinations thereof.
According to the present embodiment, the suitable wetting agent is selected from the group comprising but are not limited to sodium isopropyl naphthalene sulfonate, sodium di-isopropyl naphthalene sulphonates, sodium dioctyl sulphosuccinate, and naphthalene sulfonic acid and phenol sulphonic acid sodium salt.
According to an embodiment, wetting agents that can be added to the agrochemical formulation of the present invention include, but are not limited to Oxirane, 2-methyl-, polymer with oxirane, block (Atlas G 5000), polyarylalkoxylated phosphate esters and their potassium salts (e.g., Soprophor FLK, Stepfac TSP PE- K. Other suitable wetting agents include sodium dioctylsulfosuccinates (e.g., Geropon SDS, Aerosol OT) and ethoxylated alcohols (e.g., Trideth-6; Rhodasurf BC 610; Tersperse 4894; Soprophor BSU).
In another embodiment, emulsifier(s) which can be advantageously employed herein can be readily determined by those skilled in the art and include various nonionic, anionic, cationic, and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of non-ionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts.
Anionic emulsifiers include the oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts or sulfated polyglycol ethers, appropriate salts of phosphated polyglycol ether, or combinations thereof.
In an embodiment, colorant(s) may be selected from iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs, and trace elements, such as salts of iron, copper, manganese, boron, cobalt, molybdenum and zinc, or combinations thereof.
In an embodiment, thickener(s) or gelling agent(s) may be selected from but not limited to molasses, granulated sugar, alginates, karaya gum, jaguar gum, tragacanth gum, polysaccharide gum, mucilage, xanthan gum, or combinations thereof.
According to the present embodiment, the suitable stabilizer is selected from the group comprising but not limited to lignosulfonates, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), casein, hydroxypropyl methylcellulose (HPMC), modified starches, and hexamethylenetetramine.
In another embodiment, the binder(s) may be selected from silicates such as magnesium aluminium silicate, polyvinyl acetates, polyvinyl acetate copolymers, polyvinyl alcohols, polyvinyl alcohol copolymers, celluloses, including ethylcelluloses and methylcelluloses, hydroxymethyl celluloses, hydroxypropylcelluloses, hydroxymethylpropyl-celluloses, polyvinylpyrolidones, dextrins, malto-dextrins, polysaccharides, fats, oils, proteins, gum arabics, shellacs, vinylidene chloride, vinylidene chloride copolymers, calcium lignosulfonates, acrylic copolymers, starches, polyvinylacrylates, zeins, gelatin, carboxymethylcellulose, chitosan, polyethylene oxide, acrylimide polymers and copolymers, polyhydroxyethyl acrylate, methylacrylimide monomers, alginate, ethylcellulose, polychloroprene and syrups or mixtures thereof; polymers and copolymers of vinyl acetate, methyl cellulose, vinylidene chloride, acrylic, cellulose, polyvinylpyrrolidone and polysaccharide; polymers and copolymers of vinylidene chloride and vinyl acetate-ethylene copolymers; combinations of polyvinyl alcohol and sucrose; plasticizers such as glycerol, propylene glycol, polyglycols, or combinations thereof.
In another embodiment, antifreeze agent(s) added to the composition may be alcohols selected from the group comprising but not limited to ethylene glycol, propylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-propylenediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,4-pentanediol, 3-methyl-1,5pentanediol, 2,3-dimethyl-2,3-butanediol, trimethylol propane, mannitol, sorbitol, glycerol, pentaerythritol, 1,4-cyclohexanedimethanol, xylenol, bisphenols such as bisphenol A or the like. In addition, ether alcohols such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyoxyethylene or polyoxypropylene glycols of molecular weight up to about 4000, diethylene glycol monomethylether, diethylene glycol monoethylether, triethylene glycol monomethylether, butoxyethanol, butylene glycol monobutylether, dipentaerythritol, tripentaerythritol, tetrapentaerythritol, diglycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, heptaglycerol, octaglycerol, or combinations thereof.
