Description:Title of the Invention
“A Fluorescence Imaging Tool for Oral Cavity”

Field of the Invention
The present disclosure relates generally to field of medical devices. More specifically the present invention relates to fluorescence imaging tool for real –time visual assessment of oral cavity and to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers and early cancers or pre-cancerous alterations.
Background of Invention
Information from the background discussion that follows could be helpful in comprehending the current invention. It does not imply that any of the data presented here is previous art, pertinent to the invention being claimed at this time, or that any publication, whether explicitly or implicitly.
Fluorescence imaging is a type of non-invasive imaging technique that can help visualize biological processes taking place in a living organism. Images can be produced from a variety of methods including: microscopy, imaging probes, and spectroscopy. Fluorescence itself is a form of luminescence that results from matter emitting light of a certain wavelength after absorbing electromagnetic radiation. Molecules that re-emit light upon absorption of light are called fluorophores.

Fluorescence imaging photographs fluorescent dyes and fluorescent proteins to mark molecular mechanisms and structures. It allows one to experimentally observe the dynamics of gene expression, protein expression, and molecular interactions in a living cell. It essentially serves as a precise, quantitative tool regarding biochemical applications.

Over the past few decades, a variety of optical approaches have been employed for the early diagnosis of various types of cancer. Of these, fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. Due to their high cost and large number of components, these heavy systems appear to be very difficult to transfer from the lab to the clinic or for commercial application. But there isn't a single integrated device that looks at the anomaly in the mouth, scans the affected area, and measures the area at specific points. There is time based need and requirement for the detection of oral cavity can signify a reliable, user-friendly, and reasonably priced device.

The present disclosure relates to fluorescence imaging tool for real –time visual assessment of oral cavity and to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions.
Object of the Invention
The primary object of the invention is to develop a tool to detect or assess the clinical situation of oral cavity, devoid of invasive process, in situ real time assessment to detect changes in oral mucosa.
The secondary objective of the invention is that the tool is fluorescence imaging preferably embodied with Light Emitting Diode (LED) light source to incident onto the oral cavity tissues, Charge Coupled Device (CCD) camera to detect and generate two dimensional fluorescence spectral images and Graphic User Interface (GUI) software for automatic acquisition and processing of tissue fluorescence images.
The another objective of the invention is that the fluorescence imaging tool analyses the oral cavity non invasively in situ to assess and distinguish normal and abnormal oral cavity’s tissues, herein the fluorescence emitted from the oral cavity detected by CCD camera to generate two dimensional images.
Summary of the Invention

The present invention relates to fluorescence imaging tool based portable tool preferably real time assess oral cavity in situ, non invasively to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers and early cancers or pre-cancerous alterations, utilizes desired wavelength light from LED to produce fluorescence emitted through oral cavity tissues detected and identified using CCD cameras and GUI software.
A Fluorescence Imaging Tool for Oral Cavity comprising portable tool having size; length of 120 mm, diameter of 40 mm and weight of 140 gm, works on optical spectroscopy preferably embodied light source preferably Light Emitting Diode (LED) light source to emit the desired wavelength, incident on the oral cavity tissues and the emitted fluorescence from oral cavity tissues analysed from emitted signals detected by Charge Coupled Device (CCD) camera which generates two dimensional fluorescence spectral images automatically processed and interpreted from Graphic User Interface (GUI) software signify real time in situ non invasive visual assessment to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions.

One of the preferred embodiments of the present invention is to utilize the desired wavelength using LED light source, incident on oral cavity tissue, herein the fluorescence generated within the tissues, emitted spectral signals, analysed for normal and abnormal fluorescence images.

One of the preferred embodiments of the present invention is that the emitted fluorescence signals detected through CCD camera, which further process it to generate the fluorescence images, the generated images are evaluated for assessment of clinical situation of oral cavity.

One of the preferred embodiments of the fluorescence images generated by CCD camera can be automatically processed, developed and integrated using GUI software in real time to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions effectively.

