This invention relates to novel N-alkynyl-2-(substiluted phenoxy)alkylamides, to processes for preparing them, to compositions containing them and to methods of using them to combat fungr, especially fungal infections of plants. Certam N'-alkynyl-2-(substituted phenoxy)alkylamides are descnbed in US 4,116,677 and US 4,070,486 as being useful as herbicides or miticides Others are descnbed in US 4,168,319 as being usefiil as mildewicides Thepresent invention is concerned with the provision of particular N-alkynyl-2-(substituted phenoxy)alkylamides for use as plant fungicides Thus according to the present invention there is provided a compound of the general formula (1) (Formula Removed) wherein X, Y and Z are independently H, halogen, C1-4 alkyl (e g. methyl), halo(C1-4)alkyl (e g trifluoromethyl), C2-4 alkenyl, halo(C2-4)alkenyl, C2-4 alkynyl, halo(C2-4)alkynyl, C1-4 alkoxy (e.g methoxy), haIo(C1-4)alkoxy (e g. tnfluoromethoxy), -S(0)n(C1-4)alkyl where n is 0, 1 or 2 and the alkyl group is optionally substituted with fluoro (e.g methylthio, tri-fluoromethylsulphonyl), -OSO2(C1-4)alkyl where the alkyl group is optionally substituted with fluoro (e.g. tnfluoromethylsulphonyloxy), cyano, nitro, C1-4 alkoxycarbonyl, -CONR'R", -COR', -NR'COR" or -NR'COOR'" where R' and R" are independently H or C1-4 alkyl and R"' is C1-4 alkyl (e.g acetyl, -NHCOCH3 and -NHCO2CH3), provided that at least one of X and Z is other than H, R1 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms (e g. 2,2,2-tnfluoroethyl), with a cyano group (e.g cyanomethyi), with a C1-4 alkyl-carbony] group (e g acetylmethyl), with a C1-4 alkoxycarbonyl group (e g methoxy-carbonylmethyl and methoxycarbonylethyl) or with a hydroxy group (e g. hydroxymethyl), R2 is H, C1-4 alkyl, C1-4 alkoxymethyl or benzyloxymethyl m which the phenyl ring of the benzyl moiety is optionally substituted with C1-4 alkoxy; R3 and R4 are independently H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl provided that both are not H and that when both are other than H their combmed total of carbon atoms does not exceed 4, or R3 and R1 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one O, S or N atom and optionally substituted with halo or C1-4 alkyl; and R5 is unsubstituted C3-4 alkyl, unsubstituted C3-6 cycloalkyl or C1-4 alkyl or C3-6 cycloalkyl in which the alkyl and cycloalkyl groups are substituted with halo, hydroxy, C1-6 alkoxy, cyano. C1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di(Ci. 4)alkylaminocarbonyloxy, -S(0)n(C1-6)alkyl where n is 0, 1 or 2, triazolyl (e.g. 1,2,4-triazol-1-yl), tri(C1-4)alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy, in which the optionally substituted phenyl and thienyl rings of phenoxy, thienyloxy, benzyloxy and thienylmethoxy are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C2-4 alkenyloxy, C2-4 alkynyloxy, halo(C1-4)alkyl, halo(C1-4)alkoxy, C1-4 alkylthio, halo(C1-4)alkylthio, hydroxy(C1-4)alkyl, C1-4alkoxy(C1-4)alkyl, C3-6 cycloalkyl, C3-6 cycioalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR'^R", -NHCOR'", -NHCONR'"R", -CONR'"R", -SO2R'", -OSO2R'", -COR"', -CR'"=NR" or -N=CR"'R", in which R"' and R" are independently hydrogen. C1-4 alkyl, haIo(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy. The compounds of the invention contain at least one asymmetric carbon atom (and at least two when R3 and R4 are different) and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such. However, these mixtures may be separated into individual isomers or isomer pairs, and this invention embraces such isomers and mixtures thereof in all proportions. It is to be expected that for any given compound, one isomer may be more fungicidally active than another Except where otherwise stated, alkyl groups and alkyl moieties of alkoxy, alkylthio, etc., suitably contain from 1 to 4 carbon atoms m the form of straight or branched chains. Examples are methyl, ethyl, n-and iso-propy] and n-, sec-, iso- and tert-butyl. Where alkyl moieties contain 5 or 6 carbon atoms, examples are n-pentyl and n-hexyl. Alkenyl and alkynyl moieties also suitable contain from 2 to 4 carbon atoms in the form of straight or branched chains. Examples are allyl, ethynyl and propargyl. Halo includes fluoro, chloro, bromo and iodo. Most commonly it is fluoro, chloro or bromo and usually fluoro or chloro. The substituents X, Y and Z on the phenyl ring of formula (1) may provide a 3-, 3, 5- or 3,4, 5- substituted phenyl ring. Typically X, Y and Z are all chloro or methyl, or X and Z are both chloro or bromo and Y is H or methyl, or X and Z are both methyl or methoxy and Y is H, chloro, bromo or alkylthio, or X is methoxy, Y is H and Z is cyano or chloro, or X is methyl, Y is H and Z is ethyl, or X is chloro, bromo or trifluoromethyl and both Y and Z are H. Typically, R1 is methyl, ethyl, n-propyl, 2,2,2-trifluoromethyl, cyanomethyl, acetylmethyl, methoxycarbonylmethyl, methoxycarbonylethyl, hydroxymethyl, hydroxyethyl. Ethyl is a preferred value of R1. Typically R2 is H and at least one, but preferably both of R3 and R4 are methyl. When one of R3 and R4 is H, the other may be methyl, ethyl or n- or iso-propyl. When one of R3 and R4 is methyl, the other may be H or ethyl but is preferably also methyl R2 also includes C1-4 alkoxymethyl and benzyloxymethyl in which the phenyl ring of the benzyl group optionally carries an alkoxy substituent, e.g. a methoxy substituent. Such values of R2 provide compounds of formula (1) that are believed to be pro-pesticidal compounds. Typically R5 is n-propyl, hydroxymethyl, methoxymethyl, 1-methoxyethyl, tert-butyldimethylsiloxymethyl, 3-chloropropyl, 3-cyanopropyl, 3-methoxypropyl, 3-( 1,2,4-tria2ol-l-yl)propyl, 3-methylthiopropyl, 3-methanesulphinylpropyl or 3-methane-sulphonylpropyl. Of particular interest are compounds where R5 is hydroxymethyl, methoxymethyl, 1-methoxyethyl or tert-butyldimethylsilyloxymethyl. Also of particular interest are compounds where R5 is 3-cyanopropyl, 3-methoxypropyl, 3-(l,2,4-tnazol-l-yl)propyl, 3-methylthiopropyl, 3-methanesulphmylpropyl or 3-methanesulphonylpropyl. In one aspect the invention provides a compound of the general formula (1) wherein X, Y and Z are independently H, halogen, C1-4 alkyl (e.g. methyl), halo(C1-4)alkyl (e.g. trifluoromethyl), C2-4 alkenyl, halo(C2-4)alkenyl, C2-4 alkynyl, halo(C2-4)alkynyl,C1-4 alkoxy (e.g. methoxy), halo(C1-4)alkoxy (e.g. tnfluoromethoxy), -S(0)n(C1-4)alkyl where n is 0, 1 or 2 and the alkyl group is optionally substituted with fluoro (e.g. methylthio, tri-fluoromethylsulphonyl), -OS02(C1-4)alkyl where the alkyl group is optionally substituted with fluoro (e.g. trifluoromethylsulphonyloxy), cyano, nitro, C1-4alkoxycarbonyl, -CONR'R", -COR' or -NR'COR" where R* and R" are independently H or C1-4 alkyl (e.g. -NHCOCH3), provided that at least one of X and Z is other than H, R1 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl in which the alkyl, alkenyl and alkynyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms (e.g. 2,2,2-trifluoroethyl), with a cyano group (e.g. cyanomethyl), with a C1-4 alkylcarbonyl group (e.g. acetylmethyl), with a C1-4alkoxycarbonyl group (e.g. methoxycarbonylmethyl and methoxycarbonylethyl) or with a hydroxy group (e.g. hydroxymethyl); R2 is H, C1-4 alkyl. C1-4 alkoxymethyl or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C1-4 alkoxy; R3 and R4 are independently H, C1-3 alkyl, C=alkenyl or C2-3 alkynyl provided that both are not H and that when both are other than H their combined total of carbon atoms does not exceed 4, or R3 and R4 join with the carbon atom to which they are attached to form a 3 or 4 membered carbocyclic ring optionally containing one O, S or N atom and optionally substituted with halo or C 1.4 alkyl; and R5 is C1-4 alkyl or C3-6 cycloalkyl in which the alkyl and cycloalkyl groups are substituted with hydroxy, C1-6 alkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy, in which the optionally substituted phenyl and thienyl rings of phenoxy, thienyloxy, benzyloxy and thienylmethoxy are optionally substituted with one, two or three substituents selected from halo, hydroxy, mercapto. C1-4alkyl, C2-4 alkenyl, C2-4 alkynyl. C1-4 alkoxy, C2-4 alkenyloxy, C2-4 alkynyloxy, halo(C1-4)alkyl, halo(C1-4)alkoxy, C1-4 alkylthio, halo(C1-4)alkylthio, hydroxy(C1-4)alkyl, C1-4alkoxy(C1. 4)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR'"R", -NHCOR'", -NHCONR'"R", -CONfR'"R", --SO2R'", -OSO2R'", -COR'", -CR"'=NR" or -N=CR"'R", m which R"" and R" are independently hydrogen.C1-4 alkyl, halo(Ci-4)alkyl, C1-4 alkoxy, haIo(C1-4)alkoxyC1. 4 alkylthio, C3-6 cycloalkyl, C3-6 cycloaikyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen. C1-4 alkyl or C1-4 alkoxy In another aspect, the invention provides a compound of the general formula (1) wherein X, Y and Z are all chloro or methyl, or X and Z are both chloro or bromo and Y is H or methyl, or X and Z are both methyl or methoxy and Y is H, chloro, bromo or alkylthio, or X is methoxy, Y is H and Z is cyano or chloro, or X is methyl, Y is H and Z is ethyl, or X is chloro, bromo or trifluoromethyl and both Y and Z are H; Rj is methyl, ethyl, n-propyl, 2,2,2-trifluoromethyl, cyanomethyl, acetylmethyl, methoxycarbonyl-methyl, methoxycarbonylethyl, hydroxymethyl or hydroxyethyl; R2 is H; R3 and R4 are both methyl; and R5 is hydroxymethyl, methoxymethyl, 1-methoxyethyl, tert-butyl-dimethylsiloxymethyl, 3-chloropropyl, 3-cyanopropyl, 3-methoxypropyl, 3-(l,2,4-triazol-l-yl)propyl, 3-methylthiopropyl, 3-methanesulphinylpropyl or 3-methanesulphonyl-propyl. Preferably R1 is ethyl. Preferably R5 is methoxymethyl or 3-cyanopropyl. Compounds that form part of the mvention are illustrated in Tables I to 57 below. The compounds in Table 1 are of the general formula (1) where R1 is ethyl, R2 is H, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values given in the table Table 1 (Table Removed) Table 2 Table 2 consists of 134 compounds of the general formula (1), where R1 is methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 2 is the same as compound 1 of Table 1 except that in compound 1 of Table 2 R1 is methyl instead of ethyl. Similarly, compounds 2 to 134 of Table 2 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 2 R1 is methyl instead of ethyl. Table 3 Table 3 consists of 134 compounds of the general formula (1), where R1 is n-propyl, R2 is hydrogen, R3 and R4 are both methyl, and R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 3 is the same as compound 1 of Table 1 except that in compound 1 of Table 3 Rj is n-propyl instead of ethyl. Similarly, compounds 2 to 134 of Table 3 are the same as compounds 2 to 134 of Table 1, respectively, except that m the compounds of Table 3 R| is n-propyl instep of ethyl. Table 4 Table 4 consists of 134 compounds of the general formula (1), where R1 is 2,2,2-trifluoromethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 4 is the same