1. A synergistic agrochemical composition comprising: a. compound A, Profenofos is in amount of 15.0% to 60.0% w/w; b. compound B, Fluxametamide is in amount of 1.0% to 20.0% w/w; and c. inactive formulation excipients in amount of 20.0% to 85.0% w/w.

2. The synergistic agrochemical composition as claimed in claim 1, wherein the weight ratio of Profenofos and Fluxametamide is 15:1 to 2:1.

3. The synergistic agrochemical composition as claimed in claim 1, wherein inactive formulation excipients is selected from wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof.

4. The synergistic agrochemical composition as claimed in claim 1, wherein the formulation for the said composition is selected from water dispersible granules, wettable powder, emulsifiable concentrate, emulsion oil-in-water, micro-emulsion, oil-dispersion, suspension concentrate, suspo emulsion, mixed formulation of CS and SC (ZC).

5. The synergistic agrochemical composition as claimed in claim 4, wherein the Emulsifiable Concentrate (EC) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. emulsifier is in amount of 1.0% to 15.0% w/w; and d. solvent in amount of quantity sufficient.

6. The synergistic agrochemical composition as claimed in claim 4, wherein the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; d. dispersing agent is in amount of 1.0% to 30.0% w/w; e. wetting agent is in amount of 1.0% to 10.0% w/w; f. disintegrating agent is in amount of 1.0% to 10.0% w/w; g. defoamer is in amount of 0.50% to 5.0% w/w; h. binder is in amount of 1.0% to 20.0% w/w; and i. filler/carrier in amount of quantity sufficient.

7. The synergistic agrochemical composition as claimed in claim 4, wherein the Oil Dispersion (OD) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. dispersing agent is in amount of 1.0% to 10.0% w/w; d. emulsifier is in amount of 1.0% to 10.0% w/w; e. rheology modifier is in amount of 0.50% to 5.0% w/w; f. buffering agent is in amount of 0.1% to 5.0% w/w; and g. solvent in amount of quantity sufficient.

8. The synergistic agrochemical composition as claimed in claim 4, wherein the Micro emulsion (ME) formulation comprises: a. compound A is in amount of 1.0% to 10.0% w/w; b. compound B is in amount of 5.0% to 25.0% w/w; c. wetting agent is in amount of 1.0% to 10.0% w/w; d. emulsifier is in amount of 1.0 to 30.0% w/w; and e. solvent in amount of quantity sufficient.

9. The synergistic agrochemical composition as claimed in claim 4, wherein the Suspo Emulsion (SE) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. emulsifier is in amount of 1.0% to 10.0% w/w; d. wetting agent is in amount of 1.0% to 10.0% w/w; e. dispersing agent is in amount of 1.0 to 10.0% w/w; f. defoamer is in amount of 0.1% to 5.0% w/w; g. anti-freezing agent is in amount of 1.0% to 5.0% w/w; h. preservative is in amount of 0.10% to 5.0% w/w; i. thickener is in amount of 0.1 to 5.0% w/w; and j. solvent in amount of quantity sufficient.

10. The synergistic agrochemical composition as claimed in claim 4, wherein the Suspension Concentrate (SC) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. wetting agent is in amount of 1.0% to 10.0% w/w; d. dispersing agent is in amount of 1.0 to 10.0% w/w; e. defoamer is in amount of 0.1% to 5.0% w/w; f. anti-freezing agent is in amount of 1.0% to 5.0% w/w; g. preservative is in amount of 0.10% to 5.0% w/w; h. thickener is in amount of 0.1 to 5.0% w/w; and i. solvent in amount of quantity sufficient.

11. The synergistic agrochemical composition as claimed in claim 4, wherein the Emulsion, Oil in water (EW) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. dispersing agent is in amount of 1.0 to 10.0% w/w; d. emulsifier is in amount of 0.1% to 5.0% w/w; e. anti-freezing agent is in amount of 1.0% to 5.0% w/w; f. preservative is in amount of 1.0% to 10.0% w/w; and g. solvent in amount of quantity sufficient.

12. The synergistic agrochemical composition as claimed in claim 4, wherein the Wettable Powder (WP) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. dispersing agent is in amount of 1.0 to 10.0% w/w; d. wetting agent is in amount of 0.1% to 5.0% w/w; and e. filler/carrier in amount of quantity sufficient.

13. The synergistic agrochemical composition as claimed in claim 4, wherein the Zeon Concentrate (ZC) formulation comprises: a. compound A is in amount of 15.0% to 60.0% w/w; b. compound B is in amount of 1.0% to 20.0% w/w; c. dispersing agent is in amount of 1.0% to 10.0% w/w; d. wetting agent is in amount of 1.0 to 10.0% w/w; e. wall forming material is in amount of 0.1% to 5.0% w/w; f. anti-freezing agent is in amount of 1.0% to 5.0% w/w; g. suspending agent is in amount of 0.50% to 5.0% w/w; h. anti-foaming agent is in amount 0.10% to 5.0% w/w; i. buffering agent is in amount of 0.10% to 5.0% w/w; j. preservative is in amount of 0.1 to 5.0% w/w; k. thickener is in amount of 0.10% to 5.0% w/w; and l. solvent in amount of quantity sufficient.

14. The synergistic agrochemical composition as claimed in claims 6, 8, 9, 10 12 & 13, wherein wetting agent is selected from tristyryl phenol ethoxylate non-ionic polymer, sodium iso propyl naphthalene sulphonate, alkyl phenyl ethoxylate, aryl phenyl ethoxylate, aryl phenyl ether phosphate, alkoxylate alcohol, ethoxylated fatty alcohol, ethylene oxide-propylene oxide (EO-PO) block copolymer, alkyl aryl sulphonate, alkyl olefin sulfonate, dioctyl succinate, sodium lauryl sulfate, alkyl polyglycoside, sodium alkyl aryl taurate, sorbitol esters, sorbitol oleate, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified Tri siloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or combination thereof.

15. The synergistic agrochemical composition as claimed in claims 6, 7, 9, 10, 11, 12 & 13, wherein dispersing agent is selected from polyacrylate compound selected from a homopolymer, a block-copolymer or a random copolymer and the mixtures thereof. Polyacrylate compound selected from a group comprises poly(methyl acrylate), poly(ethyl acrylate), poly(propyl acrylate), poly(n-butyl acrylate), poly(isobutyl acrylate), poly(2-ethyl acrylate), poly(t-butyl acrylate), poly(ethylhexyl acrylate), poly(benzyl acrylate), poly(methyl methacrylate), poly(ethyl methacrylate), poly(n-butyl methacrylate), poly(isobutyl methacrylate), poly((ethylene glycol) methyl ether methacrylate), poly(methacrylate-coethylacrylate),poly(methacrylate-co-styrene), poly(methacrylate-co-butylmethacrylate), poly(n-butylmethacrylcate-co-methacrylate), poly((ethylene oxide)-co-poly(methyl acrylate)), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox 4913), nonionic comb-shaped polyacrylate (Dispersogen PSL 100), 2-Acrylamido-2-Methylpropane Sulfonic Acid, Sodium methallyl sulfonate, 3-sulfopropyl acrylate potassium salt, 3-sulfopropyl methacrylate potassium salt, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxymethyl methacrylate, Polyethylene-g-poly(n-butyl acrylate), and the mixtures thereof. Polyarylphenyl ether phosphate, Tri styryl phenol ethoxylate, ethoxylated tristryl phenol sulphate, acrylic polymer amine salt, naphthalene sulfonic acid-sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate-sodium salt, ethoxylated oleylcetyl alcohol, poly alkelene glycol ether, ethoxylated fatty alcohol, alkyl sulfonate, styrene acrylic copolymer, alkyl phenol polyglycol ether, sodium lignosulfonate, calcium lignosulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide- polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide, Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-[2,4,6-tris(1-phenylethyl)phenoxy]-, ammonium salt or combination thereof.

16. The synergistic agrochemical composition as claimed in claim 5, 7, 8, 9 & 10, wherein emulsifier is selected from castor oil ethoxylate 40 mole, Polyoxyethylenealkylphenyl ether alkyl aryl sulfonate, 3-methoxy N, N-dimethyl propionamide, Polyglyceryl-3 caprylate, Polysorbate 60 (polyoxyethylene sorbitan monostearate-Tween 60), solvents alkyl phenol, aryl phenol, alkyl phenol ethoxylate, fatty acid esters, fatty acid alkanol amides, alkoxylated fatty acid ester or a combination thereof.

17. The synergistic agrochemical composition as claimed in claim 6, 9, 10 & 13, wherein defoamer is selected from siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, silicone oil emulsion, magnesium stearate or combination thereof.

18. The synergistic agrochemical composition as claimed in claim 9, 10, 11 & 13, wherein anti-freezing agent is selected from water soluble alcohols, ethylene glycol, propylene glycol, glycerol, 1,3-butendiol, urea, magnesium sulfate heptahydrate, sodium chloride or a combination thereof.

19. The synergistic agrochemical composition as claimed in claim 9, 10 & 13, wherein thickener is selected from natural polymers (gelling agent): polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives: Carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

20. The synergistic agrochemical composition as claimed in claim 9, 10, 11 & 13, wherein preservative is selected from benzisothiazolin-3-one, formaldehyde, sodium benzoate, sodium o-phenyl phenate, potassium sorbate, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or a combination thereof.

