Abstract: The present disclosure relates generally to the field of hair care compositions. Particularly, the present disclosure provides a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall. It further relates to a process of preparation of the herbal hair oil composition.
The present disclosure relates generally to the field of hair care
compositions. Particularly, the present disclosure provides a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall. It further relates to a process of preparation of the herbal hair oil composition.
BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in
understanding the present invention. It is not an admission that any of the
information provided herein is prior art or relevant to the presently claimed
invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Hair follicle is a part of skin, resides in the dermal layer of the skin,
which is underneath the epidermis (the outermost layer of the skin). It is made up
of twenty different cell types, each having distinct functions. The hair follicle
regulates hair growth through a complex interaction between hormones,
neuropeptides and immune cells. A hair is fed by the blood vessels at the base of
the follicle to provide nourishment required for their growth.
[0004] At any given point of time, every hair on our head is at a different
stage of its growth cycle. The first stage of hair growth is called anagen and is the active growth phase which lasts for around two to seven years and determines the length of our hair. The next stage is catagen which is a regression phase. Catagen represents a transition stage which lasts for about ten days and during this phase the hair follicle shrinks and detaches from the dermal papilla. The next stage is telogen that typically lasts for about three to five months. During this stage, the hair ceases to grow any further and becomes fully keratinized. The dermal papilla enters a resting state and does not supply any nutrition to the hair, which is fully grown and no longer requires any sustenance. Around 10 to 15% of hairs on our head at any given time are in the telogen phase. The next stage is exogen and it represents the period when a resting hair reaches its terminal position, gets gradually loosened in the follicle, and finally detaches from the follicles. The last
stage is kenogen, a stage between the empty hair follicle and the growth of new hair.
[0005] Any abnormality in the hair cycle causes hair loss or alopecia. Hair
loss is generally caused by hormonal imbalance, nutritional deficiency, aging of
hair follicles, environmental factors like pollution, photo-damage. Hair loss may
also occur in various medical conditions including stress, autoimmune diseases,
and thyroid disorders. It is more common in patients undergoing chemotherapy
for treating cancer or any other autoimmune disorder. Hair loss is accompanied by
failure of regeneration of hair follicle and re-growth, causing partial or full
baldness. There are many surgical and non-surgical therapies available for treating
hair loss including hair transplantation, grafting, medications including some
herbal products in the form of serum, oil, conditioning creams etc. Significant
efforts have been put forward towards finding new and improved
compositions/formulations for promoting hair growth and prevention of hair fall
that are effective, safe, have long shelf-life and are cost effective. However, none
of the current approaches/reports seems to satisfy the existing needs.
[0006] There is therefore an unmet need in the art to develop new and
improved hair compositions that may overcome the drawbacks associated with the existing compositions. The present invention satisfies the existing needs, as well as others, and generally overcomes the deficiencies found in the prior art.
OBJECTS OF THE INVENTION
[0007] An object of the present disclosure is to provide a new and improved
hair oil composition that may overcome the limitations associated with the conventional hair oil composition.
[0008] It is an object of the present disclosure to provide a herbal hair oil
composition for stimulation of hair growth, control and prevention of hair fall.
[0009] It is an object of the present disclosure to provide a herbal hair oil
composition that is suitable for both male and female population suffering from hair loss.
[00010] It is an object of the present disclosure to provide a herbal hair oil
composition that is devoid of any chemicals or allopathic drugs.
[00011] It is an object of the present disclosure to provide a herbal hair oil
composition that is substantially devoid of any side effects.
[00012] It is an object of the present disclosure to provide a herbal hair oil
composition that exhibits superior storage stability and synergistic activity
/functional reciprocity.
[00013] It is an object of the present disclosure to provide a composition that
is easy to prepare and is economical.
[00014] Another object of the present disclosure is to provide a process of
preparation of a herbal hair oil composition.
SUMMARY OF THE INVENTION
[00015] The present disclosure relates generally to the field of hair care compositions. Particularly, the present disclosure provides a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall. It further relates to a process of preparation of the herbal hair oil composition. [00016] An aspect of the present disclosure relates to a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall, said composition comprising: i) Emblica officinalis (Amla) seed oil in an amount ranging from 1% to 5% by weight of the composition; ii) Nigella Sativa (Kalonji) oil in an amount ranging from 0.1% to 2%> by weight of the composition; iii) Thymus vulgaris (Thyme) oil in an amount ranging from 0.1% to 1% by weight of the composition; iv) Vitis vinifera (Grape) seed oil in an amount ranging from 0.1%) to 2%> by weight of the composition; v) Coffee seed oil in an amount ranging from 0.1% to 1% by weight of the composition; vi) Thuja occidentaUs (Thujawood) oil in an amount ranging from 0.1 %> to 2% by weight of the composition; vii) Cedrus deodara (Cederwood) oil in an amount ranging from 0.1% to 2% by weight of the composition; viii) Rosmarinus officinalis (Rosemary) oil in an amount ranging from 0.1 %> to 2% by weight of the
0.1% to 2% by weight of the composition; x) Eclipta Alba (Bhringraj) oil in an amount ranging from 0.1% to 1% by weight of the composition; xi) Daucus carota (Carrot) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; xii) Hibiscus sabdariffa L (Hibiscus) oil in an amount ranging from 0.1% to 2% by weight of the composition; xiii) Centella asiatica (Brahmi) oil in an amount ranging from 0.1% to 1% by weight of the composition; xiv) D-panthenol in an amount ranging from 0.1% to 1% by weight of the composition; xv) Helianthus annuus (Sunflower) Oil in an amount ranging from 1% to 10% by weight of the composition; xvi) Prunus dulcis (Sweet Almond) oil in an amount ranging from 1% to 10% by weight of the composition; xvii) Cocos nucifera (Coconut) oil in an amount ranging from 0.5% to 5% by weight of the composition; xviii) Brassica nigra (Mustard) oil in an amount ranging from 0.5% to 5% by weight of the composition; xix) Simmondsia chinensis (Jojoba) oil in an amount ranging from 0.5% to 8% by weight of the composition; xx) Lavandula officinalis (Lavender) oil in an amount ranging from 0.1% to 2% by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of the composition; and xxii) Sesamum indicum (Sesame oil) in an amount ranging from 60%) to 90% by weight of the composition. In an embodiment, the composition further comprises an additive. In an embodiment, the additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer. [00017] Another aspect of the present disclosure relates to a process for preparation of herbal oil composition for stimulation of hair growth, control and prevention of hair fall, the process comprising the steps of: i) taking an effective amount of Sesamum indicum (Sesame oil), an effective amount of Helianthus annuus (Sunflower) Oil, an effective amount of Brassica nigra (Mustard) oil, an effective amount of Cocos nucifera (Coconut) oil, an effective amount of Prunus dulcis (Sweet Almond) oil, an effective amount of Centella asiatica (Brahmi) oil, an effective amount of Eclipta Alba (Bhringraj) oil, an effective amount of Hibiscus sabdariffa L (Hibiscus) oil, an effective amount of Vitamin E and an effective amount of D-panthenol in a charging tank and stir for about 30 minutes
to obtain a first solution; ii) taking an effective amount of Nigella Sativa (Kalonji) oil, an effective amount of Thymus vulgaris (Thyme) oil, an effective amount of Daucus carota (Carrot) seed oil, an effective amount of Vitis vinifera (Grape) seed oil, an effective amount of Cedrus deodara (Cederwood) oil, an effective amount of Rosmarinus officinalis (Rosemary) oil, an effective amount of Thuja occidentalis (Thujawood) oil and an effective amount of Serenoa repens (Saw palmetto) oil in an another charging tank and stir to obtain a second solution; iii) adding the second solution into the first solution, following the addition of an effective amount of Emblica officinalis (Amla) seed oil, an effective amount of Coffee seed oil, an effective amount of Simmondsia chinensis (Jojoba) oil and an effective amount of Lavandula officinalis (Lavender) oil, and stir for about 30 minutes to obtain third solution; and iv) filter the third solution to obtain the herbal hair oil composition.
