FORM 2 THE PATENTS ACT 1970 [39 OF 1970] & THE PATENTS RULES, 2003 COMPLETE SPECIFICATION [See Section 10; rule 13] "A COMPOUND '2-PYRIDYL DERIVATIVES" AVENTIS CROPSCIENCE GMBH, of Brumngstrasse 50, 65929 Frankfurt am Main, Germany The following specification particularly describes the invention and the manner in which it is to be performed: The present invention relates to a compound 2-pyridyl derivatives'. [0001] This invention relates to compounds having fungicidal activity. [0002] In a first aspect the invention provides the use of a compound of "general formula I. complexes and salts thereof as phytopathogenie fungicides (1) [0003] where [0004] A1 is 2-pyridyI or its N-oxide, each of which may be substituted by up to four groups at least one of which is haloalkyl; [0005] Y is a formula (D) or (E); -L-A2- -L*-A3- (E) [0006] A2 is heterocyclyl or carbocyclyl each of which may be substituted; [0007] A3 is heterocyclyl or carbocyclyl, each of which may be substituted, or acyl; [00081 L is a 3-atom linker, selected from the list: -N(R5)C(=X)N(R6)-t -N(R5)C(-X)CH(R3)-, -CH(R3)N(R5)CH(R4)-, -CH(R3)N(R5)C(=X)-, -N(R3)CH(R4)C(-X)- and -0-N(R5)C(=X)-; wherein A1 is attached to the left hand .side of linker L; [0009] L1 is a 4-atom linker selected from the list: -N(R9)C(-X)-X1-CH(R7)-, -N(R9)C(=X)CH(R7)CH(R8)-, -N(R9)C(=X)C(R7)*C(R8)-% -N(R9)C(R7)=C(R8)-C(=X)--N(R9)C(R7)=C(R8)-SO?-; -N(R9)q|(R7)(R8)-SO2- and -N(R9}C(=X)C(R7)(R8)-X1-: wherein A3 is attached hand side of linker L *: Rl. R2. R3, R4. R7 and R8, whkh may be the same or different, are Rb. cyano, nitro. halogen. -ORb, -SRD or optionally substituted amino; [00111 R5 and R6 which may be the same or different, are Rb, cyano or nitro; or any R1. R3 or R5 group, together with the interconnecting atoms, can form a 3-, 4-. 5- or 6-membered ring with any R2. R4 or R6 or any R1. R2. R3. R4, R5 or R6 group, together with the interconnecting atoms can form a 5- or 6-membered ring with A2; |0012] or R1 and R2. or R7 and R8, together with the intercorlnecting atoms, may form a 3-, 4-. 5- or 6-membered ring, which may be substituted; (0013] RD is alkyl. alkenyl. alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen or acyl; 10014) X is oxygen or sulfur; [00151 X1 is oxygen, sulfur or-N(R9)s and [00161 R-9 is Rb, cyano or nitro. or R9 and A3, R1, R2, R7 or R8, together with the interconnecting atoms, may form a 3-, 4-, 5- or 6-membered ring, which may be substituted. [0017] Preferred substituents on the 2-pyridyl group (A1) are halogen, hydroxy, cyano. nitro, SF5? trialkylsilyl. optionally substituted amino, acyl. or a group -Ra„ - ORa or ~SRa or a group -C(Ra)=N-Q, where Q is -Ra, -ORa, -SRa or optionally substituted amino, wherein Ra is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl each of which may be substituted; or two adjacent substituents together with the atoms to which they are attached form an optionally substituted ring which can contain up to 3 hetero atoms. Preferably, the 2-pyridyl group is substituted at the 3 and/or 5 position. [0018] Preferred compounds are those in which one or more of the following features are present: 10019] A- is optionally substituted phenyl, optionally substituted heterocyclyl, optionally substituted cyclohexyl or optionally substituted cyclopropyl; or [0020] A3 is optionally substituted phenyl, optionally substituted heterocyclyl or acyl; or J00211 R1. R2, R3, R4. R7 and R8 are hydrogen, optionally substituted alkyl, optionally substituted phenyl, cyano, acyl or halogen (more preferably R1 and R- are hydrogen); or R5 and R&" are hydrogen, optionally substituted alkyl or acyl; or R7 and R^ are hydrogen, optionally substituted alkyl or acyl; or R^ is hydrogen or optionally substituted alkyl; or the 2-pyridyl group (A1) is substituted by alkoxy, alkyl, cyano, halogen, nitro, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl or trifluoromethyl, (preferably chlorine or trifluoromethyl). [0022] Many of the compounds of formula I are novel. Therefore, according to a further aspect, the invention provides compounds of formula I where: Y is -L-A2- and: L is -NHC(=X)NH-; and A~ is phenyl optionally substituted by halogen, haloalkyl. phenoxy. alkoxy. alkyl. CN, NC>2, S02-(N-tetrahydropyridinyI), aikylthio, acyl, phenylsulphonyl, dialkylamino, alkyl sulphonyl, benzylsulphonyl, S(phenyl substituted by halogen): or A- is cycloalkyl; or naphthyl optionally substituted by NO2; or L is-NHC(=0)CH(R3); RJ is hydrogen, alkyl, phenyl, halogen or acyloxy; A- is phenyl optionally substituted by halogen. NO? or alkoxy; or thienyl; or imidazolyl; orpyrrolinyl substituted by alkoxy; or L is -CH(R3)N(R5)CH2S RJ is N-aikylcarbamoyl or alkoxycarbonyl; R5 is hydrogen or acyl; A- is phenyl optionally substituted by alkyl. alkoxy, halogen, NO2 haloaikyl or phenoxy; or is naphthyl; or Lis-CH(R3)NHC(=0)-; RJ is N-alkylcarbamoyl or alkoxycarbonyl; A2 is phenyl optionally substituted by alkoxy. halogen. NO2. haloaikyl, phenoxy or phenyl: or is cycloalkyl; or L is -0-NHC(=O)- and A2 is phenyl substituted by alkyl; or Yis-L1-A3-and: O is -NHC(=0)(CH2)2- and A3 is phenyl substituted by alkyl; or O is -NHC(=S)NHCH2-, and A3 is phenyl; or L1 is -NHC(=O)CH(alkyl)S-, and A3 is phenyl; or L* IS -NHC(-O)OCH-, -NHC(-O)(CH2)2-> -NHC(-O)NHCH2-, -NHC(=S)NHCH2-, -N(alkyl)C(=O)CH2O- or -NHC(O0)CH2O; R' is hydrogen; R- is hydrogen or alkoxycarbonyl; AJ is phenyl optionally substituted by halogen, alkyl, phenyl, OH. alkoxy or alkoxycarbonyl: or fluorenyl; or pyridyl optionally substituted by halogen or haloaikyl; or thiadiazolvl substituted by alkyl; or benzthiazolyl optionally substituted by halogen or by phenyl substituted by halogen; or quinolinyl substituted by haloaikyl: or tnazolyl substituted by alkyl or phenyl; or tetrazolyl substituted by alkyl or cycloalkyl; or pyrimidinyl substituted by alkyl; or benzoxazolyl; or imidazolvl substituted by alkyl; or thiazolinvl substituted by alkyl and methylene: or L1 is-NHC(=0)CH(R8)N(R9)-; Rl is hydrogen; R2 is hydrogen or alkyl; R8 and R9 are each hvdroeen or alkvl: A3 is benzoyl optionally substituted by alkyl; or benzyloxycarbonyl; or alkoxycarbonyl; or L1 is-NHC(=O)CH(aIkyl)SO2-; Rl and R- are each hydrogen; A-5 is phenyl: or L1 is -NHC=OCH2X1-; where X1 and A3 form a 2-oxo-N-benzthiazolyl ring which is substituted by halogen; and Rl and R2 are each hydrogen. [0023] The invention also includes any of the compounds specifically exemplified hereinafter. [0024] Any alkyl group may be straight or branched and is preferably of 1 to 10 carbon atoms, especially 1 to 7 and particularly 1 to 5 carbon atoms. . [0025] Any alkenyl or alkynyl group may be straight or branched and is preferably of 2 to 7 carbon atoms and may contain up to 3 double or triple bonds which may be conjugated, for example vinyl, allyl, butadienyl or propargyl. [0026] Any carbocvclvl group may be saturated, unsaturated or aromatic, and contain 3 to 8 ring-atoms. Preferred saturated carbocyclyl groups are cyclopropyl. cyclopentyl or cyclohexyl. Preferred unsaturated carbocyclyl groups contain up to 3 double bonds. A preferred aromatic carbocyclyl group is phenyl. The term carbocylic should be similarly construed. In addition, the term carbocyclyl includes any fused combination of carbocyclyl groups, for example naphthyl, phenanthn'I. indanyl and indenyl. [0027] Any heterocyclyl group may be saturated, unsaturated or aromatic, and contain 5 to 7 ring-atoms up to 4 of which may be hetero-atoms such as nitrogen. oxygen and sulfur. Examples of heterocyclyl groups are furyl, thienyl. pyrrolyl. 