21. The synergistic agrochemical composition as claimed in claim 6, wherein disintegrating agent is selected from cellulose, starch, clays, bentonite, diatomaceous, colloidal silica, precipitated silica, kaolin, potassium phosphate, ammonium sulphate, sodium sulphate, sodium citrate or urea and croscarmellose sodium, crospovidone, and sodium starch glycolate or combination thereof.

22. The synergistic agrochemical composition as claimed in claim 6 & 12, wherein filler/carrier selected from silica-sand (16-40 mesh), precipitated silica, bentonite, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite, silicon dioxide, precipitated silica, china clay/kaolin clay, talc, starch, zinc and its salts (zinc sulphate, zinc oxide, zinc lactate gluconate, zinc polyflavonoid, Zinc EDTA), iron and its salt (ferrous sulphate, EDTA), copper and salts, Sulphur, humic acid-salt, fulvic acid-salt, amino acid-soy protein, jasmonic acid-salt, carboxylic acid-salt, sea weed extracts, chitosan or a combination thereof.

23. The synergistic agrochemical composition as claimed in claims 5, 7, 8, 9, 10 & 13, wherein solvent is selected from demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, acetophenone, glycerin, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, Di propylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as mixture of heavy aromatic naphtha hydrocarbon C-9 to C-16, xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, propylene carbonate, mineral oil, methylated seed oil-methyl ester of palm oil/soybean oil/castor oil/cotton seed oil/blend of two or more seed oil or combination thereof.

24. The synergistic agrochemical composition as claimed in claim 6, wherein binder is selected from lactose anhydrous, poly ethylene wax, poly vinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polyethylene oxide, polyethoxylated fatty acids, polyesters, polyamides, poly carbonates, poly urea, poly urethanes, styrene copolymer, butadiene copolymers, polyethoxylated alcohols, acrylate polymer such as polymethacrylate, poly ethyl methacrylate, poly methyl methacrylate, acrylate copolymers and styrene-acrylic copolymers or mixtures of thereof, a natural gum, lignosulphonate and water swellable binder selected from china clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite and a combination thereof.

25. The synergistic agrochemical composition as claimed in claim 7, wherein rheology modifier is selected from xanthan gum, carboxymethylcellulose (CMC), polyvinyl alcohol, bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

26. The synergistic agrochemical composition as claimed in claim 13, wherein Suspending agent is selected from natural polymers (gelling agent)-polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives-carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC); synthetic polymers-carbomers, poloxamers, polyvinyl alcohol, others-glycerin, syrup, sorbitol, clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

27. The synergistic agrochemical composition as claimed in claim 7 & 13, wherein Buffering agent is selected from sodium hydroxide, sodium dihydrogen phosphate dihydrate, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, potassium hydrogen phosphate salt solution, acetic acid & sodium acetate, ammonia & ammonium chlorides, citric acid, benzoic acid, salicylic acids, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, carboxylic acids, 2,6-di-tert-butyl-p-cresol, butylhydroxyanisole (BHT), epoxidized soybean oil (ESBO), methyl oleate, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose sodium (NaCMC), sodium dodecyl sulphate (SDS), lecithin, polysorbates, clays-bentonite clay, smectite clay, precipitated silica and various types of gums like xanthan gum or guar gum or a combination thereof.

28. The synergistic agrochemical composition as claimed in claim 13, wherein wall forming material is selected from Tetramethylene diisocyanate, Penta methylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethene diisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form;, Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetra ethylene pentaamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4′-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4′-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone or a combination thereof. Dated this 14th day of May, 2025

Description:FIELD OF INVENTION:
The present invention relates to synergistic agrochemical composition comprising a) compound A, Profenofos; b) compound B, Fluxametamide; and c) inactive formulation excipients. The present invention also relates to process for preparing the said composition.

BACKGROUND OF THE INVENTION:
In an agriculture-based economy, with inadequate resources, it is essential to resort to most economical and promising agricultural practices. It demands not only consistent efforts towards enhancing the crop yield but also efforts towards achieving fool proof protection and stability of crops against the attack of insects/pests and/or mites etc. with minimal or no side effects on the environment.

Insecticides are extensively and frequently used in commercial agriculture, leading to significant increases in crop yields and product quality. This, in turn, provides farmers with substantial economic benefit and simplifies farming activities.

Combining insecticides is a strategy employed to broaden the spectrum of insects control, enhance pest management through synergistic effect, and reduce the required dosage, thereby minimizing environmental impact. By targeting both chewing and sucking insects simultaneously, these combinations decrease the likelihood of resistance development and aid in resistance management. Additionally, they enhance residual control, reducing the need for frequent applications and lowering the overall pesticidal load in the ecosystem.

Crop protection is the practice of protecting the crop yields from insect pests, weeds, plant diseases, and other organisms that damage agricultural crops, which is critical from early stages of crop development. Preventing pests and diseases in the entire crop cycle, i.e., from root development to maturing crop, leads to increased crop quality and yield. The control of insects is extremely important in achieving high crop efficiency. Generally, insects are very destructive to crop plants and can significantly reduce crop yields and quality. Insecticides help to minimize this damage by controlling insect pests. For this purpose, in the field of agrochemical industry, numerous formulations are available for delivering active ingredients or combinations, but there is still a continues need to develop new insecticidal combinations which are more effective, less costly, less toxic, environmentally safer and have different sites of action. The use of two or more appropriate active ingredient combinations in specific dose ratios leads to synergism in crop protection.

Profenofos is a broad-spectrum organophosphorus pesticide, moderate toxicity, it is a kind of anticholinesterase, have tag, stomach poison function and interior absorption, be mainly used in the lepidoptera pest of control paddy rice, cotton and vegetable field, common insect such as cotton bollworm, beet armyworm, cabbage caterpillar, peach fruit borer etc. are had good control efficiency. It is classified under IRAC group 1. Profenofos chemically known as O-(4-Bromo-2-chlorophenyl) O-ethyl S-propyl phosphonothioate and having the structural formula as shown below:

Fluxametamide, marketed as Gracia® by Nissan Chemical, is an isoxazoline compound registered in Japan since January 2019. Its mode of action targets the GABA (γaminobutyric acid) chloride channels, acting as an inhibitor. This mechanism effectively controls a wide range of pests including Lepidoptera, Thysanoptera, Diptera, Acari, Coleoptera and some Hemiptera, while showing minimal impact on bee-visiting insects. The systemic absorption of isoxazolines enhances their effectiveness, leading to the selective inhibition of GABA- and glutamategated chloride channels in targeted pests.

This inhibition results in hyperexcitation and eventual death of the pests. Importantly, the low sensitivity of GABA channels in mammals to isoxazolines, combined with the absence of anion-inhibitory glutamate channels in mammals, contributes to its low toxicity potential in mammals. Gracia, a technical formulation containing 10% w/w of fluxametamide in an emulsifiable concentrate (EC) form, demonstrates effective control over lepidopteran pests and thrips across a wide range of crops. It is classified under IRAC group 30.

Indian Patent Application No. 201811033003 discloses a synergistic and stable pesticidal granule formulation including, an effective amount of a first ingredient and a liquid active ingredient. In use, the first ingredient is Emamectin benzoate and the liquid active ingredient is an organothiophosphate. In further use, the liquid active ingredient is an organophosphate insecticide. Specifically, the liquid active ingredient is Profenofos. The synergistic and stable pesticidal granule formulation is a synergistic and stable water dispersible granular formulation (WDG or WG). In addition, Emamectin benzoate is present in a range of approximately 1% to 3% by weight of formulation. In use, Profenofos is present in a range of approximately 32% to 40% by weight of formulation.

Indian Application Number: 202241052178 discloses a synergistic insecticidal composition comprising Flonicamid and Profenofos for controlling sucking pests. More particularly the invention provides insecticidal oil dispersion (OD) of Flonicamid and Profenofos with one or more suitable agrochemical auxiliaries, and a process thereof.

Indian Application Number: 202321059438 disclose a synergistic composition comprising Profenofos and Fenpropathrin for effective control of pests and diseases in crops. The invention also includes a process for preparing this agrochemical composition. The primary objective of this invention is to protect crops from insect pests, thereby increasing crop yield and providing benefits to farmers.

Indian Application Number: 202241056479 related to a novel synergistic insecticidal composition of organophosphate insecticide and chlorantraniliprole in EC / WDG / SC / SL / OD / OS / Solid Granules in different formulations and percentages. The invention further relates to methods and use of these mixtures for combating insects in and on plants, and for protecting such plants being infested with pests and for protecting seeds. This synergistic insecticide composition has the main effective components of profenofos and chlorantraniliprole and acts by inhibition of enzyme, acetylcholinesterase, and ryanodine receptor respectively and can generate efficient synergism and can enable broad spectrum satisfactory insect control and protect the several crop from sucking, chewing, borer pests, and soil insects for prolonged period at lower dose with no phytotoxic effect. This combination is also helpful in controlling insect vectors which transmits viral diseases in plants and can be a unique insecticide combination than the existing ones.