[00018] In an embodiment, the herbal oil composition comprises: i) Emblica officinalis (Amla) seed oil in an amount ranging from 1% to 5% by weight of the composition; ii) Nigella Sativa (Kalonji) oil in an amount ranging from 0.1% to 2% by weight of the composition; iii) Thymus vulgaris (Thyme) oil in an amount ranging from 0.1% to 1% by weight of the composition; iv) Vitis vinifera (Grape) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; v) Coffee seed oil in an amount ranging from 0.1 % to 1% by weight of the composition; vi) Thuja occidentalis (Thujawood) oil in an amount ranging from 0.1% to 2% by weight of the composition; vii) Cedrus deodara (Cederwood) oil in an amount ranging from 0.1% to 2% by weight of the composition; viii) Rosmarinus officinalis (Rosemary) oil in an amount ranging from 0.1% to 2% by weight of the composition; ix) Serenoa repens (Saw palmetto) oil in an amount ranging from 0.1% to 2% by weight of the composition; x) Eclipta Alba (Bhringraj) oil in an amount ranging from 0.1% to 1% by weight of the composition; xi) Daucus carota (Carrot) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; xii) Hibiscus sabdariffa L (Hibiscus) oil in an amount ranging from 0.1% to 2% by weight of the composition; xiii) Centella asiatica (Brahmi) oil in an amount ranging from 0.1% to 1% by weight of the
composition; xiv) Z)-panthenol in an amount ranging from 0.1% to 1% by weight of the composition; xv) Helianthus annuus (Sunflower) Oil in an amount ranging from 1% to 10% by weight of the composition; xvi) Prunus dulcis (Sweet Almond) oil in an amount ranging from 1% to 10% by weight of the composition; xvii) Cocos nucifera (Coconut) oil in an amount ranging from 0.5% to 5% by weight of the composition; xviii) Brassica nigra (Mustard) oil in an amount ranging from 0.5% to 5% by weight of the composition; xix) Simmondsia chinensis (Jojoba) oil in an amount ranging from 0.5% to 8% by weight of the composition; xx) Lavandula officinalis (Lavender) oil in an amount ranging from O.P/o to 2% by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of the composition; and xxii) Sesamum indicum (Sesame oil) in an amount ranging from 60%> to 90% by weight of the composition. In an embodiment, the composition further comprises an additive. In an embodiment, the additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer.
[00019] Other aspects, advantages, and salient features of the invention will become apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the exemplary embodiments of the invention.
BRIEF DESCRIPTION OF THE ACCOMPANYING DRAWINGS
[00020] The following drawings form part of the present specification and are
included to further illustrate aspects of the present disclosure. The disclosure may
be better understood by reference to the drawings in combination with the detailed
description of the specific embodiments presented herein.
[00021] FIG. 1 illustrate a graph depicting comparison of density of hair in
subjects treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00022] FIG. 2 illustrate a graph depicting comparison of hair growth rate in
subjects treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00023] FIG. 3 illustrate a graph depicting comparison of hair thickness in
subjects treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00024] FIG. 4A and FIG. 4B illustrate a graph depicting number of hairs
under Anagen and Telogen phase of hair growth cycle in subjects treated with hair
oil of the present disclosure (Group 1), standard product, Minoxidil Forte 5%
(Group 2) and a neutral shampoo (Group 3), in accordance with the embodiments
of the present disclosure.
[00025] FIG. 5 illustrate a graph depicting number of Vellus hairs in subjects
treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00026] FIG. 6 illustrate a graph depicting number of Terminal hairs in
subjects treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00027] FIG. 7 illustrate a graph depicting tangling of hair on a scale of 1-4 in
subjects treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance
with the embodiments of the present disclosure.
[00028] FIG. 8A and FIG. 8B illustrate a graph depicting hair pull test score
and number of hairs pulled, in subjects treated with hair oil of the present
disclosure (Group 1), standard product, Minoxidil Forte 5% (Group 2) and a
neutral shampoo (Group 3), in accordance with the embodiments of the present
disclosure.
[00029] FIG. 9 illustrate a graph depicting hair tensile strength in subjects
treated with hair oil of the present disclosure (Group 1), standard product,
Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance with the embodiments of the present disclosure.
[00030] FIG. 10A and FIG. 10B illustrate a graph depicting hair thinning in Male and Female subjects treated with hair oil of the present disclosure (Group 1), standard product, Minoxidil Forte 5% (Group 2) and a neutral shampoo (Group 3), in accordance with the embodiments of the present disclosure.
DESCRIPTION OF THE PRESENT INVENTION
[00031] The embodiments herein and the various features and advantageous details thereof are explained more comprehensively with reference to the non-limiting embodiments that are detailed in the following description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of the ways in which the embodiments herein may be practiced and to further enable those of skill in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein.
[00032] Unless otherwise specified, all terms used in disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. By means of further guidance, term definitions may be included to better appreciate the teaching of the present invention.
[00033] As used in the description herein, the meaning of "a," "an," and "the" includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of "in" includes "in" and "on" unless the context clearly dictates otherwise.
[00034] As used herein, the terms "comprise", "comprises", "comprising", "include", "includes", and "including" are meant to be non- limiting, i.e., other steps and other ingredients which do not affect the end of result can be added. The above terms encompass the terms "consisting of and "consisting essentially of.
[00035] As used herein, the terms "composition", "blend", or "mixture" are all intended to be used interchangeably.
[00036] The terms "weight percent", "vol-%", "percent by weight", "% by weight", and variations thereof, as used herein, refer to the concentration of a substance as the weight of that substance divided by the total weight of the composition and multiplied by 100. It is understood that, as used here, "percent", "%", and the like are intended to be synonymous with "weight percent", "vol-%", etc.
