Description:FIELD OF INVENTION:
The present invention relates to a pesticidal composition comprising a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate; and d) one or more inactive excipients. The present invention also relates to process for preparing the said composition.

BACKGROUND OF THE INVENTION:
4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether is a pesticide which is found to be effective against a variety of insects. It was introduced to the US in 1996, to protect cotton crops against whitefly. It has also been found useful for protecting other crops. It is also used as prevention for flea control on household pets, for killing indoor and outdoor ants and roaches. Methods of application include aerosols, bait, carpet powders, foggers, shampoos and pet collars. 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether is a juvenile hormone analog (IRAC group 7C) and an insect growth regulator. It prevents larvae from developing into adulthood and thus rendering them unable to reproduce.

4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ)- (methoxyimino)methyl]-o-toluamide is a novel isoxazoline insecticide with a wide spectrum. It is an antagonist of GABA- and Glu-gated chloride channels (GABACls and GluCls). It circumvents the fipronil resistance of pests by distinct GABACl antagonism.

Isoxazoline insecticides are a class of synthetic chemicals used to control and eliminate a wide range of pests. They work by disrupting the nervous system of insects, leading to paralysis and ultimately death. Isoxazoline compounds exhibit high efficacy against fleas, ticks, and other ectoparasites in pets. Isoxazoline compounds are effective against both adult and immature stages of various pests. Additionally, these insecticides have a fast onset of action and provide a broad spectrum of activity, making them valuable in the control of arthropod infestations.

Abamectin (also called avermectin B1) is a widely used insecticide and anthelmintic. Abamectin, is a member of the avermectin family and is a natural fermentation product of soil dwelling actinomycete Streptomyces avermitilis. Abamectin differs from ivermectin, the popular member of the avermectin family, by a double bond between carbons 22 and 25. Fermentation of Streptomyces avermitilis yields eight closely related avermectin homologs, with the B1a and B1b forms comprising the majority of the fermentation. The non-proprietary name, abamectin, refers to a mixture of B1a (~80%) and B1b (~20%). Out of all the avermectins, abamectin is the only one that is used both in agriculture and pharmaceuticals.

Avermectins bind to the glutamate-gated chloride channels that are found in invertebrate nerve and muscle cells. They cause hyperpolarization of these cells resulting in paralysis and death. Mammals only possess glutamate-gated chloride channels in the brain and spinal cord and as the avermectins have a low affinity for other mammalian ligand-gated channels and do not usually cross the blood–brain barrier, they are very safe for mammals.

Abamectin is also used as a veterinary antihelmintic. Resistance to abamectin-based antihelmintics, although a growing problem, is not as common as to other classes of veterinary antihelmintics. The benzoate salt emamectin benzoate is also used as an insecticide. Avermectins have been used to treat various ailments caused by parasites in both humans and animals. Avermectins including abamectin were studied for use as anti-alcohol therapies. Recently, ivermectin is being studied for use as an anti-inflammatory agent.

Emamectin is the 4″-deoxy-4″-methylamino derivative of abamectin, a 16-membered macrocyclic lactone produced by the fermentation of the soil actinomycete Streptomyces avermitilis. It is generally prepared as the salt with benzoic acid, emamectin benzoate, which is a white or faintly yellow powder. Emamectin is widely used in the US and Canada as an insecticide because of its chloride channel activation properties.

Emamectin, produced by the bacterium Streptomyces avermitilis, belongs to the avermectin family of compounds all of which exhibit toxicity for nematodes, arthropods, and several other pests. The benzoate salt of emamectin in particular has found widespread use as an insecticide and is approved by the EPA for use in prevention of emerald ash borer in ash trees. Emamectin is derived from avermectin B1, also known as abamectin, a mixture of the natural avermectin B1a and B1b. Emamectin has also shown promising applications in the eradication of fish lice and in fish farming.

Emamectin works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods. The compound stimulates the release of GABA from the synapses between nerve cells and while additionally increasing GABA's affinity for its receptor on the post-junction membrane of muscle cells in insects and arthropods. The stronger binding of GABA increases the cells permeability to chloride ions within the cell due to the hypotonic concentration gradient. Neurotransmission is thereby reduced by subsequent hyperpolarisation and the elimination of signal transduction.

The protection of crops and its produce from insect pest damage is essential in agriculture produce enhancement. Each year insects, plant pathogens, and weeds, destroy more than 40% of all food production. This loss occurs despite the application of pesticides and the use of a wide array of non‐chemical controls, such as, crop rotations, and biological controls. If just some of this food could be saved, it could be used to feed more than three billion people in the world who are malnourished.

To control insect pests, it is necessary to spray and use a pesticidal composition, effective for target insect pests at appropriate times throughout the cultivation period and insect life cycle. In the practice of pest control, particularly insect control, there are two main factors which determine the effectiveness of the treatment; 1) immediate action on the pests (known in the art as "knock-down action"), 2) long term action (known also as "residual action"). The effective pesticidal composition for insect control ought to qualify both these factors.

The problem of pest resistance in agricultural production is a global problem, and it has always been the focus of attention of agricultural science and technology workers. Chemical control by the use of various chemicals and formulations is an important tool in agriculture for the prevention and control of pests. Insecticides of many types and groups are reported in the literature and a large number are in use, commercially, for control of pests in agriculture. With the continuous use of chemical pesticides to control pests year after year, the increase in the use of pesticides and the unscientific use of pesticides; the resistance to pests has become increasingly serious, and the types of pests that have developed resistance have increased. At the same time, the high‐intensity use of pesticides has led to a series of problems such as excessive pesticide residues in agricultural products, environmental pollution, and increased costs for farmers to use drugs, which is not conducive to the sustainable development of agriculture.

Insecticides are pesticides that are formulated to kill, harm, repel or mitigate one or more species of insect. Insecticides work in different ways. Some insecticides disrupt the nervous system, whereas others may damage their exoskeletons, repel them or control them by some other means. The mode of action of insecticides is classified by the Insecticide Resistance Action Committee (IRAC). In this classification, a large proportion of insecticides are categorized as nerve and muscle targeting insecticides, which encompass GABAC1 antagonists (Group 2) and GluCl allosteric modulators.

Furthermore, the high-intensity use of pesticides has led to other problems as well, such as excessive pesticide residues in agricultural products, environmental pollution, and increased costs for farmers to use drugs, which is not conducive to the sustainable development of agriculture.

Combination of insecticides are being used recently to broaden the spectrum of control of insects, to improve the pest control with synergistic effect, reduce dosage, thereby reducing environmental impact, decrease chances of resistance development and to enhance residual control so lesser the number of sprays for crop protections and minimizing the pesticidal load in ecosystem.

There is however a need for improvement of these combinations. Single active combinations used over a long period of time have resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of disease and pest control.

The active ingredients known from the literature have certain disadvantages such as insufficient control efficacy, restriction of its use due to the appearance of drug‐resistant pathogenic fungi, phytotoxicity and contamination to plants, or toxicity to human beings, beasts, fishes and the like. Hence, there is a long felt need to develop novel and effective pesticidal combinations for controlling the harmful pests in plants that demonstrate high efficacy, are environmentally safe and can be advantageously formulated.

The pesticides currently in use are not that effective; and due to their prolonged indiscriminate and non‐judicious use, some pests have developed resistance to such commonly used pesticides. Their use is thereby becoming increasingly difficult.

Therefore, there is an urgent need to develop new methods and formulations for controlling these harmful pests. Therefore, there is a need to provide a pesticidal composition which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process. The present inventors have surprisingly developed an effective pesticidal combination which ameliorates the aforesaid shortcomings of the prior art.

Many binary combinations of active ingredients have been developed to broaden the spectrum of activities. In order to reduce the risk from increased number of resistant insect species, mixtures of different active compounds developed for controlling insects-pests. By combining different active compounds having different mode of action, it is possible to ensure successful control of insect-pests belongs to different orders over a relatively longer period of time and preventing development of resistance.

To address this problem, researches are trying to produce an extensive variety of active ingredients and active ingredients formulations for effective control of insects. Chemical pesticides of many types have been disclosed in the art and a large number are in commercial use. In crop protection, it is desirable in principle to increase specificity and reliability of action of pesticidal active ingredients.

