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FIELD OF INVENTION
The present invention relates to a herbal preparation beneficial in the
management of hyperpyrexia or rhinitis of viral origin. The preparation of
the present inventions may be advantageous in the management of
common cold and cough along with high temperature, high fever due to
arthritis of varying etiology etc. It may also enhance the general body
immunity and thus restrict the frequent attacks of cold and cough
among susceptible individuals without nay adverse side effect.
BACKGROUDN OF INVENTION
Immunologically competent cells are activated in respect to foreign
organism or antigenic proteins resulting in the inflammation. The
inflammatory response is usually initiated by trauma or by antigen, i.e.
viral, bacterial, protozoal or fungal. The cell damage associated with
inflammation acts on cell membranes to cause leukocytes to release
lysosomal enzymes, arachidonic acid is then liberated from precursor
compounds and various eicosanoids and synthesized. Leukotrienes have
a powerful chemotactic effect on eosinophile, neutrophils and
marophages and thus promotes to bronchoconstriction and alterations in
vascular permeability kinins neuro-peptides and histamine are also
released at the side of tissue injury, as are complement components and
other products of leukocytes and platelets. The activation of neutrophil
membranes produces oxygen-derived free radicials. The interaction of
these substances with arachidonic acid results in the generation of
chemotactic substances, thus causing inflammatory process. Drugs used
for anti-inflammatory effect are heterogeneous in chemical structure and
diverse in mechanism of action.

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Based on the above mechanism, common cold and cough (Coryza) along
with fever is one of the most common health problems among majority of
the population of the world. The onset is usually sudden with a burning
and tickling sensation in the nose accompanied by sneezing. The throat
often feels dry and sore, the head feels stuffed and there is a watery
nasal discharge. These symptoms last for one or two days, after which,
with secondary infection, the secretion becomes thick, purulent and
impedes nasal breathing.
Common cold and cough (Coryza) may lead to sinusitis which can
become chronic particularly accompanied by nasal obstruction and
headache. It may also cause infections of the lower respiratory tract,
occlusion of the Eustachian tubes causing deafness and otitis media.
Paracetamol, anti-allergic agents and antibiotics are the drug of choice
for allergic and antibiotics are the drug of choice for its management,
which have their own health hazards.
The main adverse effect is gastric and ulceration, liver toxicity, central
nervous system may also be involved.
OBJECTS OF THE INVENTION
The main object of present invention is to propose a herbal formulation
for the management of common cold and cough along with high
temperature and inflammation of varying etiology.

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Another object of present invention is to propose a herbal formulation
for control the high temperature body ache of the people suffering of
vertigo, sleeplessness, nausea palpitation and general weakness of the
individuals suffering from upper respiratory tract dysfunction.
Yet another object is to propose a herbal formulation showing its
beneficial role in the management of joint pain along with inflammation.
A further object is to propose a herbal formulation effective in the
management of heahache fatigue lethargy anorexia, indigestion etc.
among cases suffering from upper respiratory tract dysfunction like
commons cold and cough.
A still further object of the present invention is to propose a safer
remedial measure which has potential to enhance the general body
immunity of the individuals suffering from frequent cold and cough and
associated symptoms, so that the frequency of problems be reduced and
the susceptible individuals may be prevented from further pneumonia
and other such problems.
DETAIL DESCRIPTION OF THE INVENTION
According to this invention there is provided a herbal formulation for the
prevention and management of frequent common cold and cough and
associated problems comprising: at least three of the following
ingredients

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Name of plants: Doses range
1. Alstonia scholaris - Saptaparn 160-340 mg/d
2. Swertia chirata - Kirattickar 140-320 mg/d
3. Oldenlandia corymbose - Damanpaper 80-160 mg/d
4. Azadirachta indica - Neem 20-60 mg/d
5. Tinospora cordifolia - Guduchi 60-200 mg/d
6. Nyctanthes arbortristis - Parijat 60-200 mg/d
7. Aconitum heterophyllum -Ativisha 80-220 mg/d
8. Picrorhiza kurroa - Katuka 120-240 mg/d
9. Zinger officinale - Adarak 120-220 mg/d
10. Aconitum chasmanthum-vatsaynabh 120-240 mg/d
11. Operculine turpenthin -Trivritta 60-140 mg/d
12. Piper longum - Pipal 100-30 mg/d
and to be prescribed on a daily basis.
In accordance with this invention, the formulation comprises:
1. Swertia chirata - 320 md/day
2. Aconitum heterophyllum - 200 mg/day
3. Azadirachta indica - 60 mg/day
In accordance with another embodiment, the formulation comprises :
1. Alstonia scholaris - 325 mg/day