[00037] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term "about". Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
[00038] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. [00039] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments. [00040] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus if one
embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[00041] The present disclosure relates generally to the field of hair care compositions. Particularly, the present disclosure provides a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall. It further relates to a process of preparation of the herbal hair oil composition. [00042] The hair oil composition is devoid of any harmful chemical, dermatological safe, effective, exhibit synergism/functional reciprocation, and has a long shelf-life of about 3 year. The composition not only improves the hair growth, but also enhances the quality of hair and scalp region. Composition acts in a synergistic manner and reduces the hair fall and improves the hair quality and growth. It acts at cellular level and promotes follicular growth, maintains anagen hair growth, stimulates terminal as well as vellus hairs growth and provides nourishment to scalp. The present invention is well supported with the clinically proven facts like early hair growth effect, enhancement in hair density and hair volume, positive effect on hair strength and is dermatologically safe. [00043] An aspect of the present disclosure relates to a herbal hair oil composition for stimulation of hair growth, control and prevention of hair fall, said composition comprising i) Emblica officinalis (Amla) seed oil in an amount ranging from 1% to 5% by weight of the composition; ii) Nigella Sativa (Kalonji) oil in an amount ranging from 0.1% to 2% by weight of the composition; iii) Thymus vulgaris (Thyme) oil in an amount ranging from 0.1% to 1% by weight of the composition; iv) Vitis vinifera (Grape) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; v) Coffee seed oil in an amount ranging from 0.1% to 1% by weight of the composition; vi) Thuja occidentalis (Thujawood) oil in an amount ranging from 0.1 % to 2% by weight of the composition; vii) Cedrus deodara (Cederwood) oil in an amount ranging from 0.1% to 2% by weight of the composition; viii) Rosmarinus officinalis (Rosemary) oil in an amount ranging from 0.1 % to 2% by weight of the
composition; ix) Serenoa repens (Saw palmetto) oil in an amount ranging from 0.1% to 2% by weight of the composition; x) Eclipta Alba (Bhringraj) oil in an amount ranging from 0.1% to 1% by weight of the composition; xi) Daucus carota (Carrot) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; xii) Hibiscus sabdariffa L (Hibiscus) oil in an amount ranging from 0.1% to 2% by weight of the composition; xiii) Centella asiatica (Brahmi) oil in an amount ranging from 0.1% to 1% by weight of the composition; xiv) D-panthenol in an amount ranging from 0.1% to 1% by weight of the composition; xv) HeUanthus annuus (Sunflower) Oil in an amount ranging from 1% to 10% by weight of the composition; xvi) Prunus dulcis (Sweet Almond) oil in an amount ranging from 1% to 10% by weight of the composition; xvii) Cocos nucifera (Coconut) oil in an amount ranging from 0.5% to 5% by weight of the composition; xviii) Brassica nigra (Mustard) oil in an amount ranging from 0.5% to 5% by weight of the composition; xix) Simmondsia chinensis (Jojoba) oil in an amount ranging from 0.5% to 8% by weight of the composition; xx) Lavandula officinalis (Lavender) oil in an amount ranging from 0.1% to 2% by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of the composition; and xxii) Sesamum indicum (Sesame oil) in an amount ranging from 60%) to 90% by weight of the composition. In an embodiment, the composition further comprises an additive. In an embodiment, the additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer. [00044] Emblica officinalis commonly known as Amla in Hindi or Indian gooseberry in English. It is a small or medium sized deciduous tree found throughout tropical India. It is considered as one of the most important medicinal plants in Ayurveda and the strongest rasayana. Various parts of the tree are used to treat various diseases but the most important and widely used part is fruit. The green globose fruit is rich in quercetin, phyllaembic compounds, gallic acid, tannins, flavonoids, pectin and vitamin C. Amla possess antioxidant, anticarcinogenic, antitumour, antigenotoxic, anticancer, antidepressant, anti-aging, anti-inflammatory activities. It improves Immunity, reduces stress, purifies blood,
improves digestion and mental functions, and helps in weight management and skin care.
[00045] Nigella sativa also known as Kalonji, black cumin, black seed, fennel flower, small fennel Kalojeere, is an annual flowering plant of the family Ranunculaceae. It is 20-30 cm tall with finely divided, linear leaves. The flowers are delicate and colored pale blue and white with 5-10 petals. It is native to south and southwest Asia. The plant grows throughout India, Arabia and Europe. Nigella sativa is a small black seed used widely in herbal medicine. The fruit of this plant is a large and inflated capsule containing 3-7 united follicles, each having numerous seeds used as spice. The Nigella sativa is used in the treatment of asthma, high blood pressure, cancer, inflammation, rheumatoid arthritis, congestion, seizures, stomach ulcers, etc.
[00046] Thymus vulgaris commonly known as Thyme is a flowering plant of the family Lamiaceae. It is a native of southern Europe and is worldwide distributed. It is also found in Mediterranean and neighboring countries, Northern Africa and parts of Asia. It grows 15-30 cm tall and is a bushy, woody based evergreen sub-shrub with aromatic small grey-green leaves and clusters of purple or pink flowers. Thyme has been used as a flavoring agent, culinary herb and herbal medicines. Thyme is useful in the treatment of cough, diabetes, cold and chest infections. It soothes sore throat and has antiseptic, antibiotic and antifungal properties. It is useful in intestinal infections and infestations. It improves liver functioning and is appetite stimulant. It also treats bronchial, urinary infections and laryngitis and inflammation. The essential oil can be used for the treatment of rheumatic pains.
[00047] Vitis vinifera, commonly known as Grapes are native to the Mediterranean region, Central Europe, and southwestern Asia, from Morocco and Portugal north to southern Germany and east to northern Iran. It grows to 32 m in length and has a flaky bark. The leaves are 5-20 cm long and broad. The fruit is a berry known as grape. Grapes are used for making wines and also have medicinal properties. Grapes contain flavonoids (antioxidants) that relax the ageing process. Grapes are also a good source of bio-flavonoids (Vitamin P) and Manganese.
They are also rich in Vitamin B6, Thiamine, riboflavin, potassium and Vitamin C. Grapes are used to treat Asthma, stomach disorders like constipation and indigestion. Grape juice is used to treat migraine.