2/ 21 pyrrolinyl, pyrrolidinyl. imidazolyl, dioxolanyl, oxazolyl. thiazolyl. imidazolyl, imidazolinyl- imidazolidinyl. pyrazolyl. pyrazolinyl, pyrazolidinyl. isoxazolyl, isothiazolyl- oxadiazolyl. triazolyl, thiadiazolyl, pyranyl, pyridyl, piperidinyl, dioxanvk morpholino. dithianvl, thiomorpholino, pyridazinyl. pvrimidinvl. pyrazinyl, piperazinyl. sulfolanyl. tetrazolyl, triazinyf, azepinyL oxazepinyl, thiazepinyl- diazepinyl and thiazolinyl. In addition, the term heterocyclyl includes fused heterocyclyl groups, for example benzimidazolyl, benzoxazohi, imidazopyridinyl, benzoxazinyl, benzothiazinyl, oxazolopyridinyh benzofuranyl, quinolinyl, quinazolinyl, quinoxalinyl, dihydroquinazolinyl, benzothiazolyi, phthalimido. benzofuranyl, benzodiazepinyl, indolyl and isoindoiyl. The term heterocyclic should be similarly construed. [0028] Any alkyl, alkenyi, alkynyh carbocyclyl or heterocyclyl group, when substituted, may be substituted by one or more substituents. which may be the same or different, and may be selected from the.list: hydroxy; mercapto; azido; nitro; halogen; cyano; acyl; optionally substituted amino; optionally substituted carbocyclyl; optionally substituted heterocyclyl; cyanato; thiocyanato; -SF5; -ORa; - SRa and -Si(Ra)3, where Ra is alkyl. alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted. In the case of any carbocyclyl or heterocyclyl group the Visl includes additionally: aikyi, aikenyi and aikynyi. each of which may be substituted. Preferred substituents on any alkyl, alkenyl or alkynyl group are alkoxy, haloaikoxy or alkylthio, each containing 1 to 5 carbon atoms; halogen; or optionally substituted phenyl. Preferred substituents on any carbocyclyl or heterocyclyl group are alkyl, haloalkyl, alkoxy, haloaikoxy or alkylthio, each containing 1 to 5 carbon atoms; halogen; or optionally substituted phenyl. 31 [0029] In the case of any alkyl group or any unsaturated ring-carbon in any carbocyclyl or heterocyclyl group the list includes a divalent group such as oxo or imino, which may be substituted by, optionally substituted amino, Ra or ~ORa. Preferred groups are oxo. imino, alkylimino. oximino, alkyloximino or hydrazono. [0030] Any amino group, when substituted and where appropriate, may be substituted by one or two substituents which may be the same or different, selected from the list: optionally substituted alkyl. optionally substituted amino, -ORa and acyl groups. Alternatively two substituents together with the nitrogen to which they are attached may form a heterocyclyl group, preferably a 5 to 7-membered heterocyclyl group, which may be substituted and may contain other hetero atoms, for example morpholino, thiomorpholino or piperidinyl. [0031] The term acyl includes the residues of sulfur and phosphorus-containing acids as well as carboxylic acids. Typically the residues are covered by the general formulae -C(-Xa)Rc; -S(O)pRc and -P(=Xa)(ORa)(ORa), where appropriate Xa is O or S, Rc is as defined for Ra, -ORa, -SRa, optionally substituted amino or acyl; and p is 1 or 2. Preferred groups are -C(=0)Rd, -C(-S)Rd,and -S(0)pRd where Rd is alkyl, C1 to C5 alkoxy, C1 to C5 alkylthio, phenyl, heterocyclyl or amino, each of which may be substituted. [0032] By the term "salts" is meant salts the cations or anions of which are known and accepted in the art for the formation of salts for agricultural or horticultural use. Suitable salts with bases include alkali metal (e.g. sodium and potassium), alkaline earth metal (e.g. calcium and magnesium), ammonium and amine (e.g. diethanolamine, triethanolamine, octylamine, morpholine and dioctylmethylamine) salts. Suitable acid addition salts, e.g. formed by compounds of formula I containing an amino group, include salts with inorganic acids, for example hydrochlorides. sulphates, phosphates and nitrates and salts with organic acids for example acetic acid. [0033] Complexes of compounds of the invention are usually formed from a salt of formula MAn23, in which M is a divalent metal cation, e.g. copper, manganese, cobalt, nickel, iron or zinc and An is an anion, e.g. chloride, nitrate or sulfate. [0034] In cases where the compounds of the invention exist as the E and Z isomers, the invention includes individual isomers as well as mixtures thereof [0035] In cases where compounds of the invention exist as tautomeric isomers, the invention includes individual tautomers as well as mixtures thereof. [0036| In cases where the compounds of the invention exist as optical isomers (for example where R1 and R- are different), the invention includes individual isomers as well as mixtures thereof. [0037} The compounds of the invention have activity as fungicides, especially against fungal diseases of plants, e.g. mildews and particularly cereal powdery mildew (Erysiphe graminis) and vine downy mildew {Plasmopara viticold), rice blast (Pyhcularia oryzae\ cereal eyespot (Pseudocercosporella herpotrichoides), nee sheath blight {Pellicularia sasakii), grey mould (Botrytis cinerea), damping off (RhizQctonia solani), wheat brown rust (Puccinia recondita), late tomato or potato blight [Phytophthora infestans), apple scab (Venturia inaequalis), and glume blotch (Leptosphaeria nodorum). Other fungi against which the compounds may be active include other powdery mildews, other rusts, and other general pathogens of Deuteromycete, Ascomycete. Phycomycete and Basidomycete origin. [0038] The invention thus also provides a method of combating fungal pests such as phytopathogenic fungi at a locus infested or liable to be infested therewith, which comprises applying to the locus a compound of formula I or a complex or salt thereof [0039] The invention also provides an agricultural composition comprising a compound of formula I or a complex or salt thereof in admixture with an agriculturally acceptable diluent or carrier. [0040J The composition of the invention may of course include wore than one compound of the invention. [0041] In addition, the composition can comprise one or more additional active ingredients, for example compounds known to possess plant-growth regulant, herbicidal. fungicidal, insecticidal, acaricidal, antimicrobial or antibacterial properties. Alternatively the compound of the invention can be used in sequence with the other active ingredient. [0042] The diluent or carrier in the composition of the invention can be a solid or a liquid optionally in association with a surface-active agent, for example a dispersing agent, emulsifying agent or wetting agent. Suitable surface-active agents include anionic compounds such as a carboxylate, for example a metal carboxylate of a long chain fatty acid; an yV-acylsarcosinate; mono- or di-esters of phosphoric acid with fatty alcohol ethoxylates or alkyl phenol ethoxylates or salts of such esters; fatty alcohol sulfates such as sodium dodecyl sulfate, sodium ocradecyl sulfate or sodium cetyl sulfate; ethoxylated fatty alcohol sulfates; ethoxylated alkylphenol sulfates; lignin sulfonates; petroleum sulfonates; alkyl-aryl sulfonates such as alkyl-benzene sulfonates or lower alkylnaphthalene sulfonates, e.g. butyl-naphthalene sulfonate; salts of sulfonated naphthalene-formaldehyde condensates: salts of sulfonated phenol-formaldehyde condensates; or more complex sulfonates such as the amide sulfonates, e.g. the sulfonated condensation product of oleic acid and TV-methyl taurine; the dialkyl sulfosuccinates, e.g. the sodium sulfonate of dioctyl succinate; acid derivatives of alkyl glycosides and alkylpolyglycosides materials and their metal salts, e.g. alkyl