Description:Field of the Invention
(001) The present disclosure relates generally to field of medical devices. More specifically the present invention relates to an optical spectroscopy for real –time diagnosis/ screening of oral cavity cancer, noninvasively using fluorescence and reflectance from light source effectively analysed with GUI software and hardware.
Background of Invention
Information from the background discussion that follows could be helpful in comprehending the current invention. It does not imply that any of the data presented here is previous art, pertinent to the invention being claimed at this time, or that any publication, whether explicitly or implicitly.
The fact that 1.7 million cases are expected to be recorded in 2035 compared to 1 million cases reported in 2012 indicates an increase in cancer occurrences. A significant difficulty is the high mortality, as seen by the 5-year survival rate of less than 45%. In India, the primary causes of this are late diagnosis, a dearth of efficient diagnostic resources in rural regions, and a high frequency of risk factors like pan masala and tobacco use. The International Agency for Research on Cancer (IARC) reported 1.35 lakh new cases and 0.75 lakh deaths from oral cancer in India, making it the second most common cancer worldwide. India has a rapid increase in oral cancer.

To ameliorate the current situation of high morbidity and high death rates associated to oral cancer, early and effective diagnosis is required. Conventional Oral Examination (COE), oral cytology, oral brush biopsy, staining (Toluidine Blue, Lugol's Iodine, Methylene Blue), and light-based detection systems are screening techniques used to diagnose oral cancer and pre-cancer stages. The process of tissue biopsy and histological evaluation is used to confirm the diagnosis of mouth cancer. Nevertheless, this process takes a lot of time and is invasive. Determining the affected area is essential to prevent the needless removal of healthy areas.

Therefore, a non-invasive and efficient screening method is needed prior to biopsy. The different fluorophores that is naturally present in the epithelial lining and submucosa of the oral cavity cause fluorescence when exposed to UV-visible light. The main fluorophores are collagen, tryptophan, nicotinamide adenine dinucleotide (NADH), flavin adenine dinucleotide (FAD), and porphyrin. As the condition worsens, there are variations in three of these fluorophores' concentrations. Because fluorescence-based optical techniques are sensitive to modest morphological and biochemical changes as the disease progresses, they may be used for early cancer diagnosis.

Over the past few decades, a variety of optical approaches have been employed for the early diagnosis of various types of cancer. Of these, fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. Due to their high cost and large number of components, these heavy systems appear to be very difficult to transfer from the lab to the clinic or for commercial application. But there isn't a single integrated device that looks at the anomaly in the mouth, scans the affected area, and measures the area at specific points. There is time based need and requirement for the detection of oral cancer can signify a reliable, user-friendly, and reasonably priced device.

Thus, the present invention relates to an optical spectroscopy based portable device preferably utilizes two types of signals from light source that is fluorescence and reflectance are detected and analyzed the data using software to detect oral cancer at pre cancerous and cancerous stage effectively.
Object of the Invention
The primary object of the invention is to develop a portable device using principle of optical spectroscopy based on the principle of optical fluorescence and reflectance to detect and analyze the real time pre cancerous or cancerous lesion in oral cavity with economic significance and devoid of invasion to tissue, biopsy and histopathology.
The secondary objective of the invention is that the optical spectroscopy device is preferably embodied with GUI software, hardware, light source, touch screen and battery herein said software analyze the tissue data through fluorescence and reflectance.
The another objective of the invention is that the optical spectroscopy analyses the oral cavity within 15 mins non invasively to signify its suitability compare to conventional procedures, herein a predetermine wavelength light is emerging from the device analyses the fluorescence and reflectance of light after diffusing from the tissue effectively from oral cavity without altering and damaging the tissue.
Summary of the Invention

The present invention relates to an optical spectroscopy based portable device preferably utilizes two types of signals from light source that is fluorescence and reflectance are detected and analyzed the data using software to detect oral cancer at pre cancerous and cancerous stage effectively.
A Fluorescence Device for Oral Cancer comprising of a portable device of optical spectroscopy preferably embodied a light source preferably LED to emit the desired wavelength, incident on the oral cavity tissues and diffuse through it, the fluorescence and the diffused reflectance analysed from emitted signals converted into spectra separately using a GUI software configured in hardware, the data analysis displayed on the touch screen works on a conventional battery of laptop or tab.

