View All Documents & Correspondence
A Composition Comprising Ferulic Acid, And Alpha Lipoic Acid And Uses Thereof
Abstract: The present disclosure provides a composition comprising ferulic acid and alpha lipoic acid, which at particular w/w ratios enhances inhibition of intracellular cholesterol synthesis. Also provided are formulations comprising the said composition, and methods thereof.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ITC LIMITED
Inventors
1. KUDTARKAR, Kavita Gopalkrishna
2. KS, Nandakumar
3. CHANDRASEKHARAN, Lakshmanan Chittur
Specification
Claims:1. A composition for inhibition of intracellular cholesterol synthesis, said composition comprising:
- ferulic acid; and
- alpha lipoic acid,
wherein ferulic acid to alpha lipoic acid w/w ratio in said composition is in the range of 0.9:1-0.1:1.
2. The composition as claimed in claim 1, wherein ferulic acid to alpha lipoic acid w/w ratio in said composition is in the range of 0.8:1-0.2:1.
3. The composition as claimed in claim 1, wherein ferulic acid weight concentration in said composition is in the range of 5-8µg/ml, and alpha lipoic acid weight concentration in said composition is in the range of 10-25µg/ml.
4. A method of preparing a composition as claimed in any of the claims 1-3.
5. A formulation for inhibition of intracellular cholesterol synthesis, said formulation comprising:
- ferulic acid;
- alpha lipoic acid; and
- suitable carriers, diluents, and excipients,
wherein ferulic acid to alpha lipoic acid w/w ratio in said formulation is in the range of 0.9:1-0.1:1.
6. The formulation as claimed in claim 5, wherein ferulic acid to alpha lipoic acid w/w ratio in said formulation is in the range of 0.8:1-0.2:1.
7. A method of preparing a formulation as claimed in any of the claims 5-6.
8. A method of inhibiting intracellular cholesterol synthesis, said method comprising:
- obtaining a composition as claimed in any of the claims 1-3; and
- contacting said composition with the intracellular milieu of a cell capable of cholesterol synthesis,
wherein said method inhibits intracellular cholesterol synthesis.
9. A method of inhibiting intracellular cholesterol synthesis, said method comprising:
- obtaining a formulation as claimed in any of the claims 5-6; and
- contacting said formulation with the intracellular milieu of a cell capable of cholesterol synthesis,
wherein said method inhibits intracellular cholesterol synthesis.
10. A composition as claimed in any of the claims 1-3, optionally further comprises at least one suitable carrier, diluent, and excipient for use in inhibiting intracellular cholesterol synthesis.
, Description:As Attached
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 5679-CHE-2015-FER.pdf | 2020-03-18 |
| 1 | Form 5 [21-10-2015(online)].pdf | 2015-10-21 |
| 2 | 5679-CHE-2015-FORM 18 [05-09-2019(online)].pdf | 2019-09-05 |
| 2 | Form 3 [21-10-2015(online)].pdf | 2015-10-21 |
| 3 | 5679-CHE-2015-Correspondence-071215.pdf | 2016-06-09 |
| 3 | Drawing [21-10-2015(online)].pdf | 2015-10-21 |
| 4 | 5679-CHE-2015-Form 1-071215.pdf | 2016-06-09 |
| 4 | Description(Complete) [21-10-2015(online)].pdf | 2015-10-21 |
| 5 | 5679-CHE-2015-Power of Attorney-071215.pdf | 2016-06-09 |
| 6 | 5679-CHE-2015-Form 1-071215.pdf | 2016-06-09 |
| 6 | Description(Complete) [21-10-2015(online)].pdf | 2015-10-21 |
| 7 | 5679-CHE-2015-Correspondence-071215.pdf | 2016-06-09 |
| 7 | Drawing [21-10-2015(online)].pdf | 2015-10-21 |
| 8 | 5679-CHE-2015-FORM 18 [05-09-2019(online)].pdf | 2019-09-05 |
| 8 | Form 3 [21-10-2015(online)].pdf | 2015-10-21 |
| 9 | 5679-CHE-2015-FER.pdf | 2020-03-18 |
| 9 | Form 5 [21-10-2015(online)].pdf | 2015-10-21 |
Search Strategy
| 1 | 5679-CHE-2015SearchstrategyE_16-03-2020.pdf |