polygjycoside citrate or tartrate materials; or mono-, di- and tri-alkyi esters of citric acid and their metal salts. [0043] Nonionic agents include condensation products of fatty acid esters, fatty alcohols, fatty acid amides or fatty-alkyl- or alkenyl-substituted phenols with ethylene and/or propylene oxide; fatty esters of polyhydric alcohol ethers, e.g. sorbitan fatty acid esters; condensation products of such esters with ethylene oxide. e.g. polyoxyethylene sorbitan fatty acid esters; alkyl glycosides, alkyl polyglycoside materials: block copolymers of ethylene oxide and propylene oxide: acetylenic glycols such as 2.4,7.9-tetramethyl-5-decyne-4,7-diol, ethoxylated acetylenic glycols; acrylic based graft copolymers; alkoxylated siloxane surfactants: or imidazoline type surfactants, e.g. l-hydroxyethyl-2-alky[imidazoline. [0044] Examples of a cationic surface-active agent include, for instance, an aliphatic mono-, di-, or polyamine as an acetate, naphthenate or oleate; an oxygen-containing amine such as an amine oxide, polyoxyethylene alkylamine or polyoxypropylene alkylamine; an amide-linked amine prepared by the condensation of a carboxylic acid with a di- or polyamine: or a quaternary ammonium salt. [0045] The compositions of the invention can take any form known in the art for the formulation of agrochemicals, for example, a solution, an aerosol, a dispersion, an aqueous emulsion, a microemulsion, a dispersible concentrate, a dusting powder, a seed dressing, a fumigant, a smoke, a dispersible powder, an emulsifiable concentrate, granules or an impregnated strip. Moreover it can be in a suitable form for direct application or as a concentrate or primary composition which requires dilution with a suitable quantity of water or other diluent before application. [0046] A dispersible concentrate comprises a compound of the invention dissolved in one or more water miscible or semi-water miscible solvents together with one or more surface active and/or polymeric material. Addition of the formulation to water results in the crystallisation of the active ingredient, the process being controlled by the surfactants and/or polymers resulting in a fine dispersion. [0047] A dusting powder comprises a compound of the invention intimately mixed and ground with a solid pulverulent diluent, for example, kaolin. [0048] An emulsifiable concentrate comprises a compound of the invention dissolved in a water-immiscible solvent which forms an emulsion or microemulsion on addition to water in the presence of an emulsifying agent. [0049] A granular solid comprises a compound of the invention associated with similar diluents to those that may be employed in dusting powders, but the mixture is granulated by known methods. Alternatively it comprises the active ingredient absorbed or coated on a pre-formed granular carrier, for example. Fuller's earth, attapulgite, silica or limestone grit. [0050] Wettable powders, granules or grains usually comprise the active ingredient in admixture with suitable surfactants and an inert powder diluent such as clay or diatomaceous earth. [0051] Another Suitable concentrate is a flowable suspension concentrate which is formed by grinding the compound with water or other liquid, surfactants and a suspending agent. [0052] The concentration of the active ingredient in the composition of the present invention, as applied to plants is preferably within the range of 0.0001 to 1,0 per cent by weight, especially 0.0001 to 0.01 per cent by weight. In a primary composition, the amount of active ingredient can vary widely and can be, for example, from 5 to 95 per cent by weight of the composition. [0053] The invention is generally applied to seeds, plants or their habitat. Thus, the compound can be applied directly to the soil before, at or after drilling so that the presence of active compound in the soil can control the growth of fungi which may attack seeds. When the soil is treated directly the active compound can be applied in any manner which allows it to be intimately mixed with the soil such as by spraying, by broadcasting a solid form of granules, or by applying the active ingredient at the same time as drilling by inserting it in the same drill as the seeds. A suitable application rate is within the range of from 5 to 1000 g per hectare, more preferably from 10 to 500 g per hectare. J0054] Alternatively the active compound can be applied directly to the plant by, for example, spraying or dusting either at the time when the fungus has begun to appear on the plant or before the appearance of fungus as a protective measure. In both such cases the preferred mode of application is by foiiar spraying- It is generally important to obtain good control of fungi in the early stages of plant growth, as this is the time when the plant can be most severely damaged. The spray or dust can conveniently contain a pre- or post-emergence herbicide if this is thought necessary. Sometimes, it is practicable to treat the roots, bulbs, tubers or other vegetative propagule of a plant before,or during planting, for example, by dipping the roots in a suitable liquid or solid composition. When the active compound is applied directly to the plant a suitable rate of application is from 0.025 To 5 kg per hectare, preferably from 0.05 to I kg per hectare. [0055] In addition, the compounds of the invention can be applied to harvested fruits, vegetables or seeds to prevent infection during storage. [00561 In addition, the compounds of the invention can be applied to plants or parts thereof which have been genetically modified to exhibit a trait such as fungal and/or herbicidal resistance. [0057] In addition the compounds of the invention can be used to treat fungal infestations in timber and in public health applications. [0058] Compounds of the invention may be prepared, in known manner, in a variety of ways. Such processes for the preparation of novel compounds of formula I constitute a feature of the invention. [0059] Compounds of formula la. i.e. compounds of general formula I where Y is a formula (D) and L is -N(R5)C(=X)NH-. can be prepared by reacting compounds of formula II or their hydrochloride salts, with compounds of formula III according to reaction scheme 1. A preferred base is triethylamine. Scheme [0060] Compounds of formula lb. i.e. compounds of general formula I where Y is of formula (D) and L is -N(R5)C(0)CH(R3)-, may be prepared by reacting compounds of formula IV with compounds of formula II according to reaction scheme 2. A variety of methods are available to the chemist, for example, generation of the acid chloride of IV. using reagents such as phosphoryl chloride or oxalyl chloride, followed by addition of II. Alternatively, carbonyl diimidazole (CDI) can . be used to activate compounds of formula IV prior to addition of II_ Scheme 2 eg. POCI301-CDI -*- (lb) (II) [0061] Compounds of formula Ic and Id. i.e. compounds of general formula I where Y is of formula (D) and L is -CH(R3)-N(R5)-W- and W is -C-X)- or -CH(R4) wherein RJ is alkoxycarbonyl or carbamoyl respectively, can be prepared by various methods known to the skilled chemist. In particular, compounds of formula Ic or Id may be prepared from solid supponed reagents of formula V according to reaction scheme 3. wherein the black circle represents Merrifield resin. Scheme 3 (Id) (0062] Compounds of formula Ie. i.e. compounds of general formula I where Y is of formula (D) anc* L is -CH(R3)N(R5)C(=X)- may be prepared by reacting compounds of formula VI with compounds of formula VII according to