Formulation Of A Phytochemical Enriched Would Healing Cream Using Leaf Extract Of Eclipta Prostrata (False Daisy)

Abstract: ABSTRACT: The present study involves the formulation and evaluation of a phytochemical-enriched wound healing cream using the leaf extract of Ec/ipta prostrata, commonly known as False Daisy. This medicinal plant is well-known in traditional medicine for its anti-inflammatory: antimicrobial, antioxidant: and regenerative properties. The aim of this research is to scientifically harness the therapeutic potential of Ec/ipta pros/rata by incorporating its extract into a stable and effective topical cream formulation that promotes wound healing and skin regeneration.Fresh and healthy leaves of Eclipta prostra/a were collected and thoroughly washed with distilled water to remove dust and impurities. Once fully dried, the leaves were ground into a fine powder and subjected to maceration using a hydroalcoholic solvent system, specifically 50% ethanol, to extract the phytochemicals.For cream preparation, the oil phase was composed of stearic acid, cetostearyl alcohol, and white soft paraffin. Both phases were heated separately to a temperature range of 70-75"C and then emulsilred under contrnuous strrnng to form a smooth, homogenous cream base. After the emulsion cooled to around 40�C, the concentrated Ec/ipta prostrata extract was added slowly to the cream base with constant stirring to ensure uniform dispersion and to avoid the degradation of heat-sensitive compounds. The formulated cream was evaluated for several physicochemical parameters, including appearance, color, pH, spreadability, homogeneity, and stability. The cream exhibited favorable characteristics: a smooth texture, pleasant appearance, easy spreadability, acceptable pH for skin application, and no signs of phase separation during storage. The presence of key phytochemicals such as wedelolactone, ecliptine, navonoids, and polyphenols was identified, which are known to enhance the wound healing process by reducitig inflammation, preventing microbial infections, and accelerating tissue regeneration. Such herbal formulations are especially beneficial in treating minor cuts, abrasions, burns, and other superficial skin injuries, particularly for individuals seeking chemical-free and traditional remedies. The formulation is also environmentally friendly, economical, and \Veil-tolerated on sensitive skin. Further in-vitro and in-vivo studies are recommended to confirm its clinical efficacy and safety for broader therapeutic applications�iii�iii�

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