CLIAMS:1. A composition of:
a. embelin; and
b. at least one anti-fungal agent selected from the group consisting of ketoconazole, and zinc pyrithione,
wherein said composition inhibits growth of dandruff causing fungal pathogens.
2. The composition as claimed in claim 1, wherein said composition inhibits growth of Malassezia species.
3. The composition as claimed in any of the claims 1-2, wherein embelin weight percentage in said composition is in the range of 0.01-5%, and at least one anti-fungal agent weight percentage in said composition is in the range of 0.000006-0.01%.
4. The composition as claimed in any of the claims 1-2, wherein embelin to at least one anti-fungal agent w/w ratio in said composition is in the range of 1:0.0005-1:0.015.
5. A formulation comprising of a composition as claimed in any of the claims 1-4.
6. The formulation as claimed in claim 5, further comprising of:
a. at least one diluent;
b. at least one chelator;
c. at least one colorant;
d. at least one surfactant;
e. at least one structurant
f. at least one neutralizer;
g. at least one conditioner;
h. at least one preservative;
i. at least one thickener;
j. at least one acidifier; and
k. at least one fragrance.
7. The formulation as claimed in any of the claims 5-6, wherein
a. said at least one at least one diluent weight percentage is in the range of 20% to 95%;
b. said at least one chelator weight percentage is in the range of 0.005% to 4%;
c. said at least one colorant weight percentage is in the range of 0.0001% to 3%;
d. said at least one surfactant weight percentage is in the range of 0.1% to 70%;
e. said at least one structurant weight percentage is in the range of 0.01% to 5%;
f. said at least one neutralizer weight percentage is in the range of 0.005% to 3%;
g. said at least one conditioner weight percentage is in the range of 0.01% to 5%;
h. said at least one preservative weight percentage is in the range of 0.005% to 2%;
i. said at least one thickener weight percentage is in the range of 0.1% to 7%;
j. said at least one acidifier for desired pH; and
k. said at least one fragrance as per desired impact or likeability profile.
8. The formulation as claimed in any of the claims 5-7, wherein embelin to at least one anti-fungal agent w/w ratio in said formulation is in the range of 1:0.0005-1:0.015.
9. A method of reducing dandruff by inhibiting growth of dandruff causing fungal pathogen, said method comprising of:
a. obtaining a composition as claimed in any of the claims 1-4 or a formulation as claimed in any of the claims 5-8; and
b. contacting said composition or said formulation topically with dandruff causing fungal pathogen,
wherein said method inhibits dandruff causing fungal pathogen.
10. A composition as claimed in any of the claims 1-4 or a formulation as claimed in any of the claims 5-8 for use in inhibiting dandruff causing fungal pathogens.
11. A formulation comprising of:
a. 67.24 % by weight of water;
b. 0.1% by weight of disodium ethylenediaminetetraacetate;
c. 0.001% by weight of color;
d. 5% by weight of coamidopropyl betaine (29%);
e. 0.5% by weight of carbomer;
f. 20% by weight of sodium lauryl ether sulphite.1EO (70%);
g. 2% by weight of coconut monoethanolamide;
h. 0.75% by weight of sodium hydroxide;
i. 0.2% by weight of polyquaternium 10;
j. 0.2% by weight of dimethyloldimethyl hydantoin;
k. 0.0025% by weight of zinc pyrithione or 0.000625% by weight of ketoconazole;
l. 1% by weight of embelin;
m. 3% by weight of sodium chloride;
n. citric acid for desired pH; and
o. fragrance for desired impact or likeability profile.
12. A method of preparing a formulation as claimed in claim 11, said method comprising of:
a. dispersing carbomer in deionized water to form a carbomer dispersion;
b. adding disodium ethylenediaminetetraacetate, color, and coamidopropyl betaine (29%) to a);
c. mixing sodium lauryl ether sulphate.1EO (70%), and coconut monoethanolamide at 300 rpm at room temperature for 5-10 minutes and heating at 50-70°C to form a solution;
d. adding solution of c) to b) to form a liquid mixture;
e. neutralizing liquid mixture of d) with sodium hydroxide to obtain a neutralized solution;
f. mixing water, polyquaternium 10 and dimethyloldimethyl hydantoin at 300 rpm at room temperature for 5-10 minutes and heating at 40-50°C to form a solution;
g. adding solution of f) to neutralized solution of e) to form a mix;
h. adding zinc pyrithione or ketoconazole, and embelin to mix of g) to form a system;
i. thickening system of h) with sodium chloride to reach a desired viscosity of 3000 cps and adjust the final pH with citric acid to 5.5; and
j. adding fragrance to i) to obtain said formulation.
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