Abstract: The present disclosure provides for a composition comprising: a) Adhatoda vasica U@ extract; and b) Cissus quadrangularis extract, wherein the Adhatoda vasica extract to the Cissus quadrangularis extract weight ratio is in a range of 1:1.2 to 1:5. The compositions of the present disclosure are effective in improving bone health. The process for preparing the composition has also been disclosed herein.
1. A composition comprising:
a) Adhatoda vasica extract; and
b) Cissus quadrangularis extract,
U@ wherein the Adhatoda vasica extract to the Cissus quadrangularis
extract weight ratio is in a range of 1:1.2 to 1:5.
2. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
to the Cissus quadrangularis extract weight ratio is in a range of 1:1.5 to 1:4.
3. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
QP@ has a weight percentage in a range of 0.0008 % to 0.0016% with respect to
the composition.
4. The composition as claimed in claim 1, wherein the Cissus quadrangularis
extract has a weight percentage in a range of 0.0024% to 0.0032% with
respect to the composition.
QU@ 5. The composition as claimed in claim 1, wherein the Adhatoda vasica extract
comprises total alkaloids in a range of 2-4% with respect to the Adhatoda vasica extract, and vasicine in a range of 1-2% with respect to the Adhatoda vasica extract.
6. The composition as claimed in claim 1, wherein the Cissus quadrangularis
RP@ extract comprises ketosterones in a range of 10-12% with respect to the
Cissus quadrangularis extract, and natural calcium in a range of 1-2% with respect to the Cissus quadrangularis extract.
7. The composition as claimed in claim 1, wherein the composition further
comprises at least one excipient selected from a group consisting of carriers,
RU@ diluents, flavouring agents, colouring agents, emulsifiers, buffering agents,
sweeteners, and combinations thereof.
8. A process for preparing a composition as claimed in claim 1, said process
comprises:
a) obtaining the Adhatoda vasica extract;
SP@ b) obtaining the Cissus quadrangularis extract; and
c) contacting the Adhatoda vasica extract, and the Cissus
quadrangularis extract, to obtain the composition.
9. A process for preparing the composition as claimed in claim 7, said process
comprises:
U@ a) obtaining the Adhatoda vasica extract;
b) obtaining the Cissus quadrangularis extract;
c) obtaining the at least one excipient; and
d) contacting the Adhatoda vasica extract, the Cissus quadrangularis extract, and the at least one excipient, to obtain the composition.
QP@ 10. The composition as claimed in any one of the claims 1-6, wherein the
composition inhibits the production of tartarate resistant acid phosphatase (TRAP) and inhibits activity of cathepsin K. 11. The composition as claimed in any one of the claims 1-6, wherein the composition inhibits osteoclast mediated bone resorption.
| # | Name | Date |
|---|---|---|
| 1 | 201941020365-DRAWING [07-05-2024(online)].pdf | 2024-05-07 |
| 1 | 201941020365-STATEMENT OF UNDERTAKING (FORM 3) [22-05-2019(online)].pdf | 2019-05-22 |
| 2 | 201941020365-FORM 1 [22-05-2019(online)].pdf | 2019-05-22 |
| 2 | 201941020365-FER_SER_REPLY [07-05-2024(online)].pdf | 2024-05-07 |
| 3 | 201941020365-OTHERS [07-05-2024(online)].pdf | 2024-05-07 |
| 3 | 201941020365-DRAWINGS [22-05-2019(online)].pdf | 2019-05-22 |
| 4 | 201941020365-FER.pdf | 2023-11-20 |
| 4 | 201941020365-DECLARATION OF INVENTORSHIP (FORM 5) [22-05-2019(online)].pdf | 2019-05-22 |
| 5 | 201941020365-FORM 18 [24-04-2023(online)].pdf | 2023-04-24 |
| 5 | 201941020365-COMPLETE SPECIFICATION [22-05-2019(online)].pdf | 2019-05-22 |
| 6 | Correspondence by Agent_Form1-Power of Attorney(Form26)_10-07-2019.pdf | 2019-07-10 |
| 6 | 201941020365-Proof of Right (MANDATORY) [03-07-2019(online)].pdf | 2019-07-03 |
| 7 | 201941020365-FORM-26 [03-07-2019(online)].pdf | 2019-07-03 |
| 8 | Correspondence by Agent_Form1-Power of Attorney(Form26)_10-07-2019.pdf | 2019-07-10 |
| 8 | 201941020365-Proof of Right (MANDATORY) [03-07-2019(online)].pdf | 2019-07-03 |
| 9 | 201941020365-FORM 18 [24-04-2023(online)].pdf | 2023-04-24 |
| 9 | 201941020365-COMPLETE SPECIFICATION [22-05-2019(online)].pdf | 2019-05-22 |
| 10 | 201941020365-FER.pdf | 2023-11-20 |
| 10 | 201941020365-DECLARATION OF INVENTORSHIP (FORM 5) [22-05-2019(online)].pdf | 2019-05-22 |
| 11 | 201941020365-OTHERS [07-05-2024(online)].pdf | 2024-05-07 |
| 11 | 201941020365-DRAWINGS [22-05-2019(online)].pdf | 2019-05-22 |
| 12 | 201941020365-FORM 1 [22-05-2019(online)].pdf | 2019-05-22 |
| 12 | 201941020365-FER_SER_REPLY [07-05-2024(online)].pdf | 2024-05-07 |
| 13 | 201941020365-STATEMENT OF UNDERTAKING (FORM 3) [22-05-2019(online)].pdf | 2019-05-22 |
| 13 | 201941020365-DRAWING [07-05-2024(online)].pdf | 2024-05-07 |
| 14 | 201941020365-US(14)-HearingNotice-(HearingDate-12-11-2025).pdf | 2025-10-07 |
| 15 | 201941020365-FORM-26 [05-11-2025(online)].pdf | 2025-11-05 |
| 16 | 201941020365-Correspondence to notify the Controller [11-11-2025(online)].pdf | 2025-11-11 |
| 17 | 201941020365-Written submissions and relevant documents [20-11-2025(online)].pdf | 2025-11-20 |
| 18 | 201941020365-MARKED COPIES OF AMENDEMENTS [20-11-2025(online)].pdf | 2025-11-20 |
| 19 | 201941020365-FORM 13 [20-11-2025(online)].pdf | 2025-11-20 |
| 20 | 201941020365-AMMENDED DOCUMENTS [20-11-2025(online)].pdf | 2025-11-20 |
| 1 | SearchHistoryE_17-11-2023.pdf |
| 1 | Searchstrategy-FERstageE_17-11-2023.pdf |
| 2 | SearchHistoryE_17-11-2023.pdf |
| 2 | Searchstrategy-FERstageE_17-11-2023.pdf |