Therefore, one objective of the present invention is to provide synergistic pesticidal composition for the control of insect pests including but not limited to thrips, mites, stem borer, chewing pests and entire sucking pests complex, which are resistant to existing pesticidal compositions and have prolonged insect pest control.

Therefore, there still exists a need to develop pesticidal composition, which is stable, synergistic, more effective in control of insects and mites in crop and environmentally safe.

Accordingly to the demonstration of synergism by combination of existing insecticide agents, permits use of individual agents of synergistic combination at lower rates than when used alone and in many instances ameliorates increasing resistance to pesticidal effectiveness.

The present invention overcomes the limitations associated with existing formulations available in the market. This novel formulation leverages avermectin family products with synergistic properties and is a natural fermentation product of soil dwelling actinomycetes Streptomyces avermitilis, thereby enhancing the overall pharmacological efficacy. The use of these synergistic components aims to achieve a significant therapeutic effect while minimizing adverse side effects and toxicity. This innovative approach represents advancement in formulation design, offering a safer and more effective option for cancer treatment.

SUMMARY OF THE INVENTION:
The main object of the present invention is to provide a pesticidal composition comprising a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate; and d) one or more inactive excipients.

Another object of the present invention is to provide a pesticidal composition comprising a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w.

Yet another object of the present invention is to provide one or more inactive excipients is selected from the group comprising of wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof. The composition may also contain if desired, one or more auxiliary customary for crop protection compositions.

Another object of the present invention is to provide a pesticidal composition of the present invention is formulated as Water dispersible granules/Wettable granules (WDG/WG), Water soluble granules (SG), Emulsifiable granule (EG), Wettable powder (WP), Water Dispersible Powder (WDP), Soluble powder (SP), Emulsifiable powder (EP), Oil dispersible powder (OP), Soluble Tablet (ST), Capsule suspension/Micro capsule (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion water-in-oil (EO), Emulsion oil-in-water (EW), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Suspension Concentrate (SC), Suspo Emulsion (SE), Soluble Liquid/Concentrate (SL), mixed formulation of CS and SC (ZC), mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

DETAILED DESCREPTION OF THE INVENTION:
In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented here. The present technology is also illustrated by the examples herein, which should not be construed as limiting in any way.

As used herein, the terms below have the meanings indicated.

The singular forms "a," "an," and "the" may refer to plural articles unless specifically stated otherwise.

The term "about," as used herein, is intended to qualify the numerical values which it modifies, denoting such a value as variable within a margin of error. When no particular margin of error, such as a standard deviation to a mean value given in a chart or table of data, is recited, the term "about" should be understood to mean that range which would encompass the recited value and the range which would be included by rounding up or down to that figure as well, taking into account significant figures.

The embodiments, illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the terms “comprising,” “including,” “containing,” etc. shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the claimed technology. Additionally, the phrase “consisting essentially of” will be understood to include those elements specifically recited and those additional elements that do not materially affect the basic and novel characteristics of the claimed technology. The phrase “consisting of” excludes any element not specified.

As used herein, the term “excipient” refers to inert substances which are commonly used as diluent, to provide stability or to increase the activity profile of the composition or formulation without having any pesticidal activity or direct effect on the insect pests.

The present invention is to provide a pesticidal composition comprising:
a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether

or its agrochemically acceptable salts, esters and derivative;
b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide

or its agrochemically acceptable salts, esters and derivative;
c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate; and
d) one or more inactive excipients.

The present invention is to provide a pesticidal composition comprising a) compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w; b) compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w.

The composition of the present invention comprises excipients selected from the group comprising of wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof. The composition may also contain if desired, one or more auxiliary customary for crop protection compositions.

The present invention is to provide a pesticidal composition of the present invention is formulated as Water dispersible granules/Wettable granules (WDG/WG), Water soluble granules (SG), Emulsifiable granule (EG), Wettable powder (WP), Water Dispersible Powder (WDP), Soluble powder (SP), Emulsifiable powder (EP), Oil dispersible powder (OP), Soluble Tablet (ST), Capsule suspension/Micro capsule (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion water-in-oil (EO), Emulsion oil-in-water (EW), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Suspension Concentrate (SC), Suspo Emulsion (SE), Soluble Liquid/Concentrate (SL), mixed formulation of CS and SC (ZC), mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

The composition of the present invention is effective to control various insects and mites belongs to the order Hemiptera, examples-aphid, jassid, leaf hopper, mango hopper, whitefly, mealybug, scale, rice brown plant hopper (BPH); order Lepidoptera, examples-fall army worm, rice stem borer, rice leaf folder, sugarcane early shoot borer, top borer, wheat pink stem borer, fruit borer, pod borer, Maruca, cut worm, diamond back moth (DBM), looper, semi looper, pink bollworm, brinjal fruit and shoot borer, Spodoptera spp. (litura, exigua, frugiperda), Helicoverpa; from the order Coleoptera,examples-white grub, wire worm, epilachna beetle, blue beetle, girdle beetle, flea beetle, rice water weevil; from the order Orthoptera, examples-locust; from the order Thysanoptera, examples-cotton thrips, chilli thrips, black thrips; from the order Isoptera, example-termite; from the order Diptera, examples-shoot fly, stem fly, fruit fly, leaf miner; from the order Acarina, examples-red mite, red spider mite, yellow mite, pink mite, purple mite.

The insects and mites may be controlled by contacting the target insects pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of present compositions.

The crops and plants treated by present compositions are comprises of genetically modified varieties or hybrid varieties or conventional varieties of paddy/rice, wheat, maize, sugarcane, cotton, okra, brinjal, chilly, tomato, cabbage, cauliflower, potato, garlic, onion, groundnut, soybean, green gram, black gram, red gram, gram/chickpea, cucumber, melons, apple, mango, papaya, pomegranate, banana, grapes, tea, coffee, cumin, fennel, black pepper, flowers-rose, marigold etc.

The present composition can be applied to a plant or crop by spraying, dusting, broadcasting in to the soil, drenching, fertigation through drip irrigation or through coating on fertilizers.

The synergistic pesticidal composition of specific active ingredient has the special advantage of being highly active against insect pests and mites. The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combinations of the present invention allow for a broad spectrum of pest control. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.

Active Ingredients Component A Component B Component C
Examples 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether
(Formula I) 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-
(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ)- (methoxyimino)methyl]-o-toluamide
(Formula II) At least insecticide selected from Abamectin or Emamectin benzoate
% of active ingredients (w/w) 4.0% to 20.0% w/w 1.0% to 10.0% w/w 0.5% to 5.0% w/w

Further, a pesticidal composition comprising a) compound A of Formula I known as (Pyriproxyfen) 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative; b) compound B of Formula II known as (Fluxametamide) 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate; and d) one or more inactive excipients.

The present invention is to provide a pesticidal composition comprising a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w.

Further, the present invention is to provide a pesticidal composition comprising a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w; more preferably in range of 5.0 to 16.0%w/w of the composition; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w; more preferably in range of 2.0 to 8.0%w/w of the composition; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w; more preferably in range of 0.6 to 4.0%w/w of the composition.

The present invention is to provide one or more inactive excipients is selected from the group comprising of wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof. The composition may also contain if desired, one or more auxiliary customary for crop protection compositions.

Wetting is the first stage of dispersion, in which air surrounding the granular composition is substituted with water. Wetting of the composition with water cannot occur if the surface tension of the liquid is very high. Hence, it is recommended to add a wetting agent to the composition to facilitate the process of dispersion of the granules in the liquid. Non-limiting examples of wetting agents that can be used in the present invention include, but not limited to, tristyryl phenol ethoxylate non-ionic polymer, sodium iso propyl naphthalene sulphonate, alkyl phenyl ethoxylate, aryl phenyl ethoxylate, aryl phenyl ether phosphate, alkoxylated alcohol, ethoxylated fatty alcohol, ethylene oxide-propylene oxide (EO-PO) block copolymer, alkyl aryl sulphonate, alkyl olefin sulfonate, dioctyl succinate, sodium lauryl sulfate, alkyl polyglucoside, sodium alkyl aryl taurate, sorbitol esters, sorbitol oleate, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified Tri siloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form. One or more wetting agents may be used in the present composition. The wetting agent is present in an amount of 1 to 10% w/w.

