Abstract: The present disclosure pertains to a composition for bathing. Particularly, the present disclosure provides a foaming bath composition comprising: 0.2% to about 1% by weight of Lactobacillus ferment and maltodextrin; and cosmeceutically acceptable excipients. The composition is suitable for maintaining the microbiome balance of skin, helps repair skin barrier and is suitable for management of Atopic dermatitis. The composition is sulphate-free, phthalate-free and paraben-free.
DESC:FIELD OF THE INVENTION
[0001] The present disclosure pertains to a composition for bathing. Particularly the present disclosure provides a foaming bath composition comprising Lactobacillus ferment and other actives for maintaining the microbiome balance of skin and for improving skin barrier.
BACKGROUND OF THE INVENTION
[0002] The background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Skin, the largest organ of the human body, is our first line of defence that covers and protects everything inside the body. Skin helps maintain the balance of fluids, keeps pathogens at bay, heals wounds, produces vitamin D, and helps regulate body temperature. It is comprised of water, protein such as collagen, keratin etc. and lipids such as squalene. Although the skin regenerates it is essential to maintain the condition of skin as it can get dry, unhealthy, or irritable overtime that decreases its activity.
[0004] There are several factors that can affect the condition of skin including both internal and external. Internal factors include quality of food, amount of nutrition, and uptake of water; while external factors include exposure to sun, UV rays, pollution, and cosmetics used. Among cosmetics used on the skin, a soap or body bath is a cosmetic product we use on an everyday basis on the skin. Thus, the quality of one’s body bath or soap is of extreme importance for maintaining the health of the skin. People with sensitive or easily irritable skin face more problems as harsh body washes can peel the skin or rip the skin of essential moisturization while very light formulas may be ineffective in cleaning the skin. Additionally, conventional bathing compositions are not suitable for sensitive skin population with compromised skin barrier function, as they contain sulphates, parabens, or phthalates which are harmful for skin.
[0005] Thus, there is a need in the art to develop bathing compositions that are mild, devoid of harsh chemicals, help repair the skin barrier and maintain the microbiome balance.
OBJECTS OF THE INVENTION
[0006] An object of the present disclosure is to provide a foaming bath composition comprising Lactobacillus ferment and maltodextrin; and cosmeceutically acceptable excipients.
[0007] Another object of the present disclosure is to provide a foaming bath composition that repairs the skin’s barrier and maintains the microbiome balance.
[0008] Yet another object of the present disclosure is to provide a foaming bath composition that can manage atopic dermatitis and associated conditions.
SUMMARY OF THE INVENTION
[0009] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in Detailed Description section. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.
[00010] Aspects of the present disclosure provide a foaming bath composition comprising: 0.2% to about 1% by weight of Lactobacillus ferment and maltodextrin; and cosmeceutically acceptable excipients.
[00011] Aspects of the present disclosure provide a composition comprising parabiotics that is a mild foaming bath composition for sensitive skin.
[00012] In an aspect, the present disclosure provides a process of manufacturing a foaming bath composition comprising actives Lactobacillus ferment, and maltodextrin.
[00013] Other aspects of the invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learnt by the practice of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
[00014] Figure 1: illustrates reduction in SCORAD.
[00015] Figure 2: illustrates reduction in EASI score.
[00016] Figure 3: illustrates reduction in growth of staphylococcus aureus.
[00017] Figure 4: illustrates reduction in itching score.
[00018] Figure 5: illustrates increase in skin hydration.
[00019] Figure 6: illustrates reduction in transepidermal water loss.
DETAILED DESCRIPTION OF THE INVENTION
[00020] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.
[00021] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.
[00022] Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[00023] In some embodiments, numbers have been used for quantifying weights, percentages, ratios, and so forth, to describe and claim certain embodiments of the invention and are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
[00024] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[00025] As used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.
[00026] Unless the context requires otherwise, throughout the specification which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense that is as “including, but not limited to.”
[00027] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[00028] All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[00029] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified.
