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Transferrin Receptor Binding Proteins And Conjugates
Abstract: Provided herein are proteins comprising one monovalent human TfR binding domain ("human TfR binding proteins"), proteins comprising one monovalent mouse TfR binding domain ("mouse TfR binding proteins"), conjugates comprising such human or mouse TfR binding proteins, e.g., human TfR binding proteins-dsRNA conjugates, pharmaceutical compositions comprising human TfR binding proteins or conjugates, and methods of treating CNS diseases (e.g., neurodegenerative disease such as neurodegenerative synucleinopathy or tauopathy) using human TfR binding proteins or conjugates.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
27 February 2025
Publication Number
12/2025
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Applicants
ELI LILLY AND COMPANY
Lilly Corporate Center
Indianapolis, IN 46285
Inventors
1. ALAM, Riazul
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
2. ALVARADO, Alberto
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
3. ANDREWS, Forest, Hoyt
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
4. BABB, Nicholas, Alan
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
5. BALASUBRAMANIAM, Deepa
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
6. CHAUVIGNE-HINES, Lacie
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
7. CORTEZ, Guillermo, S.
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
8. CROY, Johnny, Eugene
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
9. DRIVER, David, Albert
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
10. FELLOWS, Ross, Edward
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
11. GIRARD, Daniel
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
12. GONZALEZ VALCARCEL, Isabel, C.
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
13. KULKARNI, Nalini, Hosahalli
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
14. LAWRENCE, Scott, Alan
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
15. LIU, Feng
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
16. TANI, Hiroaki
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
17. YORK, Jeremy, S.
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, IN 46206-6288
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202517017256-STATEMENT OF UNDERTAKING (FORM 3) [27-02-2025(online)].pdf | 2025-02-27 |
| 3 | 202517017256-Sequence Listing in PDF [27-02-2025(online)].pdf | 2025-02-27 |
| 4 | 202517017256-REQUEST FOR EXAMINATION (FORM-18) [27-02-2025(online)].pdf | 2025-02-27 |
| 5 | 202517017256-POWER OF AUTHORITY [27-02-2025(online)].pdf | 2025-02-27 |
| 6 | 202517017256-FORM 18 [27-02-2025(online)].pdf | 2025-02-27 |
| 7 | 202517017256-FORM 1 [27-02-2025(online)].pdf | 2025-02-27 |
| 8 | 202517017256-DRAWINGS [27-02-2025(online)].pdf | 2025-02-27 |
| 9 | 202517017256-DECLARATION OF INVENTORSHIP (FORM 5) [27-02-2025(online)].pdf | 2025-02-27 |
| 10 | 202517017256-COMPLETE SPECIFICATION [27-02-2025(online)].pdf | 2025-02-27 |
| 11 | 202517017256-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [27-02-2025(online)].pdf | 2025-02-27 |
| 12 | 202517017256-RELEVANT DOCUMENTS [06-03-2025(online)].pdf | 2025-03-06 |
| 13 | 202517017256-MARKED COPIES OF AMENDEMENTS [06-03-2025(online)].pdf | 2025-03-06 |
| 14 | 202517017256-FORM 13 [06-03-2025(online)].pdf | 2025-03-06 |
| 15 | 202517017256-AMMENDED DOCUMENTS [06-03-2025(online)].pdf | 2025-03-06 |
| 16 | 202517017256-Proof of Right [21-08-2025(online)].pdf | 2025-08-21 |
| 17 | 202517017256-FORM 3 [25-08-2025(online)].pdf | 2025-08-25 |