as compound 1 of Table 1 except that in compound 1 of Table 4 R1 is 2,2,2-trifluoromethyl instead of ethyl. Similarly, compounds 2 to 134 of Table 4 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 4 R1 is 2,2,2-tR1fluoromethyl instead of ethyl. Table 5 Table 5 consists of 134 compounds of the general formula (1), where R1 is cyanomethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 5 is the same as compound 1 of Table 1 except that in compound 1 of Table 5 R1 is cyanomethyl instead of ethyl. Similarly, compounds 2 to 134 of Table 5 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 4 R1 is cyanomethyl instead of ethyl Table 6 Table 6 consists of 134 compounds of the general formula (1), where R1 is acetylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 6 is the same as compound 1 of Table 1 except that in compound 1 of Table 6 R1 is acetylmethyl instead of ethyl. Similarly, compounds 2 to 134 of Table 6 are the same as compounds 2 to 134 of Table 1, respectively, except that m the compounds of Table 4 R1 is acetylmethyl instead of ethyl. Table 7 Table 7 consists of 134 compounds of the general formula (1), where R1 is methoxy-carbonylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound I of Table 7 is the same as compound 1 of Table 1 except that in compound 1 of Table 7 R1 is methoxycarbonyl-methyl instead of ethyl. Similarly, compounds 2 to 134 of Table 7 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 7 R1 is methoxycarbonylmethyl instead of ethyl. Table 8 Table 8 consists of 134 compounds of the general formula (1), where R1 is methoxycarbonylethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table I. Thus compound I of Table 8 is the same as compound 1 of Table 1 except that in compound 1 of Table 8 R1 is methoxycarbonylethyl instead of ethyl. Similarly, compjounds 2 to 134 of Table 8 are the same as compounds 2 , to 134 of Table 1, respectively, except that m the compounds of Table 8 R| is methoxycarbonylethyl instead of ethyl. Table 9 Table 9 consists of 134 compounds of the general formula (1), where Rj is hydroxymethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 9 is the same as compound 1 of Table 1 except that in compound 1 of Table 9 R1 is hydroxymethyl instead of ethyl. Similarly, compounds 2 to 134 of Table 9 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 9 R1 is hydroxymethyl instead of ethyl. Table 10 Table 10 consists of 134 compounds of the general formula (1), where R1 is hydroxyethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is hydroxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 10 is the same as compound 1 of Table 1 except that in compound 1 of Table 10 R1 is hydroxyethyl instead of ethyl. Similarly, compounds 2 to 134 of Table 10 are the same as compounds 2 to 134 of Table 1, respectively, except that m the compounds of Table 10 R1 is hydroxyethyl instead of ethyl. Table 11 Table 11 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and.Z have the values listed in Table 1. Thus compound 1 of Table 11 is the same as compound 1 of Table 1 except that in compound 1 of Table 11 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 11 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 11 R5 is methoxymethyl instead of hydroxymethyl. Table 12 Table 12 consists of 134 compounds of the general formula (1), where Rj is methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1 for compounds 1 to 134. Thus compound 1 of Table 12 is the same as compound 1 of Table 2 except that in compound 1 of Table 12 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 12 are the szune as compounds 2 to 134 of Table 2, respectively, except that in the compounds of Table 12 R5 is methoxymethyl instead of hydroxymethyl. Table 13 Table 13 consists of 134 compounds of the general formula (1), where Rj is /i-propyl, R2 is hydrogen, R3 and R4 are both methyl, and R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 13 is the same as compound 1 of Table 3 except that in compound 1 of Table 13 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 13 are the same as compounds 2 to 134 of Table 3, respectively, except that in the compounds of Table 13 R5 is methoxymethyl instead of hydroxymethyl. Table 14 Table 14 consists of 134 compounds of the general formula (1), where Rj 2,2,2-trifluoro-methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 14 is the same as compound 1 of Table 4 except that in compound 1 of Table 14 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 14 are the same as compounds 2 to 134 of Table 4, respectively, except that in the compounds of Table 14 R5 is methoxy-methyl instead of hydroxymethyl. Table 15 Table 15 consists of 134 compounds of the general formula (1), where R| is cyanomethyl, R2 is hydrogen, R3 and R4 are both methyl, Rs is methoxjmiethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 15 is the same as compound 1 of Table 5 except that in compound 1 of Table 15 Rs is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 15 are the same as compounds 2 to 134 of Table 5, respectively, except that in the compounds of Table 15 R5 is methoxymethyl instead of hydroxymethyl Table 16 Table 16 consists of 134 compounds of the general formula (1), where R1 is acetylmethyl, R2 is hydrogen, R3 and RA are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 16 is the same as compound 1 of Table 6 except that in compound I of Table 16 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 