Indian Application Number: 202341034887 related to a novel synergistic insecticidal composition containing organophosphate insecticides with one or more insecticide selected from diacyl hydrazine insecticide and/or macrocyclic lactone insecticide in EC / WDG / SC / SL / OD / OS / Solid Granules in different formulations and percentages. The invention further relates to methods and use of these mixtures for combating insects. The synergy of insecticide composition has the main effective components of profenofos with insecticide selected from tebufenozide and/or abamectin and acts by inhibition of enzyme, acetylcholinesterase (AChE) and act as insect growth regulator (IGR) that interferes with the molting process in insects and cause paralysis and death by affecting the chloride ion channels in nerve cells, respectively which leads to death of insects. It can generate efficient synergism. This combination is also helpful in controlling insect vectors which transmits viral diseases in crops.

Insecticide compositions typically consist of an active ingredient that targets specific pests, along with several inert ingredients that aid in the formulation's effectiveness, stability, and ease of application. The active ingredient is often a chemical compound such that disrupts the biological processes of insects, either by affecting their nervous system or interfering with their metabolic functions. Inert ingredients, which can include solvents, emulsifiers, stabilizers, and carriers, help to dissolve, dilute, or spread the active ingredient more efficiently, ensuring uniform coverage and enhancing its persistence on surfaces. Some formulations may also contain surfactants to improve the spreadability of the insecticide, or fragrances to mask odors. The precise combination of these components is designed to optimize both the potency and safety of the insecticide, ensuring effective pest control while minimizing risks to humans, animals, and the environment.

However, there remains a need for a agrochemical insecticidal composition that addresses the limitations of current formulations. Such a composition should effectively overcome existing issues while being amenable to straightforward and cost-effective manufacturing processes. This formulation should provide enhanced agrochemical activity through synergistic interactions among its components yet be simple to produce without requiring complex or resource-intensive production methods.

The present invention overcomes the limitations associated with existing formulations available in the market. The use of agrochemical combinations helps to expand the range of pest control, improve effectiveness through synergistic effects, and reduce the required dosage, thus minimizing environmental impact. These combinations are designed to target both chewing and sucking insects simultaneously, decrease the likelihood of resistance development, aid in resistance management, and extend residual control, which reduces the frequency of sprays needed for crop protection. As a result, this approach minimizes the overall pesticide load in the ecosystem. In some cases, the combination of insecticides can demonstrate additive or synergistic effects, leading to enhanced pest control.

SUMMARY OF THE INVENTION:

The main aspect of the present invention is to provide synergistic agrochemical composition comprising a) compound A, Profenofos is in amount of 15.0 to 60.0% w/w; b) compound B, Fluxametamide is in amount of 1.0 to 20.0% w/w and c) inactive formulation excipients in amount of 20.0% to 85.0% w/w.

Another aspect of the present invention is to provide synergistic agrochemical composition weight ratio of Profenofos and Fluxametamide is 15:1 to 2:1.

Yet another aspect of the present invention comprises inactive excipients selected from wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof.

Further another aspect of the present invention can be formulated as water dispersible granules, wettable powder, emulsifiable concentrate, emulsion oil-in-water, micro-emulsion, oil-dispersion, suspension concentrate, suspo emulsion, mixed formulation of CS and SC (ZC).

Further object of the present invention is to provide a synergistic agrochemical composition of Profenofos and Fluxametamide.

Yet another object of the present invention is to provide synergistic insecticidal composition demonstrating high efficacy and provide broad spectrum control of insect-pests and mites.

Further object of the present invention is to provide synergistic insecticidal composition which increases yield of treated plants.

Yet another object of the present invention is to provide synergistic insecticidal composition to delay resistance development and effective control of hard to kill and resistant insect-pests and mites.

Yet another object of the present invention is to provide residual control i.e. longer duration of control with immediate crop protection.

Another object of the present invention is to provide a method of preparing a stable and non-phytotoxic and environmentally safer formulation which improves overall plant health, yield and vigor of the treated plant.

DETAILED DESCREPTION OF THE INVENTION:
In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented here. The present technology is also illustrated by the examples herein, which should not be construed as limiting in any way.

As used herein, the terms below have the meanings indicated.

The singular forms "a," "an," and "the" may refer to plural articles unless specifically stated otherwise.

The term "about," as used herein, is intended to qualify the numerical values which it modifies, denoting such a value as variable within a margin of error. When no particular margin of error, such as a standard deviation to a mean value provide in a chart or table of data, is recited, the term "about" should be understood to mean that range which would encompass the recited value and the range which would be included by rounding up or down to that figure as well, taking into account significant figures.

The embodiments, illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the terms “comprising,” “including,” “containing,” etc. shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the claimed technology. Additionally, the phrase “consisting essentially of” will be understood to include those elements specifically recited and those additional elements that do not materially affect the basic and novel characteristics of the claimed technology. The phrase “consisting of” excludes any element not specified.

As used herein, the term “excipient” refers to inert substances which are commonly used as diluent, to provide stability or to increase the activity profile of the composition or formulation without having any pesticidal activity or direct effect on the insect weeds.

The present invention is to provide synergistic agrochemical composition comprising a) compound A, Profenofos is in amount of 15.0 to 60.0% w/w; b) compound B, Fluxametamide is in amount of 1.0 to 20.0% w/w and c) inactive formulation excipients in amount of 20.0% to 85.0% w/w.

Another aspect of the present invention is to provide synergistic agrochemical composition weight ratio of Profenofos and Fluxametamide is 15:1 to 2:1.

In an embodiment of the present invention comprises inactive excipients selected from wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof.

In an embodiment of the present invention can be formulated as water dispersible granules, wettable powder, emulsifiable concentrate, emulsion oil-in-water, micro-emulsion, oil-dispersion, suspension concentrate, suspo emulsion, mixed formulation of CS and SC (ZC).

The present compositions are effective to control various insects-pests and mites belongs to the order Hemiptera, examples-aphid, jassid, leaf hopper, mango hopper, whitefly, mealybug, scale, rice brown plant hopper (BPH); order Lepidoptera, examples-fall army worm, rice stem borer, rice leaf folder, sugarcane early shoot borer, top borer, wheat pink stem borer, fruit borer, pod borer, Maruca, cut worm, diamond back moth (DBM), looper, semi looper, pink bollworm, brinjal fruit and shoot borer, Spodoptera spp. (litura, exigua, frugiperda), Helicoverpa; from the order Coleoptera, examples-white grub, wire worm, epilachna beetle, blue beetle, girdle beetle, flea beetle, rice water weevil; from the order Orthoptera, examples-locust; from the order Thysanoptera, examples-cotton thrips, chilly thrips, black thrips; from the order Isoptera, example-termite; from the order Diptera, examples-shoot fly, stem fly, fruit fly, leaf miner; from the order Acarina, examples-red mite, red spider mite, yellow mite, pink mite, purple mite.

The present compositions are effective to control various insects-pests and mites infesting the crops like paddy, wheat, maize, sugarcane, cotton, okra, brinjal, chilly, tomato, cabbage, cauliflower, potato, garlic, onion, groundnut, soybean, green gram, black gram, red gram, gram/chickpea, cucumber, melons, apple, mango, papaya, pomegranate, banana, grapes, tea, coffee, cumin, fennel, black pepper, flowers-rose, marigold etc.

Active Ingredients Compound A Compound B
Examples Profenofos Fluxametamide
% of active ingredients (w/w) 15.0% to 60.0% w/w 1.0% to 20.0% w/w

The present invention is to provide synergistic agrochemical composition comprising a) compound A, Profenofos; b) compound B, Fluxametamide; and c) inactive formulation excipients.

Further, agrochemical composition comprising a) compound A, Profenofos is in amount of 15.0 to 60.0% w/w; b) compound B, Fluxametamide is in amount of 1.0 to 20.0% w/w.

Further aspect of the present invention is to provide agrochemical composition comprising a) compound A, Profenofos is in amount of 15.0% to 60.0% w/w; more preferably in amount of 20.0% to 52.0% w/w; b) compound B, Fluxametamide is in amount of 1.0 to 20.0% w/w; more preferably in amount of 2.0% to 17.0% w/w.

In an embodiment of the present invention comprises inactive excipients selected from wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof. The composition may also contain if desired, one or more auxiliary customary for crop protection compositions.

Wetting is the first stage of dispersion, in which air surrounding the granular composition is substituted with water. Wetting the composition with water cannot occur if the surface tension of the liquid is very high. Hence, it is recommended to add a wetting agent to the composition to facilitate the process of dispersion of the granules in the liquid. Non-limiting examples of wetting agents that can be used in the present invention include, but not limited to, tristyryl phenol ethoxylate non-ionic polymer, sodium iso propyl naphthalene sulphonate, alkyl phenyl ethoxylate, aryl phenyl ethoxylate, aryl phenyl ether phosphate, alkoxylate alcohol, ethoxylated fatty alcohol, ethylene oxide-propylene oxide (EO-PO) block copolymer, alkyl aryl sulphonate, alkyl olefin sulfonate, dioctyl succinate, sodium lauryl sulfate, alkyl polyglycoside, sodium alkyl aryl taurate, sorbitol esters, sorbitol oleate, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified Tri siloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form. One or more wetting agents may be used in the present composition.