[00030] The description that follows, and the embodiments described therein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure.
[00031] It should also be appreciated that the present disclosure can be implemented in numerous ways, including as a system, a method or a device. In this specification, these implementations, or any other form that the invention may take, may be referred to as processes. In general, the order of the steps of the disclosed processes may be altered within the scope of the invention.
[00032] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[00033] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus, if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[00034] As used herein, the term ‘Lactobacillus ferment’ refers to a parabiotic i.e. lysed probiotic with intact cell walls of Lactobacillus species.
[00035] As used herein, the term ‘skin’ refers to non-mucosal skin, excluding any body cavities.
[00036] As used herein, the term ‘atopic dermatitis’ refers to atopic eczema characterized by inflammatory dry, sensitive, or itchy skin condition, primarily caused by Staphylococcus aureus.
[00037] As used herein, the phrase “cosmeceutically acceptable excipient” refers to a constituent suitable and adapted to be used in cosmetic preparations, especially for topical application to the keratinous tissue, is compatible with the actives in the composition, and would not cause any unreasonable safety or toxicity concerns.
[00038] The term, ‘management’, or ‘treatment’ as used herein refers to alleviate, slow the progression, attenuation, prophylaxis or as such treat the existing disease or condition. Treatment also includes treating, preventing development of, or alleviating to some extent, one or more of the symptoms of the diseases or condition.
[00039] The present disclosure provides a composition that is a mild foaming bath composition for sensitive skin. The composition of the present disclosure comprises active parabiotics that balances the microbiome of skin and improves the skin barrier.
[00040] In an embodiment, the present disclosure provides a foaming bath composition comprising 0.2% to about 1% by weight of Lactobacillus ferment and maltodextrin; and cosmeceutically acceptable excipients.
[00041] In an embodiment, the Lactobacillus is selected from a group consisting of Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus casei, and the like.
[00042] In an embodiment, the cosmeceutically acceptable excipient(s) or carrier is selected from a group consisting of emollient, humectant, skin hydrant, moisturizer, thickener, stabilizers, surfactants, emulsifiers, preservatives, colorant, fragrance, preservatives, perfume, pH adjustor, thickener, colouring agent, and the like, or combinations thereof. However, a person of skill in the art would understand that any other excipient(s) well-known in the art may be selected without going beyond the scope of the present disclosure.
[00043] In an embodiment, the composition comprises Lactobacillus ferment, maltodextrin, surfactants, emollient, skin hydrant, moisturizer, carrier(s) and any other cosmeceutically acceptable excipient(s).
[00044] In a preferred embodiment, the ferment may be madenon-viable by mild heat treatment to exert the metabolites such as antimicrobial peptides (AMPs) responsible to induce anti-inflammatory response on the skin.
[00045] In an embodiment, the surfactant is selected from a group consisting of cocamidopropyl betaine, methyl cocoyl taurate, coco glucoside, sodium lauryl glucoside hydroxypropyl sulfonate, caprylyl, and the like or combination thereof.
[00046] In an embodiment, the surfactant may be selected from water and cocamidopropyl betaine and glycerin and caprylyl; capryl glucoside and sodium methyl cocoyl taurate; coco glucoside; sodium lauryl glucoside hydroxypropyl sulfonate, the like and combinations thereof.
[00047] In an embodiment, the surfactant is present in a range of 10% to 25% by weight of the composition.
[00048] In an embodiment, the emollient is selected from a group consisting of glycerin, and the like.
[00049] In an embodiment, the emollient is present in a range of 3% to 7% by weight of the composition.
[00050] In an embodiment, the skin hydrant is selected from a group consisting of hydrolyzed jojoba esters and water, and the like or combinations thereof.
[00051] In an embodiment, the skin hydrant is present in a range of 0.1% to 0.5% by weight of the composition.
[00052] In an embodiment, the moisturizer is selected from D-panthenol and the like.
[00053] In an embodiment, the moisturizer is present in a range of 0.2% to 0.8% by weight of the composition.
