View All Documents & Correspondence
Oligonucleotide Compositions And Methods Thereof
Abstract: Among other things, the present disclosure provides various oligonucleotide technologies including chirally controlled oligonucleotide compositions and technologies for manufacturing such oligonucleotide compositions. In some embodiments, a method is a method of treatment or prevention of Huntington's Disease in a subject in need thereof; a method of allele-specific knockdown of a mutant Huntingtin transcript in a subject; a method for delaying the onset of and/or reducing the severity of at least one symptom of Huntington's Disease in a subject with Huntington's Disease; a method of reducing the expression, level, amount and/or activity of a mutant Huntingtin gene or a gene product thereof; and/or a method of preparation of a medicament for treatment of Huntington's Disease, wherein the method pertains to the use of an oligonucleotide described herein, administered at a dose described herein. In some embodiments, the present disclosure provides doses, dosages, and formulations of an oligonucleotide described herein.
Notices, Deadlines & Correspondence
Patent Information
Applicants
WAVE LIFE SCIENCES LTD.
Inventors
1. LAKE, Stephen Lister
2. HU, Xiao Shelley
3. GAO, Jianxin
4. ZHANG, Yilin
5. ROSS, Philip
6. ADUDA, Vincent
7. SHIMIZU, Mamoru
8. XU, Danlin
9. BOWMAN, Keith Andrew
10. LAMORE, Sarah Diane
11. PANZARA, Michael Angelo
12. ALAM, Mohammed Rowshon
13. JANG, Hyun Gyung
14. LI-KWAI-CHEUNG, Anne-Marie
15. NARAYANAN, Padmakumar
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202517015214-STATEMENT OF UNDERTAKING (FORM 3) [21-02-2025(online)].pdf | 2025-02-21 |
| 3 | 202517015214-Sequence Listing in PDF [21-02-2025(online)].pdf | 2025-02-21 |
| 4 | 202517015214-REQUEST FOR EXAMINATION (FORM-18) [21-02-2025(online)].pdf | 2025-02-21 |
| 5 | 202517015214-POWER OF AUTHORITY [21-02-2025(online)].pdf | 2025-02-21 |
| 6 | 202517015214-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [21-02-2025(online)].pdf | 2025-02-21 |
| 7 | 202517015214-FORM 18 [21-02-2025(online)].pdf | 2025-02-21 |
| 8 | 202517015214-FORM 1 [21-02-2025(online)].pdf | 2025-02-21 |
| 9 | 202517015214-DRAWINGS [21-02-2025(online)].pdf | 2025-02-21 |
| 10 | 202517015214-DECLARATION OF INVENTORSHIP (FORM 5) [21-02-2025(online)].pdf | 2025-02-21 |
| 11 | 202517015214-COMPLETE SPECIFICATION [21-02-2025(online)].pdf | 2025-02-21 |
| 12 | 202517015214-Proof of Right [06-03-2025(online)].pdf | 2025-03-06 |
| 13 | 202517015214-FORM 3 [14-08-2025(online)].pdf | 2025-08-14 |