Dispersing agents are added to prevent agglomeration of solid particles in a liquid and keep them suspended in fluid. Accordingly, the composition of the present invention contains the dispersing agent selected from the group comprising polyacrylate compound selected from a homopolymer, a block-copolymer or a random copolymer and the mixtures thereof. Polyacrylate compound selected from a group comprises poly(methyl acrylate), poly(ethyl acrylate), poly(propyl acrylate), poly(n-butyl acrylate), poly(isobutyl acrylate), poly(2-ethyl acrylate), poly(t-butyl acrylate), poly(ethylhexyl acrylate), poly(benzyl acrylate), poly(methyl methacrylate), poly(ethyl methacrylate), poly(n-butyl methacrylate), poly(isobutyl methacrylate), poly((ethylene glycol) methyl ether methacrylate), poly(methacrylate-coethylacrylate), poly(methacrylate-co-styrene), poly(methacrylate-co-butylmethacrylate), poly(n-butylmethacrylcate-co-methacrylate), poly((ethylene oxide)-co-poly(methyl acrylate)), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox 4913), nonionic comb-shaped polyacrylate (Dispersogen PSL 100), 2-Acrylamido-2-Methylpropane Sulfonic Acid, Sodium methallyl sulfonate, 3-sulfopropyl acrylate potassium salt, 3-sulfopropyl methacrylate potassium salt, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxymethyl methacrylate, Polyethylene-g-poly(n-butyl acrylate), and the mixtures thereof. Polyarylphenyl ether phosphate, Tri styryl phenol ethoxylate, ethoxylated tristryl phenol sulphate, acrylic polymer amine salt, naphthalene sulfonic acid-sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate-sodium salt, ethoxylated oleylcetyl alcohol, poly alkelene glycol ether, ethoxylated fatty alcohol, alkyl sulfonate, styrene acrylic copolymer, alkyl phenol polyglycol ether, sodium lignosulfonate, calcium lignosulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide- polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide, Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-[2,4,6-tris(1-phenylethyl)phenoxy]-, ammonium salt. One or more dispersing agents are used in the present composition.

Antifoaming agent/defoamer is generally added to the composition to prevent foam formation as the foam prevents the efficient filling of a container. Suitable defoamer used herein, but not limited to, siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, silicone oil emulsion, magnesium stearate or combination thereof.

An anti-freezing agent is generally added to the composition, to prevent the aqueous compositions from freezing. Suitable anti-freezing agents are water soluble alcohols (ethylene glycol, propylene glycol), glycerol, 1,3-butendiol, urea, magnesium sulfate heptahydrate, sodium chloride etc.

Preservative is added to the composition for its preservation against spoilage from bacteria, yeasts and fungi. Suitable biocides useful herein, but not limited to, include benzisothiazolin-3-one, formaldehyde, sodium benzoate, sodium o-phenyl phenate, potassium sorbate, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or a combination thereof.

Thickeners simply increases the viscosity of liquid formulations. The composition comprises a thickener selected from the group comprising natural polymers (gelling agent): polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives: Carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

Carboxymethylcellulose (CMC)-sodium carboxymethyl cellulose is used in suspension concentrates to stabilize the suspension, prevent sedimentation, and modify viscosity, ensuring uniform dispersion of solid particles and improving the overall stability and texture of the formulation.

Suspending agents prevents solid particles from settling or clumping, ensuring stable and homogenous suspension. Suspending agents and thickeners are typically the same type of substance, usually a high molecular weight polymer, used to increase the viscosity of liquid formulation, preventing solid particles from settling out and ensuring stable suspension, allowing for even distribution when sprayed. They are selected from the group comprising natural polymers (gelling agent)-polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives-carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC); synthetic polymers-carbomers, poloxamers, polyvinyl alcohol, others-glycerin, syrup, sorbitol, clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

Additives that improve the flow and structure of formulation, also known as viscosity modifiers. Rheology modifiers may be hydrophilic, hydrophobic or ambiphilic. They are selected from xanthan gum, carboxymethylcellulose (CMC), polyvinyl alcohol, bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

The solvent and cosolvent used in the present invention is selected from the group comprising of demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, acetophenone, glycerin, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, Di propylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as mixture of heavy aromatic naphtha hydrocarbon C-9 to C-16, xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, propylene carbonate, mineral oil, methylated seed oil-methyl ester of palm oil/soybean oil/castor oil/cotton seed oil/blend of two or more seed oil.

The solvent may be used alone or in combination and is present in an amount quantity sufficient (QS) required to make 100% w/w formulation.

An emulsifier helps to prevent the droplets of the dispersed phase of an emulsion from flocculating or coalescing in the emulsion. Suitable emulsifier is used herein, but not limited to castor oil ethoxylate 40 mole, Polyoxyethylenealkylphenyl ether alkyl aryl sulfonate, 3-methoxy N, N-dimethyl propionamide, Polyglyceryl-3 caprylate, Polysorbate 60 (polyoxyethylene sorbitan monostearate-Tween 60), solvents alkyl phenol, aryl phenol, alkyl phenol ethoxylate, fatty acid esters, fatty acid alkanol amides, alkoxylated fatty acid ester or a combination thereof.

Disintegrating agent is selected from inert material such as cellulose, starch, clays, bentonite, diatomaceous, colloidal silica, precipitated silica, kaolin which swell by water absorption improve in dispersibility. Water soluble salts such as potassium phosphate, ammonium sulphate, sodium sulphate, sodium citrate or urea can be also used as disintegrating agents. Super disintegrants, which include croscarmellose sodium, crospovidone, and sodium starch glycolate.

Stabilizers may include sodium hydroxide, sodium dihydrogen phosphate dihydrate, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, potassium hydrogen phosphate salt solution, acetic acid & sodium acetate, ammonia & ammonium chlorides, citric acid, benzoic acid, salicylic acids, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, carboxylic acids, 2,6-di-tert-butyl-p-cresol, butylhydroxyanisole (BHT), epoxidized soybean oil (ESBO), methyl oleate, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose sodium (NaCMC), sodium dodecyl sulphate (SDS), lecithin, polysorbates, clays-bentonite clay, smectite clay, precipitated silica and various types of gums like xanthan gum or guar gum; the specific choice depending on the desired properties and application of the dispersion concentrate.

UV stabilizers are compounds that competitively absorb UV radiation and dissipate it as heat. The most commonly used UV absorbers are titanium dioxide, zinc oxide, 2-hydroxy-benzophenone, 2-hydroxy-benzotriazole derivatives, benzophenone-3, cyanoacrylates, styrenic polymers, carbon black.

The binder is water soluble, water swellable or combinations of both. The binder is a water-
soluble binder selected from a group consisting of lactose anhydrous, poly ethylene wax, poly vinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polyethylene oxide, polyethoxylated fatty acids, polyesters, polyamides, poly carbonates, poly urea, poly urethanes, styrene copolymer, butadiene copolymers, polyethoxylated alcohols, acrylate polymer such as polymethacrylate, poly ethyl methacrylate, poly methyl methacrylate, acrylate copolymers and styrene-acrylic copolymers or mixtures of thereof, a natural gum, lignosulphonate, and a combination thereof. The binder is a water swellable binder selected from a group consisting of China clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite, and a combination thereof.

Precipitated silica acts as carrier material, absorbing and holding the active ingredient while maintaining a free flowing, easily dispersible powder form, enhancing wettability by improving water contact, and often providing anti-caking properties to prevent clumping, making it crucial for consistent application of the pesticide when mixed with water for spraying on crops.

A filler/carrier selected from the group comprising silica-sand (16-40 mesh), precipitated silica, bentonite, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite, silicon dioxide, precipitated silica, china clay/kaolin clay, talc, starch, zinc and its salts (zinc sulphate, zinc oxide, zinc lactate gluconate, zinc polyflavonoid, Zinc EDTA), iron and its salt (ferrous sulphate, EDTA), copper and salts, Sulphur, humic acid-salt, fulvic acid-salt, amino acid-soy protein, jasmonic acid-salt, carboxylic acid-salt, sea weed extracts, chitosan or a combination thereof. It presents in an amount sufficient (QS) required to make 100% w/w formulation.

Hygroscopic substances added to the formulations to retain moisture, prevent rapid drying of spray droplets and enhancing the uptake. Humectant selected from urea, ammonium sulphate, glycerol, hyaluronic acid, propylene glycol, sugar alcohols, polydextrose and polysaccharides.

Wall forming material for Capsule suspension (CS) or microcapsule technology that uses membrane forming wall material to embed the core materials that need to be protected to form tiny particles, which can protect the core material from adverse environment and effectively plays its biological active functions. The wall forming material/ capsule making monomers may be selected from Tetramethylene diisocyanate, Penta methylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethene diisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form;, Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetra ethylene pentaamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4′-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4′-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone.

The composition may also contain if desired, one or more auxiliary’s customary for crop protection compositions.

The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification are still covered by the scope of present invention.

While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.

These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.

