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A Coated Lecithin Based Tablets And A Process For Coating Lecithin Based Tables

Abstract: ABSTRACT: This invention relates to a process for coating lecithin based tablets. For this, homogeneous granules are made by using predetermined size HPMC. And granulated lecithin and powdered phycocyanin are mixed. After this, coating the tablets made with proper composition of adding a coating material comprising of mixture of HPMC, Diethyl Phthalate, Phycocyanin and Ethyl Cellulose. And this invention helps effectively to reduce excipients. Further above said granules mix with phycocyanin power went moisture barrier coating for avoiding moisture absorption in end users in the form of tablets suitable for ingesting orally.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
14 February 2013
Publication Number
43/2014
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
aamohan@iprightsindia.com
Parent Application

Applicants

E.I.D. PARRY (INDIA) LIMITED
'DARE HOUSE', 4TH FLOOR, #234, N.S.C. BOSE ROAD, CHENNAI - 600 001

Inventors

1. DR. RAMANAN EZHIL ARASAN
DESIGNATION: ADVISOR, 'DARE HOUSE', 4TH FLOOR, #234, N.S.C. BOSE ROAD, CHENNAI - 600 001
2. MR. SAJIV KUMAR MENON
DESIGNATION: BUSINESS HEAD BIO AND NUTRA DIVISION, 'DARE HOUSE', 4TH FLOOR, #234, N.S.C. BOSE ROAD, CHENNAI - 600 001

Specification

FIELD OF INVENTION
This invention relates to the tableting or compressing de-oiled phosphatides (lecithin in powder form), more commonly known as granular lecithin, into a solid and cohesive form with phycocyanin powder and further made a moisture barrier coated tablet suitable for ingesting orally.

BACKGROUND OF INVENTION
According to the Food Chemicals Codex, 3rd Edition, granular lecithin is referred to as a material where the preponderance of triglycerides and fatty acids are removed and the product contains 90% or more of phosphatides representing all or certain fractions of the total phosphatide complex. Major manufacturers of oil-free lecithin have agreed upon a 95% A.I., or acetone-insolubles minimum.

OBJECTIVE OF INVENTION
Liquid and granular lecithin has long been recognized as a nutritional, dietary source of choline. This invention offers a viable alternative to the already available liquid-lecithin gelatin capsules, some of which contain up to 50% soybean oil. Commercially available granular lecithin tablets are known to contain high percentages of undesirable excipients and/or fillers, commonly used to aid in the tableting process or to create bulk for the active ingredient. In some instances, the lecithin is used as a base material for other active ingredients, i.e., vitamins and minerals. The highest content of granular lecithin found in a dry-pressed tablet has been 42%. Problems normally associated with the tableting of granular lecithin include poor flow ability and stickiness. Consequently, these inherent characteristics can produce low weight tablet, sticking, and breakage of the tablet upon ejection from tableting press. These problems were solved simply by adding a substantial amount of excipient like HPMC and made encapsulated lecithin in granules form. Surprisingly, the instant invention effectively reduced excipients. And further above said granules mix with prtycocyanin power and made the tablets and further went moisture barrier coating for to avoid moisture absorption in end users form.

PROBLEM SOLVED IN INVENTION:
1. Reduced excipients addition in lecithin tablet compare with existing lecithin tablet products.

2. Made granules lecithin with the help of HPMC (excipient) and avoided stickiness issues (while tableting) and solved each tablet weight variations (in finished tablets).

3. Made mositure barrier coating for to avoid moisture absorption in end user form of tablets.

DESCRIPTION OF INVENTION:
The characteristics most critical to the tableting process include: moisture content, flowability, and the stickiness of the de-oiled lecithin.

The flowability of the material, as determined by moisture content, stickiness and/or variability in particle size is important insofar as it determines how consistently and evenly the die cavities are filled as they rotate on the die table. Uneven or low fill weights will produce variable tablet weights as well as sticking and breakage of the tablets.

Powder form of lecithin is a very hygroscopic material; environmental conditions play a vital role in keeping the moisture content below critical levels. High temperatures and relative humidity levels can elevate the moisture content to a point where the flowability is seriously reduced, even in short exposure periods.

The mixture of granular lecithin and excipient can be compressed into any suitable form, where the method of compaction would sufficiently compress and densify the blend. The preferred excipient in this process is classed as a cellulose based materials.

