FORM 2
A BANDAGE WITH ENHANCED HEMOSTATIC EFFECT.
TECHNICAL FIELD OF INVENTION
This invention relates to a bandage with enhanced hemostatic effect. In particular this invention relates to a bandage like Band-Aid brand adhesive bandage consisting of a non-woven fabric impregnated with typha pollen.
BACKGROUND ART


Use of typha powder obtained by grinding dried inflorescence has been disclosed in WO 2004 4039387A1 Patent application No IN 03 00279 published on 2004.05.13 discloses a process for manufacturing a hemostatic agent for stopping bleeding and healing wounds. This invention discloses the steps of selecting items of a plant typha elephantine, separating a cotton like substance from the stems, autoclaving to remove mites, if any, drying and purifying the product, grinding, passing the product through a finely meshed sieve which is then sterilized by subjecting the same to Gamma rays radiation. US patent application 20040161524A1 discloses the use of this plant extract as food and drink. US 20040018261 relates to method and use of extracts of a member of Typhaceae family. This invention suggests the extraction of typha pollen rich in specific actives like flavanol glycoside, alcoholic typha pollen and vinegar typha pollen capsules, sachets, granules, solutions, syrup and the like are produced therefrom.

OBJECT OF THIS INVENTION
This invention relates to a novel bandage having enhanced hemostatic action. Typha pollen in various forms are embedded in a non-woven fabric and found to exhibit hemostatic efficacy. Enhanced hemostatic action is evidenced when a combination of these two are used to cover bleeding wounds. Our findings are that typha pollen impregnated on a non woven fabric at a concentration at which typha alone is not efficacious to render hemostasis shows a efficacy on hemostatic time. Typha powder alone or non-woven fabric alone does not give the shorter hemostat time. When combined with each other typha and non-woven fabric produce lower hemostatic time when applied to bleeding wounds.
Details of data are given herein below:

Samples Time to hemostasis in minutes
1. Untreated non woven fabric 7.62
2. 100 mg Typha pollen powder 7.266
3. 1 mg Typha pollen powder Does not stop bleeding/not able to cover incision
4. Non Woven Fabric with 1 mg Typha pollen powder 4.62
5. Non Woven Fabric with 18mgTypha pollen powder 3.24
6. Gauze Greater than 12 minutes
7. Calcium alginate 5.35

Untreated non-woven fabric and 100 mg typha pollen powder need almost equal time to stop bleeding. Further, it establishes that a combination of non-woven fabric and an amount of Typha which by itself is not able to stop bleeding, shows the minimum time to stop bleeding.
SUMMARY OF THE INVENTION:
This invention relates to a bandage with enhanced hemostatic effect. It comprises a combination of a non-woven fabric and typha pollen impregnated therein. Typha pollen may be used in a powder form or an extract of typha powder may be used for such impregnation.
BRIEF DESCRIPTION OF THE INVENTION WITH RESPECT TO PREFERRED EMBODIMENTS:
The bandage according to this invention may be prepared by impregnation of Typha pollen in a non-woven fabric. The following specific example describes a method of producing this bandage.
Preparation of the solution for impregnation: - A slurry of typha pollen powder was prepared in 1:1 ethanol: water. A broad range of the solution contained 0.25% to 10% of typha pollen powder. A preferred range contained 0.5 to 5% of typha pollen powder.

In step two, the above slurry was impregnated in a non-woven fabric and excess solution was removed by passing through rollers.
The range of deposition of typha pollen powder on a non-woven fabric may be from 1 mg to 50 mg on a 2.5 x 25 cm pad. The preferred range of deposition is 1 mg to 18 mg on 2.5 x 25 cm pad.
The last step is drying of the impregnated non-woven fabric. The treated non-woven fabric is dried at 70°C to 150°C. The bandage obtained may be covered with a fine net to prevent loss of pollen powder before actual contact with the wound.
It is also found that an extract, preferably any solvent extract of typha pollen powder or a non-woven exhibits the same hemostatic ability.
This invention relates to a bandage with enhanced hemostatic effect which comprises a non-woven fabric impregnated with typha pollen.
This invention also includes a method of preparing a bandage with enhanced hemostatic effect which comprises the step of impregnating typha pollen in non-woven fabric.
Obvious alterations and modifications known to persons skilled in the art are within the scope and ambit of this invention and the appended claims.

WE CLAIM:
1 A bandage with enhanced hemostatic effect which comprises non-woven fabric impregnated with typha pollen.
2 The bandage as claimed in claim 1 wherein the said typha pollen is in the powder form.
3 The bandage as claimed in claims 1 and 2 wherein the said bandage has from 0.25% to 10% of Typha pollen impregnated therein.
4 The bandage as claimed in claims 1 and 2 wherein a 2.5 x 25 cm bandage pad has from 1 mg to 18 mg of typha pollen impregnated therein.
5 The bandage as claimed in any of the preceding claims wherein said typha pollen is in powder form.
6 The bandage as claimed in claims 1 to 4 wherein said typha pollen is in the form of a solvent extract of pollen powder.
7. The bandage as claimed in claims 1 to 6 wherein said bandage is covered with a fine net material.

8 A method of preparing a bandage with enhanced hemostatic effect comprising the step of impregnating a non-woven fabric with a slurry extract of typha pollen powder, removing excess fluid there from and drying the same thereafter.
9 The method as claimed in claim 8 wherein said slurry is obtained by slurring said pollen powder in aqueous ethyl alcohol preferably in the range of 1:1.
10 The method as claimed in claims 8 and 9 wherein said drying is effected at 70°C tol50°C.
11 The method as claimed in claims 8 to 10 wherein the surface of the said impregnated fabric is covered with a fine net.
12 A bandage with enhanced hemostatic effect substantially as herein described.
Dated this // day of February 2005

(Karuna Goleria) of DePENNING & DePENNING Agent for Applicants