EXAMPLES:

EXAMPLE 1: Method of preparation Emulsifiable Concentrate (EC) formulation.
Table 1: Profenofos 40%+Fluxametamide 5% EC
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 40.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 5.00
Calcium salt of alkyl benzene sulphonate Emulsifier 4.00
Castor oil ethoxylate of 40 moles Emulsifier 8.00
1-methyl-2-pyrrolidone Solvent 10.00
Solvent naphtha Solvent 33.00
Total 100.00

Manufacturing process for 100 kg batch size of Profenofos 40%+Fluxametamide 5% EC
Step 1: Weighing the raw materials according to the batch size as follows:
Step 2: Add 33 kg of solvent naphtha, 10 kg of 1-methyl-2-pyrrolidone into the vessel.
Step 3: Slowly add 8 kg of castor oil ethoxylate of 40 moles and 4 kg of calcium salt of alkyl benzene sulphonate with slow stirring.
Step 4: Add 40 kg of profenofos technical and 5 kg of fluxametamide technical and mix it properly for 30 to 45 minutes.
Step 5: Collect the sample for quality check and pack it in suitable container.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 2: Storage stability-Profenofos 40%+Fluxametamide 5% EC
Parameters with specifications T0 T1 (AHS), for 14 days at 54 'C. T2- for three months at 40 'C
Profenofos content (%), (-5% to +5% range) 41.00 40.73 40.92
Fluxametamide content (%) (-5% to +10% range) 5.25 5.22 5.24
Emulsion stability (2 ml formulation in 98 ml 342 ppm hard water), maximum 2 ml creaming or sediment after 1 hour 0 ml 0.5 ml 0.4 ml
pH (5% in DM water, 6 to 8) 6.3 6.3 6.3
Cold test (at 10 ºC temperature) Any separation or creaming max. 2 ml after 1 hour No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur
Flash point (Minimum 24.5 0C) complies complies complies

The EC composition of Profenofos 40%+Fluxametamide 5% meets all the required storage stability criteria-active ingredient content, emulsion stability, pH, cold test and flash point.

Table 3: Profenofos 50%+Fluxametamide 4% EC
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 50.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 4.00
Alkyl aryl sulfonate calcium salt Emulsifier 6.00
Ethoxylated tallow amine Emulsifier 1.00
Epoxidized soybean oil Solvent 3.00
Vegetable Oil polyglycol ether Solvent 9.00
Solvent naphtha Solvent 27.00
Total 100.00

The EC composition of Profenofos 50%+Fluxametamide 4% meets all the required storage stability criteria-active ingredient content, emulsion stability, pH, cold test and flash point.

Table 4: Profenofos 25%+Fluxametamide 6% EC
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 25.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 6.00
Tristyryl phenol ethoxylate Emulsifier 6.00
Dodecyl benzene sulphonic acid-calcium salt Emulsifier 3.50
Epoxidized soybean oil Solvent 5.00
Solvent naphtha Solvent 54.50
Total 100.00

The EC composition of Profenofos 25%+Fluxametamide 6% meets all the required storage stability criteria-active ingredient content, emulsion stability, pH, cold test and flash point.

EXAMPLE 2: Method of preparation Wettable Granule (WG)/ Water Dispersible Granule (WDG).
Table 5: Profenofos 35%+Fluxametamide 8% WG
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 35.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 8.00
Sodium polycarboxylate Dispersing agent 5.00
Sodium lignosulphonate Dispersing agent 20.00
Polyvinylpyrrolidone Wetting agent 2.00
Lactose Binder 15.00
Precipitated silica Carrier 15.00
Total 100.00

Manufacturing process for 100 kg batch of Profenofos 35%+Fluxametamide 8% WG
Weighing the raw materials according to the batch size as follows:
Step 1: Charge 15 kg of precipitated silica, 15 kg of lactose, 2 kg of polyvinylpyrrolidone, 5 kg of sodium polycarboxylate and 20 kg of sodium lignosulphonate in premixing blender for homogenization for 30 minutes.
Step 2: Now add 35 kg of profenofos technical and 8 kg of fluxametamide technical and again homogenize for 30 more minutes.
Step 3: Pre-blended material is then grinded through Jet mill until a mean particle size of below 10 microns is obtained. Finely grinded material is blended in post blender till it becomes homogeneous.
Step 4: Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 5: Dough is passed through extruder to get granules having a particle size in the range of 0.5 mm to 2 mm.
Step 6: Wet granules are passed through fluid bed dryer (with moisture content < 3%) and further graded using vibrating screens.
Step 7: Final product is sent for QC approval.
Step 8: After approval material is packed in required pack sizes.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 6: Storage stability-Profenofos 35%+Fluxametamide 8% WG
Parameters T0 (initial) T1 (AHS),for 14 days at 0C T2- for three months at 40 0C
Profenofos content (%), (-5% to +5% range) 36.12 36.09 36.10
Fluxametamide content (%) (-5% to +10% range) 8.44 8.42 8.43
wettability (60 second, maximum) 22 24 24
suspensibility (minimum 70%) 86.40 85.40 86.00
pH range (5.5 to 7.5, 1% aq. Suspension) 7.2 7.1 7.2

The WG composition of Profenofos 35%+Fluxametamide 8% meets all the required storage stability criteria-active ingredient content, wettability, suspensibility and pH.

Table 7: Profenofos 40%+Fluxametamide 5% WG
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 40.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 5.00
Modified Sodium lignosulphonate Dispersing agent 7.00
Di alkyl naphthalene sulphate sodium salt Wetting agent 2.50
Ammonium Sulphate Disintegrating agent 2.00
Polydimethylsiloxane Defoamer 1.00
Lactose monohydrate Binder 2.00
Corn Starch Filler 15.00
China clay Carrier 25.50
Total 100.00

The WG composition of Profenofos 40%+Fluxametamide 5% meets all the required storage stability criteria-active ingredient content, wettability, suspensibility and pH.

EXAMPLE 3: Method of preparation Oil Dispersion (OD) formulation.
Table 8: Profenofos 27.5%+Fluxametamide 5% OD
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 27.50
Fluxametamide technical (on 100% purity basis) Active Ingredient 5.00
Calcium dodecyl benzenesulfonate Dispersing agent 4.00
Castor oil ethoxylate of 40 mole Emulsifier 5.00
Fumed silica Rheology modifier 1.00
Citric acid Buffering agent 0.50
Methyl soyate oil Solvent 57.00
Total 100.00

Manufacturing process for 100 kg batch size of Profenofos 27.5%+Fluxametamide 5% OD
Step 1: Add 1 kg of fumed silica into 57 kg of methyl soyate (oil phase), homogenized till it gets completely dissolved. It must be kept 12 to 18 hrs. prior to use.
Step 2: Charge 47 kg of solution into a designated vessel.
Step 3: Add 4 kg of calcium dodecyl benzenesulfonate, 5 kg of castor oil ethoxylate of 40 mole, 0.5 kg of citric acid and homogenize the mixture for 45 to 60 minutes using high shear homogenizer.
Step 4: Add 27.5 kg of profenofos technical and 5 kg of fluxametamide technical into this premix and again homogenize for 30 to 45 minutes until it gets uniform mixture.
Step 5: The uniform mixture should be milled at 25 °C and particle size is maintained at < 5μ.
Step 6: Now add remaining 10 kg of bentonite clay solution.
Step 7: Sending the sample to the quality analysis.
Step 8: Packing the formulated material in suitable packaging.

Storage stability study:
The composition was evaluated for its stability. The composition was determined at T0, and under accelerated heat stability (AHS) conditions for 14 days at 54°C designated as T1. The stability was also evaluated after 3 months, at 40°C, designated as T2.

Table 9: Storage stability-Profenofos 27.5%+Fluxametamide 5% OD
Parameters T0 (initial) T1 (AHS),for 14 days at 54 0C T2- for three months at 40 0C
Profenofos content (%), (-5% to +5% range) 28.45 28.42 28.43
Fluxametamide content (%) (-5% to +10% range) 5.25 5.22 5.24
Description/Appearance off white liquid with uniform dispersion off white liquid with uniform dispersion off white liquid with uniform dispersion
pH range (1% Aqueous), 4.5 to 7 6.50 6.50 6.50
Dispersion stability-Sediments (24 hrs) nil nil nil
Dispersion stability-Creaming (24 hrs) nil nil nil
Stability stable 5% separation 5% separation
pourability (95% minimum) 97.20 96.90 97.00
Persistent foam, 2 ml Max. nil nil nil

The composition of Profenofos 27.5%+Fluxametamide 5% OD meets all the required storage stability criteria-active ingredient content, pH, dispersion stability, pourability and persistent foam.

Example 4: Method of preparation Micro emulsion (ME) formulation
Table 10: Profenofos 20%+Fluxametamide 2% ME
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 20.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 2.00
Polyalkyleneoxide modified trisiloxane Wetting Agent 5.00
Tristyrylphenol ethoxylate Emulsifier 14.00
Vegetable oil ethoxylates Emulsifier 18.00
Calcium salt of alkylbenzene sulfonate Emulsifier 2.50
N-methyl pyrrolidone Solvent 5.00
Propylene carbonate Solvent 5.00
Dimethyl formanamide Solvent 28.50
Total 100.00

Manufacturing process for 100 kg batch of Profenofos 20%+Fluxametamide 2% ME
Step 1: Charge solvent 5 kg of N-methyl pyrrolidone and 5 kg of Propylene carbonate into vassel.
Step 2: Add 20 kg of Profenofos, 2 kg of Fluxametamide and 5 kg of Polyalkyleneoxide modified trisiloxane and 2.50 kg of Calcium salt of alkylbenzene sulfonate slowly and mix thoroughly till it get dissolved completely.
Step 3: Add 14 kg of Tristyrylphenol ethoxylate and 18 kg of Vegetable oil ethoxylates and 28.50 kg of Dimethyl formanamide into this premix slowly and homogenized to get uniform solution.
Step 4: Send the final formulation for QC check and pack as per the requirements.