Dispersing agents /surfactants are added to prevent agglomeration of solid particles in a liquid and keep them suspended in fluid. Accordingly, the composition of the present invention contains the dispersing agent selected from the group comprising acrylic graft copolymer, examples are 2-Acrylamido-2-Methylpropane Sulfonic Acid, Sodium methallyl sulfonate, 3-sulfopropyl acrylate potassium salt, 3-sulfopropyl methacrylate potassium salt, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxymethyl methacrylate, Polyethylene-g-poly(n-butyl acrylate), poly acrylate copolymer.; polyarylphenyl ether phosphate, Tri styryl phenol ethoxylate, ethoxylated tristyryl phenol sulphate, acrylic polymer amine salt, naphthalene sulfonic acid-sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate-sodium salt, ethoxylated oleylcetyl alcohol, polyalkelene glycol ether, ethoxylated fatty alcohol, alkyl sulfonate, styrene acrylic copolymer, alkyl phenol polyglycol ether, sodium lignosulfonate, calcium lignosulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide- polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.One or more dispersing agents is used in the present composition in an amount of 1 to 25% w/w.

Defoamer/Antifoaming agent is generally added to the composition to prevent foam formation as the foam prevents the efficient filling of a container. Suitable defoamer used herein, but not limited to, siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, silicone oil emulsion, magnesium stearate or a combination thereof and present in an amount of 0.01 to 5% w/w.

An anti-freezing agent is generally added to the composition, to prevent the aqueous compositions from freezing. Suitable anti-freezing agents are water soluble alcohols (ethylene glycol, propylene glycol), glycerol, 1,3-butendiol, urea, magnesium sulfate heptahydrate, sodium chloride etc. The anti-freezing agent is present in an amount of 0.1 to 10% w/w.

Biocide/Preservative is added to the composition for its preservation against spoilage from bacteria, yeasts and fungi. Suitable biocides useful herein, but not limited to, include benzisothiazolin-3-one, formaldehyde, sodium benzoate, sodium o-phenyl phenate, potassium sorbate, copper pyrithione, zinc pyrithione, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or a combination thereof, and is present in an amount of 0.01 to 1% w/w.

Thickener/suspending agent is necessary to add a thickener to the composition to reduce the tendency of the composition to disperse when sprayed and decrease the likelihood of it being rinsed off from the crops. The synergistic pesticidal composition comprises a thickener selected from the group comprising polysaccharides such as xanthan gum, sodium carboxymethyl cellulose, hydroxymethyl cellulose, sodium polyacrylate, bentonite clay, attapulgite clay, aluminum magnesium silicate, hydroxy propyl cellulose, polyvinyl alcohols, modifier starch, acacia gum, gelatin or a combination thereof and is present in an amount of 0.01 to 5% w/w.

An emulsifier helps to prevent the droplets of the dispersed phase of an emulsion from flocculating or coalescing in the emulsion. Suitable emulsifier is used herein, but not limited to castor oil ethoxylate 40 mole, Polyoxyethylenealkylphenyl ether alkylaryl sulfonate, 3-methoxy N, N-dimethyl propionamide, Polyglyceryl-3 caprylate, Polysorbate 60 (polyoxyethylene sorbitan monostearate-Tween 60), solventsoalkyl phenol, aryl phenol, alkyl phenol ethoxylate, fatty acid esters, fatty acid alkanol amides, alkoxylated fatty acid ester or a combination thereof. The emulsifier is present in an amount of 1 to 50% w/w.

The solvent and cosolvent used in the present invention is selected from the group comprising of demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, acetophenone, glycerine, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as Mixture of heavy aromatic naphta hydrocarbon C-9 to C-16, xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, mineral oil, methylated seed oil-methyl ester of palm oil/soybean oil/castor oil/cotton seed oil/blend of two or seed oil.

The solvent may be used alone or in combination and is present in an amount quantity sufficient (QS) required to make 100% w/w formulation.

Castor oil ethoxylate 40 moles is non-ionic surfactant that is derived from castor oil. It has variety of uses such as emulsifier, wetting agent, dispersing agent, additive, antistatic agent and as a solvent.

Rheology modifier is selected from China clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite, and a combination thereof.

Buffering agent/ pH stabilizers may include sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, potassium hydrogen phosphate salt solution, acetic acid & sodium acetate, ammonia & ammonium chlorides, citric acid, benzoic acid, salicylic acids, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, carboxylic acids, 2,6-di-tert-butyl-p-cresol, butylhydroxyanisole (BHT), epoxidized soybean oil (ESBO), methyl oleate, potassium carbonate, potassium hydroxide, sodium hydroxide and sodium dihydrogen phosphate dihydrate or combination thereof. Optionally stabilizer present in an amount of 0.05 to 2% w/w.

Common stabilizers used in dispersion concentrates include: polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose sodium (NaCMC), sodium dodecyl sulfate (SDS), lecithin, polysorbates, and various types of gums like xanthan gum or guar gum; the specific choice depending on the desired properties and application of the dispersion concentrate.

Anti-caking agents are used to prevent caking, which is the formation of lumps. They also make packaging, transport, flowability, and consumption easier. The anticaking agent may be selected from silica/silicone dioxide, calcium silicate, sodium ferrocyanide, Calcium stearate. Optionally anti-caking agents are present in an amount of 0.1 to 10% w/w.

The binder is water soluble, water swellable or combinations of both. The binder is water-
soluble binder selected from a group consisting of poly ethylene wax, poly vinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polyethylene oxide, polyethoxylated fatty acids, polyesters, polyamides, poly carbonates, poly urea, poly urethanes, styrene copolymer, butadiene copolymers, polyethoxylated alcohols, acrylate polymer such as polymethacrylate, poly ethyl methacrylate, poly methyl methacrylate, acrylate copolymers and styrene-acrylic copolymers or mixtures of thereof, a natural gum, lignosulphonate, and a combination thereof. The binder is a water swellable binder selected from a group consisting of China clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite, and a combination thereof. Binder is present in an amount in the range from 0.1 to 10% w/w.

Precipitated silica acts as carrier material, absorbing and holding the active ingredient while maintaining a free flowing, easily dispersible powder form, enhancing wettability by improving water contact, and often providing Rheology modifier, anti-caking properties to prevent clumping, making it crucial for consistent application of the pesticide when mixed with water for spraying on crops.

A filler/carrier selected from the group comprising sand, silica, precipitated silica, bentonite, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite, silicon dioxide, china clay/kaolin clay, talc, starch, zinc and its salts (zinc sulphate, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), iron and its salt (ferrous sulphate), copper and salts, sulphur, humic acid and salt, fulvic acid and salt, amino acids, sea weed extracts, chitosan or a combination thereof. It presents in an amount quantity sufficient (QS) required to make 100% w/w formulation.

Stabilizer selected from silica, bentonite clay, attapulgite clay, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite or combination thereof. It presents in an amount of 0.05 to 2.0% w/w.

Capsule suspension (CS) or microcapsule technology that uses membrane forming wall material to embed the core materials that needs to be protected to form tiny particles, which can protect the core material from adverse environment and effectively plays its biological active functions. The wall forming material/ capsule making monomers may be selected from Tetramethylene diisocyanate, Penta methylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethene diisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form;, Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetra ethylene pentaamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4′-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4′-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone. It presents in an amount in the range from 0.1 to 5% w/w.

The synergistic present composition provides the following advantages:
• Synergistic control of insect-pests and mites. Increased efficacy than their individual counterparts or their mixtures, thus allows a substantial reduction in the application rates of each of these active ingredients, while maintaining good efficacy and thereby reducing costs and residue problems.
• Broad spectrum control of insect-pests (belongs to hemiptera, homoptera, lepidoptera, coleoptera, diptera, isoptera, Thysanoptera) and mites (acarina).
• Minimizes risk of development of resistance and achieves effective and
economical control of undesired insects.
• Economically beneficial to the farmers as it provides better yield of the crop
with reduction in the number of sprays.
• Reduced possibility of hazards to the farmers due to occupational exposure.
because of reduction in the number of sprays.
• Better storage stability.
• Non-phytotoxic and environment friendly.

