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A Composition Comprising Phlorizin, And Citrulline And Uses Thereof
Abstract: The present disclosure provides a composition comprising phlorizin, and citrulline, which at particular weight ratios exhibits enhanced expression of MMP9 gene transcripts, which is a biomarker for reduction of scarring during epidermal wound healing.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ITC LIMITED
Inventors
1. KUMARI, Deva
2. CHANDRASEKHARAN, Lakshmanan Chittur
3. BANDYOPADHYAY, Balaji
Specification
Claims:1. A composition comprising:
a. phlorizin; and
b. citrulline,
wherein phlorizin to citrulline w/w ratio in said composition is in the range of 1:8.75-1:75.
2. The composition as claimed in claim 1, wherein phlorizin weight percentage in said composition is in the range of 0.002-0.008%, and citrulline weight percentage in said composition is in the range of 0.07-0.15%.
3. The composition as claimed in claim 1, wherein phlorizin to citrulline w/w ratio in said composition is 1:20
4. The composition as claimed in claim 3, wherein phlorizin weight percentage in said composition is 0.005%, and citrulline weight percentage in said composition is 0.1%.
5. The composition as claimed in any of the claims 1-4, further comprising suitable carriers, diluents, and excipients.
6. A method of preparing a composition as claimed in any of the claims 1-5.
7. A method of inhibiting scarring in epithelial wound healing, said method comprising:
a. obtaining a composition as claimed in any of the claims 1-5; and
b. contacting said composition with site of epithelial wound,
wherein said method inhibits scarring in epithelial wound healing.
8. An adhesive patch for topical application comprising a composition as claimed in any of the claims 1-5.
9. A composition as claimed in any of the claims 1-5 for use in preparing formulations to inhibit scarring in epidermal wound healing.
, Description:As Attached
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 201641010902-IntimationOfGrant29-09-2023.pdf | 2023-09-29 |
| 1 | Sequence listing [29-03-2016(online)].pdf | 2016-03-29 |
| 2 | 201641010902-PatentCertificate29-09-2023.pdf | 2023-09-29 |
| 2 | Form 5 [29-03-2016(online)].pdf | 2016-03-29 |
| 3 | Form 3 [29-03-2016(online)].pdf | 2016-03-29 |
| 3 | 201641010902-Written submissions and relevant documents [26-09-2023(online)].pdf | 2023-09-26 |
| 4 | Drawing [29-03-2016(online)].pdf | 2016-03-29 |
| 4 | 201641010902-FORM-26 [11-09-2023(online)].pdf | 2023-09-11 |
| 5 | Description(Complete) [29-03-2016(online)].pdf | 2016-03-29 |
| 5 | 201641010902-Correspondence to notify the Controller [08-09-2023(online)].pdf | 2023-09-08 |
| 6 | 201641010902-US(14)-HearingNotice-(HearingDate-12-09-2023).pdf | 2023-08-10 |
| 6 | 201641010902-Power of Attorney-040516.pdf | 2016-07-14 |
| 7 | 201641010902-Form 1-040516.pdf | 2016-07-14 |
| 7 | 201641010902-FER_SER_REPLY [28-09-2022(online)].pdf | 2022-09-28 |
| 8 | 201641010902-Correspondence-F1-PA-040516.pdf | 2016-07-14 |
| 8 | 201641010902-Annexure (.txt) [21-06-2022(online)].txt | 2022-06-21 |
| 9 | 201641010902-FORM 18 [27-03-2020(online)].pdf | 2020-03-27 |
| 9 | 201641010902-Response to office action [21-06-2022(online)].pdf | 2022-06-21 |
| 10 | 201641010902-FER.pdf | 2021-10-17 |
| 10 | 201641010902-FORM 4(ii) [20-04-2021(online)].pdf | 2021-04-20 |
| 11 | 201641010902-Response to office action [19-07-2021(online)].pdf | 2021-07-19 |
| 12 | 201641010902-FER.pdf | 2021-10-17 |
| 12 | 201641010902-FORM 4(ii) [20-04-2021(online)].pdf | 2021-04-20 |
| 13 | 201641010902-FORM 18 [27-03-2020(online)].pdf | 2020-03-27 |
| 13 | 201641010902-Response to office action [21-06-2022(online)].pdf | 2022-06-21 |
| 14 | 201641010902-Annexure (.txt) [21-06-2022(online)].txt | 2022-06-21 |
| 14 | 201641010902-Correspondence-F1-PA-040516.pdf | 2016-07-14 |
| 15 | 201641010902-FER_SER_REPLY [28-09-2022(online)].pdf | 2022-09-28 |
| 15 | 201641010902-Form 1-040516.pdf | 2016-07-14 |
| 16 | 201641010902-Power of Attorney-040516.pdf | 2016-07-14 |
| 16 | 201641010902-US(14)-HearingNotice-(HearingDate-12-09-2023).pdf | 2023-08-10 |
| 17 | 201641010902-Correspondence to notify the Controller [08-09-2023(online)].pdf | 2023-09-08 |
| 17 | Description(Complete) [29-03-2016(online)].pdf | 2016-03-29 |
| 18 | 201641010902-FORM-26 [11-09-2023(online)].pdf | 2023-09-11 |
| 18 | Drawing [29-03-2016(online)].pdf | 2016-03-29 |
| 19 | Form 3 [29-03-2016(online)].pdf | 2016-03-29 |
| 19 | 201641010902-Written submissions and relevant documents [26-09-2023(online)].pdf | 2023-09-26 |
| 20 | Form 5 [29-03-2016(online)].pdf | 2016-03-29 |
| 20 | 201641010902-PatentCertificate29-09-2023.pdf | 2023-09-29 |
| 21 | 201641010902-IntimationOfGrant29-09-2023.pdf | 2023-09-29 |
Search Strategy
| 1 | 201641010902searchE_25-09-2020.pdf |