According to an embodiment, anti-foaming agent(s) may be selected from silicone defoamers, polydimethoxysiloxane, polydimethylsiloxane, alkyl poly acrylates, castor oil, fatty acids, fatty acids esters, fatty acids sulfate, fatty alcohol, fatty alcohol esters, fatty alcohol sulfate, foot olive oil, mono & di glyceride, paraffin oil, paraffin wax, poly propylene glycol, silicones oil, vegetable fats, vegetable fats sulfate, vegetable oil, vegetable oil sulfate, vegetable wax, vegetable wax sulfate, agents based on silicon or magnesium stearate, or combinations thereof.
The present invention may further include a rheology modifier. The preferred rheology modifier includes xanthan gum, Palygorskite and clay.
In an embodiment, thickener(s) or gelling agent(s) may be selected from but not limited to molasses, xanthan gum (Rhodopol G), granulated sugar, alginates, karaya gum, jaguar gum, tragacanth gum, polysaccharide gum, mucilage, or combinations thereof.
The formulations according to the present invention may additionally comprise a biocide selected from Preservatives/biocide used may be benzothiazoles, benzisothiazolinone (Proxel GXL) or phenols, 2-bromo-2-nitropropane-1,3-diol (Bioban BP 30), 5-chloro-2-methyl-4- isothiazolin-3-one & 2 methyl-4-isothiazolin -3 one (Kathon CG/ICP).
According to the present embodiment, the suitable dispersing agent is selected from the group comprising of butylated naphthalene sulphonic acid and dioctyl sulphosuccinate, sodium salt of naphthalene sulphonates formaldehyde condensate, modified styrene acrylic polymer, sodium salt of polycarboxylates, modified polyacrylate, acrylate co-polymer, and mixture of salt of naphthalene sulphonic acid and phenol sulphonic acid condensation product, and combination thereof.
According to the present embodiment, the composition of the present invention contains a disintegration agent selected from sodium sulphate, ammonium sulphate, and sodium sulphate (anhydrous).
According to the present embodiment, the composition of the present invention contains a pH modifier selected from the group comprising trisodium citrate, citric acid, sodium carbonate, sodium bicarbonate, and potassium carbonate.
According to the present embodiment, the anti-caking agent suitable for the purpose of the present invention is precipitated silica (silicon dioxide).
According to the present embodiment, the suitable filler is selected from lactose monohydrate, china clay, starch, aluminium hydroxide, and combination thereof, present in Q.S.
In another embodiment of the present invention, the composition is formulated as water dispersible granule (WDG/WG), or wettable Powder (WP) or Suspension concentrates (SC).
The process for preparing the present agrochemical composition may be adapted or modified by a person skilled in the art using routine knowledge and standard practices in formulation science. However, all such adaptations and modifications fall within the scope of the present invention as defined in the accompanying claims.
In one embodiment of the present invention, the composition is formulated as water dispersible granule (WDG/WG) comprising of mandipropamid in an amount in the range of 10-30% by weight, azoxystrobin in an amount in the range of 10-20% by weight, wetting agent in an amount in the range of 1-5%, dispersing agent in an amount in the range of 1-15%, pH modifier agent in an amount in the range of 1-10%, amino acids in an amount in the range of 1-5% , anti-caking agent in an amount in the range of 0.1-2% and Filler Q.S by weight of the composition.
In another embodiment of the present invention, the composition is formulated as water dispersible granule (WDG/WG) comprising of mandipropamid in an amount in the range of 10-30% by weight, trifloxystrobin in an amount in the range of 10-20% by weight, wetting agent in an amount in the range of 1-10%, dispersing agent in an amount in the range of 1-15%, pH modifier agent in an amount in the range of 1-10%, anti-caking agent in an amount in the range of 0.1-2% and Filler Q.S by weight of the composition.
In one embodiment of the present invention, the composition is formulated as wettable powder (WP) comprising of mandipropamid in an amount in the range of 10-30% by weight, cymoxanil in an amount in the range of 10-30% by weight, wetting agent in an amount in the range of 1-10%, dispersing agent in an amount in the range of 1-15%, anti-caking agent in an amount in the range of 0.1-2% and Filler Q.S by weight of the composition.