The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification are still covered by the scope of present invention.

While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.

These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.

EXAMPLES:

Example 1: Method of preparation Emulsifiable concentrate (EC) formulation.

Table 1: Formula I 10%+Formula II 5%+Emamectin benzoate 1.5% EC
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 10.20
Formula II technical (93.5% purity) Active Ingredient 5.35
Emamectin benzoate technical (95% purity) Active Ingredient 1.58
Polyoxyethylene sorbitan monooleate Emulsifier 8.00
Tristyrylphenol Ethoxylate Phosphate Ester Emulsifier 6.00
N-Methyl-2-pyrrolidone Solvent 10.00
solvent naphtha Solvent 58.87
Total 100.00

Manufacturing process for 100 kg batch size of Formula I 10%+Formula II 5%+Emamectin benzoate 1.5% EC.
Step 1: Weighing the raw materials according to the batch size as follows:
Step 2: Add 58.87 kg of solvent naphtha, 10 kg of N-Methyl-2-pyrrolidone into the vessel.
Step 3: Slowly add 8 kg of Polyoxyethylene sorbitan monooleate and 6 kg of Tristyrylphenol Ethoxylate Phosphate Ester with slow stirring.
Step 4: Add 10.2 kg of Formula I technical, 5.35 kg of Formula II technical and 1.58 kg of emamectin benzoate technical and mix it properly for 30 to 45 minutes.
Step 5: Collect the sample for quality check and pack it in suitable container.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 2: Storage Stability-Formula I 10%+Formula II 5%+Emamectin benzoate 1.5% EC
Parameters with specifications T0 T1 (AHS), for 14 days at 54 'C. T2- for three months at 40 'C
Formula I content (%) (-5% to +5% range) 10.54 10.53 10.52
Formula II content (%), (-5% to +10% range) 5.42 5.41 5.40
Emamectin benzoate content (%) (-5% to +10% range) 1.62 1.62 1.61
Emulsion stability (2 ml formulation in 98 ml 342 ppm hard water), maximum 2 ml creaming or sediment after 1 hour 0 ml 0.3 ml 0.3 ml
pH (5% in DM water, 6 to 8) 6.4 6.4 6.4
Cold test (at 10 ºC temperature) Any separation or creaming max. 2 ml after 1 hour pass pass pass
Flash point (above 24.5 0C) complies complies complies

The EC composition of Formula I 10%+Formula II 5%+Emamectin benzoate 1.5% meets all the required storage stability criteria-active ingredient content, emulsion stability, pH, cold test and flash point.

Table 3: Formula I 12%+Formula II 6%+Abamectin 1.8% EC
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 12.24
Formula II technical (93.5% purity) Active Ingredient 6.42
Abamectin technical (92% purity) Active Ingredient 1.96
3-methoxy N, N-dimethyl propionamide Emulsifier 15.00
Polyoxy ethylene alkyl phenyl ether alkyl aryl sulfonate Emulsifier 4.00
Aromatic solvent (C10-C13) Solvent 60.38
Total 100.00

The EC composition of Formula I 12%+Formula II 6%+Abamectin 1.8% meets all the required storage stability criteria-active ingredient content, emulsion stability, pH, cold test and flash point.

EXAMPLE 2: Method of preparation Suspension Concentrate (SC) formulation.

Table 4: Formula I 6%+Formula II 3%+Emamectin benzoate 0.8% SC
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 6.12
Formula II technical (93.5% purity) Active Ingredient 3.21
Emamectin benzoate technical (95% purity) Active Ingredient 0.84
Acrylic Graft Copolymer (2-hydroxypropyl methacrylate) Dispersing agent 5.00
Alkyl naphthalene sulfonate formaldehyde condensate Dispersing agent 1.00
Tri siloxane ethoxylate Wetting agent 4.00
Aluminum magnesium silicate Suspending agent 1.00
Polydimethylsiloxane Anti-foaming agent 0.40
Propylene Glycol Anti-freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Precipitate Silica Rheology modifier 0.40
Xantahn gum/Polysaccharide Thickener 0.20
Demineralized water Solvent 72.63
Total 100.00

Manufacturing process for 100 kg batch size of Formula I 6%+Formula II 3%+Emamectin benzoate 0.8% SC
Weighing the raw materials according to the batch size as follows
Step 1: Preparation of gum solution: Dissolve 2 kg of 1,2-benzisothiazolin-3(2H)-one into 96 kg of Demineralized (DM) water. Now add 2 kg of Polysaccharide slowly and stir till completely dissolved to form a solution. This gum solution was made 12 to 18 hours prior to use.
Step 2: Take 62.63 kg of DM water and 5 kg of propylene glycol into designated vessel and mix thoroughly. Add 1 kg of Alkyl naphthalene sulfonate formaldehyde condensate, 5 kg of Acrylic Graft Copolymer (2-hydroxypropyl methacrylate) and 4 kg of tri siloxane ethoxylate into the vessel having water and homogenize the contents for 45 to 60 minutes using high shear homogenizer.
Step 3: Then 6.12 kg of Formula I technical, 3.21 kg of Formula II technical and 0.84 kg of emamectin benzoate technical and 1 kg of aluminium magnesium silicate were added and homogenized to get a uniform slurry for grinding.
Step 4: Then half of the quantity of polydimethyl siloxane was added to the slurry and then the slurry was subjected to three cycles of grinding in a bead mill till desired particle size achieved. Remaining half of the quantity of polydimethyl siloxane was added after the grinding process.
Step 5: Finally, add 0.4 kg of precipitated silica and 10 kg of remaining gum solution, and homogenize it to obtain the title formulation.
Step 6: Sending the sample to the quality analysis;
Step 7: Packing the formulated material in suitable packaging.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 5: Storage stability- Formula I 6%+Formula II 3%+Emamectin benzoate 0.8% SC
Parameters T0 (initial) T1 (AHS),for 14 days at 0C T2- for three months at 40 0C
Formula I content (%) (-5% to +10% range) 6.52 6.51 6.50
Formula II content (%), (-5% to +10% range) 3.45 3.44 3.43
Emamectin benzoate content (%) (-5% to +10% range) 0.88 0.87 0.87
suspensibility (minimum 80%) 98.40 98.20 97.90
pH range (6 to 8, 1% aq. Suspension) 7.00 7.00 7.00
pourability (95% minimum) 98.20 98.00 97.80
viscosity at spindle no. 62, 20 rpm (350 to 800 cps) 640 650 650
Particle size (D50<3, D90<10 micron) 2.0, 8.1 2.1, 8.2 2.1, 8.1

Formula I 6%+Formula II 3%+Emamectin benzoate 0.8% SC meets all the required storage stability criteria-active ingredient content, suspensibility, pH range, pourability, viscosity and particle size.

Table 6: Formula I 6%+Formula II 3%+Abamectin 0.8% SC (Suspension Concentrate)
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 6.12
Formula II technical (93.5% purity) Active Ingredient 3.21
Emamectin benzoate technical (95% purity) Active Ingredient 0.84
Ethoxylated tristyrylphenol Dispersing agent 4.00
Sodium naphthalene sulphonate formaldehyde condensates Dispersing agent 1.50
Ethylene oxide-propylene oxide (EO-PO) block copolymer Wetting agent 5.00
Attapulgite clay Suspending agent 0.40
Polydimethylsiloxane Anti-foaming agent 0.40
Propylene Glycol Anti-freezing agent 4.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Precipitated Silica Rheology modifier 1.00
Xantahn gum/Polysaccharide Thickener 0.20
Demineralized water Solvent 73.13
Total 100.00

SC composition of Formula I 6%+Formula II 3%+Abamectin 0.8% meets all the required storage stability criteria- ingredient content, suspensibility, pH range, pourability, viscosity and particle size.

EXAMPLE 3: Method of preparation Suspo Emulsion (SE) formulation.

