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A Fusion Molecule Comprising Microrna 29 B Analog And Uses Thereof

Abstract: The present disclosure provides a fusion molecule comprising a miRNA analog fused to a peptide via a linker for use in cosmetic skin lightening. Also provided in the disclosure are formulations comprising said fusion molecule, methods of preparation and uses thereof.

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Patent Information

Application #
Filing Date
21 October 2015
Publication Number
17/2017
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
lsmds@lakshmisri.com
Parent Application

Applicants

ITC LIMITED
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India

Inventors

1. MUTHAIYAH, Balu
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
2. JOIS, Prashant Sirigeri
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
3. H, Ramya
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India
4. BANDYOPADHYAY, Balaji
ITC LIFE SCIENCES AND TECHNOLOGY CENTRE #3. 1st Main, Peenya Industrial Area, Phase 1, Bangalore 560 058, India

Specification

Claims:1. A fusion molecule for skin lightening, said fusion molecule comprising:
a. a RNA fragment having sequence as set forth in SEQ ID NO: 1;
b. a cross-linker having structure of Figure 1;
c. a peptide having amino acid sequence as set forth in SEQ ID NO: 2,
wherein said RNA fragment 3’ end is fused to the N-terminal end of the said peptide by said cross-linker.
2. A method of preparing a fusion molecule as claimed in claim 1.
3. A formulation for topical application comprising:
a. a fusion molecule as claimed in claim 1; and
b. suitable carriers, diluents, and excipients.
4. A method of preparing a formulation as claimed in claim 3.
5. A method of cosmetic skin lightening, said method comprising:
a. obtaining a fusion molecule as claimed in claim 1; and
b. contacting said fusion molecule with skin,
wherein said method results in skin lightening.
6. The method as claimed in claim 5, wherein said fusion molecule concentration is in the range of 5pM-100nM.
7. A method of cosmetic skin lightening, said method comprising:
a. obtaining a formulation as claimed in claim 3; and
b. contacting said formulation with skin,
wherein said method results in skin lightening.
8. The method as claimed in claim 7, wherein in said formulation, fusion molecule concentration is in the range of 5pM-100nM.
9. A fusion molecule as claimed in claim 1 for use in preparation of cosmetics for topical application to inhibit skin pigmentation.

10. A fusion molecule as claimed in claim 1 for use in inhibition of skin pigmentation.
, Description:As Attached

Documents

Application Documents

# Name Date
1 5681-CHE-2015-FER.pdf 2021-10-17
1 Sequence listing [21-10-2015(online)].pdf 2015-10-21
2 5681-CHE-2015-FORM 18 [05-09-2019(online)].pdf 2019-09-05
2 Form 5 [21-10-2015(online)].pdf 2015-10-21
3 5681-CHE-2015-Correspondence-301115.pdf 2016-03-19
3 Form 3 [21-10-2015(online)].pdf 2015-10-21
4 5681-CHE-2015-Form 1-301115.pdf 2016-03-19
4 Drawing [21-10-2015(online)].pdf 2015-10-21
5 Description(Complete) [21-10-2015(online)].pdf 2015-10-21
5 5681-CHE-2015-Power of Attorney-301115.pdf 2016-03-19
6 5681-CHE-2015-Power of Attorney-301115.pdf 2016-03-19
6 Description(Complete) [21-10-2015(online)].pdf 2015-10-21
7 5681-CHE-2015-Form 1-301115.pdf 2016-03-19
7 Drawing [21-10-2015(online)].pdf 2015-10-21
8 5681-CHE-2015-Correspondence-301115.pdf 2016-03-19
8 Form 3 [21-10-2015(online)].pdf 2015-10-21
9 5681-CHE-2015-FORM 18 [05-09-2019(online)].pdf 2019-09-05
9 Form 5 [21-10-2015(online)].pdf 2015-10-21
10 Sequence listing [21-10-2015(online)].pdf 2015-10-21
10 5681-CHE-2015-FER.pdf 2021-10-17

Search Strategy

1 patentlenssearchE_04-01-2021.pdf
1 TPOE_04-01-2021.pdf
2 patentlenssearchE_04-01-2021.pdf
2 TPOE_04-01-2021.pdf