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A Composition Comprising Difluoromethylornithine And Licorice And Uses Thereof
Abstract: The present disclosure provides a composition comprising difluoromethylornithine, and licorice, which at particular weight ratios exhibits enhanced inhibition of ODC enzyme levels, which is a known marker for hair growth. The composition of the present disclosure finds utility in formulations for inhibiting hair growth on skin.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ITC LIMITED
Inventors
1. HEGDE, Ashok
2. KAREMPUDI, Pavani
3. KALSI, Gurpreet
Specification
Claims:1. A composition comprising:
a. difluoromethylornithine; and
b. licorice,
wherein difluoromethylornithine to licorice w/w ratio in said composition is in the range of 1:4 – 1:110.
2. The composition as claimed in claim 1, wherein difluoromethylornithine weight percentage in said composition is 0.00018%, and licorice weight percentage in said composition is in the range of 0.00076-0.02%.
3. The composition as claimed in claim 1, wherein difluoromethylornithine to licorice w/w ratio in said composition is 1: 109.
4. The composition as claimed in claim 3, wherein difluoromethylornithine weight percentage in said composition is 0.000182%, and licorice weight percentage in said composition is 0.02%.
5. The composition as claimed in claim 1, wherein difluoromethylornithine to licorice w/w ratio in said composition is 1: 36.
6. The composition as claimed in claim 5, wherein difluoromethylornithine weight percentage in said composition is 0.000182%, and licorice weight percentage in said composition is 0.0066%.
7. The composition as claimed in claim 1, wherein difluoromethylornithine to licorice w/w ratio in said composition is 1: 12.
8. The composition as claimed in claim 7, wherein difluoromethylornithine weight percentage in said composition is 0.000182%, and licorice weight percentage in said composition is 0.00222%.
9. The composition as claimed in claim 1, wherein difluoromethylornithine to licorice w/w ratio in said composition is 1: 4.
10. The composition as claimed in claim 9, wherein difluoromethylornithine weight percentage in said composition is 0.000182%, and licorice weight percentage in said composition is 0.00076%.
11. The composition as claimed in any of the claims 1-10, further comprising suitable carriers, diluents, and excipients.
12. A method of preparing a composition as claimed in any of the claims 1-11.
13. A method of mitigating follicular hair growth, said method comprising:
a. obtaining a composition as claimed in any of the claims 1-11; and
b. contacting said composition with hair follicles,
wherein said method mitigates follicular hair growth.
14. A composition as claimed in any of the claims 1-11 for use in preparing topical formulations to mitigate follicular hair growth.
, Description:As Attached
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | Sequence listing [30-03-2016(online)].pdf | 2016-03-30 |
| 2 | Form 5 [30-03-2016(online)].pdf | 2016-03-30 |
| 3 | Form 3 [30-03-2016(online)].pdf | 2016-03-30 |
| 4 | Drawing [30-03-2016(online)].pdf | 2016-03-30 |
| 5 | Description(Complete) [30-03-2016(online)].pdf | 2016-03-30 |
| 6 | 201641011202-Power of Attorney-170516.pdf | 2016-07-20 |
| 7 | 201641011202-Form 1-170516.pdf | 2016-07-20 |
| 7 | 201641011202-FER_SER_REPLY [31-03-2021(online)].pdf | 2021-03-31 |
| 8 | 201641011202-Correspondence-F1-PA-170516.pdf | 2016-07-20 |
| 9 | 201641011202-FORM 18 [27-03-2020(online)].pdf | 2020-03-27 |
| 9 | 201641011202-FER.pdf | 2020-07-01 |
| 10 | 201641011202-FORM 18 [27-03-2020(online)].pdf | 2020-03-27 |
| 10 | 201641011202-FER.pdf | 2020-07-01 |
| 11 | 201641011202-FORM 4(ii) [30-12-2020(online)].pdf | 2020-12-30 |
| 11 | 201641011202-Correspondence-F1-PA-170516.pdf | 2016-07-20 |
| 12 | 201641011202-Form 1-170516.pdf | 2016-07-20 |
| 12 | 201641011202-FER_SER_REPLY [31-03-2021(online)].pdf | 2021-03-31 |
| 13 | 201641011202-Correspondence to notify the Controller [30-04-2021(online)].pdf | 2021-04-30 |
| 14 | Description(Complete) [30-03-2016(online)].pdf | 2016-03-30 |
| 14 | 201641011202-Written submissions and relevant documents [19-05-2021(online)].pdf | 2021-05-19 |
| 15 | Drawing [30-03-2016(online)].pdf | 2016-03-30 |
| 15 | 201641011202-PatentCertificate30-06-2021.pdf | 2021-06-30 |
| 16 | 201641011202-IntimationOfGrant30-06-2021.pdf | 2021-06-30 |
| 16 | Form 3 [30-03-2016(online)].pdf | 2016-03-30 |
| 17 | 201641011202-US(14)-HearingNotice-(HearingDate-06-05-2021).pdf | 2021-10-17 |
| 17 | Form 5 [30-03-2016(online)].pdf | 2016-03-30 |
| 18 | 201641011202-RELEVANT DOCUMENTS [14-08-2023(online)].pdf | 2023-08-14 |
Search Strategy
| 1 | TPOtodayAE_05-04-2021.pdf |
| 2 | TPOsearchstrategyE_30-06-2020.pdf |