In one embodiment of the present invention, the composition is formulated as Suspension concentrates (SC) comprising of mandipropamid in an amount in the range of 1-20% by weight, propineb in an amount in the range of 40-70% by weight, wetting agent in an amount in the range of 1-8%, emulsifier in an amount in the range of 1-8%, dispersing agent in an amount in the range of 1-8%, disintegrating agent in an amount in the range of 0.5-20%, antifoaming agent in an amount in the range of 0.1-2%, anti-caking agent in an amount in the range of 0.1-2%, rheology modifier in an amount in the range of 0.1-2%, biocide in an amount in the range of 0.1-2% and Filler Q.S by weight of the composition.
The synergistic fungicidal composition of the present invention controls wide verity of fungi including Ascomycota, Deuteromycota, Basidiomycota and the Oomycota on a wide variety of crops.
The synergistic fungicidal composition of the present invention is also used in seed treatment to protect against diseases which impair good seed germination and seedling development.
The synergistic fungicidal composition of the present invention controls many diseases in plants which include but not limited to anthracnose, leaf spot, dollar spot, rusts, scab, powdery mildew, sheath blight downy mildew, net blotch, late blight, early blight summer patch, brown patch and rot.
Another embodiment of the present invention, the fungicidal composition of the present invention used to control fungal diseases in various crops like but not limited to rice, wheat, maize, paddy, chilli, potato, tomato, barley, sugarcane, cotton, chickpea, citrus, grapes and various other crops for general pest control.
Another embodiment of the present invention, the fungicidal composition of the present invention shows synergistic effects of better pest control with minimum fungal resistance and improved crop yield and quality.
Another embodiment of the present invention, synergistic fungicidal combination decreases the natural hazardous effect of single active ingredients and minimizes residue deposition in environment.
It is to be understood that this disclosure is not limited to a particular composition or specific constituents, which can, of course, vary and that the terminology used herein is for the purpose of describing embodiments only and is not intended to be limiting the scope of the invention. As used in this specification, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise, and equivalents thereof known to those skilled in the art and so forth.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this disclosure pertains. Although any methods and materials similar or equivalent to those described herein can be used in practice for testing of the disclosure(s), of appropriate materials and methods are described herein.
In another embodiment, alternative or multiple embodiments of the disclosure disclosed herein are not to be construed as limitations. Each embodiment can be referred to and claimed individually or in any combination with other embodiments of the disclosure. One or more embodiments of the disclosure can be included in, or deleted from, the disclosure for reasons of convenience and/or patentability.
The disclosure will now be described in more details with reference to the following examples. While the foregoing written description of the disclosure enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The disclosure should therefore not be limited by the above-described embodiment, method, and following examples, but by all embodiments and methods within the scope and spirit of the disclosure.

EXAMPLES
Example 1: Water Dispersible Granule (WDG/WG) of Mandipropamid and Azoxystrobin
Composition Charge in (%)
Mandipropamid 25
Azoxystrobin 18
Sodium lignosulfonate 10
Sodium salt of naphthalene sulphonate condensate 4
Starch (Corn/Maize) 6
Amino acids 2
Tri sodium citrate 7.5
Silica 0.5
China clay Q.S
Total 100
Manufacturing Process:
Charged required quantity mandipropamid and azoxystrobin technical in ribbon blender. Then added sodium lignosulfonate, sodium salt of naphthalene sulphonate condensate, starch (corn/maize), amino acids, tri sodium citrate, silica and finally added china clay in required quantity and homogenize it for 30 minutes. Pre-blended material was then ground through Jet mill/ air classifier mills. Finely ground material was blended in post blender till it became homogeneous (for approx. 1.5 hr).
