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Novel Scn10 A Rnai Agents And Uses Thereof
Abstract: The present invention relates to therapeutic compounds, novel RNA interference (RNAi) agents, that decrease expression of the Voltage-Gated Sodium Channel Alpha Subunit 10 (SCN10A) gene, which encodes a subunit of the Nav 1.8 or Nav 1.8 sodium channel. Such RNAi agents decrease levels of intact Nav 1.8 sodium channels and are useful in the treatment of diseases involving the regulation of SCN10A expression and function, such as chronic pain.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
27 November 2025
Publication Number
51/2025
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Applicants
ELI LILLY AND COMPANY
Lilly Corporate Center
Indianapolis, Indiana 46285
Inventors
1. ROWE CULLEN, Jennifer
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
2. EGGEN, MariJean
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
3. HUANG, Cheng-Chiu
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
4. JESSOP, Theodore Curtis
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
5. PERKINS, Douglas Raymond
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
6. SHMUSHKOVICH, Taisia
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
7. WANG, Jibo
c/o Eli Lilly and Company
P.O. Box 6288
Indianapolis, Indiana 46206-6288
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202517117867-STATEMENT OF UNDERTAKING (FORM 3) [27-11-2025(online)].pdf | 2025-11-27 |
| 3 | 202517117867-Sequence Listing in PDF [27-11-2025(online)].pdf | 2025-11-27 |
| 4 | 202517117867-REQUEST FOR EXAMINATION (FORM-18) [27-11-2025(online)].pdf | 2025-11-27 |
| 5 | 202517117867-POWER OF AUTHORITY [27-11-2025(online)].pdf | 2025-11-27 |
| 6 | 202517117867-FORM 18 [27-11-2025(online)].pdf | 2025-11-27 |
| 7 | 202517117867-FORM 1 [27-11-2025(online)].pdf | 2025-11-27 |
| 8 | 202517117867-DECLARATION OF INVENTORSHIP (FORM 5) [27-11-2025(online)].pdf | 2025-11-27 |
| 9 | 202517117867-COMPLETE SPECIFICATION [27-11-2025(online)].pdf | 2025-11-27 |
| 10 | 202517117867-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [27-11-2025(online)].pdf | 2025-11-27 |