reaction scheme 4. (VI) Scheme 4 A2C(=X)CI(VII)/ Et3N (0063] Compounds of formula If. i.e. compounds of general formula I where Y is of formula (B) and O is -N(R9)C(=X)-L2-. where I2 is -CH(R7)CH(R8)-, -C(R8)fR7)-X1- or -C(R7)=C(R8K may he prepared according to Scheme 5 by reacting compounds of formula VIII or their hydrochloride salts with compounds of formula IX in the presence of a base, where Q' is a leaving group such as halogen, preferably chlorine. A preferred base is triethylamine. Compounds of formula IX can either be isolated or venerated in situ. j J Scheme 5 [0064J Compounds of formula Ig, i.e. compounds of general formula I where Y is of formula (E) and L1 is -N(R9)C(=X)-NH-CH(R7)-, may be prepared according to Scheme 6 by reacting compounds of formula VIII or their hydrochloride salts with compounds of formula X. A preferred base is triethylamine. Scheme 6 [0065] Compounds of formula Ih, i.e. compounds of general formula I where Y is of formula (E) and L* is -N(R9)C(=X)-aR7)(R8)-Xl- wherein R7 and R8 are not both hydrogen and X is oxygen, may also be prepared according to Scheme 7 by reacting compounds of formula XI where 0 'is a leaving group, preferably bromine, with A--X'-H in the presence of a suitable base, preferably potassium tert-butoxide. Scheme 7 ]0066| Compounds of formula Ii. i.e. compounds of general formula I where Y is of formula t'E) and Ll is -N(R9)C(R7)=C(R8)-C(=X)- wherein R7 is not hydrogen, may be prepared according to Scheme 8 by reacting compounds of formula VIII or their hydrochloride salts in the presence of a suitable base such as sodium acetate with compounds of formula XIL Scheme 8 1> [0067] Compounds of formula Ij. i.e. compounds of general formula I where Y is of formula (E) and L1 is -N(R9)CH=CCRS)-C(=X)-. may be prepared according to Scheme 9 by reacting compounds of formula VIII or their hydrochloride salts in the presence of a suitable base such as sodium acetate with compounds of formula XIII. Scheme 9 5 (VIM) (XIII) (lj) [0068] Compounds of formula Ik. i.e. compounds of general formula I where Y is of formula 1.1-2.1 (10H. mi. 3.8 f 1H. bn. 5.0 (2H, br), 6.5 (1H, br). 7.4 (1H, br). 8.0 (1H. s) and8.7(lH,s) 60 s 4-PhO-phenyl m.p. 109-10°C 61 s 2-PhO-phenyl !H N.M.R 5 (ppm) 8.63 (1H. s), 8.1 (2H, d), 7.95 (1H, s), 7.65 (1H, s), 7.65 (IH. d). 7.4-6.9 (8H. m) and 5.1 (2H. d). 62 s 3-Pr'O-phenyl 'H N.M.R 5 (ppm) 8.6 (lH,s). 8.18 (1H,SK 8.04 OH. br). 7.95 (\H. s). 7.35 (1H. t), 6.86 (3H, d), 5.1 (2H. d).4.58UH.mi. 1.35 (6H.cn 63 s 3.4-diCl-phenyl JH N.M.R 5 (ppm) 8.6 flH. s). 8.0 ([H. s), 7.5-7.1 (3H.nU4.9f2H, d). 4.7 (2R d) 64 s 2-MeQ-phenyl ]H N.M.R 5 (ppm) 8.64 (1H. s), 8.05 flH. br), 7.9 (1H. s). 7.85 (1H. br). 7.5 (1H. d). 7.25 (1H. dd). 7.0 (2H. ddl 5.1 (2H. d'). 3.85 (3H. s) 100811 Example 2 ;V-K3-Chloro-5-trifluoromethvl-2-Dvridvl)methvl]-2-nivrorphenvlacetamide (Compound 1081 To a stirred suspension of 2-nitrophenylacetic acid (0.36 gj in dry Toluene (5 ml) at room temperature was added phosphorvi chloride (0.37 g) and stirring was continued overnight. Meanwhile a solution of the amine was prepared. (3-Chloro-5- tnfluoromeihyl-2-pyridyI)methylamine hydrochloride (0.49 g) in dry toluene (5 ml) and triethylamine (1,23 g) was stirred at room temperature for 1 hour and then filtered. The solid was washed with dry toluene and the combined filtrates were added dropvvise to the above suspension of acid chloride with ice-cooling. After addition, the mixture was stirred at room temperature overnight. Dtchloromethane was added and the mixture was washed with water. The aqueous layer was separated and back-extracted with dichioromethane. The combined organic extracts were washed with saturated sodium bicarbonate solution, then brine, then dried (MgSO4), and the solvent removed. The resulting residue was purified by silica gel chromatography eluting with ethyl acetate/light petroleum (b.p. 40-60°C) to give the title product, m.p. 123-4°C. (0082] The following compounds of formula In (see Table B), i.e. compounds of general formula I where Y is of formula (D) and A1 is 3-CI-5-CF3-2-pyridyl, R1 and R.2 are hydrogen and L is -NHC(=0)CH(R3)-, may be prepared by methods analogous to those of Example 2. (in) Table B Cmp R3 A2 m.p. (°C) 101 H thienyl oil 102 ethyl phenyl oil 103 MeC(=0)0- phenyl oil 104 H 2.4-diMeO-phenyl oil 105 phenyl phenyl oil 106 CI phenyl 102-3 Cmp R3 A2 m.p. (°C) 107 H 16-diCl-phenyl 136-9 108 H 2-NO2-phenyl 123-4 109 H 3-CI-phenyl 88-9 110 H 2-Cl~6-F-phenyl 133-4 111 Pri l-imidazolyl 120 112 H 134 |0083J The 'H N.M.R. data of those compounds in Table B which were not solid at room temperature are presented below. Compound 101 *H N.M.R. (CDCI3) 6(ppm) 3.9 (2H. 5), 4,7 (2H, d), 7.0 (2H. d), 7.1 (IH, br.s), 7.3 (2H. m), 7.9 (IH, s) and 8.7 (IH. 5); Compound 102 IH N.M.R. (CDCI3) o(ppm) 0.9 (3H. t). 1.9 (IH. m), 2.25 (IH. m). 3,4 (IH. t), 4.7 (2H. qdi. 6.9 (IH. bs\. 7.2-7.4 (5H. m\. 7.9 (IH. s). £.65 (IH. s); Compound 103 'H N.M.R. (CDCI3) 6(ppm) 2.25 (3H. s), 4.75 <2H, d), 6.2 (IH, s), 7.4 (3H? m), 7.5 (2H. m). 7.7 (IH, bs|. 8.0 (IH. s), 8.75 (IH. 5); Compound 104 1H N.M.R. (CDCI3) o(ppm) 3.65 (2H. s). 3.8 (3H. s), 3.9 (3H, s). 4.7 (2H, d), 6.8-7.0 (3H. m). 7.1 (IH, bs), 7.9 (IH, s), 8.75 (IH, s); and Compound 105 'HN.M.R. (CDCI3) 5(ppm)4.8 C2H. d). 5.1 (IH, s). 7.1-7.4 (IH, m), 7.9 (IH. s) and 8.65 (IH,s). 10084] Example 3 Methvl 2-[(,2-chlorobenzvl)amino1-3-[3-chloro-5-(trifluoromethvl)-2- pyridvllpropanoate (Compound 218) To a mixture of the product from stage h) below in tetrahydroturan 112 mi) and methanol (4 ml) was added IM sodium methoxide in methanol (4 drops) and the mixture was heated at 65°C for 3 days. The mixture was filtered and the solid washed successively with portions (5 ml) of methanol, dichloromethane and methanol. The combined filtrates were evaporated to give the title product. ^H N.M.R 5 tppm) 8.63 f 1H. s). 7.89 (!H. s). 7.15-7.35 (4H. m). 3.92 (3H. mj, 3.74 (3H. s). 3.42 (2H. d). (00851 Preparation of starting materials jV-/7er^Butoxvcarbonvl )giycjne cesium salt To a mixture of N-(tert-butoxycarbony)glycine (42.0 g) in water (250 ml) was added cesium carbonate (39-1 g). The mixture was stirred at room temperature for 10 minutes. The water was removed by azeotropic distillation with toluene to give the title product. 100861 Attachment to Solid Support Merrifield resin (61.2 g) was swollen in dry dimethyiformamide (350 ml). The product from stage a) (75.5. g) was added followed by more dry dimethyiformamide (250 ml) and the mixture was stirred at 65°C overnight. On cooling, the mixture was fiftered and the solid washed successively with portions (400 m\) of dimethyiformamide. dimethylformamide/water (1:1). water, dichloromethane. methanol, dichloromethane and finally methanol , 3.92 (3H. m), 3.74 (3H.SK 3.42 (2H.d) Cmp R3 R5 J A2 Characterising data 219 MeOCrO")- H 2,6-diF-phenyl 'HN.M.R 6 (ppm) 8.62 OH. s), 7.83 flH. s), 7.20 (1H. m). 6.34 (2H. mj. 3.73 (3H. m). 3.68 OH, s), 3.28 (2H. d) 220 MeOCfKM- H J2-N02-phenyl iwziES)418fM+HV Ti 1 MeOC(O)- H 2-naphthyl m/z (ES) 422 (M+HY 222 MeOC(O)- H 3.4-diMeO- phenyl m/z (ES) 433 (M+H)~ 223 MeOC(O)- H 2-CF3-phenyl w/z(ES)441 (M+HV 224 MeOC(O)- H 2.6-diCl-pheny1 [H N.M.R 5 Ippml 8.62 (1H, s). 7.89 flH. 5). 7.1-7.35 Glim). 3.83 (3H. m), 3.72 (3H.S). 3.39 f2H.m) 225 MeOC(=0)- H 3-PhO-phenyi ]H N.M.R 6 (ppm) 8.62 (1H. s), 7.83 (1H. s), 6.3-7.2 (9H. m), 3-79 (3H. m),3.7I (3H. sj. 3.38 (2H. m) 226 EtOC(-O)- H phenyl *H N.M.R S (ppm) 8.62 (1H, s), 7.88 (1H, s), 7.1-7.3 (5H. m), 4.18 (2H. q), 3.79 (3H.m), 3.38 (2H. m), 1.21 (3H. t) 227 EtOC(O)- H 4-MeO-phenyl lH N.M.R 5 (ppm) 8.63 (1H, s), 7.88 (1H, si 7.12 (2H. d). 