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3 (5 Methyl 2 Oxo 1, 3 Dioxol 4 Yl) Methyloxy 2 Trans [(4 Chloro Phenyl) Cyclohexyl][1,4]Naphthaquinone" Atovaquone Prodrug
Abstract: The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
16 September 2011
Publication Number
13/2014
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
ALKEM LABORATORIES LTD.
DEVASHISH, ALKEM HOUSE, SENAPATI BAPAT MARG,
LOWER PAREL, MUMBAI 400 013
Inventors
1. SANJAY SUKUMAR SARALAYA
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
2. AKSHAYA KUNJYANNAYA
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
3. SHASHIPRABHA
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
4. SHRIDHARA KANAKAMAJALU
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
5. KOTHAPALLI SUNDARRAJA RAO
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
6. KUPPUSWAMY NAGARAJAN
ALKEM LABORATORIES LTD.
473 D2, 13TH CROSS,
IVTH PHASE, PEENYA INDUSTRIAL AREA,
BANGALORE - 560 058
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 747-MUM-2011-ABSTRACT(14-9-2012).pdf | 2018-08-11 |
| 1 | 747-MUM-2011-REQUEST FOR POST-DATING(15-3-2012).pdf | 2018-08-11 |
| 2 | 747-MUM-2011-ASSIGNMENT(9-4-2012).pdf | 2018-08-11 |
| 2 | 747-MUM-2011-FORM 5(14-9-2012).pdf | 2018-08-11 |
| 3 | 747-mum-2011-form 3(16-3-2011).pdf | 2018-08-11 |
| 3 | 747-MUM-2011-CLAIMS(14-9-2012).pdf | 2018-08-11 |
| 4 | 747-mum-2011-form 26(16-3-2011).pdf | 2018-08-11 |
| 4 | 747-MUM-2011-CORRESPONDENCE(14-9-2012).pdf | 2018-08-11 |
| 5 | 747-MUM-2011-FORM 26(14-9-2012).pdf | 2018-08-11 |
| 5 | 747-mum-2011-correspondence(16-3-2011).pdf | 2018-08-11 |
| 6 | 747-mum-2011-form 2(title page)-(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 6 | 747-MUM-2011-CORRESPONDENCE(9-4-2012).pdf | 2018-08-11 |
| 7 | 747-MUM-2011-FORM 2(TITLE PAGE)-(14-9-2012).pdf | 2018-08-11 |
| 7 | 747-MUM-2011-DESCRIPTION(COMPLETE)-(14-9-2012).pdf | 2018-08-11 |
| 8 | 747-mum-2011-form 2(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 8 | 747-mum-2011-description(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 9 | 747-mum-2011-form 1(16-3-2011).pdf | 2018-08-11 |
| 9 | 747-MUM-2011-FORM 2(14-9-2012).pdf | 2018-08-11 |
| 10 | 747-mum-2011-form 1(16-3-2011).pdf | 2018-08-11 |
| 10 | 747-MUM-2011-FORM 2(14-9-2012).pdf | 2018-08-11 |
| 11 | 747-mum-2011-description(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 11 | 747-mum-2011-form 2(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 12 | 747-MUM-2011-DESCRIPTION(COMPLETE)-(14-9-2012).pdf | 2018-08-11 |
| 12 | 747-MUM-2011-FORM 2(TITLE PAGE)-(14-9-2012).pdf | 2018-08-11 |
| 13 | 747-MUM-2011-CORRESPONDENCE(9-4-2012).pdf | 2018-08-11 |
| 13 | 747-mum-2011-form 2(title page)-(provisional)-(16-3-2011).pdf | 2018-08-11 |
| 14 | 747-mum-2011-correspondence(16-3-2011).pdf | 2018-08-11 |
| 14 | 747-MUM-2011-FORM 26(14-9-2012).pdf | 2018-08-11 |
| 15 | 747-MUM-2011-CORRESPONDENCE(14-9-2012).pdf | 2018-08-11 |
| 15 | 747-mum-2011-form 26(16-3-2011).pdf | 2018-08-11 |
| 16 | 747-MUM-2011-CLAIMS(14-9-2012).pdf | 2018-08-11 |
| 16 | 747-mum-2011-form 3(16-3-2011).pdf | 2018-08-11 |
| 17 | 747-MUM-2011-ASSIGNMENT(9-4-2012).pdf | 2018-08-11 |
| 17 | 747-MUM-2011-FORM 5(14-9-2012).pdf | 2018-08-11 |
| 18 | 747-MUM-2011-REQUEST FOR POST-DATING(15-3-2012).pdf | 2018-08-11 |
| 18 | 747-MUM-2011-ABSTRACT(14-9-2012).pdf | 2018-08-11 |