[00054] In an embodiment, the carrier or vehicle(s) is selected from water, and the like.
[00055] In an embodiment, the carrier or vehicle is present in quantity sufficient to form the final composition or formulation to 100%. In a preferred embodiment, the carrier or vehicle is present in a range of 60% to 90% by weight of the composition.
[00056] In an embodiment, the preservative is selected from a group consisting of phenoxyethanol and ethyl hexylglycerin; and the like or combination thereof.
[00057] In an embodiment, the preservative is present in a range of 0.2% to 0.8% by weight of the composition.
[00058] In an embodiment, the perfume is selected from any well known perfume in the art, including parfum.
[00059] In an embodiment, the perfume is present in a range of 0.2% to 1.2% by weight of the composition.
[00060] In an embodiment, the pH adjustor is selected from a group consisting of citric acid monohydrate and the like.
[00061] In an embodiment, the pH adjustor is present in an amount sufficient to maintain the pH of the composition between 5 to 6, preferably 5.5.
[00062] In an embodiment, the pH adjustor is present in a range of 0.02% to 0.1% by weight of the composition.
[00063] In an embodiment, the composition comprises actives Lactobacillus ferment, maltodextrin, hydrolyzed jojoba esters, D-panthenol, carrier(s) and cosmeceutically acceptable excipient(s).
[00064] In an embodiment, the foaming bath composition comprises water; water and cocamidopropyl betaine andglycerin and caprylyl, or capryl glucoside and sodium methyl cocoyl taurate; glycerin; coco glucoside; sodium lauryl glucoside hydroxypropyl sulfonate; parfum; maltodextrin and Lactobacillus ferment; D-panthenol; phenoxyethanol and ethyl hexylglycerin; hydrolyzed jojoba esters and water; and citric acid monohydrate.
[00065] In a preferred embodiment, the foaming bath composition comprises water in a range from about 75.17% by weight of the composition; water and cocamidopropyl betaine and glycerin and caprylyl, or capryl glucoside and sodium methyl cocoyl taurate in a range from about 7.5% to about 12.5% by weight of the composition; glycerin in a range from about 3% to about 7% by weight of the composition; coco glucoside in a range from about 3% to about 6% by weight the composition; sodium lauryl glucoside hydroxypropyl sulfonate in a range from about 3% to about 6% by weight of the composition; parfum in a range from about 0.2% to about 1.2% by weight of the composition; maltodextrin and Lactobacillus ferment in a range from about 0.2% to about 1% by weight of the composition; D-panthenol in a range from about 0.2% to 0.8% by weight the composition; phenoxyethanol and ethyl hexylglycerin in a range from about 0.2% to about 0.8% by weight the composition; hydrolyzed jojoba esters and water in a range from about 0.1% to about 0.5% by weight of the composition; and citric acid monohydrate in a range from about 0.02% to about 0.1% by weight of the composition.
[00066] In some embodiments, the composition comprises other actives, such as antimicrobial agent, anti-inflammatory agents, and the like. In some embodiments, the composition comprises an additional antimicrobial agent such as antibacterial and/or antifungal agent(s).
[00067] In an embodiment, the composition is formulated into a foaming bath formulation such as an emulsion, gel, soap, foam, or cream. In an embodiment, the formulation is suitable for topical application. In a preferred embodiment, the formulation may be a rinse-off formulation.
[00068] The composition of the present disclosure restores damaged and compromised skin barrier. It strengthens skin barrier function.
[00069] The composition is dermatologically safe, clinically safe and is hypoallergenic. Therefore, it is very well suited for sensitive skins.
[00070] The composition is devoid of harsh chemicals including sulphates, parabens or phthalates.
[00071] In an embodiment, the composition is effective in cleaning the skin without drying it out and reduces trans-epidermal water loss.
[00072] The composition of the present disclosure maintains, and/or restores healthy state of the skin microbiome. In an embodiment, the composition is effective against pathogens including bacteria, such as Staphylococcus aureus.