16 are the same as compounds 2 to 134 of Table 6, respectively, except that in the compounds of Table 16 R5 is methoxymethyl instead of hydroxymethyl. Table 17 Table 17 consists of 134 compounds of the general formula (1), where R\ is methoxy-carbonylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed m Table 1. Thus compound 1 of Table 17 is the same as compound 1 of Table 7 except that in compound 1 of Table 17 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 17 are the same as compounds 2 to 134 of Table 7, respectively, except that in the compounds of Table 17 R5 is methoxymethyl instead of hydroxymethyl. Table 18 Table 18 consists of 134 compounds of the general formula (1), where R| is methoxycarbonylethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound I of Table 18 is the same as compound 1 of Table 8 except that in compound 1 of Table 18 Rj is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 18 are the same as compounds 2 to 134 of Table 8, respectively, except that in the compounds of Table 18 R5 is methoxymethyl instead of hydroxymethyl Table 19 Table 19 consists of 134 compounds of the general formula (1), where R1 is hydroxymethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 19 is the same as compound 1 of Table 9 except that in compound 1 of Table 19 R5 is methoxymethyl instead of methyl. Similarly, compounds 2 to 134 of Table 19 are the same as compounds 2 to 134 of Table 9, respectively, except that in the compounds of Table 19 R5 is methoxymethyl instead of hydroxymethyl. Table 20 Table 20 consists of 134 compounds of the general formula (1), where R1 is hydroxyethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is methoxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 20 is the same as compound 1 of Table 10 except that in compound 1 of Table 20 R5 is methoxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 20 are the same as compounds 2 to 134 of Table 10, respectively, except that in the compounds of Table 20 R1 is methoxymethyl instead of hydroxymethyl Table 21 Table 21 consists of 134 compounds of the general formula (1), where Rj is ethyl, R2 is hydrogen, R3 and R4 are both methyl, Rs is rer/-butyldimethylsilyloxymethyl and X, Y and Z have the values listed m Table 1. Thus compound 1 of Table 21 is the same as compound 1 of Table 1 except that in compound 1 of Table 21 R5 is rer/-butyldimethyl-silyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 21 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 21 R5 is tert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 22 Table 22 consists of 134 compounds of the general formula (1), where R1 is methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is tertbutyldimethylsilyloxymethyl and X, Y and Z have the values listed in Table I for compounds 1 to 134. Thus compound 1 of Table 22 is the same as compound 1 of Table 2 except that in compound 1 of Table 22 R5 is tertbutyldimethylsilyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 22 are the same as compounds 2 to 134 of Table 2, respectively, except that in the compounds of Table 22 R5 is tertbutyldimethylsilyloxymethyl instead of hydroxymethyl Table 23 Table 23 consists of 134 compounds of the general formula (1), where R1 is n-propyl, R2 is hydrogen, R3 and R4 are both methyl, and R5 is tert-butyIdimethylsilyloxymethyi and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 23 is the same as compound 1 of Table 3 except that in compound 1 of Table 23 R5 is tert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 23 are the same as compounds 2 to 134 of Table 3, respectively, except that in the compounds of Table 23 R5 is rert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 24 Table 24 consists of 134 compounds of the general formula (1), where R, 2,2,2-trifluoro-methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is tertbutyldimethylsilyIoxy-methyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 24 is the same as compound 1 of Table 4 except that in compound 1 of Table 24 R5 is lert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 24 are the same as compounds 2 to 134 of Table 4, respectively, except that in the compounds of Table 24 R5 is tert-butyldimethylsilyloxymethyl instead of hydroxymethyl Table 25 Table 25 consists of 134 compounds of the general formula (1), where R1 is cyanomethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is tertbutyldimethylsilyloxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 25 is the same as compound 1 of Table 5 except that in compound 1 of Table 25 R5 istert-butyldimethyl- silyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 25 are the same as compounds 2 to 134 of Table 5, respectively, except that in the compounds of Table 25 R5 is tertbutyldimethylsilyloxymethyl instead of hydroxymethyl. Table 26 Table 26 consists of 134 compounds of the general formula (1), where R1 is acetylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is rert-butyldimethylsilyloxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 26 is the same as compound 1 of Table 6 except that in compound 1 of Table 26 R5 is tertbutyldimethyl- silyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 26 are the same as compounds 2 to 134 of Table 6, respectively, except that in the compounds of Table 26 R5 is fer/-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 27 Table 27 consists of 134 compounds of the general formula (1), where R1 is