Example 5: Method of preparation Suspo Emulsion (SE) formulation.
Table 11: Profenofos 45%+Fluxametamide 5% SE
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 45.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 5.00
Aromatic hydrocarbon (Solvent C9) Solvent 10.00
Castor oil ethoxylate of 40 mole Emulsifier 2.00
Sodium naphthalene condensate formaldehyde Dispersing agent 2.00
Lauryl alcohol ethoxylates Wetting agent 2.00
Polydimethylsiloxane Defoamer 0.50
Propylene Glycol Anti-freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.10
Polysaccharide Thickener 5.00
Dimineralized water Solvent 23.40
Total 100.00

Example 6: Method of preparation Suspension Concentrate (SC) formulation.
Table 12: Profenofos 30%+Fluxametamide 5% SC
Components Function Content (%,w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 30.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 5.00
Polymethyl methacrylate-polyethylene glycol graft copolymer Dispersing agent 2.00
Polyethylene Polypropylene glycol mono butyl ether Dispersing agent 2.00
Fatty alcohol ethoxylate (Tridecyl alcohol ethoxylate) Wetting agent 1.50
Polydimethylsiloxane Defoamer 0.50
Propylene Glycol Anti-freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Polysaccharide Thickener 5.00
Methyl soyate oil Solvent 48.80
Total 100.00

Example 7: Method of preparation Emulsion, Oil in water (EW) formulation.
Table 13: Profenofos 30%+Fluxametamide 4% EW
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 30.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 4.00
Naphthalene sulfonic acid formaldehyde condensate-sodium salt Dispersing agent 1.00
Polystyrene Dispersing agent 1.50
Propylene-polyoxyethylene, copolymer Emulsifier 1.00
Propylene Glycol Anti-freezing agent 5.00
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Water 57.30
Total 100.00

Example 8: Method of preparation Wettable Powder (WP) formulation.
Table 14: Profenofos 40%+Fluxametamide 15% WP
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 40.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 15.00
Alkyl naphthalene sulfonate condensate Dispersing agent 5.00
Sodium lignosulphonate Dispersing agent 4.00
Sodium isopropyl naphthalene sulfonate Wetting agent 2.50
Precipitated silica Filler 1.00
Corn starch (amylose and amylopectin) Carrier 32.50
Total 100.00

Example 9: Method of preparation Zeon Concentrate (ZC) formulation.
Table 15: Profenofos 30%+Fluxametamide 4% ZC
Components Function Content (%, w/w)
Profenofos technical (on 100% purity basis) Active Ingredient 30.00
Fluxametamide technical (on 100% purity basis) Active Ingredient 4.00
Alkyl phenyl polyglycol ether Dispersing agent 2.50
Alkyl naphthalene sulfonate condensate Dispersing agent 0.50
Sodium Isopropyl Naphthalene Sulfonate Wetting agent 2.00
Polymethylene polyphenylene isocyanate Wall forming material 0.50
Diethylenetriamine Wall forming material 0.25
Magnesium sulfate heptahydrate Anti freezing agent 2.50
Tributyl phenyl polyglycol ether Suspending agent 1.50
Polydimethylsiloxane Antifoaming agent 0.30
Hydrochloric acid Buffering agent 0.50
1,2-benzisothiazolin-3(2H)-one Preservative 0.20
Mono ethylene glycol Anti freezing agent 2.50
Xanthan gum Thickener 0.15
Water Solvent/diluent 52.60
Total 100.00

Example 10
BIOLOGICAL EXAMPLES:
Evaluation of synergistic effect of agrochemical composition of the present invention:
The synergism between two or three pesticidal compounds can be evaluated as per the method given by S R Colby. Calculating Synergistic and Antagonistic Responses of Herbicide Combinations, published online by Cambridge University Press: 12 June 2017, pp. 20-22 (Weeds, Journal of The Weed society of America, Volume 15, January 1967, Issue 1, Page 20-22).

Experiment 1: Synergistic control of insect-pests in cotton.
Crop: Cotton
Plot size: 8m x 5m.
Pests: Thrips (Thrips tabaci)
Crop stage: 56 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 375 liters per hectare.
Observation method:
Thrips control (%): Count the number of live thrips per leaf, observed three leaves per plant and ten plants per plot. Calculate thrips (observed) control by given formula and calculate expected control by Colbys’ formula.

Table 16: Test protocol
S.No. Products/Test compounds Use Rate (g.a.i/h)
T1 Control (Untreated) -
T2 Profenofos 50% EC 375
T3 Profenofos 50% EC 300
T4 Profenofos 50% EC 187.5
T5 Fluxametamide 10% EC 30
T6 Fluxametamide 10% EC 37.5
T7 Fluxametamide 10% EC 45
T8 Profenofos 50%+Fluxametamide 4% EC 375+30
T9 Profenofos 40%+Fluxametamide 5% EC 300+37.5
T10 Profenofos 25%+Fluxametamide 6% EC 187.5+45
g.a.i/h-gram active ingredients per hectare; T8, T9 and T10-present compositions.

Table 17: Control of cotton thrips
S.No. Cotton thrips control (%)
3rd day 7th day 14th day
Observed Expected Colby's ratio
T1 0.0 - - 0.0 0.0
T2 64.5 - - 57.3 38.6
T3 50.8 - - 39.6 19.6
T4 36.5 - - 24.8 5.2
T5 65.7 - - 54.8 30.3
T6 72.5 - - 62,5 41.5
T7 77.8 - - 70.6 52.8
T8 100.0 87.82 1.14 98.2 95.2
T9 100.0 86.47 1.16 99.5 97.4
T10 99.3 85.90 1.16 96.5 92.6

The field trial results shows synergistic control of cotton thrips on 3, 7 and 14th day after application. On 3rd day, T8 and T9 shows complete control of thrips.
Experiment 2: Synergistic control of insect-pests in brinjal.
Crop: Brinjal
Plot size: 7m x 5m.
Pests: Jassid (Amrasca biguttulla biguttulla), Thrips (Thrips tabaci), Shoot & Fruit borer (Leucinoides orbonalis)
Crop stage: 77 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 500 liters per hectare.
Observation method:
Jassid and Thrips control (%): as per experiment 1.
Shoot & Fruit borer control (%): Count the number of healthy and infested shoots and fruits per plant, record the observations from ten plants per plot on 7th day after application.

Calculate shoot damage (%) and fruit damage (%) and re-calculate reduction in shoot damage and fruit damage.

Table 18: Treatment compositions
S.No. Products/Test compounds Use Rate (g.a.i/h)
T1 Control -
T2 Profenofos 50% EC 300
T3 Fluxametamide 10% EC 37.5
T4 Profenofos 40%+Cypermethrin 4% EC 400+40
T5 Profenofos 50%+Fenpropathrin 5% EC 750+75
T6 Profenofos 40 %+Lambda cyhalothrin 1.5% EC 400+15
T7 Profenofos 40 %+Fenpyroximate 2.5 % EC 400+25
T8 Profenofos 35%+Emamectin Benzoate 1.5% WDG 245+10.5
T9 Profenofos 40%+Fluxametamide 5% EC 300+37.5
T9-present composition, T4 to T8-prior art compositions
Table 19: Control of insect-pests in brinjal crop
S.No. Thrips control (%) Jassid control (%)
Observed Expected Colby's ratio Observed Expected Colby's ratio
T1 0.0 - - 0.0 - -
T2 37.8 - - 58.6 - -
T3 64.2 - - 76.4 - -
T4 87.4 - - 78.7 - -
T5 92.5 - - 80.2 - -
T6 84.6 - - 77.4 - -
T7 85.3 - - 75.2 - -
T8 82.5 - - 72.7 - -
T9 100.0 77.73 1.29 99.5 90.23 1.10

The results presented in Table 19, show that the present composition (T9) provides synergistic control of jassid and thrips infesting brinjal crops. The present composition (T9) provides complete control of thrips and also provides highest control of jassid as compared to all prior art treatments (T4 to T8) on 7th day after application.

Table 20: Shoot and Fruit borer control
S.No. Shoot & Fruit borer control (%) Healthy fruits per plant Increase (%) in healthy fruits over T1
Observed Expected Colby's ratio
T1 0.0 - - 9.7 0.0
T2 58.2 - - 15.8 62.9
T3 67.5 - - 16.1 66.0
T4 88.7 - - 17.7 82.5
T5 92.5 - - 17.9 84.5
T6 86.4 - - 16.9 74.2
T7 85.9 - - 17.5 80.4
T8 93.2 - - 18.2 87.6
T9 97.7 86.42 1.13 20.5 111.3

The present composition (T9) provides superior control of shoot and fruit borer as compared to known prior art compositions.

Experiment 3: Synergistic control of insect-pests in red gram
Crop: Redgram
Plot size: 10m x 4m.
Pests: Pod borer larvae (Helicoverpa armigera)
Crop stage: 95 days.
Application method: Foliar spray with battery operated backpack sprayer.
Spray volume: 420 liters per hectare.
Pod borer larval control (%): Count the number of live larvae per plant, record the observations from ten plants per plot. Calculate the larval control.