[00073] In an embodiment, the present disclosure provides a foaming bath formulation comprising actives Lactobacillus ferment, and maltodextrin.
[00074] In another embodiment, the present disclosure provides a foaming bath composition for management of atopic dermatitis and associated conditions comprising actives Lactobacillus ferment, and maltodextrin.
[00075] In an embodiment, the associated conditions may include itchy skin, dry skin, inflammation, rash, flaky skin, loss of skin barrier function and the like.
[00076] In an embodiment, the composition provides anti-inflammatory effect and improves the scoring index of atopic dermatitis (SCORAD), which is based on the extent or degree of eczema.
[00077] In an embodiment, the present disclosure provides a process of manufacturing a foaming bath composition comprising actives Lactobacillus ferment, and maltodextrin.
[00078] While the foregoing describes various embodiments of the disclosure, other and further embodiments of the disclosure may be devised without departing from the basic scope thereof. The scope of the invention is determined by the claims that follow. The invention is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.
EXAMPLES
[00079] The disclosure will now be illustrated with the following example, which is intended to illustrate the working of disclosure as per one of the embodiments and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may vary.
EXAMPLE 1
[00080] Phase I- A foaming bath composition as per the present disclosure was prepared by weighing/measuring the materials of Table 1 in a main manufacturing vessel, adding purified water and mixing well at slow speed.
Table 1: Components in Phase I
Materials Net quantity (kg)
Purified water 71.000
Water (and) Cocamidopropyl Betaine (and) Glycerin (and) Caprylyl / Capryl Glucoside (and) Sodium Methyl Cocoyl Taurate 10.000
Coco glucoside 4.000
Sodium Lauryl Glucoside Hydroxypropyl Sulfonate 3.000
[00081] Phase II- Weighed and measured the materials as per Table 2 below. Added these components one by one to main manufacturing vessel of Phase I under continuous stirring to mix well. pH was adjusted up to 5.5 for the final composition using citric acid, so quantity of citric acid may vary.
Table 2: Components in Phase II
Materials Net quantity (kg)
Hydrolyzed Jojoba Esters (and) Water 0.300
D-Panthenol 0.500
Citric Acid Monohydrate 0.030
Phenoxyethanol (and) Ethyl hexylglycerin 0.500
Parfum 0.200
[00082] Phase III: In another vessel glycerin was taken as per Table 3, lysed probiotics were added to it and mixed well, then added purified water to this mixture and then added it to the main manufacturing vessel of Phase II and mixed well.
Table 3: Components in Phase III
Materials Net quantity (kg)
Glycerin 5.000
Maltodextrin (and) Lactobacillus Ferment 0.500
Water (Aqua) 5.000
[00083] The composition was mixed uniformly and the pH of the composition was checked and set to 5.5.
Example 2: Scorad Index
[00084] It is observed that 57.7 % reduction in atopic dermatitis severity observed post 60 days of daily bath foam application (Figure 1).
Volunteer Day 1 Day 60
1 39.3 14.3
2 39.3 17.8
3 33.3 14.3
4 25.3 14.3
5 40.3 14.3
SCORAD Index assess the extent and severity of Atopic Dermatitis (AD) and evaluates improvement in AD management post treatment. In addition to objective signs such as extension, severity of signs and symptoms like erythema, oedema, lichenification and dryness, SCORAD Index also considers subjective signs like irritability and loss of sleep. After 60 days of bath foam application, 57.7% reduction in SCORAD Index is observed indicating management of subjective signs and reduction in objective signs.
Example 3: Eczema Area and Severity Index (EASI): Severity Score
[00085] It is observed that 60.6 % reduction in atopic dermatitis severity observed post 60 days of daily bath foam application (Figure 2).
Volunteer Day 1 Day 60
1 4.2 1.8
2 4.2 1.8
3 4.2 1.8
4 2.0 0.8
5 4.2 1.2
EASI Score measures the severity of clinical signs in atopic dermatitis and evaluates improvement in AD management post treatment. It assesses four AD characteristics such as erythema, thickness, scratching and lichenification on a scale of 0 (absent) to 3 (severe) in four different parts of the body, namely head & neck, upper limbs, trunk and lower limbs. After 60 days of bath foam application, 60.6% reduction in EASI score is observed indicating reduction in severity of clinical signs of AD.