Example 2: Water Dispersible Granule (WDG/WG) of Mandipropamid and Trifloxystrobin
Composition Charge in (%)
Mandipropamid 24.5
Trifloxystrobin 12
Sodium lignosulfonate 10
Sodium salt of naphthalene sulphonate condensate 6
Starch (Corn/Maize) 2
Tri sodium citrate 7.5
Silica 1
China clay Q.S
Total 100
Manufacturing Process:
Charged required quantity mandipropamid and trifloxystrobin technical in ribbon blender. Then added sodium lignosulfonate, sodium salt of naphthalene sulphonate condensate, starch (corn/maize), tri sodium citrate, silica and finally added china clay in required quantity and homogenize it for 30 minutes. Pre-blended material was then ground through Jet mill/ air classifier mills. Finely ground material was blended in post blender till it became homogeneous (for approx. 1.5 hr).
Example 3: Wettable Powder (WP) of Mandipropamid and Cymoxanil
Composition Charge in (%)
Mandipropamid 20
Cymoxanil 20
Sodium lignosulfonate 10
Sodium lauryl sulfate 8
Silica 0.5
China clay Q.S
Total 100
Manufacturing Process:
Charged required quantity mandipropamid and cymoxanil technical in ribbon blender. Then added Sodium lignosulfonate, sodium lauryl sulfate, silica, and the remaining quantity of china clay are then added and mixed thoroughly. The mixture is subjected to milling to obtain a fine powder having a particle size of D90 = 45 µm, followed by sieving and packing into moisture-resistant containers to obtain the final wettable powder formulation.

Example 4: Suspension Concentrates (SC) of Mandipropamid and Propineb
Ingredients Quantity (% w/w)
Mandipropamid 10
Propineb 65
Sodium Salt of Naphthalene Sulphonate Condensate 3
Ethoxylated Alcohols 3
Benzisothiazolinone (BIT) 0.20
Silica 0.25
Silicone emulsion 0.30
Propylene glycol 6
Xanthan gum 10
Distilled water Q. S
Total 100
Manufacturing process:
Mandipropamid and Propineb is prepared by first forming a premix slurry. Propylene glycol is charged into a vessel, followed by sequential addition of a defoamer, sodium salt of naphthalene sulphonate condensate, ethoxylated alcohols, benzisothiazolinone (BIT), silica, silicone emulsion, additional propylene glycol, xanthan gum, and finally demineralized water under continuous stirring and homogenization. The active ingredients Mandipropamid and Propineb are then added lot-wise. The resulting slurry is subjected to wet milling under controlled conditions, maintaining the temperature below 25°C, until a particle size of D90 < 10 µm is achieved. Separately, a gel is prepared by dispersing xanthan gum into a mixture of propylene glycol and BIT, followed by hydration in pre-warmed DM water. The milled slurry is then combined with hydrophobic fumed silica and the prepared xanthan gum gel under agitation to adjust rheological properties. The final formulation is homogenized and filled into containers for storage.
Example 5: Bio-Efficacy Study
Methodology:
The different combinations of Mandipropamid have been evaluated among various pathogens of different crops. The fungicidal combinations and the same solo molecules as individual were taken into note and the efficacy of all the molecules are evaluated and the synergistic effect of the combinations were drawn out using Colby ratio. The treatment details are mentioned in Table 1 along with the pathogen against which these were tested. The evaluated crops were first divided into plots for each treatment and replicated following Randomized Block Design. The spraying method followed was foliar application with the help of a knapsack sprayer and three sprays are with an interval of 10 Days. The combinations are even tested against any signs of Phytotoxicity on the respective crops.
General Information
Crops Chilli, Tomato
Irrigated / Rainfed Irrigated
Design RBD
No. of treatments 10
No. of replications 4
Plot size 5 m x 5 m
No. of Sprays Three sprays
Spray interval 10 days
Water volume 500 l/ha
Equipment used Knapsack sprayer
Table 1. Treatment Details
T.No Treatment Combination Dose
(gm ai/ha)
T1 Mandipropamid 23.4% SC 400
T2 Azoxystrobin 23% SC 500
T3 Trifloxystrobin 25% WG 87.5
T4 Cymoxanil 50% WP 1200
T5 Propineb 70% WP 1500
T6 Mandipropamid 25% + Azoxystrobin 18% WDG 625
T7 Mandipropamid 24.5% + Trifloxystrobin 12% WDG 625
T8 Mandipropamid 20% + Cymoxanil 20% WP 750
T9 Mandipropamid 10% + Propineb 16% SC 1500
T10 Untreated check -

Method of Observations:
Disease observations: select 5 random plants in the plot and the disease symptoms are scored based on disease rating scale and then the percentage disease index will be calculated.
