6 Substituted Pyridazine Compounds As Smarca2 And/Or Smarca4 Degraders

Abstract: The present invention provides 6-substituted pyridazine compounds of formula (I), which are therapeutically useful as SMARCA2 and/or SMARCA4 degraders. These compounds are useful in the treatment and/or delaying progression of diseases or disorders dependent upon SMARCA2 and/or SMARCA4 in a subject. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer or a tautomer or a prodrug thereof.

Patent Information

Application #

Filing Date

01 March 2023

Publication Number

13/2023

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

AURIGENE ONCOLOGY LIMITED

39-40, KIADB Industrial Area, Electronic City Phase II, Hosur Road, Bangalore 560100

Inventors

1. ABBINENI, Chandrasekhar

H. No: 15-21-48/14/G-3, Sri Sai Datta Enclave, Balaji Nagar, Kukatpally, Telangana. Hyderabad 500 072

2. SAMAJDAR, Susanta

Flat # R801, H. M Tambourine, Jaraganahalli, J.P. Nagar 6th Phase Bangalore 560 078

3. KUILA, Bilash

Vill+PO+PS-Shyampur, Dist-Howrah, West Bengal Howrah 711314

4. MUKHERJEE, Subhendu

132/A/3, Thakurbari Street (Kokil Bagan), P.O. Serampore, Hooghly 712201

5. TATYASAHEB GORE, Suraj

Nandur Bk, Taluka: Rahata, Dist: Ahmednagar Maharashtra 413720

Specification

Documents

Application Documents

#	Name	Date
1	202347013810.pdf	2023-03-01
2	202347013810-STATEMENT OF UNDERTAKING (FORM 3) [01-03-2023(online)].pdf	2023-03-01
3	202347013810-FORM 1 [01-03-2023(online)].pdf	2023-03-01
4	202347013810-DECLARATION OF INVENTORSHIP (FORM 5) [01-03-2023(online)].pdf	2023-03-01
5	202347013810-COMPLETE SPECIFICATION [01-03-2023(online)].pdf	2023-03-01
6	202347013810-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [01-03-2023(online)].pdf	2023-03-01
7	202347013810-Proof of Right [04-08-2023(online)].pdf	2023-08-04
8	202347013810-FORM 3 [11-08-2023(online)].pdf	2023-08-11
9	202347013810-FORM 3 [07-02-2024(online)].pdf	2024-02-07
10	202347013810-FORM 18 [30-07-2024(online)].pdf	2024-07-30
11	202347013810-FORM 3 [31-07-2024(online)].pdf	2024-07-31