methoxy-carbonylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is rer/-butyldimethylsilyi-oxymethyl and X, Y and Z have the values listed in Table I. Thus compound 1 of Table 27 is the same as compound 1 of Table 7 except that in compound 1 of Table 27 R5 is tertbutyldimethylsilyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 27 are the same as compounds 2 to 134 of Table 7, respectively, except that in the compounds of Table 27 R5 is rerr-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 28 Table 28 consists of 134 compounds of the general formula (1), where R1 is methoxy-carbonylethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is tert-butyldimethylsilyl-oxymethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 28 is the same as compound 1 of Table 8 except that in compound 1 of Table 28 R5 is /ert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 28 are the same as compounds 2 to 134 of Table 8, respectively, except that in the compounds of Table 28 R5 is /err-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 29 Table 29 consists of 134 compounds of the general formula (1), where R| is hydroxymethyl, R2 IS hydrogen, R3 and R4 are both methyl, R5 is /ert-butyldimethylsilyloxy-methyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 29 is the same as compound 1 of Table 9 except that in compound 1 of Table 29 R5 is tert-butyldimethylsilyloxymethyl instead of methyl. Similarly, compounds 2 to 134 of Table 29 are the same as compounds 2 to 134 of Table 9, respectively, except that in the compounds of Table 29 R5 is tert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 30 Table 30 consists of 134 compounds of the general formula (1), where R1 is hydroxyethyl, R2 is hydrogen, Rj and R4 are both methyl, R5 is rerr-butyldimethylsilyl-Dxymethyl and X, Y and Z have the values listed in Table 1. Thus comf)ound 1 of Table 30 is the same as compound 1 of Table 10 except that in compound 1 of Table 30 R5 is tert-butyldimethyIsilyloxymethyl instead of hydroxymethyl Similarly, compounds 2 to 134 of Table 30 are the same as compounds 2 to 134 of Table 10, respectively, except that in the compounds of Table 30 R1 is tert-butyldimethylsilyloxymethyl instead of hydroxymethyl. Table 31 Table 31 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1 Thus compound 1 of Table 31 is the same as compound 1 of Table 1 except that in compound 1 of Table 31 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 31 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 31 R5 is 1-methoxyethyl instead of hydroxymethyl Table 32 Table 32 consists of 134 compounds of the general formula (1), where R| is methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1 for compounds 1 to 134. Thus compound 1 of Table 32 is the same as compound 1 of Table 2 except that in compound 1 of Table 32 R5 is 1-methoxy-ethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 32 are the same as compounds 2 to 134 of Table 2, respectively, except that m the compounds of Table 32 R5 is 1-methoxyethyl instead of hydroxymethyl. Table 33 Table 33 consists of 134 compounds of the general formula (1), where R\ is «-propyl, R2 is hydrogen, R3 and R4 are both methyl, and R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1 Thus compound 1 of Table 33 is the same as compound 1 of Table 3 except that in compound 1 of Table 33 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 33 are the same as compounds 2 to 134 of Table 3, respectively, except that in the compounds of Table 33 R5 is 1-methoxyethyl instead of hydroxymethyl Table 34 Table 34 consists of 134 compounds of the general formula (1), where R1 2,2,2-trifluoro-methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 34 is the same as compound 1 of Table 4 except that in compound 1 of Table 34 R5 is I-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 34 are the same as compounds 2 to 134 of Table 4, respectively, except that in the compounds of Table 34 R5 is 1-methoxyethyl instead of hydroxymethyl. Table 35 Table 35 consists of 134 compounds of the general formula (1), where R1 is cyanomethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 35 is the same as compound 1 of Table 5 except that in compound 1 of Table 35 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 35 are the same as compounds 2 to 134 of Table 5, respectively, except that in the compounds of Table 35 R5 is 1-methoxyethyl instead of hydroxymethyl. Table 36 Table 36 consists of 134 compounds of the general formula (1), where R1 is acetylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 36 is the same as compound 1 of Table 6 except that in compound 1 of Table 36 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 36 are the same as compounds 2 to 134 of Table 6, respectively, except that in the compounds of Table 36 R5 is 1-methoxyethyl instead of hydroxymethyl. Table 37 Table 37 consists of 134 compounds of the general formula (1), where R1 is methoxy-carbonylmethyl, R2 is hydrogen, R3 and R4 are both methyl, Rs is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 37 is the same as compound 1 of Table 7 except that in compound 1 of Table 37 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 37 are the same as compounds 2 to 134 of Table 7, respectively, except that in the compounds of Table 37 R5 is 1-methoxyethyl instead of hydroxymethyl Table 38 Table 38 consists of 134 compounds of the general formula (1), where R1 is methoxycarbonylethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 