[00048] Coffea - the genus coffea is a genus of flowering plants of the family Rubiaceae. Coffea species are small trees or shrubs indigenous to tropical and southern Africa and tropical Asia. The shrub and small tree grow to a height of 3-3.5 m. The fruit contains two seeds called coffee beans. The fruit and seeds both contain a large amount of caffeine. The seeds (coffee beans) are used to flavor beverages and products. The fruits are edible red or purple in color. The two most popular species of coffee are coffea arabica which accounts for 60-80% of world coffee production and Coffea canephora which accounts for about 20-40%. [00049] Thuja occidentalis is an evergreen coniferous small or medium sized tree of the family Cupressaceae. It is also known as northern white cedar or eastern arborvitae and tree of life. It is native to eastern Canada and much of the north, central and upper northeastern United States. It grows to a height of 15 m and has fan-like branches and scaly leaves. The seed cones are slender, yellow green, ripening to brown, in color. It is cultivated in northern Europe and in Brazil as an ornamental tree. Thuja occidentalis has been used in herbal and homeopathic preparations. It is used for treating acute and chronic infections of upper respiratory tract, warts and also used as an adjunctive antibiotic, immuno-stimulant. The essential oil has been used as cleansers, disinfectants, insecticides, room sprays and soft soaps. The Northern white cedar is commercially used for rustic fencing and posts, lumber, poles, and in construction of log cabins. [00050] Cedrus deodara is also known as the deodar cedar or Himalayan cedar or deodar. It is a large evergreen coniferous tree reaching 40-50 m in height. It is a native to the western Himalaya in Eastern Afghanistan, northern Pakistan and India. In India it is found in Jammu and Kashmir, Himachal Pradesh, Uttrakhand, Sikkim, Arunachal Pradesh and the Darjeeling region of West Bengal. It has needle shaped leaves borne singly on long shoots. The leaves are bright green to glaucous blue green in color. The female cones are barrel shaped
and disintegrate to produce winged seeds. Essential oil is prepared from inner wood which is used as insect repellent. It also has antifungal properties. [00051] Rosmarinus officinalis, commonly called rosemary is an aromatic evergreen shrub of the mint family Lamiaceae. It is native to Mediterranean region and Asia. Its leaves are needle shaped and flowers are white, pink, purple or blue in color. Rosmarinus officinalis can withstand droughts for a lengthy period of time. It is used as a decorative plant in gardens and can control pests. The leaves provide flavor to various foods. The rosemary oil is used to provide fragrance to body perfumes or emit an aroma into a room. Rosemary is also rich in volatile oils, flavonoids and phenolic acids which are antiseptic and anti¬inflammatory.
[00052] Serenoa repens is commonly known as saw palmetto. It is a small palm and its leaves are terminated in a rounded fan of about 20 leaflets. The length of the leaves is about l-2m. Leaves are light green inland and silvery white in coastal regions. The flowers are yellowish-white in color and fruit is reddish back drupe. It is widespread in a subtropical Southeastern United States and grows to a maximum height of about 7-10 ft. It is a slow growing and long-lived plant. The extract of Serenoa repens is used in the treatment of Prostate cancer. [00053] Eclipta alba is also known as Bhringraj in Hindi and is a member of the family Asteraceae. It is an annual, erect and branched herb, often rooting at nodes and grows up to a height of 3m. Leaves are opposite, sessile and lance shaped. It is native to India and southwest America and is also found in China and Brazil. It has white colored flowers; roots are well developed and are cylindrical and grayish in color. It grows in moist places throughout the world. It rejuvenates memory, hair, teeth, bones, vision and hearing and may cure edema, fevers, liver disorders and rheumatic joint pains.
[00054] Daucus carota is commonly known as wild carrot, bird's nest, bishop's lace and Queen Annes's lace and is a member of the family Apiaceae or Umbelliferae. It is native of temperate regions of Europe and Southwest Asia and naturalized to North America and Australia. It is a herbaceous biennial plant that grows between 30-60cm in height and bears white colored flowers. The wild
carrot is diuretic and acts as a good cleansing medicine. An infusion of leaves can be used to treat kidney stones formation and cystitis. The seeds are diuretic, and their infusion is used to treat oedema, flatulent indigestion and menstrual problems.
[00055] Hibiscus sabdariffa L commonly known as Roselle is a member of the Malvaceae family. It is a native of West Africa. It is an annual and perennial herb growing up to 2-2.5 m in height. It is an aromatic, cooling herb that has diuretic effects. The plant is known to be antiseptic, aphrodisiac, astringent, digestive, purgative, demulcent and resolvent. For improving the digestive and kidney functions, the leaves and flowers are used internally as tonic tea. The seeds are known to be diuretic, laxative and tonic. In the treatment of abscesses, bilous conditions, cancer, cough, debility, dyspepsia, dysuria, fever, heart ailments, hypertension and neurosis the plant is used as a remedy.
[00056] Centella asiatica commonly known as Centella or Asiatic pennywort or Gotu kola or Brahmi is a perennial plant of the family Apiaceae. It is native to the wetlands of Asia, Indian subcontinent, Southeast Asia and wetland regions of Southeastern US. The stems are creeping stolons and are green-reddish in color. The plant bears white or pinkish to red in color flowers. The flowers are born in small round bunches near the surface of the soil. The leaves are borne on pericladial petioles. Centella asiatica has been used to treat mental disorders. It also improves memory. It is anti-leprosy, diuretic, and used in insomnia, asthma, abdominal disorders and fever.
[00057] Helianthus annuus commonly known as sunflower and is a member of the family compositae. It is native to the western US, Canada and northern Mexico. The plant reaches a height of 3m, leaves are broad, rough and alternate. The stem of the plant is erect, rough and hairy. The flower of the sunflower is actually a "flower head" of numerous small individual five petaled flowers (florets). They are of yellow, red, orange or other colors. The flower in the center of the head is called a disk flower which matures into fruit (sunflower seeds). Leaves of the plant are used to prepare a tea which is astringent, diuretic and expectorant and can be used in treating high fevers. The leaves can also be
crushed and can be used as poultice on sores, swellings, snake bites and spider bites. The flowers are used to prepare a tea which is used in the treatment of Malaria and lung ailments.
[00058] Prunus dulcis commonly known as Almond in English and badam in Hindi, is a member of the family Rosaceae. It is native to Iran and central Asia. It is a deciduous tree which grows upto 4-10 m in height. The leaves have serrated margins and are 8-13 cm long. The color of the flower is white to pale pink. The flowers have five petals produced singly or in pairs. The almond is the seed of the tree. Almonds are used in the treatment of kidney stones, gallstones and constipation. The almond oil is applied on dry skin and is also used in aromatherapy. The leaves can be used to treat diabetes.
[00059] Sesamum indicum is a flowering plant and is a member of the family Pedaliaceae. Wild relatives of the plant can be found in Africa and in India. In tropical regions of the world the plant is widely naturalized. The plant is cultivated for its seeds which are edible. Sesamum indicum is the cultivated type species which originated in India and is tolerant to drought like conditions. It is used externally in treatment of haemorrhoids and ulcers. The oil can be mixed with lime water and can be applied externally on burns, boils and ulcers. [00060] Cocos nucifera commonly known as coconut tree, come under Arecaceae family. It is a large palm that grows up to 30 m in height and leaves are pinnate and about 4-6 m long.
[00061] Brassica nigra also called as black mustard is a member of the family Cruciferae. It is an annual plant and is native of tropical regions of North Africa, temperate regions of Europe and some parts of Asia. The plant has stalked leaves and reaches upto a height of about 80-90 cm. The seeds are black or brown in color. The flowers are yellow in color having four yellow colored petals. Mustard is used for treating alopecia, epilepsy, snake bite and toothache. The seed can be used internally as appetizer, digestive, diuretic, emetic and tonic. In the treatment of indurations of liver and spleen a decoction of the seeds can be used. It can also treat carcinoma, throat tumours and imposthumes.
