6 (4 Hydroxy Phenyl 3 Styryl 1 H Pyrazolo(3,4 B) Pyridine 4 Carboxylic

6 (4 Hydroxy Phenyl 3 Styryl 1 H Pyrazolo(3,4 B) Pyridine 4 Carboxylic Acid Amide Derivatives As Kinase Inhibitors

Abstract: 6-(4-Hydroxy-phenyl)-3-styryl-1 H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I, in which R1, R2, R3, R4 and R5 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Patent Information

Application #

Filing Date

12 September 2011

Publication Number

52/2014

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

SANOFI

174, AVENUE DE FRANCE, 75013 PARIS

Inventors

1. LOEHN, MATTHIAS

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH, 65926 FRANKFURT AM MAIN

2. MENDEZ-PEREZ, MARIA

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH, 65926 FRANKFURT AM MAIN

3. PFEIFFER-MAREK, STEFANIA

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH, 65926 FRANKFURT AM MAIN

4. KANNT, AIMO

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH, 65926 FRANKFURT AM MAIN

5. BEGIS, GUILLAUME

C/O SANOFI, DEOARTEMENT BREVETS, 174 AVENUE DE FRANCE 75013 PARIS

6. DUCLOS, OLIVIER

C/O SANOFI, DEOARTEMENT BREVETS, 174 AVENUE DE FRANCE 75013 PARIS

7. JEANNOT, FEDERIC

C/O SANOFI, DEOARTEMENT BREVETS, 174 AVENUE DE FRANCE 75013 PARIS

Specification

PLS SEE ATTACHEMENTS.

Documents

Application Documents

#	Name	Date
1	3128-CHE-2011 FORM-3 12-09-2011.pdf	2011-09-12
1	abstract3128-CHE-2011.jpg	2014-12-22
2	3128-CHE-2011 FORM-2 12-09-2011.pdf	2011-09-12
2	3128-CHE-2011 CORRESPONDENCE OTHERS 14-03-2012.pdf	2012-03-14
3	3128-CHE-2011 FORM-1 12-09-2011.pdf	2011-09-12
3	3128-CHE-2011 FORM-3 14-03-2012.pdf	2012-03-14
4	3128-CHE-2011 CORRESPONDENCE OTHERS 21-02-2012.pdf	2012-02-21
4	3128-CHE-2011 DISCRIPTION(COMPLE)1 12-09-2011.pdf	2011-09-12
5	3128-CHE-2011 DISCRIPTION(COMPLE) 12-09-2011.pdf	2011-09-12
5	3128-CHE-2011 FORM-1 21-02-2012.pdf	2012-02-21
6	3128-CHE-2011 CORRESPONDENCE 12-09-2011.pdf	2011-09-12
6	3128-CHE-2011 ABSTRACT 12-09-2011.pdf	2011-09-12
7	3128-CHE-2011 CLAIMS 12-09-2011.pdf	2011-09-12
8	3128-CHE-2011 CORRESPONDENCE 12-09-2011.pdf	2011-09-12
8	3128-CHE-2011 ABSTRACT 12-09-2011.pdf	2011-09-12
9	3128-CHE-2011 DISCRIPTION(COMPLE) 12-09-2011.pdf	2011-09-12
9	3128-CHE-2011 FORM-1 21-02-2012.pdf	2012-02-21
10	3128-CHE-2011 CORRESPONDENCE OTHERS 21-02-2012.pdf	2012-02-21
10	3128-CHE-2011 DISCRIPTION(COMPLE)1 12-09-2011.pdf	2011-09-12
11	3128-CHE-2011 FORM-3 14-03-2012.pdf	2012-03-14
11	3128-CHE-2011 FORM-1 12-09-2011.pdf	2011-09-12
12	3128-CHE-2011 FORM-2 12-09-2011.pdf	2011-09-12
12	3128-CHE-2011 CORRESPONDENCE OTHERS 14-03-2012.pdf	2012-03-14
13	abstract3128-CHE-2011.jpg	2014-12-22
13	3128-CHE-2011 FORM-3 12-09-2011.pdf	2011-09-12