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A Composition For Enhanced Dermal Extracellular Maintenance And Protection And Uses Thereof

Abstract: The present disclosure relates to a composition comprising oleanolic acid, amino acid, dipeptide, and peptide for enhanced dermal barrier protection and maintenance. The present disclosure also provides a formulation comprising said composition for topical cosmetic application to delay skin aging.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
19 February 2014
Publication Number
35/2015
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
lsmds@lakshmisri.com
Parent Application

Applicants

ITC LIMITED
ITC-LIFE SCIENCE AND TECHNOLOGY CENTER #3, 1st Main, Peenya Industrial Area, Phase 1, Bangalore - 560 058

Inventors

1. JOIS, Prashanth
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
2. KUMARI, Deva
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
3. H, Ramya
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
4. SRINIVASAN, Yuvaraj
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
5. DIXIT, Ajay Kumar
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
6. CHANDRASEKHARAN, Lakshmanan Chittur
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore - 560 058
7. BANDYOPADHYAY, Balaji
ITC R&D centre, Peenya Industrial Area, Ist Phase, Bangalore- 560 058

Specification

CLIAMS:1. A composition for enhanced epidermal barrier maintenance and protection, said composition comprising:
a. oleanolic acid;
b. amino acid;
c. dipeptide; and
d. peptide.
2. The composition as claimed in claim 1, wherein the amino acid is L-histidine.
3. The composition as claimed in claim 1, wherein the dipeptide is L-carnosine.
4. The composition as claimed in claim 1, wherein the peptide is selected from the group consisting of Ala-Ala-Asp, and Ile-Glu-Pro-Asp, preferably Ile-Glu-Pro-Asp.
5. The composition as claimed in claim 1, wherein the concentration of oleanolic acid is in the range of 0.5-4µM, preferably 2µM.
6. The composition as claimed in claim 1, wherein the concentration of amino acid is in the range of 0.5-4mM, preferably 2.5mM.
7. The composition as claimed in claim 1, wherein the concentration of dipeptide is in the range of 5-50mM, preferably 20mM.
8. The composition as claimed in claim 1, wherein the concentration of peptide is in the range of 2-20µM, preferably 10µM.
9. The composition as claimed in claim 1, wherein the w/w ratio of oleanolic acid: amino acid : dipeptide : is 1:424: 4596: 5.4

10. A formulation for topical application comprising the composition as claimed in claim 1, further comprising suitable carriers, excipients or diluents.
,TagSPECI:As Attached

Documents

Application Documents

# Name Date
1 SRP.txt.txt 2014-02-21
2 IDF7 SRP COMPLETE SPECIFICATION AS FILED.pdf 2014-02-21
3 FORM 5.pdf 2014-02-21
4 FORM 3.pdf 2014-02-21
5 FIGURES-IDF-7 SRP.pdf 2014-02-21
6 799-CHE-2014 POWER OF ATTORNEY 07-05-2014.pdf 2014-05-07
7 799-CHE-2014 FORM-1 07-05-2014.pdf 2014-05-07
8 799-CHE-2014 CORRESPONDENCE OTHERS 07-05-2014.pdf 2014-05-07
9 799-CHE-2014-FORM 18 [10-01-2018(online)].pdf 2018-01-10
10 799-CHE-2014-FER.pdf 2019-11-22

Search Strategy

1 searchstrategy_14-11-2019.pdf