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A Fusion Molecule Comprising Microrna 25 3 P Analog And Uses Thereof

Abstract: The present disclosure provides a fusion molecule comprising a miRNA analog fused to a peptide via a linker for use in cosmetic skin lightening. Also provided in the disclosure are formulations comprising said fusion molecule, methods of preparation and uses thereof.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
21 October 2015
Publication Number
17/2017
Publication Type
INA
Invention Field
BIO-CHEMISTRY
Status
Email
lsmds@lakshmisri.com
Parent Application
Patent Number
Legal Status
Grant Date
2024-01-31
Renewal Date

Applicants

ITC LIMITED
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India

Inventors

1. MUTHAIYAH, Balu
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
2. JOIS, Prashant Sirigeri
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
3. H, Ramya
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
4. BANDYOPADHYAY, Balaji
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India

Specification

Claims:1. A fusion molecule for skin lightening, said fusion molecule comprising:
a. a RNA fragment having sequence as set forth in SEQ ID NO: 1;
b. a cross-linker having structure of Figure 1;
c. a peptide having amino acid sequence as set forth in SEQ ID NO: 2,
wherein said RNA fragment 3’ end is fused to the N-terminal of the said peptide by said cross-linker.
2. A method of preparing a fusion molecule as claimed in claim 1.
3. A formulation for topical application comprising:
a. a fusion molecule as claimed in claim 1; and
b. suitable carriers, diluents, and excipients.
4. A method of preparing a formulation as claimed in claim 3.
5. A method of cosmetic skin lightening, said method comprising:
a. obtaining a fusion molecule as claimed in claim 1; and
b. contacting said fusion molecule with skin,
wherein said method results in skin lightening.
6. The method as claimed in claim 5, wherein said fusion molecule concentration is in the range of 10pM-100nM.
7. A method of cosmetic skin lightening, said method comprising:
a. obtaining a formulation as claimed in claim 3; and
b. contacting said formulation with skin,
wherein said method results in skin lightening.
8. The method as claimed in claim 7, wherein in said formulation, fusion molecule concentration is in the range of 10pM-100nM.
9. A fusion molecule as claimed in claim 1 for use in preparation of cosmetics for topical application to inhibit skin pigmentation.

10. A fusion molecule as claimed in claim 1 for use in inhibition of skin pigmentation.
, Description:N/A

Documents

Orders

Section Controller Decision Date

Application Documents

# Name Date
1 5683-CHE-2015-IntimationOfGrant31-01-2024.pdf 2024-01-31
1 Sequence listing [21-10-2015(online)].pdf 2015-10-21
2 5683-CHE-2015-PatentCertificate31-01-2024.pdf 2024-01-31
2 Form 5 [21-10-2015(online)].pdf 2015-10-21
3 Form 3 [21-10-2015(online)].pdf 2015-10-21
3 5683-CHE-2015-AMMENDED DOCUMENTS [25-01-2024(online)].pdf 2024-01-25
4 Drawing [21-10-2015(online)].pdf 2015-10-21
4 5683-CHE-2015-FORM 13 [25-01-2024(online)].pdf 2024-01-25
5 Description(Complete) [21-10-2015(online)].pdf 2015-10-21
5 5683-CHE-2015-MARKED COPIES OF AMENDEMENTS [25-01-2024(online)].pdf 2024-01-25
6 5683-CHE-2015-Written submissions and relevant documents [25-01-2024(online)].pdf 2024-01-25
6 5683-CHE-2015-FORM 18 [05-09-2019(online)].pdf 2019-09-05
7 5683-CHE-2015-Response to office action [27-07-2021(online)].pdf 2021-07-27
7 5683-CHE-2015-FORM-26 [10-01-2024(online)].pdf 2024-01-10
8 5683-CHE-2015-FER.pdf 2021-10-17
8 5683-CHE-2015-Correspondence to notify the Controller [08-01-2024(online)].pdf 2024-01-08
9 5683-CHE-2015-Response to office action [04-08-2022(online)].pdf 2022-08-04
9 5683-CHE-2015-US(14)-HearingNotice-(HearingDate-11-01-2024).pdf 2023-12-19
10 5683-CHE-2015-Response to office action [04-08-2022(online)].pdf 2022-08-04
10 5683-CHE-2015-US(14)-HearingNotice-(HearingDate-11-01-2024).pdf 2023-12-19
11 5683-CHE-2015-Correspondence to notify the Controller [08-01-2024(online)].pdf 2024-01-08
11 5683-CHE-2015-FER.pdf 2021-10-17
12 5683-CHE-2015-FORM-26 [10-01-2024(online)].pdf 2024-01-10
12 5683-CHE-2015-Response to office action [27-07-2021(online)].pdf 2021-07-27
13 5683-CHE-2015-FORM 18 [05-09-2019(online)].pdf 2019-09-05
13 5683-CHE-2015-Written submissions and relevant documents [25-01-2024(online)].pdf 2024-01-25
14 5683-CHE-2015-MARKED COPIES OF AMENDEMENTS [25-01-2024(online)].pdf 2024-01-25
14 Description(Complete) [21-10-2015(online)].pdf 2015-10-21
15 5683-CHE-2015-FORM 13 [25-01-2024(online)].pdf 2024-01-25
15 Drawing [21-10-2015(online)].pdf 2015-10-21
16 5683-CHE-2015-AMMENDED DOCUMENTS [25-01-2024(online)].pdf 2024-01-25
16 Form 3 [21-10-2015(online)].pdf 2015-10-21
17 5683-CHE-2015-PatentCertificate31-01-2024.pdf 2024-01-31
17 Form 5 [21-10-2015(online)].pdf 2015-10-21
18 Sequence listing [21-10-2015(online)].pdf 2015-10-21
18 5683-CHE-2015-IntimationOfGrant31-01-2024.pdf 2024-01-31

Search Strategy

1 search-patentlensE_08-01-2021.pdf

ERegister / Renewals

3rd: 29 Apr 2024

From 21/10/2017 - To 21/10/2018

4th: 29 Apr 2024

From 21/10/2018 - To 21/10/2019

5th: 29 Apr 2024

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6th: 29 Apr 2024

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7th: 29 Apr 2024

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8th: 29 Apr 2024

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9th: 29 Apr 2024

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10th: 29 Apr 2024

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11th: 04 Sep 2025

From 21/10/2025 - To 21/10/2026