Abstract: The present disclosure relates to a composition comprising oleanolic acid, amino acid, dipeptide, and peptide for enhanced dermal barrier protection and maintenance. The present disclosure also provides a formulation comprising said composition for topical cosmetic application to delay skin aging.
CLIAMS:1. A composition for enhanced epidermal barrier maintenance and protection, said composition comprising:
a. oleanolic acid;
b. amino acid;
c. dipeptide; and
d. peptide.
2. The composition as claimed in claim 1, wherein the amino acid is L-histidine.
3. The composition as claimed in claim 1, wherein the dipeptide is L-carnosine.
4. The composition as claimed in claim 1, wherein the peptide is selected from the group consisting of Ala-Ala-Asp, and Ile-Glu-Pro-Asp, preferably Ile-Glu-Pro-Asp.
5. The composition as claimed in claim 1, wherein the concentration of oleanolic acid is in the range of 0.5-4µM, preferably 2µM.
6. The composition as claimed in claim 1, wherein the concentration of amino acid is in the range of 0.5-4mM, preferably 2.5mM.
7. The composition as claimed in claim 1, wherein the concentration of dipeptide is in the range of 5-50mM, preferably 20mM.
8. The composition as claimed in claim 1, wherein the concentration of peptide is in the range of 2-20µM, preferably 10µM.
9. The composition as claimed in claim 1, wherein the w/w ratio of oleanolic acid: amino acid : dipeptide : is 1:424: 4596: 5.4
10. A formulation for topical application comprising the composition as claimed in claim 1, further comprising suitable carriers, excipients or diluents.
,TagSPECI:As Attached
| # | Name | Date |
|---|---|---|
| 1 | SRP.txt.txt | 2014-02-21 |
| 2 | IDF7 SRP COMPLETE SPECIFICATION AS FILED.pdf | 2014-02-21 |
| 3 | FORM 5.pdf | 2014-02-21 |
| 4 | FORM 3.pdf | 2014-02-21 |
| 5 | FIGURES-IDF-7 SRP.pdf | 2014-02-21 |
| 6 | 799-CHE-2014 POWER OF ATTORNEY 07-05-2014.pdf | 2014-05-07 |
| 7 | 799-CHE-2014 FORM-1 07-05-2014.pdf | 2014-05-07 |
| 8 | 799-CHE-2014 CORRESPONDENCE OTHERS 07-05-2014.pdf | 2014-05-07 |
| 9 | 799-CHE-2014-FORM 18 [10-01-2018(online)].pdf | 2018-01-10 |
| 10 | 799-CHE-2014-FER.pdf | 2019-11-22 |
| 1 | searchstrategy_14-11-2019.pdf |