[00062] Simmondsia chinensis also known as Jojoba, goat nut, deer nut, pignut, wild hazel, quinine nut, coffeeberry and gray box bush. It is a member of the family Simmondsiaceae. It is native to southwestern North America. It is endemic to North America. The plant is a shrub that grows up to 1-2 m in height, leaves are oval in shape, 2-4 cm long, waxy, thick and gray green in color and flowers are greenish-yellow. The flowers have 5-6 sepals and no petals. Jojoba oil can be produced from the plant. The seeds are used to extract a liquid wax ester which can be applied to the skin to lessen the effects of sores, psoriasis, wound etc. The plant can be used to treat kidney disorders, colds, cancer, dysuria, obesity, parturition, aching eyes and warts.
[00063] Lavandula angustifolia is commonly called lavender or true lavender or English lavender. It is a flowering plant and is a member of the family Lamiaceae. It is native to Spain, France, Italy and Croatia. It is an aromatic shrub which grows upto 1-2 m in height, leaves are evergreen, color of the flower is pinkish purple (lavender colored). Lavender has a soothing effect on the nervous system. The extracted essential oil is used to apply on skin as an antiseptic, and is also used in aromatherapy.
[00064] In an embodiment, the mineral supplement(s) includes but not limited to, iron, zinc, copper, magnesium and calcium and combinations thereof. However, a person skilled in the art would appreciate that any other mineral supplements) or a combination of mineral supplement(s) can be utilized to serve the intended purpose.
[00065] In an embodiment, the fragrance agent(s) includes but not limited to, menthol, benzyl alcohol, eugenol, phenoxyethanol, isopropyl palmitate, isopropyl myristate, benzyl salicylate, phenylethyl salicylate, thymol, isoamyl salicylate, triton X-100 surfactant, benzoic acid, benzyl benzoate, methyl salicylate, phenol, oleic acid, caproic acid or carbaryl and mixture thereof. However, a person skilled in the art would appreciate that any other fragrance agent(s) or a combination of fragrance agent(s) can be utilized to serve the intended purpose. [00066] In an embodiment, the colouring agent(s) includes but not limited to, tartrazine, quinoline yellow, sunset yellow, amaranth, ponceau 4R, erythrosine,
red 2G, allura red AC, patent blue V, indigo carmine, brilliant blue FCF, fast green FCF, green S, iron oxides and mixture thereof. However, a person skilled in the art would appreciate that any other colouring agent(s) or a combination of colouring agent(s) can be utilized to serve the intended purpose. [00067] In an embodiment, the preservative(s) includes but not limited to, parabens such as methyl and propyl paraben, sorbic acid, potassium sorbate, sodium benzoate, quaternium-15, methylchloroisothiazolinone, and Iodopropynyl butylcarbamate (IPBC) and natural preservatives such as citrus oils and mixture thereof. However, a person skilled in the art would appreciate that any other preservative(s) or a combination of preservative(s) can be utilized to serve the intended purpose.
[00068] In an embodiment, the skin absorption enhancer(s) to facilitate absorption of the composition through the skin of the patient includes but not limited to, pentane 1,5-diol, N-dodecyl-2-pyrrot)done and its acetate analogue, fatty acids such as oleic acid, terpenes, esters such as isopropyl myristate, khellin and khellin analogues, methyl nicotinate, MSM-decylmethylsulfoxide, diethylene glycol, citric acid, pyruvic acid, phenoxyethanol, transcutol, phosphatidyl choline, a medium chain triglyceride oil (MCT oil), water and mixture thereof. However, a person skilled in the art would appreciate that any other skin absorption enhancer(s) or a combination of skin absorption enhancer(s) can be utilized to serve the intended purpose.
[00069] .The composition in the form of 'hair oil' promotes the hair growth, activates hair follicles, retard hair fall, improves hair quality and is suitable for daily use for both men and women.
[00070] Another aspect of the present disclosure relates to a process for preparation of herbal oil composition for stimulation of hair growth, control and prevention of hair fall, the process comprising the steps of: i) taking an effective amount of Sesamum indicum (Sesame oil), an effective amount of Helianthus annuus (Sunflower) Oil, an effective amount of Brassica nigra (Mustard) oil, an effective amount of Cocos nucifera (Coconut) oil, an effective amount of Prunus dulcis (Sweet Almond) oil, an effective amount of Centella asiatica (Brahmi) oil,
an effective amount of Eclipta Alba (Bhringraj) oil, an effective amount of Hibiscus sabdariffa L (Hibiscus) oil, an effective amount of Vitamin E and an effective amount of D-panthenol in a charging tank and stir for about 30 minutes to obtain a first solution; ii) taking an effective amount of Nigella Sativa (Kalonji) oil, an effective amount of Thymus vulgaris (Thyme) oil, an effective amount of Daucus carota (Carrot) seed oil, an effective amount of Vitis vinifera (Grape) seed oil, an effective amount of Cedrus deodara (Cederwood) oil, an effective amount of Rosmarinus officinalis (Rosemary) oil, an effective amount of Thuja occidentalis (Thujawood) oil and an effective amount of Serenoa repens (Saw palmetto) oil in an another charging tank and stir to obtain a second solution; iii) adding the second solution into the first solution, following the addition of an effective amount of Emblica officinalis (Amla) seed oil, an effective amount of Coffee seed oil, an effective amount of Simmondsia chinensis (Jojoba) oil and an effective amount of Lavandula officinalis (Lavender) oil, and stir for about 30 minutes to obtain third solution; and iv) filter the third solution to obtain the herbal hair oil composition.
[00071] In an embodiment, the herbal oil composition comprises: i) Emblica officinalis (Amla) seed oil in an amount ranging from 1% to 5% by weight of the composition; ii) Nigella Sativa (Kalonji) oil in an amount ranging from 0.1% to 2% by weight of the composition; iii) Thymus vulgaris (Thyme) oil in an amount ranging from 0.1% to 1% by weight of the composition; iv) Vitis vinifera (Grape) seed oil in an amount ranging from 0.1% to 2% by weight of the composition; v) Coffee seed oil in an amount ranging from 0.1 % to 1% by weight of the composition; vi) Thuja occidentalis (Thujawood) oil in an amount ranging from 0.1% to 2% by weight of the composition; vii) Cedrus deodara (Cederwood) oil in an amount ranging from 0.1% to 2% by weight of the composition; viii) Rosmarinus officinalis (Rosemary) oil in an amount ranging from 0.1% to 2% by weight of the composition; ix) Serenoa repens (Saw palmetto) oil in an amount ranging from 0.1% to 2% by weight of the composition; x) Eclipta Alba (Bhringraj) oil in an amount ranging from 0.1 % to 1% by weight of the composition; xi) Daucus carota (Carrot) seed oil in an amount ranging from 0.1%
to 2% by weight of the composition; xii) Hibiscus sabdariffa L (Hibiscus) oil in an amount ranging from 0.1% to 2% by weight of the composition; xiii) Centella asiatica (Brahmi) oil in an amount ranging from 0.1% to 1% by weight of the composition; xiv) Z)-panthenol in an amount ranging from 0.1% to 1% by weight of the composition; xv) Helianthus annuus (Sunflower) Oil in an amount ranging from 1% to 10% by weight of the composition; xvi) Prunus dulcis (Sweet Almond) oil in an amount ranging from 1% to 10% by weight of the composition; xvii) Cocos nucifera (Coconut) oil in an amount ranging from 0.5% to 5% by weight of the composition; xviii) Brassica nigra (Mustard) oil in an amount ranging from 0.5% to 5% by weight of the composition; xix) Simmondsia chinensis (Jojoba) oil in an amount ranging from 0.5% to 8% by weight of the composition; xx) Lavandula officinalis (Lavender) oil in an amount ranging from O.P/o to 2% by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of the composition; and xxii) Sesamum indicum (Sesame oil) in an amount ranging from 60%> to 90% by weight of the composition. In an embodiment, the composition further comprises an additive. In an embodiment, the additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer.
