Methods Of Reducing Contaminants In Protein Purification

Abstract: Provided herein are improved methods of purifying an Fc-containing protein from a mixture comprising the Fc-containing protein and one or more host cell protein (HCP). The methods generally involve applying the mixture to a chromatography column comprising a protein A chromatography matrix, and washing the chromatography matrix with a sodium caprylate wash buffer.

Patent Information

Application #

Filing Date

19 June 2025

Publication Number

31/2025

Publication Type

INA

Invention Field

BIO-CHEMISTRY

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

Lilly Corporate Center P.O. Box 6288 Indianapolis, Indiana 46206-6288

Inventors

1. HUEBNER, Amy Lynn

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206

2. BLANC, Timothy

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

Documents

Application Documents

#	Name	Date
1	202517058953-STATEMENT OF UNDERTAKING (FORM 3) [19-06-2025(online)].pdf	2025-06-19
2	202517058953-Sequence Listing in txt [19-06-2025(online)].txt	2025-06-19
3	202517058953-Sequence Listing in PDF [19-06-2025(online)].pdf	2025-06-19
4	202517058953-REQUEST FOR EXAMINATION (FORM-18) [19-06-2025(online)].pdf	2025-06-19
5	202517058953-PRIORITY DOCUMENTS [19-06-2025(online)].pdf	2025-06-19
6	202517058953-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [19-06-2025(online)].pdf	2025-06-19
7	202517058953-FORM 18 [19-06-2025(online)].pdf	2025-06-19
8	202517058953-FORM 1 [19-06-2025(online)].pdf	2025-06-19
9	202517058953-FIGURE OF ABSTRACT [19-06-2025(online)].pdf	2025-06-19
10	202517058953-DRAWINGS [19-06-2025(online)].pdf	2025-06-19
11	202517058953-DECLARATION OF INVENTORSHIP (FORM 5) [19-06-2025(online)].pdf	2025-06-19
12	202517058953-COMPLETE SPECIFICATION [19-06-2025(online)].pdf	2025-06-19
13	202517058953-FORM-26 [29-07-2025(online)].pdf	2025-07-29