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Process For Preparation Of Ionizable Lipids

Abstract: ABSTRACT PROCESS FOR PREPARATION OF IONIZABLE LIPIDS The present invention provides a process of preparing an ionizable lipid that is a crucial lipid 5 for the development of mRNA-based therapeutics. More particularly, the present invention provides a process of preparing an ionizable lipid, having structure as that of FDA approved lipids (such as ALC-0315), by reacting a carboxylic acid with a chlorinating agent, followed by reaction with an ester and an amine to provide the said ionizable lipid.

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Patent Information

Application #
Filing Date
01 July 2025
Publication Number
28/2025
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application

Applicants

INDIAN INSTITUTE OF SCIENCE
Sir CV Raman Road, Bangalore Karnataka India 560012

Inventors

1. Pradipta Behera
Department of Organic Chemistry, Indian Institute of Science Sir CV Raman Road, Bangalore Karnataka India 560012
2. Sourav Baidya
Department of Organic Chemistry, Indian Institute of Science Sir CV Raman Road, Bangalore Karnataka India 560012
3. Sharat Sarmah
Department of Organic Chemistry, Indian Institute of Science Sir CV Raman Road, Bangalore Karnataka India 560012
4. Mrinmoy De
Department of Organic Chemistry, Indian Institute of Science Sir CV Raman Road, Bangalore Karnataka India 560012

Specification

Description:as filed pdf documents , Claims:as filed pdf documents

Documents

Application Documents

# Name Date
1 202541062563-STATEMENT OF UNDERTAKING (FORM 3) [01-07-2025(online)].pdf 2025-07-01
2 202541062563-PROOF OF RIGHT [01-07-2025(online)].pdf 2025-07-01
3 202541062563-POWER OF AUTHORITY [01-07-2025(online)].pdf 2025-07-01
4 202541062563-FORM-9 [01-07-2025(online)].pdf 2025-07-01
5 202541062563-FORM-8 [01-07-2025(online)].pdf 2025-07-01
6 202541062563-FORM FOR SMALL ENTITY(FORM-28) [01-07-2025(online)].pdf 2025-07-01
7 202541062563-FORM 18A [01-07-2025(online)].pdf 2025-07-01
8 202541062563-FORM 1 [01-07-2025(online)].pdf 2025-07-01
9 202541062563-EVIDENCE OF ELIGIBILTY RULE 24C1f [01-07-2025(online)].pdf 2025-07-01
10 202541062563-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [01-07-2025(online)].pdf 2025-07-01
11 202541062563-EVIDENCE FOR REGISTRATION UNDER SSI [01-07-2025(online)].pdf 2025-07-01
12 202541062563-EDUCATIONAL INSTITUTION(S) [01-07-2025(online)].pdf 2025-07-01
13 202541062563-DECLARATION OF INVENTORSHIP (FORM 5) [01-07-2025(online)].pdf 2025-07-01
14 202541062563-COMPLETE SPECIFICATION [01-07-2025(online)].pdf 2025-07-01
15 202541062563-FER.pdf 2025-08-25
16 202541062563-FORM 3 [11-09-2025(online)].pdf 2025-09-11
17 202541062563-FER_SER_REPLY [21-11-2025(online)].pdf 2025-11-21
18 202541062563-CLAIMS [21-11-2025(online)].pdf 2025-11-21

Search Strategy

1 202541062563_SearchStrategyNew_E_202541062563E_20-08-2025.pdf