[00072] The hair oil composition of the present invention improves the overall health of the epidermis, dermis and hair follicle leading to healthy hair growth. It increases the blood circulation to the scalp and stimulates growth of hair follicles. By improving the blood circulation to the scalp, it provides nourishment to the hair follicles and promotes hair growth. It also quenches the free radicals, thereby preventing premature graying and hair loss. It further prevents hair damage, dryness and reduces the fizziness. EXAMPLE [00073] HAIR OIL COMPOSITION
Table 1: A HAIR OIL COMPOSITION
S.NO. INGREDIENTS AMOUNT
(ing)
i) Emblica officinalis (Amla seed) oil 2.5
ii) Nigella Sativa (Kalonji) oil 0.5
iii) Thymus vulgaris (Thyme) oil 0.25
iv) Vitis vinifera (Grape seed) oil 0.5
v) Coffee seed oil 0.25
vi) Thuja occidentalis (Thujawood) oil 0.5
vii) Cedrus deodara (Cederwood) oil 0.5
viii) Rosmarinus officinalis (Rosemary) oil 0.6
ix) Serenoa repens (Saw palmetto) oil 0.5
x) EcliptaAlba (Bhringraj) oil 0.25
xi) Daucus carota (Carrot) seed oil 0.5
xii) Hibiscus sabdariffa L (Hibiscus) oil 0.5
xiii) Centella asiatica (Brahmi) oil 0.25
xiv) D-panthenol 0.25
xv) Helianthus annuus (Sunflower) Oil 5
xvi) Prunus dulcis (Sweet Almond) oil 5
xvii) Cocos nucifera (Coconut) oil 1.5
xviii) Brassica nigra (Mustard) oil 2
xix) Simmondsia chinensis (Jojoba) oil 3
xx) Lavandula officinalis (Lavender) oil 0.5
xxi) Vitamin E 0.25
xxii) Sesamum indicum (Sesame oil) 74.9
Total 100g
[00074] PREPARATION OF HAIR OIL COMPOSITION
About 74.9g Sesame Oil, 5.0g Sunflower Oil, 2.0g Mustard Oil, 1.5g of Coconut Oil, 5.0g Sweet Almond Oil, 0.25g Brahmi Oil, 0.25g bhringraj Oil, 0.5g Hibiscus Oil, 0.25g Vitamin E and 0.25g D-Panthenol were taken and charged into a charging tank and stirred for about 30 min to obtain first solution. About 0.5g Kalonji Oil, 0.25g Thyme Oil, 0.5g Carrot Seed Oil, 0.5g Grape Seed Oil, 0.5g Cedarwood Oil, 0.6g Rosemary Oil, 0.5g Thujawood Oil and 0.5g of Saw palmetto Oil were taken and charged into another charging tank and stirred to obtain second solution. The above prepared second solution was added into the first solution, stirred, followed by the addition of 2.5g Amla Seed Oil, 0.25g Coffee Seed Oil, 3.0g Jojoba Oil and 0.5g Lavender Oil and stirred for about another 30 minutes to obtain a third solution. The third solution was passed through any conventional filter to obtain herbal hair oil composition [00075] EFFICACY STUDIES OF THE HAIR OIL COMPOSITION The efficacy of the hair oil composition disclosed in Table 1 herein-above was extensively tested using a series of preclinical tests comprising of proliferative effects on human hair follicle dermal papilla cells (DPC), keratinocytes and fibroblasts; organ culture of mouse vibrissae hair follicles, and telogen to anagen transition assay using pigmented mice. The experimental data indicates considerable effects in cellular proliferation assays; stimulation of bulb thickness in organ culture assays, induction of anagen, and faster hair re-growth in animal testing. Ocular and dermal safety assessments were performed using in-vitro assays that indicate high safety profile of the composition.
Trials were conducted on both male and female population and it shows that there was about 6% to 12% increase in hair density (hair follicles/cm2 area), 8% to 22 % increase in hair growth rate (hair length/um/day) and about 12% to 14% increase in tensile strength as compared to control (baseline) after 3 months of application of the hair oil. Further, there was an improvement in anagen to telogen ratio, terminal and vellus count, hair thickness, reduction in hair fall and positive effect on hair quality such as hair texture and hair volume.
The evaluation was carried out for a period of 16 weeks on total 90 subjects that were equally divided into three groups: Group 1, Group 2 and Group 3. In each group there were equal number of males and females animal between age group of 18 to 45 years. Group 1 represents the subjects treated with the hair oil composition (applied 8 ml, once daily at night) disclosed in Table 1 of the present disclosure; Group 2 represents the subjects treated with a standard product (Minoxidil Forte 5%, applied 1 ml, once daily at night) and Group 3 represents subjects treated with a neutral shampoo (washed twice a week). [00076] EFFICACY PARAMETERS [00077] Hair Density
An evaluation of hair density was done by quantifying number of hair follicles in per square cm area using trichoscan software and the same is being illustrated in FIG. 1. As can be seen in FIG. 1, subjects treated with the hail oil of the present disclosure (Group 1) and Group-2 showed statistically significant improvement in hair density from 1st month until the end of study when compared to baseline and subjects of Group-3 at all the time points.. Improvement in hair follicular density is a sign of follicular regeneration and hair re-growth. [00078] Hair Growth Rate
The evaluation of hair growth rate (um/day) assessment was done using trichoscan software. As can be seen in FIG. 2, subjects treated with the hair oil of the present disclosure (Group 1) and Group-2 showed significant improvement in hair growth rate from 1st month until the end of the study when compared to baseline and subjects of Group-3 at all the time points. [00079] Hair Thickness
Hairs were evaluated for their thickness using Casalite Nova at its cross section closer to the roots. As can be seen in FIG. 3, subjects treated with the hair oil of the present disclosure (Group 1) and Group-2 showed significant improvement in hair thickness by the end of the study when compared to baseline. While group 3 showed no statistical significant improvement in comparison to baseline. Improvement in hair thickness is a sign of a healthy hair. [00080] Anagen and Telogen phase of hair growth cycle
Anagen is the active or "growing" phase of the cycle when the cells in the root of the hair divide at a rapid rate. Hair grows approximately 1 cm a month. Telogen is the resting phase in the hair growth cycle when the hair follicle is completely inactive. Normally 6% to 8% of all hairs are in this stage. Anagen and Telogen measurements were done using Phototrichogram. As can be seen in FIG. 4A, the Group 1 and Group 2 showed statistically significant improvement in Anagen up to 2 months when compared to baseline. At 3rd month no significant change was observed in Group 1 when compared with baseline. Similarly, as can be seen in FIG. 4B, the Group 1 and Group 2 showed statically significant decrease in Telogen up to 2 month when compared to baseline. At 3rd month no significant change was observed in Group 1 when compared with baseline. [00081] Vellus Hair Count
Vellus hair is short, thin, light colored hair that develops on human body in childhood. Vellus hair is also newly developed short, thin and light-colored hair and is common in both men and women. Vellus count was measured using phototrichogram. As can be seen in FIG. 5, Group 1 showed statistically significant improvement in vellus count at all time points in comparison to baseline. Group 2 showed statistically significant improvement at 2nd and 3rd months in comparison to baseline, while Group 3 showed no statistical improvement at all points in comparison to baseline. [00082] Terminal Hair Count
Terminal hairs are characterized by being thick, long and dark as compared with vellus hair. Terminal count was measured using phototrichogram. As can be seen in FIG. 6, Group 1 and Group 2 showed statistically significant improvement in terminal count at all time points in comparison to baseline. While Group 3 showed no statistical improvement at all points in comparison to baseline. [00083] Hair Tangling
The assessment for hair tangling was performed in terms of force required to pass the comb through the length of hair. Subjects were asked to comb five strokes. Hair tangling of the subjects were measured using a scale of 1-4, wherein: 1= <25%, 2= 25-50%, 3=50-75% and 4=75-100%. As shown in FIG. 7, Group 1
showed statistically significant improvement in hair de-tangling at 1st month, and Group 2 showed statically significant improvement in hair de-tangling at 3rd month.