38 is the same as compound 1 of Table 8 except that in compound 1 of Table 38 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 38 are the same as compounds 2 to 134 of Table 8, respectively, except that in the compounds of Table 38 R5 is 1-methoxyethyl mstead of hydroxymethyl. Table 39 Table 39 consists of 134 compounds of the general formula (1), where R1 is hydroxymethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 39 is the same as compound 1 of Table 9 except that in compound 1 of Table 39 R5 is 1 -methoxyethyl instead of methyl. Similarly, compounds 2 to 134 of Table 39 are the same as compounds 2 to 134 of Table 9, respectively, except that in the compounds of Table 39 R5 is I-methoxyethyl instead of hydroxymethyl. Table 40 Table 40 consists of 134 compounds of the general formula (1), where R1 is hydroxyethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 1-methoxyethyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 40 is the same as compound 1 of Table 10 except that in compound 1 of Table 40 R5 is 1-methoxyethyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 40 are the same as compounds 2 to 134 of Table 10, respectively, except that in the compounds of Table 40 R5 is 1-methoxyethyl instead of hydroxymethyl. Table 41 Table 41 consists of 134 compounds of the general formula (I), where R1 is ethyl, R2 is hydrogen, R1 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 41 is the same as compound 1 of Table I except that in compound 1 of Table 41 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 41 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 41 R5 is 3-cyanopropyl instead of hydroxymethyl Table 42 Table 42 consists of 134 compounds of the general fonnula (1), where R1 is methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed m Table 1 for compounds 1 to 134. Thus compound 1 of Table 42 is the same as compound 1 of Table 2 except that in compound 1 of Table 42 R5 is 3-cyanopropyl instead of hydrox>TOethyl. Similarly, compounds 2 to 134 of Table 42 are the same as compounds 2 to 134 of Table 2, respectively, except that in the compounds of Table 42 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 43 Table 43 consists of 134 compounds of the general formula (1), where R1 is n-propyl, R2 is hydrogen, R3 and R4 are both methyl, and R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 43 is the same as compoimd 1 of Table 3 except that in compound 1 of Table 43 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 43 are the same as compounds 2 to 134 of Table 3, respectively, except that in the compounds of Table 43 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 44 Table 44 consists of 134 compounds of the general formula (1), where R1 2,2,2-tnfluoro-methyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 44 is the same as compound 1 of Table 4 except that in compound 1 of Table 44 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 44 are the same as compounds 2 to 134 of Table 4, respectively, except that in the compounds of Table 44 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 45 Table 45 consists of 134 compounds of the general formula (1), where R1 is cyanomethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound I of Table 45 is the same as compound 1 of Table 5 except that m compound 1 of Table 45 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 45 are the same as compounds 2 to 134 of Table 5, respectively, except that in the compounds of Table 45 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 46 Table 46 consists of 134 compounds of the general formula (1), where R\ is acetylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 46 is the same as compound 1 of Table 6 except that in compound 1 of Table 46 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 46 are the same as compounds 2 to 134 of Table 6, respectively, except that m the compounds of Table 46 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 47 Table 47 consists of 134 compounds of the general formula (1), where R1 is methoxy-carbonylmethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 47 is the same as compound 1 of Table 7 except that in compound 1 of Table 47 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 47 are the same as compounds 2 to 134 of Table 7, respectively, except that in the compounds of Table 47 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 48 Table 48 consists of 134 compounds of the general formula (1), where R1 is methoxycarbonylethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyan6propyl and X, Y and Z have the values listed in Table 1. Thus pompound 1 of Table 48 is the same as compound 1 of Table 8 except that in compound 1 of Table 48 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 48 are the same as compounds 2 to 134 of Table 8, respectively, except that in the compounds of Table 48 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 49 Table 49 consists of 134 compounds of the general formula (1), where R1 is hydroxymethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 49 is the same as compound 1 of Table 9 except that in compound 1 of Table 49 R5 is 3-cyanopropyl instead of methyl. Similarly, compounds 2 to 134 of Table 49 are the same as compounds 2 to 134 of Table 9, respectively, except that in the compounds of Table 49 R5 is 3-cyanopropyI instead of hydroxymethyl Table 50 Table 50 consists of 134 compounds of the general