Table 7: Formula I 8%+Formula II 4%+Emamectin benzoate 0.9% SE
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 8.16
Formula II technical (93.5% purity) Active Ingredient 4.28
Emamectin benzoate technical (95% purity) Active Ingredient 0.95
Blend of calcium salt of alkyl benzene sulphonic acid and polyethoxyether of nonyl phenol Emulsifier 10.00
Aromatic solvent (C-9) Solvent 25.00
Ethoxylated Tristyryl phenol
Sulphate Dispersing agent 1.00
Tristyryl phenol ethoxylate Dispersing agent 1.50
Acrylic polymer amine salt Dispersing agent 0.50
Trisiloxane ethoxylate Wetting agent 2.00
Citric acid Buffering agent 0.10
Siloxane polyalkylene oxide Anti foaming agent 0.20
Polypropylene glycol Anti freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Precipitate silica Filler 0.20
Xanthan gum Thickener 0.20
Diluent water Solvent 40.71
Total 100.00

Manufacturing process for 100 kg batch size of Formula I 8%+Formula II 4%+Emamectin benzoate 0.9% SE
Step 1: Weighing the raw materials according to the batch size as follows:
Step 2: Preparation of gum solution: Dissolve 2 kg of 1,2-benzisothiazolin-3(2H)-one into 96 kg of Demineralized (DM) water. Now add 2 kg of Polysaccharide slowly and stir till completely dissolved to form a solution. This gum solution was made 12 to 18 hours prior to use.
Step 3: Preparation of EC phase: Add 25 kg of aromatic solvent C-9, 10 kg of Blend of calcium salt of alkyl benzene sulphonic acid and polyethoxyether of nonyl phenol into other vessel having slow stirring. Add 8.16 kg of Formula I technical and mix it properly for 30 to 45 minutes.
Step 4: Preparation of SC phase: Charge 30.71 kg of DM water and 5 kg of propylene glycol into designated vessel and mix thoroughly.
Step 5: Add 1 kg of Ethoxylated Tristyryl phenol Sulphate, 1.5 kg of Tristyryl phenol ethoxylate, 0.5 kg of acrylic polymer amine salt, 2 kg of tri siloxane ethoxylate and half quantity of siloxane polyalkylene oxide into the vessel and homogenize the mixture for 45 to 60 minutes using high shear homogenizer.
Step 6: Add 4.28 kg of Formula II technical and 0.95 kg of emamectin benzoate technical to this premix slowly and homogenized to get uniform slurry ready for grinding.
Step 7: Before grinding, add half quantity of siloxane polyalkylene oxide, 0.1 kg of citric acid and do grinding process in Dyno mill till desired particle size achieved.
Step 8: Preparation of SE formulation: Now add EC phase slowly into this milled slurry using slow stirring and homogenize the mixture for 30 to 45 minutes.
Step 9: Finally add 10 kg of gum solution to this formulation.
Step 10: Collect the sample quality check and packing.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 8: Storage Stability-Formula I 8%+Formula II 4%+Emamectin benzoate 0.9% SE
Parameters T0 (initial) T1 (AHS),for 14 days at 0C T2- for three months at 40 0C
Formula I content (%) (-5% to +10% range) 8.54 8.52 8.53
Formula II content (%) (-5% to +10% range) 4.43 4.42 4.42
Emamectin benzoate content (%) (-5% to +10% range) 0.98 0.97 0.98
suspensibility (minimum 80%) 98.40 98.20 97.90
pH range (7 to 10, 1% aq. Suspension) 7.00 7.00 7.00
pourability (95% minimum) 98.20 98.00 97.80
Viscosity at spindle no. 62, 20 rpm (350 to 800 cps) 640 650 650
Particle size (D50<3, D90<10 micron) 2.0, 8.1 2.0, 8.2 2.0, 8.2

SE composition of Formula I 8%+Formula II 4%+Emamectin benzoate 0.9% meets all the required storage stability criteria- ingredient content, suspensibility, pH range, pourability, viscosity and particle size.

EXAMPLE 4: Method of preparation Oil Dispersion (OD) formulation.

Table 9: Formula I 10%+Formula II 6%+Abamectin 1.4% OD
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 10.20
Formula II technical (93.5% purity) Active Ingredient 6.42
Abamectin technical (92% purity) Active Ingredient 1.52
Tristyrylphenol-polyglycolether-phosphate Dispersing agent 4.50
Octylphenol ethoxylate Emulsifier 8.00
Tri siloxane ethoxylate Wetting agent 5.00
Polydimethylsiloxane Anti-foaming agent 0.30
Propylene Glycol Anti-freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Bentonite clay Stabilizer 2.00
Citric acid Buffering agent 0.20
Methyl soyate Solvent 56.66
Total 100.00

Manufacturing process for 100 kg batch size of Formula I 10%+Formula II 6%+Abamectin 1.4% OD.
Step 1: Preparation of Bentonite clay solution: Add 2 kg of bentonite clay into 56.66 kg of methyl soyate (oil phase), homogenized till it gets completely dissolved. It must be kept 12 to 18 hrs. prior to use.
Step 2: Charge 46.66 kg of solution into a designated vessel.
Step 3: Add 4.5 kg of Tristyrylphenol-polyglycolether-phosphate, 8 kg of octyl phenol ethoxylate, 5 kg of tri siloxane ethoxylate, 0.3 kg of polydimethylsiloxane, 5 kg of propylene glycol, 0.2 kg of 1,2-benzisothiazolin-3(2H)-one and 0.2 kg of citric acid and homogenize the mixture for 45 to 60 minutes using high shear homogenizer.
Step 4: Add 10.2 kg of Formula I technical, 6.42 kg of Formula II technical and 1.52 kg of abamectin technical into this premix and again homogenized for 30 to 45 minutes until it gets uniform mixture.
Step 5: The uniform mixture should be milled at 25 °C and particle size is maintained at < 5μ.
Step 6: Now add remaining 10 kg of bentonite clay solution.
Step 7: Sending the sample to the quality analysis;
Step 8: Packing the formulated material in suitable packaging.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 10: Storage stability- Formula I 10%+Formula II 6%+Abamectin 1.4% OD
Parameters T0 (initial) T1 (AHS),for 14 days at 54 0C T2- for three months at 40 0C
Formula I content (%) (-5% to +10% range) 10.38 10.37 10.37
Formula II content (%), (-5% to +10% range) 6.82 6.81 6.81
Abamectin content (%) (-5% to +10% range) 1.50 1.49 1.49
Description/Appearance ivory colour uniform dispersion ivory colour uniform dispersion ivory colour uniform dispersion
pH range (5 to 8, 1% aq. Suspension) 6.25 6.21 6.20
Dispersion stability-Sediments (24 hrs) nil nil nil
Dispersion stability-Creaming (24 hrs) nil nil nil
Stability stable 10% separation 10% separation
pourability (95% minimum) 98.20 98.10 98.10
Viscosity at spindle no. 62, 20 rpm 280 275 275
Persistant foam nil nil nil
Particle size distribution (microns) D10 0.29 1.07 1.09
Particle size distribution (microns) D50 0.93 2.55 2.58
Particle size distribution (microns) D90 2.18 5.40 5.52

The composition of Formula I 10%+Formula II 6%+Abamectin 1.4% OD meets all the required storage stability criteria-active ingredient content, pourability, pH range, visocity and particle size test.
EXAMPLE 5: Method of preparation Micro Emulsion (ME) formulation.

Table 11: Formula I 10%+Formula II 5%+Abamectin 1.5% ME.
Ingredients Function Percent (w/w)
Formula I technical (98% purity) Active Ingredient 10.20
Formula II technical (93.5% purity) Active Ingredient 5.35
Abamectin technical (92% purity) Active Ingredient 1.63
Polyoxyethylene sorbitan monooleate Emulsifier 10.00
Tristyrylphenol Ethoxylate Phosphate Ester Emulsifier 20.00
Cyclohexanone Solvent 40.00
N-Methyl-2-pyrrolidone Solvent 12.82
Total 100.00

The composition of Formula I 10%+Formula II 5%+Abamectin 1.5% ME meets all the required storage stability criteria-active ingredient content, persistent foam, emulsion stability, density and pH.