One of the preferred embodiments of the present invention is to utilize the desired wavelength non invasively without alerting or damaging the tissue part and analysed the data within 15 min.

One of the preferred embodiments of the present invention is to utilize the desired wavelength non invasively without alerting or damaging the tissue part and analysed the data within 15 min.

One of the preferred embodiments of the present invention is GUI software embodied in the housing of the device analyses the data and displays the spectra of fluorescence and reflectance separately on the touch screen of the device.

Brief Description of Drawings

The following thorough explanation of the various aspects of the invention, taken in conjunction with the corresponding drawing that represents various aspects and other features of the disclosure invention.
Figure 1: Flow chart of method to operate the device

Detailed Description of the Invention

The following description is of exemplary embodiments only and is not intended to limit the scope, applicability or configuration of the invention in any way. Rather, the following description provides a convenient illustration through explanation and figures for implementing exemplary embodiments of the invention. Various changes to the described embodiments may be made in the function and arrangement of the ingredients described without departing from the scope of the invention.
The use of “including”, “comprising” or “having” variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items. The terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items. Further, the use of terms “first”, “second”, and “third”, and the like, herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another.
A non-invasive and efficient screening method is needed prior to biopsy by utilizing fluorophores that is naturally present in the epithelial lining and sub mucosa of the oral cavity cause fluorescence when exposed to UV-visible light. As fluorescence-based optical techniques are sensitive to modest morphological and biochemical changes as the disease progresses, they may be used for early cancer diagnosis. Over the past few decades, a variety of optical approaches have been employed for the early diagnosis of various types of cancer. Of these, fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. Due to their high cost and large number of components, these heavy systems appear to be very difficult to transfer from the lab to the clinic or for commercial application. But there isn't a single integrated device that looks at the anomaly in the mouth, scans the affected area, and measures the area at specific points. There is time based need and requirement for the detection of oral cancer can signify a reliable, user-friendly, and reasonably priced device.

Thus, the present invention relates to an optical spectroscopy based portable device preferably utilizes two types of signals from light source that is fluorescence and reflectance are detected and analyzed the data using software to detect oral cancer at pre cancerous and cancerous stage effectively.

A Fluorescence Device for Oral Cancer comprising of a portable device of optical spectroscopy preferably embodied a light source preferably LED to emit the desired wavelength, incident on the oral cavity tissues and diffuse through it, the fluorescence and the diffused reflectance analysed from emitted signals converted into spectra separately using a GUI software configured in hardware, the data analysis displayed on the touch screen works on a conventional battery of laptop or tab.
Preferred embodiments of a fluorescence device for oral cancer
i) Main Housing or Hardware: The body of optical spectroscopy device that is hardware having configured with light source, touch screen and software.
ii) Light Source: The optical spectroscopy device uses the LED light source which emits the desired spectroscopic wavelength light that incident at oral cavity. Fluorescence and reflectance is analysed accordingly with usage of software.
iii) GUI software: GUI software is the preferred embodiment of the present device configured into the housing, analyses or processes the data of emitted fluorescence and reflectance coming from the oral cavity tissues into spectra. The spectra is analysed, documented and reflected on the touch screen.
iv) Touch Screen: One of the preferred embodiment of the present device is touch screen is provided to display the spectroscopic data analysed by the GUI software herein the separate readings of fluorescence and reflectance emitted from oral tissues displayed. The touch screen is user friendly and easy to operate.
v) Battery: The present device works on the conventional batteries, specifically used in laptops or tabs, embodied into the main housing of the device.
As the different components of the present device are small in size, enables it to portable from one location to another and easy to operate thereof.
Table no. 01: Preferred embodiments of the device

Sr No. Name of Embodiments Role/ Application
01 Main Housing or Hardware Configured various components of device
02 Light Source Emits the desired wavelength light for fluorescence and reflectance effect
03 GUI Software Analyses the emitted light from the oral cavity tissue
04 Touch Screen Displays the processed data of GUI software
05 Battery Power source for working of Device

