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Novel Rna Therapeutics And Uses Thereof
Abstract: The present invention relates to novel therapeutic compounds, known as RNAi agents, that decrease expression of the ANGPTL8 receptor (expressed by the ANGPTL8 gene), thereby decreasing expression of mRNA and protein expression. Such RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression and function, such as dyslipidemia, a cardiovascular disorder, or a cardiometabolic disorder.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
22 July 2025
Publication Number
32/2025
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Applicants
ELI LILLY AND COMPANY
Lilly Corporate Center
Indianapolis, Indiana 46285
Inventors
1. EGGEN, Marijean
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
2. WANG, Jibo
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
3. CHENG, Christine Chih-Tao
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
4. BEYER, Thomas Patrick
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
5. LACKNER, Gregory Lawrence
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
6. WILSON, Takako
c/o ELI LILLY AND COMPANYP.O. Box 6288Indianapolis, Indiana 46206-6288
7. ANTONELLIS, Patrick Joseph
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
8. BAWEL, Seth Andrew
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
9. MILES, Rebecca Ruth
c/o ELI LILLY AND COMPANY
P.O. Box 6288
Indianapolis, Indiana 46206-6288
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202517069638-STATEMENT OF UNDERTAKING (FORM 3) [22-07-2025(online)].pdf | 2025-07-22 |
| 3 | 202517069638-Sequence Listing in PDF [22-07-2025(online)].pdf | 2025-07-22 |
| 4 | 202517069638-REQUEST FOR EXAMINATION (FORM-18) [22-07-2025(online)].pdf | 2025-07-22 |
| 5 | 202517069638-POWER OF AUTHORITY [22-07-2025(online)].pdf | 2025-07-22 |
| 6 | 202517069638-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [22-07-2025(online)].pdf | 2025-07-22 |
| 7 | 202517069638-FORM 18 [22-07-2025(online)].pdf | 2025-07-22 |
| 8 | 202517069638-FORM 1 [22-07-2025(online)].pdf | 2025-07-22 |
| 9 | 202517069638-DECLARATION OF INVENTORSHIP (FORM 5) [22-07-2025(online)].pdf | 2025-07-22 |
| 10 | 202517069638-COMPLETE SPECIFICATION [22-07-2025(online)].pdf | 2025-07-22 |
| 11 | 202517069638-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [22-07-2025(online)].pdf | 2025-07-22 |