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A Bone Benefitting Composition, And Method Of Preparation There Of

Abstract: The present disclosure provides for a composition comprising: a) Adhatoda vasica U@ extract; and b) Cissus quadrangularis extract, wherein the Adhatoda vasica extract to the Cissus quadrangularis extract weight ratio is in a range of 1:1.2 to 1:5. The compositions of the present disclosure are effective in improving bone health. The process for preparing the composition has also been disclosed herein.

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Patent Information

Application #
Filing Date
22 May 2019
Publication Number
48/2020
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
iprdel@lakshmisri.com
Parent Application

Applicants

ITC LIMITED
ITC LIFE SCIENCES & TECHNOLOGY CENTRE #3, 1ST MAIN, PEENYA INDUSTRIAL AREA, PHASE-1, BANGALORE 560 058, INDIA

Inventors

1. DSOUZA, Avin
Life Sciences and Technology Centre, ITC Limited, #3, 1st Main, Peenya Industrial Area, Phase I, Bangalore 560 058, India
2. GOPAL, Ganesh
Life Sciences and Technology Centre, ITC Limited, #3, 1st Main, Peenya Industrial Area, Phase I, Bangalore 560 058, India

Specification

1. A composition comprising:
a) Adhatoda vasica extract; and
b) Cissus quadrangularis extract,
U@ wherein the Adhatoda vasica extract to the Cissus quadrangularis
extract weight ratio is in a range of 1:1.2 to 1:5.
2. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
to the Cissus quadrangularis extract weight ratio is in a range of 1:1.5 to 1:4.
3. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
QP@ has a weight percentage in a range of 0.0008 % to 0.0016% with respect to
the composition.
4. The composition as claimed in claim 1, wherein the Cissus quadrangularis
extract has a weight percentage in a range of 0.0024% to 0.0032% with
respect to the composition.
QU@ 5. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
comprises total alkaloids in a range of 2-4% with respect to the Adhatoda vasica extract, and vasicine in a range of 1-2% with respect to the Adhatoda vasica extract.
6. The composition as claimed in claim 1, wherein the Cissus quadrangularis
RP@ extract comprises ketosterones in a range of 10-12% with respect to the
Cissus quadrangularis extract, and natural calcium in a range of 1-2% with respect to the Cissus quadrangularis extract.
7. The composition as claimed in claim 1, wherein the composition further
comprises at least one excipient selected from a group consisting of carriers,
RU@ diluents, flavouring agents, colouring agents, emulsifiers, buffering agents,
sweeteners, and combinations thereof.
8. A process for preparing a composition as claimed in claim 1, said process
comprises:
a) obtaining the Adhatoda vasica extract;
SP@ b) obtaining the Cissus quadrangularis extract; and

c) contacting the Adhatoda vasica extract, and the Cissus
quadrangularis extract, to obtain the composition.
9. A process for preparing the composition as claimed in claim 7, said process
comprises:
U@ a) obtaining the Adhatoda vasica extract;
b) obtaining the Cissus quadrangularis extract;
c) obtaining the at least one excipient; and
d) contacting the Adhatoda vasica extract, the Cissus quadrangularis extract, and the at least one excipient, to obtain the composition.
QP@ 10. The composition as claimed in any one of the claims 1-6, wherein the
composition inhibits the production of tartarate resistant acid phosphatase (TRAP) and inhibits activity of cathepsin K. 11. The composition as claimed in any one of the claims 1-6, wherein the composition inhibits osteoclast mediated bone resorption.

Documents

Application Documents

# Name Date
1 201941020365-DRAWING [07-05-2024(online)].pdf 2024-05-07
1 201941020365-STATEMENT OF UNDERTAKING (FORM 3) [22-05-2019(online)].pdf 2019-05-22
2 201941020365-FORM 1 [22-05-2019(online)].pdf 2019-05-22
2 201941020365-FER_SER_REPLY [07-05-2024(online)].pdf 2024-05-07
3 201941020365-OTHERS [07-05-2024(online)].pdf 2024-05-07
3 201941020365-DRAWINGS [22-05-2019(online)].pdf 2019-05-22
4 201941020365-FER.pdf 2023-11-20
4 201941020365-DECLARATION OF INVENTORSHIP (FORM 5) [22-05-2019(online)].pdf 2019-05-22
5 201941020365-FORM 18 [24-04-2023(online)].pdf 2023-04-24
5 201941020365-COMPLETE SPECIFICATION [22-05-2019(online)].pdf 2019-05-22
6 Correspondence by Agent_Form1-Power of Attorney(Form26)_10-07-2019.pdf 2019-07-10
6 201941020365-Proof of Right (MANDATORY) [03-07-2019(online)].pdf 2019-07-03
7 201941020365-FORM-26 [03-07-2019(online)].pdf 2019-07-03
8 Correspondence by Agent_Form1-Power of Attorney(Form26)_10-07-2019.pdf 2019-07-10
8 201941020365-Proof of Right (MANDATORY) [03-07-2019(online)].pdf 2019-07-03
9 201941020365-FORM 18 [24-04-2023(online)].pdf 2023-04-24
9 201941020365-COMPLETE SPECIFICATION [22-05-2019(online)].pdf 2019-05-22
10 201941020365-FER.pdf 2023-11-20
10 201941020365-DECLARATION OF INVENTORSHIP (FORM 5) [22-05-2019(online)].pdf 2019-05-22
11 201941020365-OTHERS [07-05-2024(online)].pdf 2024-05-07
11 201941020365-DRAWINGS [22-05-2019(online)].pdf 2019-05-22
12 201941020365-FORM 1 [22-05-2019(online)].pdf 2019-05-22
12 201941020365-FER_SER_REPLY [07-05-2024(online)].pdf 2024-05-07
13 201941020365-STATEMENT OF UNDERTAKING (FORM 3) [22-05-2019(online)].pdf 2019-05-22
13 201941020365-DRAWING [07-05-2024(online)].pdf 2024-05-07
14 201941020365-US(14)-HearingNotice-(HearingDate-12-11-2025).pdf 2025-10-07
15 201941020365-FORM-26 [05-11-2025(online)].pdf 2025-11-05
16 201941020365-Correspondence to notify the Controller [11-11-2025(online)].pdf 2025-11-11
17 201941020365-Written submissions and relevant documents [20-11-2025(online)].pdf 2025-11-20
18 201941020365-MARKED COPIES OF AMENDEMENTS [20-11-2025(online)].pdf 2025-11-20
19 201941020365-FORM 13 [20-11-2025(online)].pdf 2025-11-20
20 201941020365-AMMENDED DOCUMENTS [20-11-2025(online)].pdf 2025-11-20

Search Strategy

1 SearchHistoryE_17-11-2023.pdf
1 Searchstrategy-FERstageE_17-11-2023.pdf
2 SearchHistoryE_17-11-2023.pdf
2 Searchstrategy-FERstageE_17-11-2023.pdf