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Novel Fas Rnai Therapeutics And Uses Thereof

Abstract: The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the FAS receptor (expressed by the FAS gene), thereby decreasing expression of FAS mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of FAS expression and function, such as autoimmune hepatitis.

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Patent Information

Application #
Filing Date
26 June 2025
Publication Number
28/2025
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application

Applicants

ELI LILLY AND COMPANY
Lilly Corporate Center Indianapolis, Indiana 46285

Inventors

1. BAWEL, Seth Andrew
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
2. JESSOP, Theodore Curtis
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
3. WANG, Jibo
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
4. LACKNER, Gregory Lawrence
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
5. HAMANG, Matthew Joseph
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
6. ANTONELLIS, Patrick Joseph
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
7. WILSON, Takako
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

Documents

Application Documents

# Name Date
1 202517061137-STATEMENT OF UNDERTAKING (FORM 3) [26-06-2025(online)].pdf 2025-06-26
3 202517061137-Sequence Listing in txt [26-06-2025(online)].txt 2025-06-26
4 202517061137-Sequence Listing in PDF [26-06-2025(online)].pdf 2025-06-26
5 202517061137-REQUEST FOR EXAMINATION (FORM-18) [26-06-2025(online)].pdf 2025-06-26
6 202517061137-PROOF OF RIGHT [26-06-2025(online)].pdf 2025-06-26
7 202517061137-POWER OF AUTHORITY [26-06-2025(online)].pdf 2025-06-26
8 202517061137-FORM 18 [26-06-2025(online)].pdf 2025-06-26
9 202517061137-FORM 1 [26-06-2025(online)].pdf 2025-06-26
10 202517061137-DECLARATION OF INVENTORSHIP (FORM 5) [26-06-2025(online)].pdf 2025-06-26
11 202517061137-COMPLETE SPECIFICATION [26-06-2025(online)].pdf 2025-06-26
12 202517061137-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [26-06-2025(online)].pdf 2025-06-26
13 202517061137-FORM 3 [01-09-2025(online)].pdf 2025-09-01