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Amyloid Precursor Protein (App) Rn Ai Agents

Abstract: Provided herein are APP RNAi agents and compositions comprising an APP RNAi agent. Also provided herein are methods of using the APP RNAi agents or compositions comprising an APP RNAi agent in reducing APP expression and/or treating APP associated neurological diseases.

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Patent Information

Application #
Filing Date
11 March 2026
Publication Number
14/2026
Publication Type
INA
Invention Field
BIO-CHEMISTRY
Status
Email
Parent Application

Applicants

ELI LILLY AND COMPANY
Lilly Corporate Center Indianapolis, Indiana 46285

Inventors

1. ALAM, Riazul
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
2. CHEN, Jee-Wei Emily
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
3. CROY, Carrie Hughes
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
4. DRIVER, David Albert
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
5. FRITSCHI, Sarah Katharina
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
6. GIRARD, Daniel Scott
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
7. GONZALEZ VALCARCEL, Isabel C.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
8. MARTINEZ, Ruben Martin
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
9. MILES, Rebecca Ruth
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
10. OZER, Hatice Gulcin
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
11. PERKINS, Douglas Raymond
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
12. WANG, Jibo
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

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