The observations were taken 1 day before spraying and at 10 Days after spraying.
Take the observation on the crop safety of the fungicide i.e., Phytotoxicity / softener observation of fungicide after application at 5 and 10 Days after application.
Parameters of Observations:
The disease severity is measured by an index, measured as –
Percent disease index (PDI) will be calculated by using following formula –
PDI = (Sum of all disease ratings)/(Total no.of leaves x Maximum disease grade) x 100
The percent reduction is calculated by the following formula –
% Reduction = ( PDI in control plot-PDI in treated plot )/(PDI in control plot)× 100
Colby’s Method: The combined effect of Pesticidal combinations is the sum of their individual effects. Colby’s method is an approach to evaluate the synergistic, additive, or antagonistic effects due to the interactions of two pesticides as a combination.
Colby’s method calculates expected response and a ratio is calculated between expected response and observed response.
The formula for expected response is as follows-
two way combinations -
E = (A+B) - ((A*B)/100)
A represents pesticide 1, B represents pesticide 2
The observed response is the actual percent control achieved
Colby’s ratio = Observed response (O)/Expected response (E).
If the ratio is,
< 1 = Antagonistic effect
= Additive effect
> 1 = Synergistic effect
Results:
The fungicide combinations of Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 65% SC formulations applied at 625 gm/ha, 625 gm/ha, 750 gm/ha and 1000 ml/ha were effective against wide range of diseases, so the different diseases controlled in different crops in the field experiments were enlisted below,
Chilli Anthracnose (Colletotrichum capsici)
Tomato Late Blight (Phytophthora infestans)

Example – 5.1: Chilli -Anthracnose
Table 2. Synergistic Effect of Mandipropamid Combinations against Anthracnose Disease Incidence on Chilli Crop
T.No Treatment Combination Dose
(gm or ml/ha) % PDI
Expected (E) Observed (O)
T1 Mandipropamid 23.4% SC 400 57.52
T2 Azoxystrobin 23% SC 500 47.77
T3 Trifloxystrobin 25% WG 87.5 44.16
T4 Cymoxanil 50% WP 1200 45.33
T5 Propineb 70% WP 1500 43.73
T6 Mandipropamid 25% + Azoxystrobin 18% WDG 625 77.81 89.62
(O/E) 1.15
T7 Mandipropamid 24.5% + Trifloxystrobin 12% WDG 625 76.28 87.60
(O/E) 1.15
T8 Mandipropamid 20% + Cymoxanil 20% WP 750 76.78 86.35
(O/E) 1.12
T9 Mandipropamid 10% + Propineb 16% SC 1500 76.10 83.36
(O/E) 1.10
The efficacy of Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations were evaluated against Colletotrichum capsici (Anthracnose) in chilli crops through percent disease incidence (PDI). The study was conducted in a randomized block design with net plot size of 5m x 5m. The crop was raised by following all the agronomic practices, three consecutive sprays were done with knapsack sprayer with 10 days spray interval (Table 2).
The percent disease index was calculated at the end of each spray, the percent reduction in PDI at the end of third spray has been presented in Table 2. The results indicate that the fungicidal combinations were highly effective against Anthracnose in chilli when applied in combination than when applied alone. The results revealed 89.62%, 87.60%, 86.35% and 83.36% disease suppression (percent reduction in PDI) in Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations treatments. The percent disease index in solo treatments did not record any satisfactory or considerable control. The present combinations viz., Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations were highly promising in control of Anthracnose of chilli by recording a synergistic effect with a colby ratio of 1.15, 1.15, 1.12 and 1.10 respectively.
Table 3. Efficacy of Spray Application of Mandipropamid Combinations against Anthracnose in Chilli.