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2. Oldenlandia corymbosa - 210 mg/day
3. Tinospora cordifolia - 200 mg/day
4. Nyctanthes arbortristic - 250 mg/day
Hydro-alcoholic extract of Aconitum heterophyllum (165 mg/day)
Nyctanthese arbortristic (125 mg/day) Piper longum (220 mg/day)
Alstonia scholaris (275 mg/day) Oldenlandia corymbosa (110 mg/day)
Aconitum chasmanthum (175 mg/day) Zinger officinale (185 mg/day
having anti-allergic, anti-inflammatory and analgesis properties.
Organic extract of Swertia chirata (22 mg/day), Piper longum (175
mg/day) Nyctanthes arbortristic (125 mg/day), Tinospora cordifolia (130
mg/day) Zinger officinale (150 mg/day) Aconitum heterophyllum (170
mg/day) Operculine turpenthin (85 mg/day) and having anti-allergic
immunomodulatory and analgesic.
Organic extract of Azadirachta indica (25 mg/day), Alstonia scholaris
(175 mg/day) Tinospora cordifolia (110 mg/day) Nyctanthes arbortristic
(85 mg/day), Picrorhiza kurroa (175 mg/day), Operculine turpenthin
(100 mg/day) Aconitum heterophyllum (150 mg/day), Swertia chirata
(225 mg/day), Zinger officinale (150 mg/day) having immonomodulatory
and improvement in psychological status.
Organic extract of Swertia chirata (210 mg/day), Piper longum (185
mg/day), Oldenlandia corymbosa (100 mg/day), Tinospora cordifolia
(125 mg/day), Zinger officinale (150 mg/day), Picrorhiza kurroa (155
mg/day), Nyctanthes arbortristic (110 mg/day), Aconidum chasmnathu
(150 mg/day), and having anti-inflammatory and analgesic property.

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Organic extract of Operculine turpenthin (110 mg/day), Zinger officinale
(165 mg/day), Aconitum heterophyllum (145 mg/day), Azadirachta
indica (40 mg/day), Swertia chirata (210 mg/day), Alstonia scholaris
(225 mg/day), Nyctanthes arbortristic (110 mg/day), Picrorhiza kurroa
(150 mg/day), Tinospora cordifolia (125 mg/day), Oldenlandia
corymbosa (115 mg/day).
The following twelve plants Alstonia scholaris (260 mg/day), Swertia
chirata (260 mg/day), Oldenlandia corymbosa (100 mg/day), Azadirachta
indica (40 mg/day), Tinospora cordifolia (100 mg/day), Nyctanthes
arbortristic (100 mg/day), Aconitum heterophyllum (120 mg/day),
Picrorhiza kurroa (180 mg/day), Zinger officinale (160 mg/day),
Aconitum chasmanthum (120 mg/day), Operculine turpenthin (160
mg/day), Piper longum (180 mg/day), and having anti-allergic, anti-
pyretic, anti-inflammatory and immunomodulatory effects.
The formulation may also comprise a known additive such as minerals,
vitamin, salts, fillers (for capsulation or to prepare syrup or tablets) and
binders, required to be present in trace amount.
Name of the plants : Hindi Name
1. Alstonia scholaris Saptaparn
2. Swertia chirata Kirattickar
3. Oldenlandia corymbose Damanpaper
4. Azadirachta indica Neem
5. Tinospora cordifolia Guduchi