Table 21: Pod borer larval control in redgram crop
Products/Test compounds Rate (g.a.i/h) Red gram pod borer larval control (%)
7th day 15th day
Observed Expected Colby Ratio
T1-Control - 0.0 - - 0.0
T2-Profenofos 50% EC 245 50.8 - - 25.7
T3-Profenofos 50% EC 280 58.2 - - 36.2
T4-Fluxametamide 10% EC 56 77.2 - - 60.8
T5-Fluxametamide 10% EC 35 58.6 - - 37.5
T6-Profenofos 35%+Fluxametamide 8% WG 245+56 100.0 88.78 1.13 97.4
T8-Profenofos 40%+Fluxametamide 5% WG 280+35 97.5 82.69 1.18 91.3

Both the present compositions (T6 and T8) provides synergistic control of red gram pod borer larvae on 7th and 15th day after application.

Experiment 4:
Crop & Pests: Bottle gourd, Pumpkin beetle
Products/Test compounds Rate (g.a.i./h) Pumpkin beetle control (%)
Observed Expected Colby's ratio
Control 0 0.0 - -
Profenofos 50% EC 275 65.8 - -
Fluxametamide 10% EC 50 41.5 - -
Profenofos 27.5%+Fluxametamide 5% OD 275+50 98.8 79.99 1.24

Experiment 5
Crop & Pests: Tomato, Leaf miner
Products/Test compounds Rate (g.a.i./h) Leaf miner control (%)
Observed Expected Colby's ratio
Control 0 0.0 - -
Profenofos 50% EC 300 64.4 - -
Fluxametamide 10% EC 30 42.5 - -
Profenofos 20%+Fluxametamide 2% ME 300+30 97.5 79.53 1.23

Experiment 6
Crop & Pests: Maize, Fall armyworm (FAW)
Products/Test compounds Rate (g.a.i./h) FAW larval control (%)
Observed Expected Colby's ratio
Control 0.0 0.0 - -
Profenofos 50% EC 281.25 65.8 - -
Fluxametamide 10% EC 31.25 56.2 - -
Profenofos 45%+Fluxametamide 5% SE 281.25+31.25 96.5 85.02 1.14

Experiment 7
Crop & Pests: Okra, Fruit borer and Jassid
Products/Test compounds Rate (g.a.i./h) Fruit borer larval control (%) Jassid control (%)
Observed Expected Colby's ratio Observed Expected Colby's ratio
Control 0 0 - - 0 - -
Profenofos 50% EC 250 54.2 - - 52.8 - -
Fluxametamide 10% EC 50 75.6 - - 82.6 - -
Profenofos 50%+Fluxametamide 10% EW 250+50 98.7 88.82 1.11 100 91.79 1.09

Experiment 8
Crop & Pests: Sugarcane, Black bug
Products/Test compounds Rate (g.a.i./h) Black bug control (%)
Observed Expected Colby's ratio
Control 0 0.0 - -
Profenofos 50% EC 200 42.6 - -
Fluxametamide 10% EC 75 72.8 - -
Profenofos 40%+Fluxametamide 15% WP 200+75 99.2 84.39 1.18

Experiment 9
Crop & Pests: Chilli, Black thrips
Products/Test compounds g.a.i./h Black Thrips control (%)
Observed Expected Colby's ratio
Control 0 0.0 - -
Profenofos 50% EC 375 55.8 - -
Fluxametamide 10% EC 50 72.5 - -
Profenofos 30%+Fluxametamide 4% ZC 375+50 98.3 87.85 1.12

The various formulations of Profenofos+Fluxametamide have been evaluated for its efficacy against different insect pests and found synergistic and highly efficacious against different insect pests.

The experimental results show that present compositions provide broad spectrum control of insect-pests belonging to distinct species and orders (Lepidoptera, Thysanoptera, Homopteran, Hemiptera, Coleoptera and Acarina) and found to be safe to cotton, brinjal, red gram, bottle gourd, tomato, maize, okra, sugarcane and chilli crops.
, Claims:Claims:
I/We Claims:
1. A synergistic agrochemical composition comprising:
a. compound A, Profenofos is in amount of 15.0% to 60.0% w/w;
b. compound B, Fluxametamide is in amount of 1.0% to 20.0% w/w; and
c. inactive formulation excipients in amount of 20.0% to 85.0% w/w.

2. The synergistic agrochemical composition as claimed in claim 1, wherein the weight ratio of Profenofos and Fluxametamide is 15:1 to 2:1.

3. The synergistic agrochemical composition as claimed in claim 1, wherein inactive formulation excipients is selected from wetting agent, dispersing agent, antifoaming agent/defoamer, anti-freezing agent, biocide/preservative, thickener/suspending agent, disintegrating agent, emulsifier, solvent, pH stabilizer, anti-caking agent, humectant, binder, filler/carrier and wall forming materials or combination thereof.

4. The synergistic agrochemical composition as claimed in claim 1, wherein the formulation for the said composition is selected from water dispersible granules, wettable powder, emulsifiable concentrate, emulsion oil-in-water, micro-emulsion, oil-dispersion, suspension concentrate, suspo emulsion, mixed formulation of CS and SC (ZC).

5. The synergistic agrochemical composition as claimed in claim 4, wherein the Emulsifiable Concentrate (EC) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. emulsifier is in amount of 1.0% to 15.0% w/w; and
d. solvent in amount of quantity sufficient.

6. The synergistic agrochemical composition as claimed in claim 4, wherein the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
d. dispersing agent is in amount of 1.0% to 30.0% w/w;
e. wetting agent is in amount of 1.0% to 10.0% w/w;
f. disintegrating agent is in amount of 1.0% to 10.0% w/w;
g. defoamer is in amount of 0.50% to 5.0% w/w;
h. binder is in amount of 1.0% to 20.0% w/w; and
i. filler/carrier in amount of quantity sufficient.

7. The synergistic agrochemical composition as claimed in claim 4, wherein the Oil Dispersion (OD) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. dispersing agent is in amount of 1.0% to 10.0% w/w;
d. emulsifier is in amount of 1.0% to 10.0% w/w;
e. rheology modifier is in amount of 0.50% to 5.0% w/w;
f. buffering agent is in amount of 0.1% to 5.0% w/w; and
g. solvent in amount of quantity sufficient.

8. The synergistic agrochemical composition as claimed in claim 4, wherein the Micro emulsion (ME) formulation comprises:
a. compound A is in amount of 1.0% to 10.0% w/w;
b. compound B is in amount of 5.0% to 25.0% w/w;
c. wetting agent is in amount of 1.0% to 10.0% w/w;
d. emulsifier is in amount of 1.0 to 30.0% w/w; and
e. solvent in amount of quantity sufficient.

9. The synergistic agrochemical composition as claimed in claim 4, wherein the Suspo Emulsion (SE) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. emulsifier is in amount of 1.0% to 10.0% w/w;
d. wetting agent is in amount of 1.0% to 10.0% w/w;
e. dispersing agent is in amount of 1.0 to 10.0% w/w;
f. defoamer is in amount of 0.1% to 5.0% w/w;
g. anti-freezing agent is in amount of 1.0% to 5.0% w/w;
h. preservative is in amount of 0.10% to 5.0% w/w;
i. thickener is in amount of 0.1 to 5.0% w/w; and
j. solvent in amount of quantity sufficient.

10. The synergistic agrochemical composition as claimed in claim 4, wherein the Suspension Concentrate (SC) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. wetting agent is in amount of 1.0% to 10.0% w/w;
d. dispersing agent is in amount of 1.0 to 10.0% w/w;
e. defoamer is in amount of 0.1% to 5.0% w/w;
f. anti-freezing agent is in amount of 1.0% to 5.0% w/w;
g. preservative is in amount of 0.10% to 5.0% w/w;
h. thickener is in amount of 0.1 to 5.0% w/w; and
i. solvent in amount of quantity sufficient.

11. The synergistic agrochemical composition as claimed in claim 4, wherein the Emulsion, Oil in water (EW) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. dispersing agent is in amount of 1.0 to 10.0% w/w;
d. emulsifier is in amount of 0.1% to 5.0% w/w;
e. anti-freezing agent is in amount of 1.0% to 5.0% w/w;
f. preservative is in amount of 1.0% to 10.0% w/w; and
g. solvent in amount of quantity sufficient.

12. The synergistic agrochemical composition as claimed in claim 4, wherein the Wettable Powder (WP) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. dispersing agent is in amount of 1.0 to 10.0% w/w;
d. wetting agent is in amount of 0.1% to 5.0% w/w; and
e. filler/carrier in amount of quantity sufficient.

13. The synergistic agrochemical composition as claimed in claim 4, wherein the Zeon Concentrate (ZC) formulation comprises:
a. compound A is in amount of 15.0% to 60.0% w/w;
b. compound B is in amount of 1.0% to 20.0% w/w;
c. dispersing agent is in amount of 1.0% to 10.0% w/w;
d. wetting agent is in amount of 1.0 to 10.0% w/w;
e. wall forming material is in amount of 0.1% to 5.0% w/w;
f. anti-freezing agent is in amount of 1.0% to 5.0% w/w;
g. suspending agent is in amount of 0.50% to 5.0% w/w;
h. anti-foaming agent is in amount 0.10% to 5.0% w/w;
i. buffering agent is in amount of 0.10% to 5.0% w/w;
j. preservative is in amount of 0.1 to 5.0% w/w;
k. thickener is in amount of 0.10% to 5.0% w/w; and
l. solvent in amount of quantity sufficient.