formula (1), where R1 is hydroxyethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-cyanopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 50 is the same as compound 1 of Table 10 except that in compound 1 of Table 50 R5 is 3-cyanopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 50 are the same as compounds 2 to 134 of Table 10, respectively, except that in the compounds of Table 50 R5 is 3-cyanopropyl instead of hydroxymethyl. Table 51 Table 51 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is n-propyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 51 is the same as compound 1 of Table 1 except that in compound 1 of Table 51 R5 is n-propyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 51 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 51 R5 is n-propyl instead of hydroxymethyl. Table 52 Table 52 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-chloropropyl and X, Y and Z have the values listed in Table I. Thus compound 1 of Table 52 is the same as compound 1 of Table 1 except that in compound 1 of Table 52 R5 is 3-chloropropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 52 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 52 R5 is 3-chloropropyl instead of hydroxymethyl. Table 53 Table 53 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-methylthiopropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 53 is the same as compound 1 of Table 1 except that in compound 1 of Table 53 R5 is 3-methylthiopropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 53 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 53 R5 is 3-methylthiopropyl instead of hydroxymethyl. Table 54 Table 54 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-methanesulphinylpropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 54 is the same as compound 1 of Table 1 except that in compound 1 of Table 54 R5 is 3-methanesulphinylpropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 54 are the same as compounds 2 to 134 of Table I, respectively, except that m the compounds of Table 54 R5 is 3-methanesulphinylpropyl instead of hydroxymethyl Table 55 Table 55 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-methanesuIphonylpropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 55 is the same as compound 1 of Table 1 except that in compound 1 of Table 55 R5 is 3-methanesulphonylpropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 55 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 55 R5 is 3-methanesulphonylpropyl instead of hydroxymethyl. Table 56 Table 56 consists of 134 compounds of the general formula (1), where R1 is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-(l,2,4-triazol-l-yl)propyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 56 is the same as compound 1 of Table 1 except that in compound 1 of Table 56 R5 is 3-(l,2,4-triazol-l-yl)propyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 56 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Jable 56 R5 is 3-{l,2,4-tnazol-l-yl)propyl instead of hydroxymethyl Table 57 Table 57 consists of 134 compounds of the general formula (1), where Ri is ethyl, R2 is hydrogen, R3 and R4 are both methyl, R5 is 3-methoxypropyl and X, Y and Z have the values listed in Table 1. Thus compound 1 of Table 57 is the same as compound I of Table 1 except that in compound 1 of Table 57 R5 is 3-methoxypropyl instead of hydroxymethyl. Similarly, compounds 2 to 134 of Table 57 are the same as compounds 2 to 134 of Table 1, respectively, except that in the compounds of Table 57 R5 is 3-methoxypropyl instead of hydroxymethyl The compounds of formula (1) may be prepared as outlined in Schemes 1 to 7 below in which X, Y, Z, R1, R2, R3, R4 and R5 have the meanings given above, R is C1-4 alkyl, R6 and R7 are H or methyl but not both methyl, L is a leaving group such as a halide, for example iodide, an alkyl or aryl sulphonyloxy group, for example methylsulphonyloxy and tosyloxy or a Inflate, Hal is halogen, Ra is hydrogen or C1-3 alkyl, Rb is hydrogen or C1-3alkyl, provided that the total number of carbon atoms in R1 and Rb do not exceed three. Rc is C1-6 alkyl, optionally substituted benzyl or optionally substituted thienylmethyl and Rd has the meaning ascnbed to it in the text. As shown in Scheme 1, the compounds of general formula (I) may be prepared by reacting a phenol of the general formula (2) with a compound of the general formula (3) in the presence of a base in a suitable solvent. Typical solvents include N,Ndimethyl-formamide and N-methyIpyrrolidin-2-one. Suitable bases include potassium carbonate, sodium hydride or diiiopropylethylamine. Phenols of the general formula (2) are either commercially available or are known in the literature or may be prepared from known compounds by standard procedures. Scheme 1 (Scheme Removed) As shown in Scheme 2, compounds of general formula (3) may be prepared by reacting an amine of the general formula (5) with an acid halide of the general formula (4), or the corresponding acid anhydride, in the presence of a suitable inorganic or organic base, such as potassium carbonate, sodium hydride or disopropylethylamine, in a solvent such as dichloromethane or tetrahydrofuran. Scheme 2 (Scheme Removed) As shown m Scheme 3, amines of the general formula (5), wherein R2 is H, correspond to amines of the general formula (9) and may be prepared by alkylation of a silyl-protected aminoalkyne of the general formula (7) using a suitable base, such