Treatments Dose
(g or ml / ha) Percent Disease Index (PDI) after Every Spray % Reduction over Control Yield
(t/ha)
Pre 1 2 3 AVG
Mandipropamid 23.4% SC 400 11 10 17 23 15.25 57.52 29.26
Azoxystrobin 23% SC 500 12 14 18 31 18.75 47.77 30.06
Trifloxystrobin 25% WG 87.5 12.4 12 23.78 32 20.05 44.16 26.19
Cymoxanil 50% WP 1200 12.5 12 24 30 19.63 45.33 31.46
Propineb 70% WP 1500 11.8 11 27 31 20.20 43.73 30.88
Mandipropamid 25% + Azoxystrobin 18% WDG 625 11.9 0 0 3 3.73 89.62 37.78
Mandipropamid 24.5% + Trifloxystrobin 12% WDG 625 12.8 0 0 5 4.45 87.60 36.69
Mandipropamid 20% + Cymoxanil 20% WP 750 12.6 0 2 5 4.90 86.35 34.46
Mandipropamid 10% + Propineb 16% SC 1500 11.9 0 4 8 5.98 83.36 35.89
Untreated check - 12.6 28 45 58 35.90 0.00 16.68
SeM± (Standard error of Mean) 3.904 0.009
CD (Critical difference) 11.390 0.027
The efficacy of the Mandipropamid combinations were presented in the table 3. The Percent disease index was recorded between 11 to 12.8% before spraying (pre-treatment) and at the end of three sprays the PDI recorded combinations viz., Mandipropamid 25% + Azoxystrobin 18% WDG (3%), Mandipropamid 24.5% + Trifloxystrobin 12% WDG (5%), Mandipropamid 20% + Cymoxanil 20% WP (5%) and Mandipropamid 10% + Propineb 16% SC (8%). The average PDI among the combinations ranged between 3.73% to 5.98% which was low and proved the effective control of anthracnose by the mandiporpamid combinations. In the meanwhile, the same combinations recorded chilli yield ranging between 34.46 t/ha to 37.78 t/ha which implied the combinations effectively controlled the pathogen while showing syngergy along with high yield in chilli crop.
Table 4. Phytotoxicity of Mandipropamid Combinations and other Fungicides on Chilli
Treatments Days Visual Rating Scale
Yellowing Necrosis Wilting Vein
Clearing Leaf Tip / Margin Dying Stunting / Dwarfing
Mandipropamid 23.4% SC @ 400ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Azoxystrobin 23% SC @ 500ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Trifloxystrobin 25% WG @ 87.5gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Cymoxanil 50% WP @ 1200gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Propineb 70% WP @1500gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 25% + Azoxystrobin 18% WDG @ 625gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 24.5% + Trifloxystrobin 12% WDG @ 625gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 20% + Cymoxanil 20% WP @ 750gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 10% + Propineb 16% SC @ 1500 ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Untreated Check 5 0 0 0 0 0 0
10 0 0 0 0 0 0
The phytotoxicity effect of Mandipropamid combinations and solo fungicides showed no signs of phytotoxicity in the chilli crop. Hence, the combination is safe for the usage of Anthracnose control in Chilli crop (Table 4).
Example – 5.2: Tomato - Late blight
Table 5. Synergistic Effect of Mandipropamid Combinations against Late Blight Disease Incidence on Tomato Crop
T.No Treatment Combination Dose
(gm or ml/ha) % PDI
Expected (E) Observed (O)
T1 Mandipropamid 23.4% SC 400 50.32
T2 Azoxystrobin 23% SC 500 51.14
T3 Trifloxystrobin 25% WG 87.5 48.26
T4 Cymoxanil 50% WP 1200 52.42
T5 Propineb 70% WP 1500 49.27
T6 Mandipropamid 25% + Azoxystrobin 18% WDG 625 75.73 91.68
(O/E) 1.21
T7 Mandipropamid 24.5% + Trifloxystrobin 12% WDG 625 74.30 90.76
(O/E) 1.22
T8 Mandipropamid 20% + Cymoxanil 20% WP 750 76.36 90.12
(O/E) 1.18
T9 Mandipropamid 10% + Propineb 16% SC 1500 74.80 90.50
(O/E) 1.21
The efficacy of Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations were evaluated against Phytophthora infestans (late blight) in tomato crops through percent disease incidence (PDI). The study was conducted in a randomized block design with net plot size of 5m x 5m. The crop was raised by following all the agronomic practices, three consecutive sprays were done with knapsack sprayer with 10 days spray interval (Table 5).
