Description:FIELD OF INVENTION:
The present invention relates to the synthesis of two series of di-heterocyclic chalcones using heterocyclic aldehyde and 3-acetyl pyridine. More particularly, the present invention discloses the synthesis, analysis, assessment of biological activities and in silico studies of the di-heterocyclic chalcones.

BACKGROUND OF INVENTION:
Cancer is one of the deadliest metastatic diseases, which itself is a combination of multiple diseases. The number of cancer cases diagnosed in the United States in 2024 are almost a little over 2 million. Most cases are reported in prostate, breast, lung, and colon cancer among which breast cancer is the leading cancer among women. There are many FDA-approved drugs available in the market and heterocyclic units are major constituents of most of them. Both synthetic and naturally occurring chalcones show enhanced activity against lung, breast, and colon cancer, and also against neurodegenerative disorders such as Alzheimer’s and Parkinson’s with potent MAO-A a , Claims:WE CLAIM:
1. Di heterocyclic chalcone compounds comprising:
- indole and pyridine-based di heterocyclic chalcone, as represented by Formula A;

Formula A
- pyrrole and pyridine-based di heterocyclic chalcone, as represented by Formula B;

Formula B
wherein, chalcone of formula A comprises of N-alkylated indole-3-carboxaldehyde and 3-acetyl pyridine and chalcone of formula B comprises of N-alkylated pyrrole-2-carbaldehyde and 3-acetyl pyridine,
such that the synthesized chalcones are potent inhibitory agents for major types of cancer.
2. The synthesized chalcone compounds as claimed in claim 1, wherein the solvent employed is ethanol or methanol or a combination of methanol and ethanol.
3. The synthesized chalcone compounds as claimed in claim 1, wherein the said chalcones were synthesized at room temperature under nitrogen or argon atmosphere.
4. The synthesized chalcone compounds as claimed in claim 1, wherein the chalcones were synthesized using NaOH or KOH or pyridine or piperidine as a base.
5. The s