6.79 (2H. d), 4.10 (2H.q). 3.81 (3H.s).3.73(3R m). 3.38 (2H. mi. 1.23 (3H.t) 228 EtOC(O)- H 2-Cl-phenyl 1H N.M.R 5 (ppm) 8.62 (1H. s). 7.86 (1H, s), 7.1 -7.4 (4H. m>, 4.19 (2H. q), 3.89 (3H. m). 3.40 (2H. m), 1.23 (3H. t) 229 EtOC(O)- H 2.6-diF-phenyl ^H N.M.R 5 (ppmj 8.61 (1H. s). 7.82 (lH.s), 7.21 (lH,m).6.82(2H.t). 4.16 (2H. q), 3.91 (3H. m), 3.38 (2H. d), 1.22 (3H.t) 230 EtOC(O)- H 2 -NO2 -phenyl 1H N.M.R 5 (ppm) 8.62 (1H. s), 7.87 (2H. m). 7.35-7.55 (3H. m) 4.20 (2H. m). 4.08 (2H. ml. 3.36 (m), 3-37 (2H. m), 1.14 (3H.0 WO 01/11965 Cmp R3 R= A2 Characterising daia 231 EtOC(=0)= H 2-naphthyl RM.RStppmiS.ei (IRs). 7.25-7.9'(8R m). 3.8-4.3 (5R m). 3.41 (2H,m). K24(3H.f) 232 EtOC(O)- H 3.4-diMeO phenyl {H N.M.ft 5 (ppm) 8.64 (1R s). 7.89 (IR s). 6.78 (3Rm), 4.19 (2Rq), 3.86 OR s), 3.81 (3R s), 3.75 (2R m). 3.39 (2Rm). 1.24 (3RD 233 EtOC(=OV H 2-CF3-phenyI ]H N.M.R 8 (ppm) 8.66 (1R s). 7.91 (1R s), 7.3-7.65 (4R m}. 4.21 (2R m), 3.98 (3H,m/, 3.41 (3R m'K 1.26 (3R t) 234 EtOC(O)- H 2.4-diCl-phenyl lH N.M.R 5 (ppm) 8.64 (IR s), 7.89 OR s). 7.1-7.35 (3H.m). 4.20 (2R m). 3.86 OR m). 3.40 (2R m), 1.24 (3H. t) 235 EtOC(O)- H 3-PhO-phenyl !H N.M.R 6 (ppm) 8.62 f 1R s), 7.83 (1R s), 6.8-7.4 (9R m), 4.18 (2R q), 3.77 (3H. m), 3.38 (2R m), 1.22 OR t) 236 MeNHC(=0)- H 2-naphthyl m/z (ESI 422 (M+H)' 237 MeNHC(O)- H 2,4-diCl- phenyl m/z(ES)440(M+H)' 238 MeNHC(-O)- H 3-PhO-phenyl m/r{ESU64(M+HV 239 MeOC(=0)- H (phenyl »i/?(ES)373(M+H)_ [00941 Example 4 Methvl 2"bromobenzovlamino-3-('3-chloro-S-trifluoromethvl-2-pvridvl)propionate (Compound 321) To a mixture of the product from Example 3 stage g) in dry dichloromethane was added triethylamine and the solution was stirred for 15 minutes. 2-Bromobenzoyl chloride in dry dichloromethane was added, and the mixture was stirred at room temperature overnight. The mixture was filtered and the solid was washed successively with portions (125 ml) of dichloromethane (x2). methanol, dichloromethane. methanol, dichloromethane (x2), methanol and diethyl ether (x2). TC The solid was dried in a vacuum oven overnight. To this solid in letrahvdrofuran (12 ml) and methanol (4 ml) was added IM sodium methoxide in methanol (4 drops) and the mixture was heated at 65°C for 3 days. The mixture was filtered and the solid washed successively with portions (5 ml) of methanol, dichloromethane and methanol. The combined filtrates were evaporated to give the title product. lH N.M.R 5 ippm) 8.62 fs). 7.31 (s), 7.56 (2H. m), 7.37 (m). 7.29 {m). 5.40 (m). 3.76 (3H,s) and 3.71 (2H, m). (0095J The following compounds of formula Iq (see Table D); i.e. compounds of Jii general formula I where Y is of formula (D) and A1 is 3~Cl-5-CF3-2-pyridyl. R' and R- are hydrogen and L is -CH(R-1)NHC(=0)-, may be prepared by methods analogous to those of Example 4. H (Iq) Table D Cmp R3 A2 Characterising data 301 EtNHC(=0)- 4-MeO-phenyl *H N.M.R 5 (ppm) 8.66 (IH, s), 7.91 (IH, s). 7.89 (IH, d). 7.77 (2H, d). 6,94 (2H. d), 6.32 (IH. d), 6.32 (1H. d). 5.21 (1H. m). 3.97 (3H, s), 3,55 (2H. m), 3.25 (2H. ml. 1.08 (3H,t) 302 EtNHCf^O)- 2.6-diCI-phenyl 'HN.M.RS (ppm) 8.60 (1H. s). 7.91 (IH, s). 7.2-7.4 (3H. m). 6.74 (IH. m), 5.33 (IH, m). 3.62 (2R m), 3.29 (2H. m), 1.12 (3H. t) 303 EtNHC(=0)- cyclo propyl «/r(ES)364(M+H)~ 304 EtNHC(=0> phenyl m/z (BS) 400 (M+HY 305 EtNHC(O)- cyclohexyl m/z (ES) 406 (M+HV Cmp R3 A2 Characterising data 306 EtNHC(=OV 4-Cl-phenyl fli/z(ES)435(M+Hr 307 EtNHC(=0)- 3-NO2-phenyl /w/r (ES) 445 (M+HV 308 EtNHC(O)- 3-CF3-phenyl m/-r(ES)468(M+HV 309 EiNHC(=0)- 4-PhO-phenyl m/z(ES)416(M+HY 310 EtNHC(-O)- 2-Br-phenyl m/z('ES)478(M+Hr 311 MeNHC(-0V cyclopropyl 'HN.M.R 5 (ppm) 8.67 (IH. s), 7.92 (IH, s). 6.70 (IH. bri. 5.09 (IH. m). 3.46 (2H, m), 2.80 OH. m). 1.42 (IH, m). 0.97 (2H, m).0.81 (2H.m> 312 MeNHC(=0)- cyclohexyl ]H N.M.R 5 (ppm) 8.64 (IH.s). 7.91 (IH. s). 7.08 (IH, d|, 6.68 (IH, m), 5.04 (IH. q), 3 A3 (2H, ml 2.73 (3H. mh 1.2-2.3 (33H. m) 313 MeNHC(-O)- 2.6-diCl-phenyl IHN.M.R 6 (ppm) 8.62 (IH. s). 7-85 (IH, s), 7,46 (IH, d). 7.34 (3H. m)? 4.82 (IH, m), 5.36 (IH, m), 3.62 (2H. m), 2.84 (3H. d) 314 MeNHC(^O)- phenyl /n/z(ES)386(M+H)+ 315 MeNHC(=0)- 4-MeO-phenyl m/z(ES)416.(M+Hr 316 MeNHC(-O)- 4-biphenylyl m/z (ES) 462 (M+H)* 317 MeOC(-O)- phenyl lH N.M.R 5 (ppm) 8.95 (IH. s), 7.93 (2H. m). 7.26 (3H. m). 5.38 (IH. m), 3.76 (3H. s),3.70{2H,m> 318 MeOCf-O)- cyclohexyl •HN.M.R 5 (ppm) 8.66 (IH. s). 7.91 (IH, s), 6.63 (IH. d). 5.18 (IH. m), 3.71 (3H, s), 3.57 (2H. m), 1.2-2.15 (1 IH. m) 319 Me0C(O)~ 2,6-diCl-phenyl !H N.M.R 5 (ppm) 8.60 (1H, s), 7.95 (IH. s), 7.28 (3H, mK 1-03 (IH, d). 5.42 (2H. m), 3.74 (5H. m) 320 MeOC(O)- 4-biphenyly! ]H N.M.R 6 (ppm) 8.72 (IH, s), 7.92 (IH. s), 7.35-7.9 (9H. m), 5.39 (IH, m), 3.78 (3H.s).3.70(2H.m) 321 MeOC(=0)- 2-Br-phenyl 'H N.M.R 5 (ppm) 8.62 (IH, s), 7.31 (IH, s), 7.56 (2H. m). 7.37 (IH. m), 7.29 (IH, m), 5.40 (IH, m), 3.76 (3H, s), 3.71 (2H. m) Cmp R3 A2 Characterising data 322 EtOC(=0)- cyclohexyl iHN.M.R 5 tppm) 8.64 (IH. s). 7.92 (IH. s). 6.64 (IH. d), 5.16 (IH. mi. 4.18 (2H, m). 3.59 (2H. m). 0.3-2.2 (1 IH. m). 1.22 (3H, t) 323 EtOC(O)- 4-MeO-phenyi >HN.M.R 5 (ppm) 8.69 (IH. s). 7.91 (IH. s), 7.77 (2H. d). 7.38 (IH. dl 8.92 (2H. d), 5.32 (IH. m). 4.20 (2H. mi. 3.34 (3H. t). 3.67 (2H.m) 324 EiOC(=OV 3-CF3~phenyi ^HN.M.R 5 (ppm) 8.68 (IH. si. 8.06 (IH. s), 7.96 (2H, m), 7.30 (2H. m). 7.60 (2R m). 5.36 (IH. m), 4.21 (2H. mi 3.71 (2H, m). 1.23 (3H,t), 325 Etoa-O)- 2.6-diCl-phenyi fHN.M.RS(ppml 8.62 OH. s>. 7.94 (1H. s). 7.26 (3R m). 7.04 (IH. d). 5.41 (IH, m), 4.21 (2H. m), 3.73 (2H. mj. 1.22 (3R t) 326 EtOC(=0)- 2-Br-phenyl lH N.M.R 5 (ppm) 8.64 (IH. s). 7.93 (IH, s), 7.57 (IH. m). 7.33 (IH, m), 7.26 (IH. m). 5.39 (IH. m), 4.22 (2H, m), 3-75 (2H, ml, 1.23 (3H,t) 327 MeOC(-O). cyclopropyl m/z(ES135l(M+H1' 328 MeOC(=0)- 4-MeO-phenyl m/2(ES)417(M+H)_ 329 MeOC(=0)- 4-Cl-phenyl m/z (ES)42\ (M+H)" 330 MeOC(O)- 3-N02-phenyI m/s (ES) 432 (M+H)" 331 MeOC(O)- 3-CF3-phenyl /»/z(ES)455(M+H)" 332 EtOC(O)- cyclopropyl m/z (ES) 365 (M+H)" 333 EtOC(=0)- phenyl m/z (ES) 401 (M+H)* 334 EiOC(=0)~ 4-Cl-phenyI m/z (ES) 435 (M+H)" 335 EtOC(O)- 3-NCb-phenyI m/z (ES) 446 (M+H)* 336 EtOC(O)- 4-biphenylyi m/z (ES) 477 (M+H)" 337 MeNHC(=0)- 4-CI-phenyl m/z (ES) 420 (M+H)" 338 MeNHC(-O)- j-NCh-phenyl m/z (ES) 431 (M+H)" 339 MeNHC(=0)- 3-CF3-phenyl m/z(ES)454(M+HV 340 MeNHC(-O)- 2-Br-phenyl m/z (ES) 464 (M+H)" f00961 Example 5 jV-f2-f3-Chloro-5-Trifluoromeihvl-2-pvridy])ethv31-2,6-dichlorobenzamide (Compound 401) To a suspension of 2~(3-chloroo-trifluoromethyl-2-pyridyl)ethylammonium chloride (0.2 g) in dry dichloromethane at 10°C was added 2.6-dichlorobenzoyi chloride (0,13 ml) followed by dropwise addition of dry triethylamine (0,3 ml). The mixture was wanned with stirring to 22°C over 18 hours. The mixture was evaporated on to flash silica. Chromatography over silica eluting with 20-50% diethyl ether in light petroleum (b.p. 40-60°C) gave the title product, m.p. 103-5°C. 100971 Preparation of Startiniz Material 2-(3-Chloro-5-trifluoromethvl-2-Pvridvnethvlammonium chloride To a solution of the product from Example 6 (1.0 g) in ethanol (10ml) was added hydrazine hydrate (0.15 ml) and the mixture was heated under reflux for 3 hours. . Concentrated hydrochloric acid (1 ml) was added and the mixture was heated at 80°C for 1 hour to give a filterable precipitate. The mixture was cooled to 10°C. filtered and then evaporated to dryness in vacuo- The residue was dissolved in water (10 ml) and then basified to greater than pH 10 using 2M aqueous sodium hydroxide solution. The aqueous solution was ether extracted (3x15 ml) and the combined .'