Example 4: Staphylococcus aureus
[00086] It is observed that 100 % of all the subjects showed NO GROWTH in Staphylococcus aureus after 60 days of daily application using bath foam application (Figure 3).
Volunteer Day 1 Day 60
1 No Growth No Growth
2 Scanty Growth No Growth
3 Mild Growth No Growth
4 Scanty Growth No Growth
5 No Growth No Growth
Staphylococcus aureus is associated with the severity, pathogenesis and exacerbation of AD. Increase in colonization triggers Th2 and IgE response which
exacerbates inflammation and itching which further increases risk of various invasive infections. After 60 days of bath foam application, 100% reduction in growth of Staphylococcus aureus is observed indicating reduction in severity of clinical signs of AD.
Example 5: Visual Analogue Scale (VAS)
[00087] There is 40% reduction in pruritus severity observed post 60 days of daily bath foam application (Figure 4).
Volunteer Day 1 Day 60
1 3 1
2 4 1
3 5 1
4 4 1
5 4 1
Itching Score helps to assess severity of pruritis, a disease-defining symptom of atopic dermatitis. After 60 days of bath foam application, 40% reduction in pruritis is observed indicating reduction in severity of clinical signs of AD.
Example 6: Moisture Content
[00088] For affected area, skin hydration at the epidermis and the upper dermis is increased by 57.9% after 60 days of daily bath foam application (Figure 5).
Volunteer Day 1 Day 60
1 12.5 30
2 15.9 21.9
3 14.4 31.3
4 29.4 36.2
5 24.8 35.6
Measuring moisture content is one of the important factors in AD as it helps to assess the skin’s integrity and the degree of skin hydration of the epidermis layer. After 60 days of bath foam application, 57.9% increase in skin hydration at the epidermis and the upper dermis is observed which helps in management of clinical signs of AD.
Example 7: Transdermal water loss
[00089] For affected area, transepidermal water loss (TEWL) is decreased by 33.9% after 60 days of daily bath foam with parabiotic application (Figure 6).
Volunteer Day 1 Day 60
1 13.1 7.4
2 18.1 12.5
3 16.5 7.5
4 8.1 7.8
5 12.8 10.1
TEWL helps in assessing the barrier function of skin in atopic dermatitis. It assesses the quantity of condensed water that diffuses across a fixed area of stratum corneum to the skin surface per unit time. Due to dysfunction of skin barrier, patients with AD display higher TEWL. After 60 days of bath foam application, 33.9% decrease in TEWL is observed which indicates lesser water loss and better management of clinical signs of AD.
[00090] From the foregoing, it will be appreciated that, although specific embodiments of the invention have been described herein merely for purposes of illustration, various modifications may be made without deviating from the spirit and scope of the invention and should not be construed so as to limit the scope of the invention or the appended claims in any way.
ADVANTAGES OF INVENTION
[00091] The present disclosure provides a composition that is a mild foaming bath composition for sensitive skin that maintains the microbiome balance and repairs the skin barrier.
[00092] The present disclosure provides a foaming bath composition that is paraben-free, phthalate-free and sulphate-free.
[00093] The present disclosure provides a foaming bath composition that helps in management of Atopic dermatitis.
,CLAIMS:1. A foaming bath composition comprising:
0.2% to about 1% by weight of Lactobacillus ferment and maltodextrin; and cosmeceutically acceptable excipients.
2. The composition as claimed in claim 1, wherein the Lactobacillus is selected from a group consisting of Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus casei.
3. The composition as claimed in claim 1, wherein the cosmeceutically acceptable excipients is selected from a group consisting of emollient, humectant, skin hydrant, moisturizer, thickener, stabilizers, surfactants, emulsifiers, preservatives, colorant, fragrance, preservatives, perfume, pH adjustor, thickener and colouring agent or combinations thereof.
