Claims:1. A composition for cosmetic inhibition of skin pigmentation, said composition comprising:
a. chrysin; and
b. xanthohumol,
wherein chrysin to xanthohumol molar ratio is in the range of 1:0.025 to 1:2.
2. The composition as claimed in claim 1, wherein chrysin to xanthohumol molar ratio is in the range of 1:0.15-1:1.
3. A composition for promoting epithelial wound closure, said composition comprising:
a. chrysin; and
b. xanthohumol,
wherein chrysin to xanthohumol molar ratio is in the range of 1:.05:1:2.
4. The composition as claimed in claim 3, wherein chrysin to xanthohumol molar ratio is in the range of 1:1-1:2.
5. A formulation for topical application to inhibit skin pigmentation, said formulation comprising:
a. chrysin; and
b. xanthohumol,
wherein chrysin to xanthohumol molar ratio is in the range of 1:0.025-1:2.
6. The formulation a claimed in claim 5, wherein chrysin to xanthohumol molar ratio is in the range of 1:0.15-1:1,
7. A formulation for topical application to promote epithelial wound closure, said formulation comprising:
a. chrysin; and
b. xanthohumol,
wherein chrysin to xanthohumol molar ratio is in the range of 1:0.5 to 1:2.
8. The formulation as claimed in claim 7, wherein chrysin to xanthohumol molar ratio is in the range of 1:1-1:2.
9. The formulation as claimed in any of the claims 5-8, further comprising at least one chelant, at least one structurant, at least one emollient, at least one feel enhancer, at least one neutralizer, at least one preservative, and combinations thereof.
10. A method of preparing a composition as claimed in any of the claims 1-4 or a formulation as claimed in any of the claims 5-9.
11. A method of inhibiting skin pigmentation, said method comprising:
a. obtaining a composition as claimed in any of the claims 1-2 or a formulation as claimed in any of the claims 5-6 or 9; and
b. contacting said composition or formulation with skin,
wherein said method inhibits skin pigmentation.
12. A method of promoting epithelial wound closure, said method comprising:
a. obtaining a composition as claimed in claim 3-4 or a formulation as claimed in any of the claims 7-9; and
b. contacting said composition or formulation with site of wound,
wherein said method promotes epithelial wound closure.
13. A formulation for topical application to inhibit skin pigmentation or promote epithelial wound closure, said formulation comprising:
a. water having weight percentage of q.s. to 100%;
b. disodium EDTA having weight percentage of 0.05%;
c. carbomer having weight percentage of 0.05%;
d. xanthum gum having weight percentage of 0.1%;
e. glycerine having weight percentage of 3%;
f. butylene glycol having weight percentage of 2%;
g. caprylic/capric triglyceride having weight percentage of 4%;
h. isopropyl myristate having weight percentage of 2%;
i. dimethicone having weight percentage of 1%;
j. triethanol amine having weight percentage of 0.08%;
k. chrysin having weight percentage in the range of 0.0001-5%;
l. xanthohumol having weight percentage in the range of 0.0001-7%; and
m. phenoxyethanol having weight percentage of 0.5%.
14. A method of preparing a formulation as claimed in claim 13, comprising the steps of:
a. mixing water, disodium EDTA, carbomer, xanthum gum, glycerine, and butylene glycol in a container under constant stirring at 200-400rpm for 10-20 minutes at a temperature in the range of 22 °C to 27 °C to obtain mix A;
b. adding caprylic/capric triglyceride, isopropyl myristate, and dimethicone to mix A and mixing under constant stirring at 200-400rpm for 5-15 minutes, at a temperature in the range of 22 °C to 27 °C to obtain mix B;
c. adding triethanol amine to mix B and mixing under constant stirring at 300-500rpm for 5-15 minutes at a temperature in the range of 22 °C to 27 °C until a pH in the range of 6.2 to 7.0 is achieved to obtain mix C;
d. adding chrysin and xanthohumol to mix C and mixing under constant stirring at 200-400rpm for 2-10 minutes at a temperature in the range of 22 °C to 27 °C to obtain mix D; and
e. adding phenoxyethanol to mix D and mixing under constant stirring at 200-400rpm for 2-10 minutes to obtain said formulation.
, Description:As Attached