.o extracts were brine washed (2x10 ml). The organic extract was dried (M2SO4). the filtrate acidified with 6M hydrogen chloride in diethyl ether (5 ml) and evaporated to dryness. The solid residue was triturated with ethyl ether, filtered and dried in vacuo to give the title compound, m.p. 188-92°C [00981 Example 6 2-f2-r3-Chloro-5-i'trifluoromethyl)-2-pvridvl]ethvn-1.3-isoindolinedione (Compound 402) To a solution of the product from Example 7 (5.63 g) in glacial acetic acid (50 ml) was added 48% hydrogen bromide solution (10 ml) and the mixture was heated at 120°C for 2 hours. The cold mixture was evaporated in vacuo and partitioned between water (100 ml) and dichloromethane (100 ml). The aqueous layer was separated and extracted with dichloromethane (2x10 ml). The combined extracts were water washed (2x20 ml), dried (MGSO4), and evaporated onto flash silica. Chromatography over silica eluting with 3-30% diethyl ether in light petroleum (b.p 4G-60°C) gave the title compound, m.p. 147-8°C. [00991 Example 7 Diethyl 2-[3-chloro-5-(trifluoromethvl)-2-pvridvl1-2-rfL3-dioxo-2,3-dihydro-l//-2- isoindolvOmethvnmalonate (Compound 403) To a suspension of 60% sodium hydride (0.65 g) in dry dimethylformamide (20 ml) at 0°C was added a solution of diethyl 2-(3-chloro-5-trifluoromethyi-2-pyridyl)maionate (5 g) in dry dimethylformamide (10 ml) and the mixture was stirred for 15 minutes. A solution of A^bromomethylphthaiimide (3.55 g) in dry dimethylformamide (10 ml) was added dropwise and the mixture was warmed with stirring to 22°C over 18 hours. Glacial acetic acid (1 ml) was added and the mixture was poured into cold water (500 ml). The aqueous solution was extracted with diethyl ether (3x150 ml) and the combined extract was water washed (3x100 ml). The organic extract was dried (MgSO4) and evaporated to give a crude product. Trituration with diethyl ether/light petroleum (b.p. 40-60°C) (1:1) gave the title compound, m.p, 159-61 °C. [01001 Preparation of Starting Materials Diethyl 2-G-chloro-5-trifluorornethyl-2-pvridvl)malonate To a suspension of 60% sodium hydride in mineral oil (5.28 g) in dry dimethylformamide (50 ml) at 0°C was added a solution of diethyl malonate (10 ml) in dry dimethylformamide (25 ml) and the mixture was stirred for 30 minutes. A solution of 2.3-dichloro-5-(lrifluoromethyl)pyridine (9.8 ml) in dry dimethylformamide (10 ml) was added dropwise and the mixture warmed with stirring to 22°C over 18 hours. Acetic acid (7.5 ml) in diethyl ether (20 ml) was added dropwise and the mixture was stirred until hydrogen evolution had ceased. The mixture was diluted with diethvl ether (600 ml) and then water washed (3x200 ml). The organic extract was dried (MgSO4) and evaporated onto flash silica. Chromatography over silica eluting with 0-20% diethyl ether in lighi petroleum (b.p, 40-60°C) gave the title compound. * H N.M.R. (CDCI3) 6(ppm) I -28 (6H. t. 2x CH3CHO. 4.30 (4H. q. 2xCH,CH,), 5.24 (1H. s. CH(CCKEt)2 7.96 (1H. s. pv-H), S.74C1H.S. py-H). 101011 Example 8 (Compound 501) To a solution of 0-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyI} hydroxylamine (0.4 g) and triethylamine (0.18 g) in tetrahydrofuran (20 ml) was added 2.6- dichlorobenzoyl chloride (0.37 g). The reaction mixture was stirred for 20 hours at room temperature before filtering the solution and evaporation of the filtrate. The resulting residue was redissoived in ethyl acetate and washed successively with dilute hydrochloric acid, saturated sodium bicarbonate solution and water. The organic phase was dried, filtered and evaporated to yield the crude product which was further purified by silica gel column chromatography to give the title compound. [01021 Preparation of Starting Material f9-(r3-Chloro-5-(trifluoromethvIV2-pvridvl1methvll hvdroxvlamme To a solution of jV-hydroxyphthalimide (3.55 g) in dimethviformamide (50 ml) was added potassium carbonate (3.0 g) to give a thick, yellow suspension which was Stirred for 1 hour. 3-Chloro-2-chIoromethyl-5-trifluoromethylpyridine (5.0 g) was added and the reaction stirred at room temperature for 20 hours. The mixture was filtered and the filtrate poured into water. The resulting white solid was isolated by filtration, washed with water, redissoived in ethyl acetate and the organic solution dried and evaporated to yield the intermediate phthalimide as a white solid. The phthalimide (2.0 g) was dissolved in methanol (20 ml) and the resulting solution treated with hydrazine hydrate (0.42 g). The reaction was left to stand for 19 hours before heating at reflux for 3 hours to yield a white precipitate. The reaction mixture was filtered and the methanol filtrate evaporated. The residue was treated with diethyl ether and refiltered. Evaporation of the filtrate yielded the title compound as a green yellow oil. (0I03J The following compounds of general formula I where Y is of formula (D) and 5 AI is 3-CIo-CF3-2-pyridyI. R1 and R2 are hydrogen and L is -0-NHC(=O) may be prepared by methods analogous to those of Example 8: Compound 501 m.p. 127-9°C and o Compound 502 m.p. I08-10°C CF. 101041 Example 9 N-[(3-Chjoroo-trifluoromeihvl-2-pvridvl)methvl")-3-(2-tolvnpropionamide (Compound 6021 To a mixture of (3-chioro-5-trifluoromethyl-2-pyridyl)methylamine hydrochloride (1 mmol. 0.247 g) in tetrahvdrofuran (5 ml) was added triethylarnine (2 mmol. 0.202 g) at room temperature and the mixture was stirred at room temperature for I hour. The mixture was filtered and the filtrate added to a solution of 3-(2-tolyl)propionyl chloride (1.1 mmol. 0.2 g) in tetrahvdrofuran (5 ml) at room temperature. After 4 hours stirring at room temperature the solvent was evaporated and the residue washed with water. The solid was filtered and washed with diethyl ether/light petroleum (1:20) to give the title product, m.p. 152-3°C. ■*!' [0105] Example 10 N-Benzvl-N'-(3-chlooro-5-,trifluoromethr\-2-pvridv)methvlthliourea (Compound 604) 5 To a mixture of (,3-chloro-5-trifluoromethyl-2-pyridyr)methylamine hydrochloride (0.12 g) and benzylisothiocyanate (0.11 g J in dry teirahydrofuran (10 ml) was added iriethylamine (10 drops) and the mixture stiired at room temperature for 12 hours. The solvent was evaporated and ethyl acetate added. The mixture was washed with 2M hydrochloric acid and then with saturated sodium bicarbonate solution. The .i o organic laver was separated and the solvent removed to give the title product. ' H N.M.R. S(ppm) 4.7 (2H. broad si. 4.95 (2H. d), 6.9 (1H. broad s). 7.3-7.55 (6H. m), 7.95 (lH.s) and 8.58 (lH,s). |0106I Example 11 .5 .V-r(3-Chloro-5-trifluoromethvl-2-Dvridvhmethvn-2-phenvlthiopropanamide (Compound 615) A mixture of thiophenol (55 mg) and potassium tert-butoxide (56 mg) in teirahydrofuran (5 ml) was stirred at room temperature for 30 minutes. Starting material (see below) (173 mg) was added and the mixture was heated at 65°C with . v stirring for 2 hours. When cool, the mixture was evaporated and the residue was purified by silica gel chromatography to give the title product. H N.M.R. 5(ppm) 1.6 (3h. d). 3.9 (1H, q), 4.67 (2H. d), 7.25 (3H. m). 7.38 (2H. m). 