as n-butyl lithium, followed by reaction with a suitable alkylating reagent R5L, such as an alkyl iodide, for example, methyl iodide, to form an alkylated compound of the general formula (8). In a similar procedure, a silyl-protected aminoalkyne of the general formula (7) may be reacted with a carbonyl derivative RaCORb, for example formaldehyde, using a suitable base, such as n-butyl lithium, to provide an aminoalkyne (8) containing a hydroxyalkyl moiety. The silyl protecting group may then be removed from a compound of the general formula (8) with, for example, an aqueous acid to form an aminoalkyne of the general formula (9). Aminoalkynes of the general formula (9) may be further derivatised, for instance when R5 is a hydroxyalkyl group, for example, by reacting a compound of the general formula (9) with a silylating agent (R)3SiCl, for example /-butyldimethylsilyl chloride, to give a derivative silylated on oxygen of the general formula (9a). In addition, a compound of the general formula (9) may be treated with a base, such as sodium hydride or potassium bis(trimethylsilyl)amide followed by a compound RcL to give a compound of the general formula (9b). In an alternative sequence, a compound of general formula (8) may be treated with a base, such as sodium or potassium bis(trimethylsilyl)amide, followed by a compound RcL, where L represents a halogen or sulphonate ester such as OSO2Me, or OSO2-4-tolyl, for example ethyl iodide, to give compounds of the general formula (8a), which, after removal of the silyl protecting group, give compounds of the general formula (9b). Compounds of general formula (8), where R5 is, for example, 3-chIoropropyI can be reacted with a metal cyanide salt, such as sodium cyanide, to give compounds of general formula (8b), which can then be hydrolysed, with for example an aqueous acid, to give the amines of general formula (8c) Compounds of general formula (8), where R5 is, for example, 3-chloropropyl can be hydrolysed, with for example an aqueous acid, to give amines of general formula (8d). (Scheme Removed) Scheme 3 Silyl-protected aminoalkynes of the general formula (7) may be obtained by reacting amines of general formula (6) with l,2-bis-(chlorodimethylsilyl)ethane in the presence of a suitable base, such as a tertiary organic amine base, for example, triethylamine. Amines of the general formula (6) are either commercially available or may be prepared by standard literature methods (see, for example, EP-N-0834498). Alternatively, as shown in Scheme 4, compounds of the general formula (1) may be prepared by condensing a compound of the general formula (11), wherein Rd is H with an amine of the general formula (5) using suitable activating reagents such as 1-hydroxy-benzotriazole and N-(3-dimethylaminopropyl)-N-ethyl-carbodiimide hydrochloride. Where R2 is other than hydrogen, the R2 group may be introduced into an aminoalkyne of the general formula (9) by known techniques to form an amine of the general formula (5). Scheme 4 (Scheme Removed) Compounds of the general formula (12) may be prepared by the hydrolysis of the corresponding esters of general formula (11), wherein Rd is C1-4 alkyl, using known techniques. The esters of the general formula (11), wherein Rd is C1-4 alkyl and also acids of the general formula (11), wherein R1 is H, may be prepared by reacting a compound of the general formula (2) with an ester or acid of the general formula (10a) in the presence of a suitable base, such as potassium carbonate or sodium hydride, in a suitable solvent, such as A'^A^-dimethylformamide. The esters or acids of the general formula (10a) are either commercially available or may be prepared by standard literature methods from commercially available materials. Alternatively, as shown in Scheme 4, compounds of the general formula (11) may be prepared under Mitsunobu conditions by reacting a compound of the general formula (2) with a compoimd of the general formula (1 Ob), wherein R1 is C1-4 alkyl, using a phosphine, such as triphenyl phosphine, and an azoester, such as diethyl azodicarboxylate. Similarly, compounds of the general formula (1) may be prepared by reacting a compound of general formula (l0d) with a compound of the general formula (2) under Mitsunobu conditions using a phosphine, such as triphenyl phosphine, and an azoester, such as diethyl azodicarboxylate. Compounds of general formula (l0d) may be prepared from a compound of general formula (l0c) and an amine of general formula (5) usmg suitable activating reagents such as 1-hydroxybenzotriazole and N-(3-din|ethylamino-propyl)-A''-ethyl-carbodiimide hydrochloride. Compounds (10b) and (l0c) are either known compounds or may be made from known compounds. In another method, the compounds of the general formula (1) may be prepared by reacting an acid halide of the general foraiula (13) with an amine of the general formula (5) in a suitable solvent, such as dichloromethane, in the presence of a tertiary amine, such as triethylamine, and an activating agent, such as 4-dimethylaminopyridine. As shown in Scheme 5, an acid halide of the general formula (13) may be prepared by chlorinating a compound of the general formula (12) with a suitable chlorinating agent, such as oxalyl chlonde, in a suitable solvent, such as dichloromethane, and in the presence of, for example, N,N-dimethylformamide. The compounds of the general formula (12) correspond to the compounds of general formula (11), wherein R