Brief Description of Drawings

The following thorough explanation of the various aspects of the invention, taken in conjunction with the corresponding drawing that represents various aspects and other features of the disclosure invention.
Figure 1: Flow chart of method to operate the device

Detailed Description of the Invention

The following description is of exemplary embodiments only and is not intended to limit the scope, applicability or configuration of the invention in any way. Rather, the following description provides a convenient illustration through explanation and figures for implementing exemplary embodiments of the invention. Various changes to the described embodiments may be made in the function and arrangement of the ingredients described without departing from the scope of the invention.
The use of “including”, “comprising” or “having” variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items. The terms “a” and “an” herein do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced items. Further, the use of terms “first”, “second”, and “third”, and the like, herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another.
A non-invasive and efficient screening method is needed prior to biopsy by utilizing fluorophores that is naturally present in the epithelial lining and sub mucosa of the oral cavity cause fluorescence when exposed to UV-visible light. As fluorescence-based optical techniques are sensitive to modest morphological and biochemical changes as the disease progresses, they may be used for early cancer diagnosis. Over the past few decades, a variety of optical approaches have been employed for the early diagnosis of various types of cancer. Of these, fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. Due to their high cost and large number of components, these heavy systems appear to be very difficult to transfer from the lab to the clinic or for commercial application. But there isn't a single integrated device that looks at the anomaly in the mouth, scans the affected area, and measures the area at specific points. There is time based need and requirement for the detection of oral cancer can signify a reliable, user-friendly, and reasonably priced device.

Thus, the present disclosure relates to fluorescence imaging tool for real –time visual assessment of oral cavity and to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions.
A Fluorescence Imaging Tool for Oral Cavity comprising portable tool having size; length of 120 mm, diameter of 40 mm and weight of 140 gm, works on optical spectroscopy preferably embodied light source preferably Light Emitting Diode (LED) light source to emit the desired wavelength, incident on the oral cavity tissues and the emitted fluorescence from oral cavity tissues analysed from emitted signals detected by Charge Coupled Device (CCD) camera which generates two dimensional fluorescence spectral images automatically processed and interpreted from Graphic User Interface (GUI) software signify real time in situ non invasive visual assessment to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions.
Preferred embodiments of a fluorescence imaging tool for oral cavity
i) Main Housing: The fluorescence imaging tool for oral cavity preferably consist of Light Emitting Diode (LED) light source, Charge Coupled Device (CCD) camera and GUI software is user friendly real time in situ technique to assess and distinguish normal and abnormal oral cavity’s tissues for clinical significance particularly in oral cancer or pre cancerous stage by analysing fluorescence images therein. The fluorescence imaging tool having size; length of 120 mm, diameter of 40 mm and weight of 140 gm.
ii) Light Emitting Diode (LED) light source: LED source is an important source to emit light of desire wavelength to produce fluorescence spectroscopic effect herein light incident on oral cavity tissue, wherein fluorescence generated within the tissues, emitted spectral signals, analysed for normal and abnormal fluorescence images.
iii) Charge Coupled Device (CCD) camera: The emitted fluorescence signals from the oral cavity tissues are detected through CCD camera, which further process it to generate the fluorescence images, the generated images are evaluated for assessment of clinical situation of oral cavity.
iv) Graphic User Interface (GUI) software: The fluorescence images generated by CCD camera can be automatically processed, developed and integrated using GUI software in real time to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers, early cancers or pre-cancerous conditions effectively.
Table no. 01: Preferred embodiments of the device

Sr No. Name of Embodiments Role/ Application
01 Main Housing Configured various components of device with size; length of 120 mm, diameter of 40 mm and weight of 140 gm.
02 Light Emitting Diode (LED) light source Emits the desired wavelength light for fluorescence effect within oral cavity tissue
03 Charge Coupled Device (CCD) camera Detection of fluorescence signals and conversion it into fluorescence images
04 GUI software Automatic processing and integration of fluorescence images generated by CCD camera

