Apparatuses For And Methods Of Concentrating Biomolecules

Abstract: An apparatus is described for concentrating biomolecules in solution such as oligonucleotide containing solutions via tangential flow filtration (TFF) where the apparatus can concentrate the oligonucleotides to a concentration > 100 mg/mL. Also described are methods of concentrating a biomolecule containing solution such as oligonucleotide containing solutions via TFF for high dose/low volume applications.

Patent Information

Application #

Filing Date

14 April 2025

Publication Number

18/2025

Publication Type

INA

Invention Field

BIO-MEDICAL ENGINEERING

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

Lilly Corporate Center Indianapolis Indiana 46206 6288

Inventors

1. MASON McKensie Lee

c/o Eli Lilly And Company P.O. Box 6288 Indianapolis Indiana 46206 6288

2. MOOMAW John Fletcher

c/o Eli Lilly And Company P.O. Box 6288 Indianapolis Indiana 46206 6288

3. QIAN Ken Kangyi

c/o Eli Lilly And Company P.O. Box 6288 Indianapolis Indiana 46206 6288

4. WU Lina

c/o Eli Lilly And Company P.O. Box 6288 Indianapolis Indiana 46206 6288

Specification

Documents

Application Documents

#	Name	Date
1	202517035970-STATEMENT OF UNDERTAKING (FORM 3) [14-04-2025(online)].pdf	2025-04-14
3	202517035970-Sequence Listing in PDF [14-04-2025(online)].pdf	2025-04-14
4	202517035970-REQUEST FOR EXAMINATION (FORM-18) [14-04-2025(online)].pdf	2025-04-14
5	202517035970-POWER OF AUTHORITY [14-04-2025(online)].pdf	2025-04-14
6	202517035970-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [14-04-2025(online)].pdf	2025-04-14
7	202517035970-FORM 18 [14-04-2025(online)].pdf	2025-04-14
8	202517035970-FORM 1 [14-04-2025(online)].pdf	2025-04-14
9	202517035970-DRAWINGS [14-04-2025(online)].pdf	2025-04-14
10	202517035970-DECLARATION OF INVENTORSHIP (FORM 5) [14-04-2025(online)].pdf	2025-04-14
11	202517035970-COMPLETE SPECIFICATION [14-04-2025(online)].pdf	2025-04-14
12	202517035970-Proof of Right [07-10-2025(online)].pdf	2025-10-07
13	202517035970-FORM 3 [07-10-2025(online)].pdf	2025-10-07