14. The synergistic agrochemical composition as claimed in claims 6, 8, 9, 10 12 & 13, wherein wetting agent is selected from tristyryl phenol ethoxylate non-ionic polymer, sodium iso propyl naphthalene sulphonate, alkyl phenyl ethoxylate, aryl phenyl ethoxylate, aryl phenyl ether phosphate, alkoxylate alcohol, ethoxylated fatty alcohol, ethylene oxide-propylene oxide (EO-PO) block copolymer, alkyl aryl sulphonate, alkyl olefin sulfonate, dioctyl succinate, sodium lauryl sulfate, alkyl polyglycoside, sodium alkyl aryl taurate, sorbitol esters, sorbitol oleate, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol, trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified Tri siloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or combination thereof.

15. The synergistic agrochemical composition as claimed in claims 6, 7, 9, 10, 11, 12 & 13, wherein dispersing agent is selected from polyacrylate compound selected from a homopolymer, a block-copolymer or a random copolymer and the mixtures thereof. Polyacrylate compound selected from a group comprises poly(methyl acrylate), poly(ethyl acrylate), poly(propyl acrylate), poly(n-butyl acrylate), poly(isobutyl acrylate), poly(2-ethyl acrylate), poly(t-butyl acrylate), poly(ethylhexyl acrylate), poly(benzyl acrylate), poly(methyl methacrylate), poly(ethyl methacrylate), poly(n-butyl methacrylate), poly(isobutyl methacrylate), poly((ethylene glycol) methyl ether methacrylate), poly(methacrylate-coethylacrylate),poly(methacrylate-co-styrene), poly(methacrylate-co-butylmethacrylate), poly(n-butylmethacrylcate-co-methacrylate), poly((ethylene oxide)-co-poly(methyl acrylate)), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox 4913), nonionic comb-shaped polyacrylate (Dispersogen PSL 100), 2-Acrylamido-2-Methylpropane Sulfonic Acid, Sodium methallyl sulfonate, 3-sulfopropyl acrylate potassium salt, 3-sulfopropyl methacrylate potassium salt, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxymethyl methacrylate, Polyethylene-g-poly(n-butyl acrylate), and the mixtures thereof. Polyarylphenyl ether phosphate, Tri styryl phenol ethoxylate, ethoxylated tristryl phenol sulphate, acrylic polymer amine salt, naphthalene sulfonic acid-sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate-sodium salt, ethoxylated oleylcetyl alcohol, poly alkelene glycol ether, ethoxylated fatty alcohol, alkyl sulfonate, styrene acrylic copolymer, alkyl phenol polyglycol ether, sodium lignosulfonate, calcium lignosulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide- polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide, Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-[2,4,6-tris(1-phenylethyl)phenoxy]-, ammonium salt or combination thereof.

16. The synergistic agrochemical composition as claimed in claim 5, 7, 8, 9 & 10, wherein emulsifier is selected from castor oil ethoxylate 40 mole, Polyoxyethylenealkylphenyl ether alkyl aryl sulfonate, 3-methoxy N, N-dimethyl propionamide, Polyglyceryl-3 caprylate, Polysorbate 60 (polyoxyethylene sorbitan monostearate-Tween 60), solvents alkyl phenol, aryl phenol, alkyl phenol ethoxylate, fatty acid esters, fatty acid alkanol amides, alkoxylated fatty acid ester or a combination thereof.

17. The synergistic agrochemical composition as claimed in claim 6, 9, 10 & 13, wherein defoamer is selected from siloxane polyalkylene oxide, polydimethyl siloxane, polysiloxane emulsion, vegetable oil-based antifoam, silicone oil emulsion, magnesium stearate or combination thereof.

18. The synergistic agrochemical composition as claimed in claim 9, 10, 11 & 13, wherein anti-freezing agent is selected from water soluble alcohols, ethylene glycol, propylene glycol, glycerol, 1,3-butendiol, urea, magnesium sulfate heptahydrate, sodium chloride or a combination thereof.

19. The synergistic agrochemical composition as claimed in claim 9, 10 & 13, wherein thickener is selected from natural polymers (gelling agent): polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives: Carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

20. The synergistic agrochemical composition as claimed in claim 9, 10, 11 & 13, wherein preservative is selected from benzisothiazolin-3-one, formaldehyde, sodium benzoate, sodium o-phenyl phenate, potassium sorbate, 2-bromo-2-nitropropane-1,3-diol, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or a combination thereof.

21. The synergistic agrochemical composition as claimed in claim 6, wherein disintegrating agent is selected from cellulose, starch, clays, bentonite, diatomaceous, colloidal silica, precipitated silica, kaolin, potassium phosphate, ammonium sulphate, sodium sulphate, sodium citrate or urea and croscarmellose sodium, crospovidone, and sodium starch glycolate or combination thereof.

22. The synergistic agrochemical composition as claimed in claim 6 & 12, wherein filler/carrier selected from silica-sand (16-40 mesh), precipitated silica, bentonite, attapulgite, ceramic, montmorillonite, pumice, sepiolite, diatomaceous earth, clay, dolomite, calcite, silicon dioxide, precipitated silica, china clay/kaolin clay, talc, starch, zinc and its salts (zinc sulphate, zinc oxide, zinc lactate gluconate, zinc polyflavonoid, Zinc EDTA), iron and its salt (ferrous sulphate, EDTA), copper and salts, Sulphur, humic acid-salt, fulvic acid-salt, amino acid-soy protein, jasmonic acid-salt, carboxylic acid-salt, sea weed extracts, chitosan or a combination thereof.

23. The synergistic agrochemical composition as claimed in claims 5, 7, 8, 9, 10 & 13, wherein solvent is selected from demineralized (DM) water, alcohols such as ethanol, propanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, acetophenone, glycerin, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol, monomethyl ether, Di propylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; heavy aromatic hydrocarbons such as mixture of heavy aromatic naphtha hydrocarbon C-9 to C-16, xylene, toluene, naphthalene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; carboxamide; aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, Di isopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; alkyl amide, amides such as dimethylformamide, alkyl pyrrolidone, N-methyl-2-pyrrolidone, N-octyl pyrrolidone, N,N-dimethyldecanamide, N, N-dimethyloctanamide, N, N-dimethylamine, N,N-dimethylmethanamide; nitriles such as acetonitrile; organosulfur compound such as alkyl sulfoxide, dimethyl sulfoxide, propylene carbonate, mineral oil, methylated seed oil-methyl ester of palm oil/soybean oil/castor oil/cotton seed oil/blend of two or more seed oil or combination thereof.

24. The synergistic agrochemical composition as claimed in claim 6, wherein binder is selected from lactose anhydrous, poly ethylene wax, poly vinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol, polyethylene oxide, polyethoxylated fatty acids, polyesters, polyamides, poly carbonates, poly urea, poly urethanes, styrene copolymer, butadiene copolymers, polyethoxylated alcohols, acrylate polymer such as polymethacrylate, poly ethyl methacrylate, poly methyl methacrylate, acrylate copolymers and styrene-acrylic copolymers or mixtures of thereof, a natural gum, lignosulphonate and water swellable binder selected from china clay, bentonite, fuller’s earth, zeolite, quartz, precipitated silica, palygorskite, sepiolite, halloysite and a combination thereof.

25. The synergistic agrochemical composition as claimed in claim 7, wherein rheology modifier is selected from xanthan gum, carboxymethylcellulose (CMC), polyvinyl alcohol, bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

26. The synergistic agrochemical composition as claimed in claim 13, wherein Suspending agent is selected from natural polymers (gelling agent)-polysaccharides such as xanthan gum, guar gum, acacia gum, gelatin; cellulose derivatives-carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methylcellulose (MC); synthetic polymers-carbomers, poloxamers, polyvinyl alcohol, others-glycerin, syrup, sorbitol, clays & minerals: bentonite clay, attapulgite clay, sodium polyacrylate, aluminum magnesium silicate, or a combination thereof.

27. The synergistic agrochemical composition as claimed in claim 7 & 13, wherein Buffering agent is selected from sodium hydroxide, sodium dihydrogen phosphate dihydrate, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, calcium carbonate, potassium hydrogen phosphate salt solution, acetic acid & sodium acetate, ammonia & ammonium chlorides, citric acid, benzoic acid, salicylic acids, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, carboxylic acids, 2,6-di-tert-butyl-p-cresol, butylhydroxyanisole (BHT), epoxidized soybean oil (ESBO), methyl oleate, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose sodium (NaCMC), sodium dodecyl sulphate (SDS), lecithin, polysorbates, clays-bentonite clay, smectite clay, precipitated silica and various types of gums like xanthan gum or guar gum or a combination thereof.

28. The synergistic agrochemical composition as claimed in claim 13, wherein wall forming material is selected from Tetramethylene diisocyanate, Penta methylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethene diisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form;, Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetra ethylene pentaamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4′-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4′-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone or a combination thereof.

Dated this 14th day of May, 2025