Example 6
BIOLOGICAL EXAMPLES:
Evaluation of synergistic effect of pesticidal composition of the present invention:
The synergism between two or three pesticidal compounds can be evaluated as per the method given by S R Colby. Calculating Synergistic and Antagonistic Responses of Herbicide Combinations, published online by Cambridge University Press: 12 June 2017, pp. 20-22 (Weeds, Journal of The Weed society of America, Volume 15, January 1967, Issue 1, Page 20-22).

Experiment 1: Synergistic control of thrips in cotton crop.
Crop: Cotton
Plot size: 8 m x 5m.
Pests: Thrips (Thrips tabaci).
Crop stage: 65 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 440 liters per hectare.
Methodology: Thrips control (%): Count the number of live thrips per leaf, 3 leaves per plant and 10 plants per treatment. Calculate Thrips control by given formula (as observed control) and calculate expected control by Colbys’ formula.

Table 12: Treatment details
S.No. Treatments details active Ingredients (g) formulation (ml)
T1 Control (water spray only) - -
T2 Formula I 10% EC 40 400.0
T3 Formula I 10% EC 60 600.0
T4 Formula I 10% EC 80 800.0
T5 Formula II 10% EC 50 500
T6 Formula II 10% EC 40 400
T7 Formula II 10% EC 10 100
T8 Abamectin 1.9% EC 15 789.5
T9 Abamectin 1.9% EC 10 526.3
T10 Abamectin 1.9% EC 5 263.2
T11 Formula I 8%+Formula II 10% EC 40+50 500
T12 Formula I 12%+Formula II 8% EC 60+40 500
T13 Formula I 16%+Formula II 2% EC 80+10 500
T14 Formula I 8%+Abamectin 3% EC 40+15 500
T15 Formula I 12%+Abamectin 2% EC 60+10 500
T16 Formula I 16%+Abamectin 1% EC 80+5 500
T17 Formula II 10%+Abamectin 3% EC 50+15 500
T18 Formula II 8%+Abamectin 2% EC 40+10 500
T19 Formula II 2%+Abamectin 1% EC 10+5 500
T20 Formula I 8%+Formula II 10%+Abamectin 3% EC 40+50+15 500
T21 Formula I 12%+Formula II 8%+Abamectin 2% EC 60+40+10 500
T22 Formula I 16%+Formula II 2%+Abamectin 1% EC 80+10+5 500
T20 to T22-present compositions; T11 to T19 are prior art combinations.

Table 13: Synergistic control of cotton thrips
S.No. Thrips control (%)
7 DAA 14 DAA
Observed Expected Ratio Observed Expected Ratio
T1 0.0 - - 0.0 - -
T2 22.3 - - 8.4 - -
T3 41.5 - - 30.4 - -
T4 57.6 - - 48.3 - -
T5 86.2 - - 82.6 - -
T6 71.7 - - 64.8 - -
T7 40.6 - - 27.6 - -
T8 66.9 - - 59.2 - -
T9 55.3 - - 43.7 - -
T10 30.2 - - 16.2 - -
T11 88.7 89.28 0.99 80.7 84.06 0.96
T12 81.4 83.44 0.98 70.3 75.50 0.93
T13 71.7 74.81 0.96 57.6 62.57 0.92
T14 76.8 74.28 1.03 57.3 62.63 0.91
T15 74.5 73.85 1.01 53.8 60.82 0.88
T16 71.3 70.40 1.01 47.7 56.68 0.84
T17 96.8 95.43 1.01 90.8 92.90 0.98
T18 88.3 87.35 1.01 76.5 80.18 0.95
T19 60.5 58.54 1.03 34.3 39.33 0.87
T20 100.0 96.45 1.04 99.3 93.50 1.06
T21 100.0 92.60 1.08 100.0 86.21 1.16
T22 97.2 82.42 1.18 92.8 68.63 1.35
DAA-Days after Application

The trial results show present compositions (T20 to T22) provide higher control of cotton thrips on 7th and 14th DAA with higher colby’s ratio (>1.04). All the present compositions (T20 to T22) provide synergistic and residual control of thrips on 14th DAA, whereas all prior art combinations fail to provide synergistic control.

Experiment 2: Control of sucking pests in cucumber.
Crop: Cucumber
Plot size: 18 m x 4 m
Pests: Jassid (Emposca spp.), Whitefly (Bemisia tabaci), Thrips (Frankliniella occidentalis).
Crop stage: 52 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 440 liters per hectare.
Observation method: As per experiment 1.

Fruit count: Record the number of healthy/marketable fruits per vine on 14th day after application. Record observations from 10 vines per treatment.

Table 14: Treatment details
S.No. Treatments Dose per hectare
active Ingredients (g) formulation (ml)
T1 Control (water spray only) - -
T2 Formula I 10% EC 75 750
T3 Formula II 10% EC 37.5 375
T4 Abamectin 1.9% EC 11.25 592
T5 Flonicamid 15%+Fluxametamide 5%+Abamectin 1.5% ME 112.5+37.5+11.25 750
T6 Pyriproxyfen 9.5%+Fluxametamide 4.5%+Flonicamid 13% SE 97.5+33.75+71.25 750
T7 Formula I 10%+Formula II 5%+Abamectin 1.5% ME 75+37.5+11.25 750
T7-present composition, T5 and T6-ternary prior art composition
Table 15: Residual control provided by present compositions
S.No. Jassid control (%) at 7 DAA Whitefly control (%) at 7 DAA Thrips control (%) at 7 DAA Number of fruits per vine % increase in fruits over T1
O E Ratio O E Ratio O E Ratio
T1 0.0 - - 0.0 - - 0.0 - - 7.8 0.0
T2 46.2 - - 70.8 - - 53.5 - - 9.5 21.4
T3 75.8 - - 35.7 - - 67.8 - - 12.9 64.3
T4 40.3 - - 50.3 - - 59.3 - - 11.2 42.9
T5 92.6 - - 83.8 - - 92.8 - - 15.7 100.0
T6 91.8 - - 93.5 - - 83.4 - - 14.9 90.1
T7 97.8 92.23 1.06 98.6 90.67 1.09 97.5 93.91 1.04 18.7 138.5
O-Observed control, E-Expected control as per colby’s formula, Ratio-colby’s ration (O/E)

The present composition (T7) provides synergistic and residual control of jassid, whitefly and thrips in cucumber and also yielded highest number of healthy fruits per vine. The present composition (T7) produces 38.5% and 48.4% higher fruits as compared to prior art composition T5 and T6 respectively.

Experiment 3: Epilachna beetle control in bottlegourd.
Crop: Bottlegourd
Plot size: 20 m x 4 m
Pests: Epilachna beetle
Crop stage: 72 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 480 liters per hectare.
Observation method: count the number of live beetle per leaf, observe 20 leaves per treatment randomly. Calculate % beetle control.
Table 16: Treatment details
Treatments Dose per hectare Epilachna beetle control (%) on 7 DAA
active Ingredients (g) formulation (ml) O E Ratio
T1-Control (water spray only) - - 0.0 - -
T2-Formula I 10% EC 75 750 18.6 - -
T3-Formula II 10% EC 45 450 70.5 - -
T4-Abamectin 1.9% EC 10.5 553 50.7 - -
T5-Pyriproxyfen 7.5%+Tolfenpyrad 12%+Abamectin 0.8% OD 75+120+8 1000 91.8 - -
T6-Formula I 10%+Formula II 6%+Abamectin 1.4% OD 75+45+10.5 750 99.5 88.16 1.13
T6-present composition, T5-ternary prior art combination
The present composition (T6) provides synergistic and higher control of epilachna beetle as compared to prior art composition (T5).

Experiment 4: Red spider mite control in Okra crop.
Crop: Okra
Plot size: 6 m x 5 m
Pests: Red Spider mite (Tetranychus urticae)
Crop stage: 83 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 500 liters per hectare.
Observation method: count the number of motile stages of mite per spot (20x hand microscopic filed), 3 spots per leaf. Observe 25 leaves per treatment randomly. Calculate % red spider mite control.

