Methods For The Preparation Of Sstr4 Agonists And Salts Thereof

Abstract: Method for preparing SSTR4 agonist compounds. Method for preparing SSTR4 agonist compounds through a diasteromerically selective cyclization reaction without the need for a separate epimerization step. Novel intermediates for preparing SSTR4 agonist compounds. Novel salts of certain SSTR4 agonists, such as (1R,5S,6r)-N-(2-(1-Methyl-1H-indazol-3-yl)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide succinate and as (1R,5S,6r)-N-(2-(1-Methyl-1H-indazol-3-yl)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide adipate. Methods of treatment of pain, such as osteoarthritic, neuropathic, and lower back pain through the administration of certain SSTR4 agonists and pharmaceutically acceptable salts thereof.

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