[00084] Hair Pull Test
A bundle of about 50-60 hair were grasped between two fingers. A constant traction force in the direction of hair growth was used to pull out the hair. Pulled hair were counted and documented. Visible bulb or root of the pulled hair was considered as an indicative of weaker roots. Hair pull test was done on 4 sites and the average of four was taken for analysis. To avoid any error due to applied force, the assessment was performed by dermatologists. As can be seen in FIG. 8A, Group 1 illustrates a significant reduction in hair pull test score from 2nd month onwards in comparison to baseline. While Group-2 and Group 3 showed statistically significant reduction in hair pull test score at 3rd month in comparison to baseline. Further, FIG. 8B shows the number of hairs pulled. All the groups showed statistically significant reduction in number of hairs pulled at 2nd and 3rd month in comparison to the baseline. [00085] Hair Tensile Strength
The hair fibers were attached in root to tip alignment, and were pulled at a fixed force and speed by using force gauge. The force at which hair breaks was recorded and analyzed. Higher the break force, higher the tensile strength of the hair. As can be seen in FIG. 9 Group 1 and Group 2 illustrate significant improvement in tensile strength at 3rd month when compared with the baseline. Group 3 showed no statistically improvement in number of tensile strength at month 3 in comparison to baseline. [00086] Hair Thinning
The dermatological visual assessment of hair loss was performed by using Photo-numerical linear scale - MSCR 10-point scale for male and female subjects was used. Screening was done using Norwood scale for male subjects and Ludwig scale for female subjects. As can be seen in FIG.10A, on the Norwood scale for male, the mean value of Group 1 was higher than other Groups. Similarly,
FIG.IOB illustrates that on the Ludwig scale for female, the mean value of Group 1 was higher than the other groups.
Table 2 - Summary of Performance and Dermatological Parameters
Parameters Clinical assessment
Hair density
(hair follicles/cm2 area) 6 to 12% increase in hair density after three months of treatment
Hair Growth Rate (hair length/um/day) 8 to 22% increase in hair growth after three months of treatment
Hair thickness (um) 2 to 4% increase in hair thickness in 3 months
Anagen follicle ratio (%) 1 to 2 % increase in anagen follicle ratio in 3 months
Telogen follicle ratio (%) 6 to 10% decrease in telogen follicle ratio in 3 months
Vellus hair count (%) 9 to 22% increase in vellus hair count in 3 months
Terminal hair count (%) 5 to 9% increase in terminal hair count in 3 months
Hair Tangling Significant improvement
Hair Pull test Significant improvement in hair pull test
Hair tensile strength 12 to 14% increase in hair tensile strength after three months treatment
Hair Thinning No hair thinning was observed
ADVANTAGE OF THE INVENTION
[00087] The present disclosure provides a new and improved hair oil
composition that has overcome the limitations associated with the conventional
hair oil composition.
[00088] The present disclosure provides a herbal hair oil composition for
stimulation of hair growth, control and prevention of hair fall.
[00089] The present disclosure provides a herbal hair oil composition that is
suitable for both male and female population suffering from hair loss.
[00090] The present disclosure provides a herbal hair oil composition that is
devoid of any chemicals or allopathic drugs.
[00091] The present disclosure provides a herbal hair oil composition that is
substantially devoid of any side effects such as dryness, irritation in scalp and
other side-effects.
[00092] The present disclosure provides a herbal hair oil composition that
exhibits superior storage stability and synergistic activity /functional reciprocity.
[00093] The present disclosure provides a herbal hair oil composition that
induces cellular level growth and provides nourishment to hair and scalp.
[00094] The present disclosure provides a herbal hair oil composition that not
only treat the thinning of hair but also induce anagen hair growth and promote
terminal hair growth.
[00095] The present disclosure provides a herbal hair oil composition that acts
quickly as well as has a long-lasting effect.
[00096] The present disclosure provides a composition that is easy to prepare
and is economical.
[00097] The present disclosure provides a process of preparation of a herbal
hair oil composition.
We Claim:
1. A herbal hair oil composition for stimulation of hair growth, control and
prevention of hair fall, said composition comprising:
i) Emblica officinalis seed oil in an amount ranging from 1% to 5%
by weight of the composition;
ii) Nigella Sativa oil in an amount ranging from 0.1% to 2% by
weight of the composition; iii) Thymus vulgaris oil in an amount ranging from 0.1% to 1% by
weight of the composition;
iv) Vitis vinifera seed oil in an amount ranging from 0.1% to 2% by
weight of the composition;
v) Coffee seed oil in an amount ranging from 0.1% to 1% by weight
of the composition;
vi) Thuja occidentalis oil in an amount ranging from 0.1% to 2% by
weight of the composition; vii) Cedrus deodara oil in an amount ranging from 0.1% to 2% by
weight of the composition; viii) Rosmarinus officinalis oil in an amount ranging from 0.1% to 2%
by weight of the composition; ix) Serenoa repens oil in an amount ranging from 0.1% to 2% by
weight of the composition;
x) Eclipta Alba oil in an amount ranging from 0.1% to 1% by weight
of the composition; xi) Daucus carota seed oil in an amount ranging from 0.1% to 2% by
weight of the composition; xii) Hibiscus sabdariffa L oil in an amount ranging from 0.1% to 2%
by weight of the composition; xiii) Centella asiatica oil in an amount ranging from 0.1% to 1% by
weight of the composition;
xiv) Z)-panthenol in an amount ranging from 0.1% to 1% by weight of
the composition; xv) Helianthus annuus oil in an amount ranging from 1% to 10% by
weight of the composition; xvi) Prunus dulcis oil in an amount ranging from 1% to 10% by
weight of the composition; xvii) Cocos nucifera oil in an amount ranging from 0.5% to 5% by
weight of the composition; xviii) Brassica nigra oil in an amount ranging from 0.5% to 5% by
weight of the composition; xix) Simmondsia chinensis oil in an amount ranging from 0.5% to 8%
by weight of the composition; xx) Lavandula officinalis oil in an amount ranging from 0.1% to 2%
by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of
the composition; and xxii) Sesamum indicum in an amount ranging from 60% to 90% by weight of the composition. The composition as claimed in claim 1, wherein the composition further comprises an additive.