This process involves the tableting of de-oiled soybean phosphatides suitable for oral ingestion. The soy phosphatides, or granular lecithin, possessing an appropriate moisture level and fulfilling the requirements set for aerated density and percent compressibility, are first dry blended with a preferred excipient (HPMC) and made lecithin graules.

This dry-granules lecithin is then mix well with phycocyanin and put through a tableting press at compaction pressures sufficient to form a solid and cohesive mass. More particularly, we have discovered that the moisture level in the granular lecithin should be below about 2%.

The solid, non-brittle dosage may then be coated with any suitable food grade moisture barrier materials, so as to provide not only a shiny, finished surface, but to strengthen the tablet and to retard the hygroscopicity of the lecithin.

KEY POINTS OF PHYCOLIV INVENTION

1. First time we made product in the composition of lecithin and phycocyanin for liver health.

2. Phycocyanin Pigment is an Algal Bile Protein admixed with Lecithin phospholipids.

3. Phycocyanin is a powerful hepatic antioxidant when admixed with Lecithin could synergistically help prevent liver cell damage.

Uses:

1) Helps improve liver health overall

2) Promotes Liver health in people with Diabetes, Obesity, alcoholic and non alcoholic Fatty liver.

WE CLAIM
1. A process for coating lecithin based tablets, characterized in that it consists of the successive stages of:

a. preparing a homogenous granules of lecithin by mixing Lecithin powder with HPMC of predetermined size by using sievers.

b. preparing a mixture of granulated lecithin with powdered phycocyanin.

c. preparing lecithin tablets with the said mixture of granulated lecithin and Phycocyanin powder

d. further coating the prepared tablets by spraying a coating material comprising of mixture of HPMC, Diethyl Phthalate, phycocyanin and Ethyl Cellulose as anti moisture coating.

e. drying thereafter the coated tablets, and

f. collecting and storing the dried coated tablets

2. The process as claimed in claim 1, wherein said lecithin is atleast in the range of 80-90% by weight of the tablet composition.

3. The process as claimed in claim 1, wherein said phycocyanin is atleast in the range of 10-20% by weight of the tablet composition.

4. The process as claimed in claim 1, wherein coating material is atleast 5 -10%.

5. The process as claimed in claim 1 wherein the moisture level is atleast in the range of 3 - 8% by weight of the tablet composition.

6. A coated lecithin based tablet containing a mixture of granulated lecithin and powdered phycocyanin and coated with a coating material comprising of mixture of HPMC, Diethyl Phthalate, Phycocyanin and Ethyl Cellulose.

Dated this on the 13th day of February, 2013.

Applicant's Name: E.I.D. Parry (India) Limited

Documents

Application Documents

# Name Date
1 651-CHE-2013 ABSTRACT 14-02-2013.pdf 2013-02-14
1 651-CHE-2013 POWER OF ATTORNEY 14-02-2013.pdf 2013-02-14
2 651-CHE-2013 CLAIMS 14-02-2013.pdf 2013-02-14
2 651-CHE-2013 FORM-5 14-02-2013.pdf 2013-02-14
3 651-CHE-2013 CORRESPONDENCES OTHERS 14-02-2013.pdf 2013-02-14
3 651-CHE-2013 FORM-3 14-02-2013.pdf 2013-02-14
4 651-CHE-2013 DESCRIPTION (COMPLETE) 14-02-2013.pdf 2013-02-14
4 651-CHE-2013 FORM-2 14-02-2013.pdf 2013-02-14
5 651-CHE-2013 FORM-1 14-02-2013.pdf 2013-02-14
6 651-CHE-2013 DESCRIPTION (COMPLETE) 14-02-2013.pdf 2013-02-14
6 651-CHE-2013 FORM-2 14-02-2013.pdf 2013-02-14
7 651-CHE-2013 CORRESPONDENCES OTHERS 14-02-2013.pdf 2013-02-14
7 651-CHE-2013 FORM-3 14-02-2013.pdf 2013-02-14
8 651-CHE-2013 CLAIMS 14-02-2013.pdf 2013-02-14
8 651-CHE-2013 FORM-5 14-02-2013.pdf 2013-02-14
9 651-CHE-2013 ABSTRACT 14-02-2013.pdf 2013-02-14
9 651-CHE-2013 POWER OF ATTORNEY 14-02-2013.pdf 2013-02-14