Table 17: Red Spider mite control in Okra crop
Treatments Dose per hectare Red mite control (%) at 7 DAA
active Ingredients (g) formulation (ml) O E Ratio
T1-Control (unsprayed) - - 0.0 - -
T2-Formula I 10% EC 75 750 27.3 - -
T3-Formula II 10% EC 45 450 45.2 - -
T4-Abamectin 1.9% EC 10.5 553 60.8 - -
T5-Chlorantraniliprole 3.6%+Fluxametamide 5%+Abamectin 1.5% SC 18+25+7.5 500 88.5 - -
T6-Formula I 12%+Formula II 6%+Abamectin 1.8% EC 48+24+7.2 750 97.6 84.38 1.16
T6-present composition, T5- ternary prior art composition
The present composition (T6) provides synergistic and higher control of red spider mite as compared to prior art composition (T5).

Experiment 5: Insect-pests control in brinjal crop.
Crop: Brinjal
Plot size: 8 m x 5 m
Pests: Shoot & Fruit borer (Leucinoides orbonalis), Whitefly (Bemisia tabaci)
Crop stage: 75 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 500 liters per hectare.
Observation method:
Shoot & Fruit borer control (%): Count the number of healthy and infested shoots & fruits per plant. Record the observations from 10 plants per treatment. Calculate % shoot & fruit borer incidence and recalculate shoot & fruit borer control as observed value.

Fruit count: Count the number of healthy/marketable fruits per plant. Record the observation from 10 plants per treatment. Present the data as average number of healthy/marketable fruits per plant.

Whitefly control (%): Count the number of live whitefly per leaf, 3 leaves (each one from top, middle and lower canopy of plant) per plant. Record the observations from 10 plants randomly selected per treatment. Calculate % whitefly control.

Table 18: Treatment details
S.No. Treatments Dose per hectare
active Ingredients (g) formulation (g or ml)
T1 Control (water spray only) - -
T2 Formula I 10% EC 75 750
T3 Formula II 10% EC 37.5 375
T4 Emamectin benzoate 1.9% EC 11.25 592
T5 Formula I 10%+Formula II 5% EC 75+37.5 750
T6 Formula I 10%+Emamectin benzoate 1.5% EC 75+11.25 750
T7 Formula II 5%+Emamectin benzoate 1.5% EC 37.5+11.25 750
T8 Fluxametamide 10%+Chlorantraniliprole 10%+Emamectin benzoate 3.75% WG 20+20+7.5 200
T9 Formula I 10%+Formula II 5%+Emamectin benzoate 1.5% EC 75+37.5+11.25 750
T9-present composition, T8-prior art ternary composition, T5 to T7-prior art binary composition

Table 19: Control of insect-pests in brinjal crop
S.No. Fruit & Shoot borer control (%) Whitefly control (%) No. of healthy fruits per plant Increase (%) in healthy fruits per plant over T1
Observed Expected Colby Ratio Observed Expected Colby Ratio
T1 0.0 - - 0.0 - - 6.8 0.0
T2 18.2 - - 71.5 - - 9.2 35.3
T3 65.8 - - 36.2 - - 10.5 54.4
T4 60.8 - - 41.6 - - 9.8 44.1
T5 70.5 72.02 0.98 82.2 81.82 1.00 12.7 86.8
T6 65.7 67.93 0.97 84.5 83.36 1.01 15.8 132.4
T7 87.3 86.59 1.01 60.7 62.74 0.97 14.5 113.2
T8 80.5 - - 54.7 - - 16.6 144.1
T9 99.2 89.03 1.11 98.6 89.38 1.10 18.8 176.5

The present composition (T9) provides synergistic control of shoot & fruit borer and whitefly in brinjal crop and also yielded highest number of healthy fruits per plant.

Experiment 6: Pod borer larval control in Redgram crop.
Crop: Red gram
Plot size: 10 m x 5 m
Pests: Pod borer larvae (Helicoverpa armigera)
Crop stage: 108 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 500 liters per hectare.
Observation method:
Pod borer larval control (%): count the number of live larvae (all stages) per plant and record the observations from 10 plants randomly selected per treatment. Calculate larval control (%).

Table 20: Pod borer larval control in red gram crop
Treatments Dose per hectare Larval control (%)
active Ingredients (g) formulation (ml) Observed Expected Colby Ratio
T1-Control (water spray only) - - 0.0 - -
T2-Formula I 10% EC 80 800 10.9 - -
T3-Formula II 10% EC 40 400 67.3 - -
T4-Emamectin benzoate 5% SG 9 180 56.4 - -
T5- Fluxametamide 2.25%+Chlorantraniliprole 2.25%+Pyriproxyfen 6% SC 22.5+22.5+60 1000 91.2 - -
T6-Formula I 8%+Formula II 4%+Emamectin benzoate 0.9% SE 80+40+9 750 99.8 87.29 1.14
T6-present composition; T5-ternary prior art composition
The present composition (T6) provides synergistic control of pod borer larvae on 14th days in red gram crop.

Experiment 7: Control of Mango Hopper.
Crop: Mango
Plot size: 1 tree per treatment
Pests: Mango Hopper (Amritodus atkinsoni)
Crop stage: 14 yrs, pea size mango fruiting stage.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 20 liters per tree.
Observation method:
Mango Hopper control (%): Count the number of live hoppers (all stages) per inflorescence (panicle with flowers), record the observations from 20 inflorescence per tree. Calculate % hopper control.

Table 21: Mango Hopper control
Treatments Dose per hectare Mango Hopper control (%)
active Ingredients (g) formulation (ml) Observed Expected Colby Ratio
T1-Control (water spray only) - - 0.0 - -
T2-Formula I 10% EC 75 750 25.8 - -
T3-Formula II 10% EC 37.5 375 70.5 - -
T4-Emamectin benzoate 5% SG 10 200 25.8 - -
T5-Pyriproxyfen 5%+Tolfenpyrad 10%+Emamectin benzoate 0.56% SE 62.5+125+7 1250 94.6 - -
T6-Formula I 6%+Formula II 3%+Emamectin benzoate 0.6% SC 75+37.5+10 750 98.8 83.76 1.18
T6-present composition, T5-ternary prior art composition

The present composition (T6) provides synergistic control of mango hopper on 7th day and magnitude of control was higher than prior art composition (T5).
, C , Claims:Claims:
I/we claim,
1. A pesticidal composition comprising:
a. compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether

Formula I
or its agrochemically acceptable salts, esters and derivative;
b. compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide

Formula II
or its agrochemically acceptable salts, esters and derivative;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate; and
d. one or more inactive excipients.

2. The pesticidal composition as claimed in claim 1, wherein a) compound A of Formula I known as 4-phenoxyphenyl (RS)-2(2-pyridyloxy) propyl ether or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w; b) compound B of Formula II known as 4-[(5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-1,2-oxazol-3-yl]-N-[(EZ) -(methoxyimino)methyl]-o-toluamide or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w; c) compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w.

3. The pesticidal composition as claimed in claim 1, wherein one or more inactive excipients is selected from the group comprising of wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof.

4. The pesticidal composition as claimed in claim 1, wherein the formulation for the said composition is selected from Water dispersible granules/Wettable granules (WDG/WG), Water soluble granules (SG), Emulsifiable granule (EG), Wettable powder (WP), Water Dispersible Powder (WDP), Soluble powder (SP), Emulsifiable powder (EP), Oil dispersible powder (OP), Soluble Tablet (ST), Capsule suspension/Micro capsule (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion water-in-oil (EO), Emulsion oil-in-water (EW), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Suspension Concentrate (SC), Suspo Emulsion (SE), Soluble Liquid/Concentrate (SL), mixed formulation of CS and SC (ZC), mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

5. The pesticidal composition as claimed in claim 4, wherein the Emulsifiable concentrate (EC) formulation comprises:
a. compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w;
b. compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w;
d. emulsifier is in amount of 3.0 to 16.0 w/w; and
e. solvent in amount of quantity sufficient.