The composition as claimed in claim 2, wherein the additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer. A process for preparation of herbal oil composition for stimulation of hair growth, control and prevention of hair fall, the process comprising the steps of:
i) taking an effective amount of Sesamum indicum oil, an effective amount of Helianthus annuus oil, an effective amount of Brassica nigra oil, an effective amount of Cocos nucifera oil, an effective amount of Prunus dulcis oil, an effective amount ofCentella asiatica oil, an effective amount of Eclipta Alba oil, an effective amount of
Hibiscus sabdariffa L oil, an effective amount of Vitamin E and an effective amount of D-panthenol in a charging tank and stir for about 30 minutes to obtain a first solution; ii) taking an effective amount of Nigella Sativa oil, an effective amount of Thymus vulgaris oil, an effective amount of Daucus carota seed oil, an effective amount of Vitis vinifera seed oil, an effective amount of Cedrus deodara oil, an effective amount of Rosmarinus officinalis oil, an effective amount of Thuja occidentalis oil and an effective amount of Serenoa repens oil in an another charging tank and stir to obtain a second solution; iii) adding the second solution into the first solution, following the addition of an effective amount of Emblica officinalis seed oil, an effective amount of Coffee seed oil, an effective amount of Simmondsia chinensis oil and an effective amount of Lavandula officinalis oil, and stir for about 30 minutes to obtain third solution; and iv) filter the third solution to obtain the herbal hair oil composition. 5. The Process as claimed in claim 4, wherein the herbal oil composition comprises:
i) Emblica officinalis seed oil in an amount ranging from 1% to 5% by
weight of the composition;
ii) Nigella Sativa oil in an amount ranging from 0.1% to 2% by
weight of the composition; iii) Thymus vulgaris oil in an amount ranging from 0.1% to 1% by
weight of the composition;
iv) Vitis vinifera seed oil in an amount ranging from 0.1% to 2% by
weight of the composition;
v) Coffee seed oil in an amount ranging from 0.1% to 1% by weight
of the composition;
vi) Thuja occidentalis oil in an amount ranging from 0.1% to 2% by
weight of the composition;
vii) Cedrus deodara oil in an amount ranging from 0.1% to 2% by
weight of the composition; viii) Rosmarinus officinalis oil in an amount ranging from 0.1% to 2%
by weight of the composition; ix) Serenoa repens oil in an amount ranging from 0.1% to 2% by
weight of the composition;
x) Eclipta Alba oil in an amount ranging from 0.1% to 1% by weight
of the composition; xi) Daucus carota seed oil in an amount ranging from 0.1% to 2% by
weight of the composition; xii) Hibiscus sabdariffa L oil in an amount ranging from 0.1% to 2%
by weight of the composition; xiii) Centella asiatica oil in an amount ranging from 0.1% to 1% by
weight of the composition; xiv) Z)-panthenol in an amount ranging from 0.1% to 1% by weight of
the composition; xv) Helianthus annuus oil in an amount ranging from 1% to 10% by
weight of the composition; xvi) Prunus dulcis oil in an amount ranging from 1% to 10% by
weight of the composition; xvii) Cocos nucifera oil in an amount ranging from 0.5% to 5% by
weight of the composition; xviii) Brassica nigra oil in an amount ranging from 0.5% to 5% by
weight of the composition; xix) Simmondsia chinensis oil in an amount ranging from 0.5% to 8%
by weight of the composition; xx) Lavandula officinalis oil in an amount ranging from 0.1% to 2%
by weight of the composition; xxi) Vitamin E in an amount ranging from 0.1% to 1% by weight of
the composition; and
xxii) Sesamum indicum in an amount ranging from 60% to 90% by weight of the composition.
6. The process as claimed in claim 5, wherein the composition further comprises an additive.
7. The process as claimed in claim 6, wherein additive is selected from any or a combination of a mineral supplement, a fragrance agent, a colouring agent, a preservatives and a skin absorption enhancer.
| # | Name | Date |
|---|---|---|
| 1 | 202111029840-STATEMENT OF UNDERTAKING (FORM 3) [02-07-2021(online)].pdf | 2021-07-02 |
| 2 | 202111029840-POWER OF AUTHORITY [02-07-2021(online)].pdf | 2021-07-02 |
| 3 | 202111029840-FORM 1 [02-07-2021(online)].pdf | 2021-07-02 |
| 4 | 202111029840-DRAWINGS [02-07-2021(online)].pdf | 2021-07-02 |
| 5 | 202111029840-DECLARATION OF INVENTORSHIP (FORM 5) [02-07-2021(online)].pdf | 2021-07-02 |
| 6 | 202111029840-COMPLETE SPECIFICATION [02-07-2021(online)].pdf | 2021-07-02 |
| 7 | 202111029840-RELEVANT DOCUMENTS [24-08-2024(online)].pdf | 2024-08-24 |
| 8 | 202111029840-RELEVANT DOCUMENTS [24-08-2024(online)]-1.pdf | 2024-08-24 |
| 9 | 202111029840-POA [24-08-2024(online)].pdf | 2024-08-24 |
| 10 | 202111029840-POA [24-08-2024(online)]-1.pdf | 2024-08-24 |
| 11 | 202111029840-MSME CERTIFICATE [24-08-2024(online)].pdf | 2024-08-24 |
| 12 | 202111029840-FORM28 [24-08-2024(online)].pdf | 2024-08-24 |
| 13 | 202111029840-FORM-26 [24-08-2024(online)].pdf | 2024-08-24 |
| 14 | 202111029840-FORM 18A [24-08-2024(online)].pdf | 2024-08-24 |
| 15 | 202111029840-FORM 13 [24-08-2024(online)].pdf | 2024-08-24 |
| 16 | 202111029840-FORM 13 [24-08-2024(online)]-1.pdf | 2024-08-24 |
| 17 | 202111029840-Power of Authority [04-09-2024(online)].pdf | 2024-09-04 |
| 18 | 202111029840-PETITION u-r 6(6) [04-09-2024(online)].pdf | 2024-09-04 |
| 19 | 202111029840-Covering Letter [04-09-2024(online)].pdf | 2024-09-04 |
| 20 | 202111029840-Response to office action [06-09-2024(online)].pdf | 2024-09-06 |
| 21 | 202111029840-FER.pdf | 2025-09-10 |
| 1 | 202111029840_SearchStrategyNew_E_patseerandtkdlsearchE_09-09-2025.pdf |