7.9 OH. s), 8-0 (1H. broads) and 8.7 (IH, s). :s [01071 Preparation of starting material .V-rn-Chloro-5-trif]uoromethvI-2-Dvridy)methvll-2-bromopropionamide To a mixture of (3-chloro-5-trifluoromethyl-2-pyridyl)methylamine hydrochloride (1.0 g) in teirahydrofuran (5 ml) and triethylamine (0.41 g) which had been stirred at room temperature for 30 minutes, was added a mixture of 2-bromopropionic acid : o (0.62 g) and carbonyldiimidazole (0.65 g) in tetrahydrofuran (5 ml) which had also been stirred at room temperature for 30 minutes. The combined mixture was stirred at room temperature for 12 hours and then the solvent was removed. The residue was partitioned between diethyl ether and water and the layers separated. The organic phase was dried (MgSO4) and the solvent removed to sive the title product. 5 101081 Example 12 3-0-Chloro-5-trif]uoromethvU2-nvridvl)meth\iamino)-l-phenvlbut-2-enone (Compound 610) To a suspension of (3"Chloro-5-trifluoromethyl^-pyndyl)methylamine hydrochloride (2.5 g) in dry tetrahydrofuran (20 mi) was added anhydrous sodium acetate (1.64 g) and benzoyl acetone (l.62g). The suspension was stirred at 20°C for 18 hours, then heated at 50°C for 4 hours. The mixture was evaporated and the residue partitioned between ethyl acetate and wafer. The organic extracts were dried (MgSO4), filtered and evaporated to give a solid. The solid was triturated with diethyl ether, filtered and washed with diethyl ether to give the title product, m.p. 123-5°C. 101091 Example 13 3-f3-Chloro-5-trifluoromethvl-2-pvridvnmethvlamino)-l-('2.6-dichlorophenvl)- propenone (Compound 612) 2 0 The title compound was prepared in analogous fashion to Example 4 replacing benzoyl acetone with l-(2,6-dichlorophenyI)-3-hydroxypropenone (see below). Purification was performed by silica gel chromatography eluting with 2% triethylamine in diethyl ether/light petroleum (b.p. 40-60aC) (1:1) to give a mixture of E and Z isomers.I H N.MR. S(ppm) 4.54 (2H. m, py-Cto). 4.76 (2H. m. py-^ CH2), 5.24 OH, m, HNCH=CH)7 5.60 OH. m. HNCH=CH). 6,72 (IH. broad s. NH), 7.02-7.35 (8H. m. 2xHNCH=CH-; 6xAr-H), 7.42 (IH. broad s. NH), 7.96 (2H. d. 2xpy4i): 8.7 (IH. s. py-H): 8.86 (IH. s. py-H) and 10,5 (4H. broad s. 2xN+H2CI). [01101 Preparation of starting materials l-(2.6-Dichlorophenvn-3-dimethvlaminopropenone To a solution of 2.6-dichloroacetophenone (2 g) in dry dimethylformamide dimethyl acetal (10 ml) was added pyridinium 4-toIuene sulfonate (0.2 g). The mixture was 5 stirred under nitrogen and heated to reflux for 90 minutes. An azeotrope of dimethylformamide dimethylacetal/methanol was distilled under nitrogen to complete loss of 2.6-dichloroacetophenone by thin layer chromatography. The cold mixture was evaporated to give a solid. The solid was triturated with 10% diethyl ether in light petroleum (b.p. 40-60°C), filtered and washed with the same to give the [0 title compound, m.p. 98-100°C. (0111] l-(2.6-DichlorQphenvlV3-hydroxvpropenone To a solution of the product from stage a) (1,2 g) in acetone (20 ml) and water (2 ml) was added dry Amberlyst 15 resin (2 g) and the mixture was refluxed with stirring '5 under nitrogen for 18 hours. The solution was vacuum filtered and the filtrate evaporated. The residue was dissolved in diethyl ether (50 mi) and dried (MgSO4). The filtrate was presorbed onto silica gel (10 g) and purified by silica gel chromatography gradient eiuting with 20 to 30% diethyl ether in light petroleum (b.p. 40-60°C) to give the title compound. w 101121 Example 14 (9-Fluorenvlmethvl'i JV-f(3-Chloro-5-trif1uoromethvl-2-pvridvnmethvncarbamate (Compound 601) A mixture of the starting material (see below) (1.97 g). dioxane (40 ml), water (20 15 ml) and concentrated hydrochloric acid (10 ml) was refluxed for 48 hours. On cooling, diethyl ether (100 ml) was added and the layers separated. The organic layer was washed with water (50 ml), dried (MgSO4) and the solvent removed to give a solid which was recrystallised from toluene, m.p. 159-61°C. (01131 Preparation of starting material (9-Fluorenvlmethvn A-n'3-chloro-5-trifluoromeihvl-2-PvndvI)-q- ethoxvcarbonvimethvllcarbamate To a mixture of 3-chloroo-trifluoromethyi-2-pyridyl-a-ethoxycarbonylmethyl ammonium chloride (1.91 gj in dichioromethane (25 ml) and triethylamine (0.85 ml). vvas added A'-(9-fluorenylmethoxycarbonyloxy)succinimide (2.02 g) and the mixture was stirred at room temperature for 90 minutes. Water (15 ml) was then added and rhe layers separated. The aqueous phase was extracted with dichioromethane and the combined organic layers were dried (MgSO.4) and the solvent removed. The residue was purified by silica gel chromatography gradient eluting with diethyl ether/light petroleum (b.p. 40-60°O to give the title compound. [0114) The following compounds of formula Ir (see Table E). i.e. compounds of general formula I where Y is of formula (E) and A1 is 3-Cl-5-CF3-2-pyridyl and R1 is hydrogen, may be prepared by methods analogous to the above Examples. (Ir) Table E Cmp L1 R2 A3 m.p. (°C) 601 -NH-C(O)0-CH2- H 9-fluorenyl 159-61 602 -NH-C(-OWCH2)2- H 2-tolyi 152-3 603 -NH-C{=0)NH-CH2- H ■ phenyl oil 604 -NH-C(=S)NH-CH2- H phenyl oil 605 ~NH-C(=0)NH-CH2- H 3-Cl-5-CF3'2-pyridyl 153-4 606 -N(E0-C(=O)CH2O- COoEt phenyl 96-9 Cmp L1 R2 A3 m.p. (°C) 607 -NH-C(=0)CH20- H phenyl 123 608 -NH-C(=Q)CH2S- H phenyl 102-3 609 -NHC(-0)CH=CH- H phenyl 110-1 610 ! -NHC(Me)=CH-a=0)- H phenyl 123-5 611 -NHC(=0)CH=CH- lH 2.6-diCl-phenyl 168-9 612 -NHCH=CH-C0O)- H 2.6-diCl-phenyt 129 613 -NH-C(=0)-C(Me)20- H 4-CI-phenyl 65 614 -NH-C(O)-CH(Me)0- H 2,6-diCl-phenyl 131 615 -NH-C(=0)-CH(Me)S- H phenyl oil 616 -NH-C(O)CH20- H 2.4-diCl-pheny! 149 617 -NH-C(O)CH20- H 4-Cl-phenyl 116 618 -NH-C(0)CH2S- H 3-(4-toivl)-1.2.4-thiadiazol-5- yl 162 619 -NH~C(O)CH20- H 4-tolyI 116 620 -NH-C(=0)CH2CK H 4-Cl-benzthiazol-2-yl 106 621 -NH-C(=0)CH20- H 2-biphenylyl 93 622 -NH-C(=0)CH20- H 3,5-diCI-2-tolyl 100 623 -NH-C(=0)CH2O H 2-Cl-phenyl 82 624 -NH-C(=0)CH2S- H 4.6-diO-3-iolyl 118 625 -NH-C(=0)CH2S- H 4-tolyl 109 626 -NH-C(=0)CH(Me)0- H 4-CI-phenyl oil 627 -NH-C(=0)CH(Me)0- H phenyl 88. 628 -NH-C(-0)CH(Me)0- H 6 Cl-3-tolyl oil 629 -NH-C(=0)CH(Ph)0- H 5-Cl-2-tolyl 150 630 -NH-C(-0}CH(- CH2OMe)0- H 2,4.5-triCl-phenyl 152 631 -NH-C(=0)CH(Me)0- H 2-tolyI 150 632 -NH-C(=0)CH(-CH2OMe)0- H 2,4-diCl-phenyl 80 Cmp Ll R2 A3 m.p. (°C) 633 -NH-Cf=0)CH(Et)0- H 4-CI-2-OH-phenyl 83 634 -NH-C(O)CH(Ph)0- H 2.4.5-triCl-phenyl 138 635 -NH~C(=0)CH(Me)S- H 7-CF3-quinolin-4-yl 131 636 -NH-C(=0)CH(Me)S- H benzihiazol-2-yl 108 637 -NH-C(=0)CH(Me)S- H 3-(2-Cl-phenyl)-1.2.4-thiadiazol-5-yl oil 638 -NH-C(=0)CH(Me)S- H 2-Me-1 -Ph-1.2.4-tnazol~3yl oil 639 -NH-C(=0)CH(Me)S- H 3-Me-1.2.4-thiadiazol-5-yi oil 640 -NH-C(=0)CH(Me)S- H 1 -cyclohexylteirazol-5-yi oil 641 -NH-C(O)CH0vle)S- H oil 642 -NH-C(-0)CH(Me)S- H 5-CF3*benzthiazol-2-yl 120 643 -NH-C(=0)CH(Me)S- H 5-Cl-benzthiazol-2-yI 132 644 -NH-C(0)CH(Me)S- H 2-pyridyl oil 645 -NH-C(=0)CH(Me)S- H 1 -Me-tetrazol-5-yI 98 646 -NH-C(-0)CH(Me)S- H 4,6-diMe-pyrimidin-2-yI 132 647 -NH-C(=0)CH(Me)S- H benzoxazol-2-yt 72 648 -NH-C(0)CH(Me)S- H 2-MeO-phenyl 100 649 -NH-C{=0)CH(Me)S- H l-Me-imidazol-2-yl oil 650 -NH-C(=0)CHfMe)S- H l-Me-1.3.4-triazol-2-yl 98 651 -NH-C(=0)CH(Me)S- H 5-CF3-2-pyridyl 98 652 -NH-C<=0)CH(Me)S- H 5-Me-1.3.4-thiadiazol-2-yl oil 653 -NH-C(=0)CH(Me)S- H 2-(C02Me)-phenyl 118 654 -NH-C{=0)CH(Me)S- H 3-CI -5-CF3-2-pyridyl 104 655 r-NH-C(-0)CH(Me)S- H 2-Cl-phenyl 73 656 -NH-C(=0)CH(Me)S- . H 2.6'diCI-pheny] 75 657 -NH-Cf=0)CH(Me)0- H 4-Br-3.5-diMe-phenyl 121 Compound 603 'H N.M.R. (CDCI3) 6('ppm) 4.4 (2H. s). 4.7 (2H. s). 7.2-7.4 (5H, mi. 7.9 (IH. si and S.65HH.5): 5 Compound 626 !H N.M.R. (CDCI3) ofppm) 1.55 (3H, d). 4.75 OH. m). 6.8 OH. d). 7.2 (2H. d). 7.7 (IH. br.s). 7.85 f IH, s) and 8.6 (IH. s}; Compound 628 lH N.M.R. (CDCI3) S(ppm) 1.55 OH. d). 2.3 OH. s). 4.75 OH. m). 6.65 (IH. m), 6.8(lH.sk 7.2 (lH.m), 7.7 (IH. br.s). 7.85 (lH.s) and 8.6 (lH.s); Compound 637 1H N.M.R. (CDCI3) 6H N.M.R. (CDCl3)5(ppm) 1.15-2.0 (13H. m), 4.0-4.1 (IH. m). 