The percent disease index was calculated at the end of each spray, the percent reduction in PDI at the end of third spray has been presented in Table 5. The results indicate that the fungicidal combinations were highly effective against Late Blight in Tomato when applied in combination than when applied alone. The results revealed 91.68%, 90.76%, 90.12% and 90.50% disease suppression (percent reduction in PDI) in Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations treatments. The percent disease index in solo treatments did not record any satisfactory or considerable control. The present combinations viz., Mandipropamid 25% + Azoxystrobin 18% WDG, Mandipropamid 24.5% + Trifloxystrobin 12% WDG, Mandipropamid 20% + Cymoxanil 20% WP and Mandipropamid 10% + Propineb 16% SC formulations were highly promising in control of Anthracnose of chilli by recording a synergistic effect with a colby ratio of 1.21, 1.22, 1.18 and 1.21 respectively.

Table 6. Efficacy of Spray Application of Mandipropamid Combinations against Late Blight in Tomato.
Treatments Dose
(g or ml / ha) Percent Disease Index (PDI) after Every Spray % Reduction over Control Yield
(t/ha)
Pre 1 2 3 AVG
Mandipropamid 23.4% SC 400 12.9 11 24 29 19.23 50.32 36.68
Azoxystrobin 23% SC 500 13.4 10.23 20 32 18.91 51.14 34.55
Trifloxystrobin 25% WG 87.5 13.6 12.5 24 30 20.03 48.26 35.01
Cymoxanil 50% WP 1200 13.2 11.23 24.23 25 18.42 52.42 38.10
Propineb 70% WP 1500 13.3 11.23 22 32 19.63 49.27 36.24
Mandipropamid 25% + Azoxystrobin 18% WDG 625 12.78 0 0 0.1 3.22 91.68 43.31
Mandipropamid 24.5% + Trifloxystrobin 12% WDG 625 12.9 0 0 1.4 3.58 90.76 45.79
Mandipropamid 20% + Cymoxanil 20% WP 750 13.3 0 0 2 3.83 90.12 42.57
Mandipropamid 10% + Propineb 16% SC 1500 12.7 0 0 2 3.68 90.50 43.46
Untreated check - 12.8 34 48 60 38.70 0.00 26.01
SeM± 4.342 0.004
CD 12.667 0.011
The efficacy of the Mandipropamid combinations were presented in the table 3. The Percent disease index was recorded between 12.7 to 13.6% before spraying (pre-treatment) and at the end of three sprays the PDI recorded combinations viz., Mandipropamid 25% + Azoxystrobin 18% WDG (0.1%), Mandipropamid 24.5% + Trifloxystrobin 12% WDG (1.4%), Mandipropamid 20% + Cymoxanil 20% WP (2%) and Mandipropamid 10% + Propineb 16% SC (2%). The average PDI among the combinations ranged between 3.22% to 3.83% which was low and proved the effective control of late blight by the mandiporpamid combinations. In the meanwhile, the same combinations recorded tomato yield ranging between 42.57 t/ha to 45.79 t/ha which implied the combinations effectively controlled the pathogen while showing syngergy along with high yield in tomato crop.