4. The composition as claimed in claim 3, wherein the surfactant is selected from the group consisting of cocamidopropyl betaine, methyl cocoyl taurate, coco glucoside, sodium lauryl glucoside hydroxypropyl sulfonate and caprylyl or combination thereof.
5. The composition as claimed in claim 4, wherein the surfactant is present in the range of 10% to 25% by weight of the composition.
6. The composition as claimed in claim 3, wherein the emollient is glycerin.
7. The composition as claimed in claim 6, wherein the emollient is present in the range of 3% to 7% by weight of the composition.
8. The composition as claimed in claim 3, wherein the skin hydrant is selected from a group consisting of hydrolyzed jojoba esters and water or combinations thereof.
9. The composition as claimed in claim 8, wherein the skin hydrant is present in the range of 0.1% to 0.5% by weight of the composition.
10. The composition as claimed in claim 3, wherein the moisturizer is D-panthenol.
11. The composition as claimed in claim 10, wherein the moisturizer is present in the range of 0.2% to 0.8% by weight of the composition.
12. The composition as claimed in claim 3, wherein the vehicle is water.
13. The composition as claimed in claim 12, wherein the vehicle is present to make quantity sufficient and preferably in the range of 60 % to 90 % by weight of the composition.
14. The composition as claimed in claim 3, wherein the preservatives are selected from a group of consisting of phenoxyethanol and ethyl hexylglycerin or combination thereof.
15. The composition as claimed in claim 14, wherein the preservatives are present in the range of 0.2% to 0.8% by weight of the composition.
16. The composition as claimed in claim 3, wherein the perfume is parfum.
17. The composition as claimed in claim 16, wherein the perfume is present in the range from 0.2% to about 1.2% by weight of the composition.
18. The composition as claimed in claim 3, wherein the pH adjustor is citric acid monohydrate.
19. The composition as claimed in claim 18, wherein the pH adjustor is present in an amount sufficient to maintain the pH of the composition between 5 to 6.
20. The composition as claimed in claim 19, wherein the pH adjustor is present in the range from 0.02% to 0.1% by weight of the composition.
| # | Name | Date |
|---|---|---|
| 1 | 202121044213-STATEMENT OF UNDERTAKING (FORM 3) [29-09-2021(online)].pdf | 2021-09-29 |
| 2 | 202121044213-PROVISIONAL SPECIFICATION [29-09-2021(online)].pdf | 2021-09-29 |
| 3 | 202121044213-POWER OF AUTHORITY [29-09-2021(online)].pdf | 2021-09-29 |
| 4 | 202121044213-FORM FOR SMALL ENTITY(FORM-28) [29-09-2021(online)].pdf | 2021-09-29 |
| 5 | 202121044213-FORM FOR SMALL ENTITY [29-09-2021(online)].pdf | 2021-09-29 |
| 6 | 202121044213-FORM 1 [29-09-2021(online)].pdf | 2021-09-29 |
| 7 | 202121044213-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [29-09-2021(online)].pdf | 2021-09-29 |
| 8 | 202121044213-EVIDENCE FOR REGISTRATION UNDER SSI [29-09-2021(online)].pdf | 2021-09-29 |
| 9 | 202121044213-DECLARATION OF INVENTORSHIP (FORM 5) [29-09-2021(online)].pdf | 2021-09-29 |
| 10 | 202121044213-Proof of Right [31-12-2021(online)].pdf | 2021-12-31 |
| 11 | 202121044213-ENDORSEMENT BY INVENTORS [29-09-2022(online)].pdf | 2022-09-29 |
| 12 | 202121044213-DRAWING [29-09-2022(online)].pdf | 2022-09-29 |
| 13 | 202121044213-CORRESPONDENCE-OTHERS [29-09-2022(online)].pdf | 2022-09-29 |
| 14 | 202121044213-COMPLETE SPECIFICATION [29-09-2022(online)].pdf | 2022-09-29 |