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6. Nyctanthes arbortristis Parijat
7. Aconitum heterophyllum Ativisha
8. Picrorhiza kurroa Katuka
9. Zinger officinale Adarak
10. Aconitum chasmanthum vatsaynabh
11. Operculine turpenthin Trivritta
12. Piper longum Pipal
Thus any known additives or supplement is added to prepare the final
formulation if required and present in trace amount. Reference is made
here in capsule form. However, it would be apparent that the preparation
may also be in the form of table/syrup.
Preferably the preparation comprises of:
Name of plants:
1. Alstonia scholaris - Saptaparn 260 mg/ day
2. Swertia chirata - Kirattickar 260 mg/day
3. Oldenlandia corymbose - Damanpaper 100 mg/day
4. Azadirachta indica - Neem 40 mg/day
5. Tinospora cordifolia - Guduchi 100 mg/day
6. Nyctanthes arbortristis -Parijat 100 mg/day
7. Aconitum heterophyllum-Ativisha 120 mg/day
8. Picrorhiza kurroa - Katuka 180 mg/day
9. Zinger officinale - Adarak 160 mg /day
10. Aconitum chasmanthum-vatsaynabh 120 mg/day
11. Operculine turpenthin -Trivritta 80 mg/day
12. Piper longum - Pipal 180 mg/day

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(The above doses are given in two divided doses per day)
About the plants:
1. Alstonia scholaris : It belongs to Apocynaceae family also
kwown as saptaparn. It is found throughout India. The bark is
used for medicine. It contains, alkaloids, Ditamine, Echitamine,
fatty acids and resinous substances.
2. Swertia chirata: It belongs to Hentianaceae family also known
as kirattickar found upto 4000-10000 ft, Madhya Pradesh and
South India. Root of the plant is used for medicinal purpose.
Swertinin, Swertitanin, Swertianin, Serchirin, decussating,
friedelin and β-sitosterol are isolated from root of the plant. The
hydro-alcoholic extract of the plant.

3. Oldenlandia corymbosa: It belongs to Rubiaceae family also
known as Daman paper. It widely grows in foot hill of mountain of
western ghats and North eastern parts of India. The whole plant
extract contains oleanolic and ursolic acids,rsitosterol, alkaloids,
tannins and D-mannitol. The extract is used for fever, gastric,
irritability , nervous depression and liver complaints . The
alcoholic extract of the whole plant has shown immunomodulatory
and anti-inflammatory properties.
4. Azadirachta indica: It belongs to family Meliaceae commonly
known as Neem, found all over India. Whole plant is used as
medicine. The compounds like nimbin, B sitosterol and

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meldenindiol are isolated from green leaves. "Nimbidin" the active
chemical isolated from Neem showed anti-gastric ulcer activity as well
as anti-inflammatory, antibiotic and anti-septic properties.
5. Tinospora Cordifolia: It belongs to family Menispermaceae and
widely distributed through out tropical India, Burma, Andaman
and Ceylon. Stem is used for medicinal purpose. Leaves of this
plant are rich in Protein, calcium and phosphorus. Faranalactone,
Clrodame and new compound "jatrorrhigine" are isolated from
stem of this plant from root. Aqueous extract of stem showed anti-
inflammatory, analgesic, anti-pyretic and immunomodulatory
properities.
6. Nyctanthes arbortristis: It belongs to Oleaceae family commonly
known as Parijata. Leaves, flower, seeds and bark are used for
medicinal purpose. D-mannitol, B-amyrin, B-sitosterol,
hentriacontane, benzoic acid, oleanolic acid, Nyctanthic acid and
friedelin are isolated from leaves of Parijata. The studies
demonstrated the alcoholic extract of leaves of Parijata have
tranguillising, antipyretic, purgative and anti-inflammatory
properties.
7. Aconitum heterophyllum: It belongs to family Ranunculaceae. It
is found at altitude of 2300-2900 meters. Leaves and root is used
for medicine purpose. "Heteratisine", the active chemical
constituent is found in hydro-alcoholic extract of this plant,