Table 7. Phytotoxicity of Mandipropamid Combinations and other Fungicides on Tomato
Treatments Days Visual Rating Scale
Yellowing Necrosis Wilting Vein
Clearing LeafTip / Margin Dying Stunting / Dwarfing
Mandipropamid 23.4% SC @ 400ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Azoxystrobin 23% SC @ 500ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Trifloxystrobin 25% WG @ 87.5gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Cymoxanil 50% WP @ 1200gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Propineb 70% WP @1500gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 25% + Azoxystrobin 18% WDG @ 625gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 24.5% + Trifloxystrobin 12% WDG @ 625gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 20% + Cymoxanil 20% WP @ 750gm/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Mandipropamid 10% + Propineb 16% SC @ 1500 ml/ha 5 0 0 0 0 0 0
10 0 0 0 0 0 0
Untreated check 5 0 0 0 0 0 0
10 0 0 0 0 0 0
The phytotoxicity effect of the Mandipropamid combinations and solo of same fungicides showed no signs of phytotoxicity in the tomato crop. Hence, the combination is safe for the usage of Late Blight control in Tomato crop (Table 7)
The above examples and results are intended to illustrate certain specific embodiments of the invention and should not be construed as limiting its broader applicability. It is understood that:
The invention is not limited to the precise compositions or constituent concentrations disclosed herein. Variations in formulation components and ratios may be employed by those skilled in the art without departing from the essence of the invention.
The terminology used throughout this specification is for descriptive purposes only and is not intended to limit the scope of the claims. Unless context dictates otherwise, singular terms include their plural equivalents, and vice versa.
All technical and scientific terms used herein carry their commonly accepted meanings as understood by practitioners skilled in the relevant field.
While specific materials, methods, and field conditions have been described, substitutes and equivalents that achieve substantially similar results are considered within the purview of this disclosure. Any modifications, adaptations, or substitutions of the formulations, test protocols, or crop sequences that are apparent to a person skilled in the art are considered to fall within the scope of the invention as defined by the appended claims.
All patents, published applications, and other references cited in this disclosure are incorporated herein by reference and are considered to indicate the level of ordinary skill in the art relevant to this invention. ,CLAIMS:CLAIMS
We Claim:
A synergistic fungicidal composition comprising:
Mandipropamid or agrochemically acceptable salt(s) thereof;
At least one more fungicide selected from strobilurin class, cymoxanil, and propineb or agrochemically acceptable salt(s) thereof; and
One or more agriculturally acceptable excipients.
The synergistic fungicidal composition as claimed in claim 1, comprising
mandipropamid in an amount in the range of 1-40% by weight;
at least one more fungicide selected from strobilurin class, cymoxanil, and propineb in an amount in the range of 1-80% by weight; and
at least one agriculturally acceptable excipient in the range of 0.01-80% by weight.
The synergistic fungicidal composition as claimed in claim 1, the strobilurin fungicide is azoxystrobin.
The synergistic fungicidal composition as claimed in claim 1, the strobilurin fungicide is trifloxystrobin.
The composition as claimed in claim 1, wherein the agrochemically acceptable excipients are selected from the group comprising wetting agent(s), emulsifier(s), colorant(s), surfactant(s), thickener(s)/binder(s), antifreeze agent(s), anti-foaming agent(s), antioxidant(s), solvent(s)/carrier, preservative(s), glidant(s), anticaking agent(s), pH regulating agent(s), buffering agent(s), filler(s), formulation aid(s), disintegrant(s), or combinations thereof.
The synergistic fungicidal composition as claimed in claim 4, wherein, the preferred composition and formulation thereof comprises Suspension concentrate (SC), Wettable poewder (WP) and Water dispersible granule (WG or WDG).
A stable synergistic fungicidal water dispersible granule (WDG/WG) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight;
Azoxystrobin or agrochemically acceptable salt(s) thereof is present in the range of 1-20% by weight;
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
A stable synergistic fungicidal water dispersible granule (WDG/WG) formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight;
Trifloxystrobin or agrochemically acceptable salt(s) thereof is present in the range of 1-20% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
A stable synergistic fungicidal wettable Powder (WP) formulation formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight;
Cymoxanil or agrochemically acceptable salt(s) thereof is present in the range of 1-40% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.
A stable synergistic fungicidal suspension concentrates (SC) formulation formulation comprising:
Mandipropamid acceptable salt(s) thereof is present in the range of 1-40% by weight;
Propineb or agrochemically acceptable salt(s) thereof is present in the range of 1-80% by weight; and
At least one agrochemically acceptable excipient in an amount in the range of 0.01-80% by weight.