6. The pesticidal composition as claimed in claim 4, wherein the Suspension Concentrate (SC) formulation comprises:
a. compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w;
b. compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w;
d. dispersing agent is in amount of 1.0 to 10.0% w/w;
e. wetting agent is in amount of 2.0 to 8.0% w/w;
f. suspending agent is in amount of 0.1 to 5.0% w/w;
g. anti-foaming agent is in amount of 0.1 to 5.0% w/w;
h. anti-freezing agent is in amount of 0.1 to 5.0% w/w;
i. preservative is in amount of 0.05 to 1.0% w/w;
j. rheology modifier is in amount of 0.05 to 2.0% w/w;
k. thickener is in amount of 0.01 to 5.0% w/w; and
l. solvent in amount of quantity sufficient.

7. The pesticidal composition as claimed in claim 4, wherein the Suspo Emulsion (SE) formulation comprises:
a. compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w;
b. compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w;
d. emulsifier is in amount of 1.0 to 15.0% w/w;
e. dispersing agent is in amount of 1.0 to 25.0% w/w;
f. wetting agent is in amount of 1.0 to 10.0% w/w;
g. buffering agent is in amount of 0.01 to 3.0% w/w;
h. anti-foaming is in amount of 0.1 to 2.0% w/w;
i. anti-freezing agent is in amount of 1.0 to 10.0% w/w;
j. preservative is in amount of 0.01 to 1.0% w/w;
k. filler is in amount of 0.1 to 10.0% w/w;
l. thickener is in amount of 0.01 to 5.0% w/w; and
m. solvent in amount of quantity sufficient.

8. The pesticidal composition as claimed in claim 4, wherein the Oil Dispersion (OD) formulation comprises:
a. compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w;
b. compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w;
d. dispersing agent is in amount of 1.0 to 10.0% w/w;
e. emulsifier is in amount of 1.0 to 10.0% w/w;
f. wetting agent is in amount of 2.0 to 10.0 w/w;
g. anti-foaming agent is in amount of 0.1 to 3.0% w/w;
h. anti-freezing agent is in amount of 2.0 to 8.0% w/w;
i. preservative is in amount of 0.01 to1.0% w/w;
j. stabilizer is in amount of 0.05 to 2.0% w/w;
k. buffering agent is in amount of 0.05 to 2.0% w/w; and
l. solvent in amount of quantity sufficient.

9. The pesticidal composition as claimed in claim 4, wherein the Micro Emulsion (ME) formulation comprises:
a. compound A of Formula I or its agrochemically acceptable salts, esters and derivative is in amount of 4.0 to 20.0% w/w;
b. compound B of Formula II or its agrochemically acceptable salts, esters and derivative is in amount of 1.0 to 10.0% w/w;
c. compound C at least one insecticide selected from Abamectin or Emamectin benzoate is in amount of 0.5 to 5.0% w/w;
d. emulsifier is in amount of 1.0 to 40.0% w/w; and
e. solvent in amount of quantity sufficient.

10. The pesticidal composition as claimed in claim 6, claim 7 & claim 8, wherein wetting agent is selected from tristyryl phenol ethoxylate non-ionic polymer, sodium iso propyl naphthalene sulphonate, alkyl phenyl ethoxylate, aryl phenyl ethoxylate, aryl phenyl ether phosphate, alkoxylated alcohol, ethoxylated fatty alcohol, ethylene oxide-propylene oxide (EO-PO) block copolymer, alkyl aryl sulphonate, alkyl olefin sulfonate, dioctyl succinate, sodium lauryl sulfate, alkyl polyglucoside, sodium alkyl aryl taurate, sorbitol esters, sorbitol oleate, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified Tri siloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or combination thereof.

11. The pesticidal composition as claimed in claim 6, claim 7 & claim 8, wherein dispersing agent is selected from acrylic graft copolymer, 2-Acrylamido-2-Methylpropane Sulfonic Acid, Sodium methallyl sulfonate, 3-sulfopropyl acrylate potassium salt, 3-sulfopropyl methacrylate potassium salt, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxymethyl methacrylate, Polyethylene-g-poly(n-butyl acrylate), poly acrylate copolymer; polyarylphenyl ether phosphate, Tri styryl phenol ethoxylate, ethoxylated tristyryl phenol sulphate, acrylic polymer amine salt, naphthalene sulfonic acid-sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate-sodium salt, ethoxylated oleylcetyl alcohol, polyalkelene glycol ether, ethoxylated fatty alcohol, alkyl sulfonate, styrene acrylic copolymer, alkyl phenol polyglycol ether, sodium lignosulfonate, calcium lignosulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide- polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide or combination thereof.

12. The pesticidal composition as claimed in claim 5, claim 7, claim 8 and claim 9, wherein emulsifier is selected from castor oil ethoxylate 40 mole, Polyoxyethylenealkylphenyl ether alkylaryl sulfonate, 3-methoxy N, N-dimethyl propionamide, Polyglyceryl-3 caprylate, Polysorbate 60, polyoxyethylene sorbitan monostearate-Tween 60, Polyoxyethylene sorbitan monooleate, solventsoalkyl phenol, aryl phenol, alkyl phenol ethoxylate, fatty acid esters, Tristyrylphenol Ethoxylate Phosphate Ester, Polyoxy ethylene alkyl phenyl ether alkyl aryl sulfonate, fatty acid alkanol amides, alkoxylated fatty acid ester or a combination thereof.

13. The pesticidal composition as claimed in claim 6, claim 7 & claim 8, wherein antifoaming agent is selected from siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, silicone oil emulsion, magnesium stearate or a combination thereof.

14. The pesticidal composition as claimed in claim 7 & claim 8, wherein anti-freezing agent is selected from water soluble alcohols, ethylene glycol, propylene glycol, glycerol, 1,3-butendiol, urea, magnesium sulfate heptahydrate, sodium chloride or a combination thereof.

15. The pesticidal composition as claimed in claim 6 & claim 7, wherein rheology modifier is selected from China clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite, and a combination thereof.

16. The pesticidal composition as claimed in claim 7 & claim 8, wherein thickener/suspending agent is selected from polysaccharides, xanthan gum, sodium carboxymethyl cellulose, hydroxymethyl cellulose, sodium polyacrylate, bentonite clay, attapulgite clay, aluminum magnesium silicate, hydroxy propyl cellulose, polyvinyl alcohols, modifier starch, acacia gum, gelatin or a combination thereof.

17. The pesticidal composition as claimed in claim 6, claim 7 & claim 8, wherein preservative is selected from 1,2-benzisothiazolin-3(2H)-one, formaldehyde, sodium benzoate, sodium o-phenyl phenate, potassium sorbate, copper pyrithione, zinc pyrithione, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or a combination thereof.

18. The pesticidal composition as claimed in claim 7 & claim 8, wherein buffering agent is selected from sodium hydroxide, potassium hydrogen phosphate salt solution, acetic acid & sodium acetate, ammonia & ammonium chlorides, citric acid, benzoic acid, salicylic acids, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, calcium carbonate, carboxylic acids, 2,6-di-tert-butyl-p-cresol, butylhydroxyanisole (BHT), epoxidized soybean oil (ESBO), methyl oleate, potassium carbonate, potassium hydroxide, sodium hydroxide and sodium dihydrogen phosphate dihydrate or combination thereof.

19. The pesticidal composition as claimed in claim 7, wherein filler is selected from sand, silica, precipitated silica, bentonite, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite, silicon dioxide, china clay/kaolin clay, talc, starch, zinc and its salts (zinc sulphate, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), iron and its salt (ferrous sulphate), copper and salts, sulphur, humic acid and salt, fulvic acid and salt, amino acids, sea weed extracts, chitosan or a combination thereof.

20. The pesticidal composition as claimed in claim 8, wherein stabilizer is selected from silica, bentonite clay, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite or combination thereof.

21. The pesticidal composition as claimed in claim 5, claim 6, claim 7, claim 8 & claim 9, wherein solvent is selected from demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, acetophenone, glycerin, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, Di propylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as mixture of heavy aromatic naphtha hydrocarbon C-9 to C-16, xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, propylene carbonate, mineral oil, methylated seed oil, methyl ester of palm oil/soybean oil/castor oil/cotton seed oil/blend of two or more seed oil or combination thereof.

Dated this 18th day of February, 2025