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showed Analgesic, Anti-inflammatory, anti pyretic and astringent
property.
8. Picrohiza Kurroa: It belongs to Scrophulariaceae family . It is
perennial herb. Root part of this plant is used. Kutkin, flavonoids,
saponin and alkaloid are isolated from this plant. The alcoholic
extract have shown protective role against hepatotoxicity. The
immunomodulatory property has been proven in various studies.
9. Zinger officinale: Is also known as sthunti belongs to family
Zingiberaceae found through out India. The tuberous part
contains protein, carbohydrate, minerals, calcium, Gingerin,
gingeral, shogaol and Zingerone. It has analgesi, anti-
inflammatory and digestive properties.
10. Aconitum chasmanthum: It belongs to Ranuncnlaceae family
commonly known as Vatsaynabh found at altitude of 2500-3900
meters in central and western Himalayas. Dries tuberous root is
used as a remedy. Active chemical compound "chasmanine" is
isolated from tuberous, has analgesis, astringent and anti-
inflammatory property.
11. Operculine turpenthin: It belongs to family Convolvulaceae also
known as Trivritta. Root bark and stem is used for medicinal
purposes Scopoletin, glucose, rhamnose, fructose, turpethinic
acids are isolated from root of these plant. The aqueous extract
showed anti-inflammatory property.

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12. Piper longum: It belongs to Piperaceae family also known as
papal. Fruit and root is used for medicinal purpose. The active
chemicals isolated from root are , Piperlongumine,
Piperlonguminine, Piperine and Sesamin which have shown anti-
inflammatory, immunomodulatory properties.
Example-1:
When the hydro-alcoholic extract of Alstonia scholaris (6mg/kg),
Swertia chirata(6mg/kg), Oldenlandia corymbosa (3mg/kg), Azadirachta
indica (3mg/kg), Tinospora cordifolia ( 4mg/kg), Nyctanthes arbortristis
(3mg/kg), Aconitum heterophyllum (4mg/kg), Picrothiza Kurroa
(4mg/kg), Zinger officinale (5 mg/kg), Acontium
Chasmanthum(4mg/kg), Operculine turpenthin( 3mg/kg) , Piper
longum(5mg/kg) was given orally to the histamine induced experimental
rats for a week time a significant reduction in histamine and histaminase
level was noticed indicating reduction in allergic reactions than the
control group.
Example-II:
The hydro-alcoholic extract of Alstonia scholaris (125-350mg/day),
Oldenlandia corymbosa(180-325mg/day), Tinospora cordifolia (150-
325mg/day), Nyctanthes arbortristis(150-275mg/day), was orally
administered to the cases suffering from common cold and cough
frequently reported, normalization of fever with reduced cough and
sneezing.

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Example-III:
The hydro-alcoholic extract of the plant Aconitum heterophllum (60-
200mg/day), Nyctanthes arbortristis (50-17mg/day), Piper longum (150-
300mg/day), Alstonia scholaris (125-320mg/day), Oldenlandia
corymbosa (75-150mg/day), Aconidum chasmanthu (110-225mg/day),
Zinger officinale (120-200mg/day), was given to the cases suffering form
Coryza improvement in body ache and breathing troubles along with
reduction in body temperature and cough.
Example-IV:
When the hydro-alcoholic extract of Swertia chirata (130-275mg/day),
Piper longum (75-250mg/day), Nyctanthes arbortistis (50-175mg/day),
Tinospora cordifolia (50-170mg/day), Zinger officinale (100-200mg/day),
Aconitum hetrophyllum (75-200mg/day), Operculine turpenthin (50-
125mg/day), was mixed and given orally to the subjects under study
showed improvement in joint pain and inflammation, improvement in
fatigability, lethargy, anorexia, indigestion etc. Simultaneously the
important associated complaints like fever, body ache and weakness also
improved significantly.
Example-V:
The organic extract of Azadirachta indica (15-45mg/day), Alstonia
scholaris (125-250mg/day), Tinospora cordifolia (75-150mg/day),
Nyctanthes arbortristis (50-150mg/day), Picrorhiza kurroa (120-
225mg/day), Operculine turpenthin (75-125mg/day), Aconitum
hetrophyllum (120-200mg/day), Swertia chirata (150-300mg/day),
Zinger officinale (120-200mg/day), was given orally as per day schedule