4.6 (2H. s). 7.8 (IH. 5), 8.0 (1R br.s) and 8.6 (1H, s); Compound 641 *H N.M.R. (CDCI3) 5(ppm) 1.25 (3H, s). 1.35 (3H. s). 1.5 OH. d). 4.45 (IH. q). 4.75 (2H, qdj. 5.05 (2H. d), 7.85 (IH. s). 8.15 (IH. br.s) and 8.6 (IH. s): Compound 644 f H N.M.R. (CDCI3) 6(ppm) 1.6 OH. d). 4.5-4.75 (3H. m). 7.0 (IH. t). 7.1 (IH. m), 7.4 (IH. m). 7.8 (IH. s). 8.4 (IH, d). 8.55 (IH. s) and 8.7 (IH. br.s); Compound 649 lH N.M.R. (CDCI3) 5(ppm) 1.5 (3H. d). 3.5 (3R s). 4.15 (1H. q. 4.6 (2R qd). 6. (1R s), 7.0 (IH. s). 7.8 (1R s). 8.65 (\H. s) and 8.75 f lH. br.s); and Compound 652 1H N.M.R. {CDCI3} 6(ppm) 1.6 (3H. d). 2.65 (3R s). 4.65 (3H. mi. 7.8 (IH. ml. 8.15 HRbr.si and 8.6 (IH.s). [0115] The following compounds of formula Is (see Table F). i.e. compounds of general formula I where Y is a formula (E) and A1 is 3-CI-5-CF3-2-pyridyl, R* is hydrogen and L1 is -NHC<=G)CH('R8)N(R9K mav be prepared by methods analogous to the above Examples. (Is) Table F Cmp R2 R8 R9 A3 m.p. (°C) 701 H H H 2-Me-benzoyl 126 702 H Me (racemic) H benzyloxycarbonyl 114 703 H Pr» . H isopropyloxycarbonyl 134 704 H Bui H isopropyloxycarbonyl 142 705 H Bu Me isopropyloxycarbonyl oil 706 Me Pri H isopropyloxycarbonyl 151 707 Me Bu H isopropy loxy carbony 1 134 708 Me Bu Me isopropyloxycarbonyl oil WO 01/11965 Compound 801 m.p. 148°C CF and Compound 802 m.p. 185°C CF [0116] Test Example Compounds were assessed for activity against one or more of the following: Phytophthora infestans: late tomato blight Plasmopara viticola: vine downy mildew Erysiphe graminisf. sp. tritici: wheat powdery mildew Pyricularia oryzae; rice blast Leptosphaeria nodorum, glume blotch [0117] Aqueous solutions or dispersions of the compounds at the desired concentration, including a wetting agent, were applied by spray or by drenching the stem base of the test plants, as appropriate. After a given time, plants or plant parts were inoculated with appropriate test pathogens before or after application of the compounds as appropriate, and kept under controlled environmental conditions suitable for maintaining plant growth and development of the disease. After an appropriate time, the degree of infection of the affected part of the plant was visually estimated. Compounds are assessed on a score of 1 to 3 where 1 is little or no ontrol, 2 is moderate control and 3 is aood to total control. At a concentration of 500 ppm ivrfM or less, the following compounds stored 2 or more against the fungi specified, Phvtophihora infestans: 31 and 105-7. Plasmopara viticola: 50. 55, 104. 105. 201. 21. 221. 222. 224. 225. 227. 230. 232, 233. 234. 235, 328 and 606. Ervswhe graminis i so. tritici: 4,25.26.39,40.44. 101. 20L 214. 304. 305. 306. 308. 310, 312. 313. 603. 606 and 642. Pvricularia arvzae: 111,112. 306. 312, 606. 624. 645. 65Q and 701. Lemowhaerig mdontm: 13. 105. 107. 108.201,229.232.238,317.336 i r and 626. WE CLAIM: 1. A compound '2-pyridyl derivatives' represented by general formula I, complexes and salts thereof R"1 R2 0) where A1 is 2-pyridyl or its N-oxide, each of which is substituted by up to four groups at least one of which is haloalkyl; Y is a formula (D) or (E): -L-A2- (D) -L1-A3- (E) A2 is heterocyclyl or carbocyclyl, each of which may be substituted; A3 is heterocyclyl or carbocyclyl, each of which may be substituted, or acyl; L is a 3-atom linker, selected from the list: -N(R5)C(=X)N(R6)-, - N(R5)C(=X)CH(R3)-, -CH(R3)N(R5)CH(R4)-, -CH(R3)N(R5)C(=X)-, -N(R3)CH(R4)C(=X)- and -0-N(R5)C(=X)-; wherein A1 is attached to the left hand side of linker L; L1 is a 4-atom linker selected from the list: -N(R9)C(=X)- Xi-CH(R7)-, -N(R9)C(=X)CH(R7)CH(R8)-, -N(R9)C(=X)C (R7)=C(R8)-, -N(R9)C(R7)=C(R8)-C(-X)-, -N(R9)C(R7)=C(R8)-SO2-J N(R9)C(-X)C(R7)(R8)-SO2- and -N(R9)C(=X)C(R7)(R8)-Xi-; wherein A1 is attached to the left hand side of linker L1; R1, R2, R3, R4, R7 and R8, which may be the same or different, are Rb, cyano, nitro, halogen, -ORb, -SRb or optionally substituted amino; R5 and R6 which may be the same or different, are Rb, cyano or nitro; or any R1, R3 or R5 group, together with the interconnecting atoms, can -50- form a 3-, 4-, 5- or 6-membered ring with any R2, R4 or R6 or any R1, R2, R3, R4, R5 or R6 group, together with the interconnecting atoms can form a 5- or 6-membered ring with A2; or R1 and R2, or R7 and Rs, together with the interconnecting atoms, may form a 3-, 4-, 5- or 6-membered ring, which may be substituted; Rb is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen or acyl; X is oxygen or sulfur; XI is oxygen, sulfur or -N(R9)-; and R9 is Rb, cyano or nitro, or R9 and A3, R1, R2, R7 or R8, together with the interconnecting atoms, may form a 3-, 4-, 5- or 6- membered ring, which may be substituted. 2. A compound of formula I as defined in claim 1 or a complex or salt thereof in which: Y is -L-A2- and: i) L is -NHC(=X)NH-; and A2 is phenyl optionally substituted by halogen, haloalkyl, phenoxy, alkoxy, alkyl, CN, NO2, S02-(N-tetrahydro-pyridinyl), alkylthio, acyl, phenylsulphonyl, dialkylamino, alkylsulphonyl, benzylsulphonyl, S(phenyl substituted by halogen); or A2 is cycloalkyl; or naphthyl optionally substituted by NO2; or ii) L is -NHC(=0)CH(R3)-; R3 is hydrogen, alkyl, phenyl, halogen or acyloxy; A2 is phenyl optionally substituted by halogen, NO2 or alkoxy; or thienyl; or imidazolyl; or pyrrolinyl substituted by alkoxy; or Hi) L is -CH(R3)N(R5)CH2S R3 is N-alkylcarbamoyl or alkoxycarbonyl; R5 is hydrogen or acyl; A2 is phenyl optionally substituted by alkyl, alkoxy, halogen, NO2, haloalkyl or phenoxy; or is naphthyl; or iv) L is -CH(R3)NHC(=0)-; -51- R3 is N-alkylcarbamoyl or alkoxycarbonyl; A2 is phenyl optionally substituted by alkoxy, halogen, NOa, haloalkyl, phenoxy or phenyl; or is cycloalkyl; or v) L is -O-NHC(=O)- and A2 is phenyl substituted by alkyl; or Yis-L!-A3-and: a) L1 is -NHC(=0)(CH2)2-, and A3 is phenyl substituted by alkyl; or b) L1 is -NHC(=S)NHCH2-, and A3 is phenyl; or c) Li is -NHC(-0)CH(alkyl)S-, and A» is phenyl; or d) L1 is -NHC(=O)OCH2-, -NHC(=0)(CH2)2-, -NHC(=0)NHCH2-, -NHC(=S)NHCH2-, -N(alkyl)C(=0)CH20- or -NHC(=0)CH2O-; R1 is hydrogen; R2 is hydrogen or alkoxycarbonyl; A3 is phenyl optionally substituted by halogen, alkyl, phenyl, OH, alkoxy or alkoxycarbonyl; or fluorenyl; or pyridyl optionally substituted by halogen or haloalkyl; or thiadiazolyl substituted by alkyl; or benzthiazolyl optionally substituted by halogen or by phenyl substituted by halogen; or quinolinyl substituted by haloalkyl; or triazolyl substituted by alkyl or phenyl; or tetrazolyl substituted by alkyl or cycloalkyl; or pyrimidinyl substituted by alkyl; or benzoxazolyl; or imidazolyl substituted by alkyl; or thiazolinyl substituted by alkyl and methylene; or e) L1 is -NHC(=0)CH(Rs)N(R9)-; R1 is hydrogen; R2 is hydrogen or alkyl; R8 and R9 are each hydrogen or alkyl; A3 is benzoyl optionally substituted by alkyl; or benzyloxycarbonyl; or alkoxycarbonyl; or f) Li is -NHC(=0)CH(alkyl)SO2-; R1 and R2 are each hydrogen; A3 is phenyl; or g) L1 is -NHC(=0)CH2X1-; where X1 and A3 form a 2-oxo-N- -52- benzthiazolyl ring which is substituted by halogen; and Rl and R2 are each hydrogen. 3. A fungicidal composition comprising-one or more compounds as claimed in claim 1, or a complex or salt thereof, in admixture with an agriculturally acceptable diluent or carrier, the amount of active ingredient varying from 5 to 95 per cent by weight of the composition. Dated this 25th day of January, 2002. [VINEET ROHILLA] OF REMFRY & SAGAR ATTORNEY FOR THE APPLICANTS -53-