Steps involved in the method to operate the device

i) Emitting the desired wavelength from LED light: The oral cavity tissues to be investigated are introduced to LED light source for spectroscopic effect, herein the oral cavity tissue are exposed to LED light in situ to produce fluorescence effect and emits the spectral signals.

ii) Detecting and Generating the Fluorescence Images: The emitted fluorescence spectral signals by oral cavity tissues are detected, processed and converted to generation of fluorescence images using Charge Coupled Device (CCD) camera for the clinical visual assessment and interpretation of normal and abnormal clinical conditions.

iii) Automatic Processing of the Fluorescence Images: The generated fluorescence images from the CCD camera are processed and developed automatically using Graphic User Interface (GUI) software in real time with speedy analysis of images to draw the clinical inference. (Table No. 1)

Method to operate the device
Emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ for 10 to 15 min to produce fluorescence effect through emission of spectral signals; detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation; processing the generated fluorescence images from the CCD camera which acquire and interpreted, automatically using Graphic User Interface (GUI) software in real time for 10 to 15 min with speedy analysis of images to draw the clinical inference. (Table No. 1 and Figure No. 1 )
Example 1
Emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ for 10 min to produce fluorescence effect through emission of spectral signals; detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation in real time to draw the clinical inference.
Example 2
Emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ for 10 min to produce fluorescence effect through emission of spectral signals; detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation; processing the generated fluorescence images from the CCD camera which acquire and interpreted, automatically using Graphic User Interface (GUI) software in real time with speedy analysis of images to draw the clinical inference.
Example 3
Emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ for 15 min to produce fluorescence effect through emission of spectral signals; detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation in real time to draw the clinical inference.
Example 4
Emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ for 15 min to produce fluorescence effect through emission of spectral signals; detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation; processing the generated fluorescence images from the CCD camera which acquire and interpreted, automatically using Graphic User Interface (GUI) software in real time with speedy analysis of images to draw the clinical inference.
Scope of the Invention

Fluorescence spectroscopy has separately emerged as the most successful and has been extensively investigated by researchers. This method is less time-consuming and has good sensitivity and specificity. The present portable fluorescence image tool preferably real time assess oral cavity in situ, non invasively to identify oral lesions to confirm the clinical situations preferably helpful to diagnose oral cancers and early cancers or pre-cancerous alterations, utilizes desired wavelength light from LED to produce fluorescence emitted through oral cavity tissues detected and identified using CCD cameras and GUI software, signify the economical benefit due to low costing configuration can be beneficial for clinical visual assessment of oral cavity preferably oral cancers, early cancers or pre-cancerous conditions in patients effectively in future.

It is to be understood that the present invention is not limited to the embodiments described above, it should be clear that various modifications and alterations can be made along with various features of one embodiment included in other embodiments, within the scope of the present invention.
, Claims:We claim,
1- A fluorescence imaging tool for oral cavity comprising a portable tool characterized in that a Light Emitting Diode (LED) light source; a Charge Coupled Device (CCD) camera and a Graphic User Interface (GUI) software effectively analysed generated fluorescence images of oral cavity tissues for visual assessment preferably to detect oral lesions, oral cancers, early cancers or pre-cancerous conditions.
2- The fluorescence imaging tool for oral cavity as claimed in claim 1, having size; length of 120 mm, diameter of 40 mm and weight of 140 gm.

3- The fluorescence imaging tool for oral cavity as claimed in claim 1, operates through a method comprises the following steps:
i) emitting the desired wavelength light through Light Emitting Diode (LED), exposed to oral cavity tissue in situ to produce fluorescence effect through emission of spectral signals;

ii) detecting the emitted fluorescence spectral signals by oral cavity tissues, processed and generation it into fluorescence images using Charge Coupled Device (CCD) camera for visual assessment and interpretation;

iii) processing the generated fluorescence images from the CCD camera which acquire and interpreted, automatically using Graphic User Interface (GUI) software in real time for 10 to 15 min with speedy analysis of images to draw the clinical inference.