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to the subjects improvement in sleeplessness, nausea, palpitation and
general weakness was recorded.
Example-VI:
The organic extract of Swertia chirata (150-275mg/day), Piper longum
(120-250mg/day), Oldenlandia corymbosa (80-120mg/day), Tinospora
cordifoila (75-175mg/day), Aconidum chasmanthu (125-175mg/day),
Picrorhiza Kurroa (125-200mg/day), Nyctanthes arbortrstis (75-
150mg/day) Zinger officinale (130-185mg/day) was orally given to the
subjects suffering form severe cold 8B cough with high fever showed
significant improvement in clinical symptoms and the pro-inflammatory
markers like prostaglandin, C-reactive protein, Interlukin-6, TNF-a, also
reduced following fifteen days of therapy.
Example -VII:
The hydro-alcoholic extract of Operculline turpenthin (75-125 mg/day),
Zinger officinale (125-185 mg/day), Aconitum heterophyllum (100-200
mg/day), Azadirachta Indica (25-50 mg/day), Swertia chirata ( 150-275
mg/day), Alstonia scholaris (175-300 mg/day), Tinospora cordifolia (100-
175 mg/day), Oldenlandia corymbosa (85-150 mg/day) was mixed and
orally administered to the study subject for fifteen days marked
reduction is histamine and histaminase levels were measured indicating
anti-allergic and analgesic property of the test drug.

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Example - VIII:
The organic extract of Alstonic scholaris (160-340 mg/day), Swertia
chirata (140-320 mg/day), Oldenlandi corymbosa (80-160 mg/day),
Azadirachta indica (20-60 mg/day), Tinospra cordifolia (60-20 mg/day),
Nyctanthes arbortristis (60-200 mg/day), Aconitum heterophyllum (80-
200 mg/day), Picrorhiza kurroa (120-240 mg/day), Zinger officinale (120-
220 mg/day), Aconitum chasmanthum (120-240 mg/day), Operculine
turpenthin (60-140 mg/day), Pipe longum (100-300 mg/day), exerted
maximum beneficial role on the major complaints like high temperature,
severe cold and cough and associated symptoms. A continuous follow up
study indicated the increased immunity and reduced frequency of the
clinical condition.
It is to be noted that the present invention is susceptible to
modifications, adaptations and changes by those skilled in the art. Such
variant embodiments employing the concepts and features of this
invention are intended to be within the scope of the present invention,
which is further set forth under the following claims:-

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WE CLAIM;
1. A herbal formulation for the prevention and management of
frequent common cold and cough and associated problems
comprising: at least three of the following ingredients
Name of plants: Doses range
1. Alstonia scholaris - Saptaparn 160-340 mg/d
2. Swertia chirata - Kirattickar 140-320 mg/d
3. Oldenlandia corymbose - Damanpaper 80-160 mg/d
4. Azadirachta indica - Neem 20-60 mg/d
5. Tinospora cordifolia - Guduchi 60-200 mg/d
6. Nyctanthes arbortristis - Parijat 60-200 mg/d
7. Aconitum heterophyllum -Ativisha 80-220 mg/d
8. Picrorhiza kurroa - Katuka 120-240 mg/d
9. Zinger officinale - Adarak 120-220 mg/d
10. Aconitum chasmanthum -vatsaynabh 120-240 mg/d
11. Operculine turpenthin -Trivritta 60-140 mg/d
12. Piper longum - Pipal 100-30 mg/d
and to be prescribed on a daily basis.
2. A herbal formulation as claimed in claim 1 wherein a hydro-alcoholic
extract of three plants having a potent anti-allergic property
comprising of:

