Novel Linkers For Sustained Delivery Of Therapeutics

Abstract: Linkers for the connection of a therapeutic to another moiety, such as an Fc region of an antibody. Linkers with two or more maleimide functional groups which can undergo nucleophilic conjugate addition reactions. Methods of increasing the duration of action of a therapeutic by attaching to a novel linker and an Fc region of an antibody. Antibody-Drug conjugates, which have increased duration of action over the drug alone.

Patent Information

Application #

Filing Date

25 July 2025

Publication Number

33/2025

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

Lilly Corporate Center Indianapolis, Indiana 46285

Inventors

1. CORTEZ, Guillermo

c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

2. LOPES, Daniel Christopher

c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

3. MUPPIDI, Avinash

c/o Eli Lilly and CompanyP.O. Box 6288Indianapolis, Indiana 46206-6288

4. STOKELL, David John

c/o Eli Lilly and CompanyP.O. Box 6288Indianapolis, Indiana 46206-6288

5. WANG, Yan

c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

Documents

Application Documents

#	Name	Date
1	202517070911-STATEMENT OF UNDERTAKING (FORM 3) [25-07-2025(online)].pdf	2025-07-25
2	202517070911-Sequence Listing in txt [25-07-2025(online)].txt	2025-07-25
3	202517070911-Sequence Listing in PDF [25-07-2025(online)].pdf	2025-07-25
4	202517070911-REQUEST FOR EXAMINATION (FORM-18) [25-07-2025(online)].pdf	2025-07-25
5	202517070911-PRIORITY DOCUMENTS [25-07-2025(online)].pdf	2025-07-25
6	202517070911-POWER OF AUTHORITY [25-07-2025(online)].pdf	2025-07-25
7	202517070911-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [25-07-2025(online)].pdf	2025-07-25
8	202517070911-FORM 18 [25-07-2025(online)].pdf	2025-07-25
9	202517070911-FORM 1 [25-07-2025(online)].pdf	2025-07-25
10	202517070911-DECLARATION OF INVENTORSHIP (FORM 5) [25-07-2025(online)].pdf	2025-07-25
11	202517070911-COMPLETE SPECIFICATION [25-07-2025(online)].pdf	2025-07-25
12	202517070911-MARKED COPIES OF AMENDEMENTS [28-07-2025(online)].pdf	2025-07-28
13	202517070911-FORM 13 [28-07-2025(online)].pdf	2025-07-28
14	202517070911-AMMENDED DOCUMENTS [28-07-2025(online)].pdf	2025-07-28
15	202517070911-Proof of Right [15-09-2025(online)].pdf	2025-09-15