Steps involved in the method to operate the device

i) Locating the oral cavity tissue: The oral cavity tissues to be investigated are located and introduced to spectroscopic light source.

ii) Light Emission: By switching “On” the switch of the light source, emission of preferred wavelength falls on to the oral cavity tissue, the emitted spectroscopic and diffuse reflectance emission of light comes back to the device for analysis.

iii) Processing the emitted spectroscopic signals: Emitted spectroscopic signals from the oral cavity tissue are processed using GUI software, herein the software process, analyse and document the data and reflects by displaying it on the touch screen provided on the device, effectively works from the power of conventional battery of laptop or tab. (Table No. 1)

Method to operate the device
Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis, recording both; the emitted fluorescence lights from the oral cavity; and the reflecting light emits after diffusing from the tissue separately, processing and analysing the input data emitted fluorescence and reflectance light from oral cavity tissues form GUI software, herein GUI software analyses the data separately and effectively; displaying the process data of fluorescence and reflectance on the touch screen of the device; documenting and storing the data in software for future use. The optical spectroscopy device works on the power of conventional battery of laptop or tab. The overall investigation is operated from 10 to 15 min. (Table No. 1)
Example 1
Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis, recording the emitted fluorescence lights from the oral cavity for 10 mins, processing and analysing the input data emitted fluorescence light from oral cavity tissues form GUI software, herein GUI software analyses the data separately and effectively; displaying the process data of fluorescence on the touch screen of the device; documenting and storing the data in software for future use.
Example 2
Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis, recording the emitted fluorescence lights from the oral cavity for 15 mins, processing and analysing the input data emitted fluorescence light from oral cavity tissues form GUI software, herein GUI software analyses the data separately and effectively; displaying the process data of fluorescence on the touch screen of the device; documenting and storing the data in software for future use.
Example 3
Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis, recording the reflecting light emits after diffusing from the tissue for 10 mins of emitted reflectance light software, herein GUI software analyses the data separately and effectively; displaying the process data of reflectance on the touch screen of the device; documenting and storing the data in software for future use.
Example 4
Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis, recording the reflecting light emits after diffusing from the tissue for 15 mins of emitted reflectance light software, herein GUI software analyses the data separately and effectively; displaying the process data of reflectance on the touch screen of the device; documenting and storing the data in software for future use.
Scope of the Invention

Fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. Due to their high cost and large number of components, these heavy systems appear to be very difficult to transfer from the lab to the clinic or for commercial application, thus has limitations so overcome the loopholes of existing technologies the present device develop to an optical spectroscopy based portable device preferably utilizes two types of signals from light source that is fluorescence and reflectance are detected and analyzed the data using GUI software to detect oral cancer at pre cancerous and cancerous stage non invasively and effectively, signify the economical benefit due to low costing configuration can be beneficial for oral cancer patients in future.

It is to be understood that the present invention is not limited to the embodiments described above, it should be clear that various modifications and alterations can be made along with various features of one embodiment included in other embodiments, within the scope of the present invention.
, Claims:We claim,
1- A Fluorescence Device for Oral Cancer comprising a portable device of optical spectroscopy characterized in that Graphic User Interface (GUI) software; hardware; a LED light source; a touch screen and a battery effectively analysed fluorescence and reflectance of oral cavity tissues to detect pre cancerous and cancerous lesions.

2- The fluorescence device for oral cancer as claimed in claim 1, operates through a method comprises the following steps:
i) Locating the oral cavity of the investigational personnel, the espoused oral cavity tissues are introduced to spectroscopic light emission of desired wavelength of analysis;

ii) recording both, the emitted fluorescence lights from the oral cavity and the reflecting light emits after diffusing from the tissue separately;

iii) processing and analysing the input data emitted fluorescence and reflectance light from oral cavity tissues form GUI software, herein GUI software analyses the data separately and effectively;

iv) displaying the process data of fluorescence and reflectance on the touch screen of the device; and

v) documenting and storing the data in software for future use.