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1. Swertia chirata - 320 md/day
2. Aconitum heterophyllum - 200 mg/day
3. Azadirachta indica - 60 mg/day
3. A herbal formulation as claimed in claim 1 and beneficial in the
prevention and management of common cold and cough along with
its associated problems having anti-pyretic and anti-allergic
properties comprising of:
1. Alstonia scholaris - 325 mg/day
2. Oldenlandia corymbosa - 210 mg/day
3. Tinospora cordifolia - 200 mg/day
4. Nyctanthes arbortristic - 250 mg/day
4. A herbal formulation as claimed in claim 1 comprising a Hydro-
alcoholic extract of Aconitum heterophyllum (165 mg/day)
Nyctanthese arbortristic (125 mg/day) Piper longum (220 mg/day)
Alstonia scholaris (275 mg/day) Oldenlandia corymbosa (110 mg/day)
Aconitum chasmanthum (175 mg/day) Zinger officinale (185 mg/day
having anti-allergic, anti-inflammatory and analgesis properties.
5. A herbal formulation as claimed in claim 1 comprising an Organic
extract of Swertia chirata (22 mg/day), Piper longum (175 mg/day)
Nyctanthes arbortristic (125 mg/day), Tinospora cordifolia (130
mg/day) Zinger officinale (150 mg/day) Aconitum heterophyllum (170
mg/day) Operculine turpenthin (85 mg/day) and having anti-allergic
immunomodulatory and analgesic.

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6. A herbal formulation as claimed in claim 1 comprising an Organic
extract of Azadirachta indica (25 mg/day), Alstonia scholaris (175
mg/day) Tinospora cordifolia (110 mg/day) Nyctanthes arbortristic
(85 mg/day), Picrorhiza kurroa (175 mg/day), Operculine turpenthin
(100 mg/day) Aconitum heterophyllum (150 mg/day), Swertia chirata
(225 mg/day), Zinger officinale (150 mg/day) having
immonomodulatory and improvement in psychological status.
7. A herbal formulation as claimed in claim 1 comprising an
Organic extract of Swertia chirata (210 mg/day), Piper longum
(185 mg/day), Oldenlandia corymbosa (100 mg/day), Tinospora
cordifolia (125 mg/day),,Zinger officinale (150 mg/day), Picrorhiza
kurroa (155 mg/day), Nyctanthes arbortristic (110 mg/day),
Aconidum chasmnathu (150 mg/day), and having anti-
inflammatory and analgesic property.
8. A herbal formulation as claimed in claim 1 comprising an Organic
extract of Operculine turpenthin (110 mg/day), Zinger officinale (165
mg/day), Aconitum heterophyllum (145 mg/day), Azadirachta indica
(40 mg/day), Swertia chirata (210 mg/day), Alstonia scholaris (225
mg/day), Nyctanthes arbortristic (110 mg/day), Picrorhiza kurroa
(150 mg/day), Tinospora cordifolia (125 mg/day), Oldenlandia
corymbosa (115 mg/day).
9. A herbal formulation as claimed in claim 1comprising The following
twelve plants Alstonia scholaris (260 mg/day), Swertia chirata (260
mg/day), Oldenlandia corymbosa (100 mg/day), Azadirachta indica
(40 mg/day), Tinospora cordifolia (100 mg/day), Nyctanthes
arbortristic (100 mg/day), Aconitum heterophyllum (120 mg/day),

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Picrorhiza kurroa (180 mg/day), Zinger officinale (160 mg/day),
Aconitum chasmanthum (120 mg/day), Operculine turpenthin (160
mg/day), Piper longum (180 mg/day), and having anti-allergic, anti-
pyretic, anti-inflammatory and immunomodulatory effects.
10. A plant based formulation substantially as herein described.

"A herbal formulation for the prevention and management of frequent common cold and cough and associated problems".
This invention relates to a herbal formulation for the prevention and management of frequent common cold and cough and associated problems comprising: at least three of the following ingredients
Name of plants: Doses range
1. Alstonia scholaris - Saptaparn 160-340 mg/d
2. Swertia chirata - Kirattickar 140-320 mg/d
3. Oldenlandia corymbose - Damanpaper 80-160 mg/d
4. Azadirachta indica - Neem 20-60 mg/d
5. Tinospora cordifolia - Guduchi 60-200 mg/d
6. Nyctanthes arbortristis - Parijat 60-200 mg/d
7. Aconitum heterophyllum -Ativisha 80-220 mg/d
8. Picrorhiza kurroa - Katuka 120-240 mg/d
9. Zinger officinale - Adarak 120-220 mg/d
10. Aconitum chasmanthum-vatsaynabh 120-240 mg/d
11. Operculine turpenthin -Trivritta 60-140 mg/d
12. Piper longum - Pipal 100-30 mg/d
and to be prescribed on a daily basis.