Abstract: The present invention relates to a herbal composition for the treatment of asthma comprising (a) Tephrosia purpura (Sarphooka), (b) Cuscuta reflexa (Aftimoon Kasoos), (c) Morinda citrifolia (Noni), (d) Terminnalia arjuna (Arjun Bark), (e) Piper longum (Pipal Bari) and (f) Piper nigrum (Kali Mirch), and a process for preparing the composition. The composition is useful for the treatment of asthma.
FIELD OF THE INVENTION:
The present invention represents to a herbal powder composition for the treatment of asthma. More precisely, the invention is directed to a novel herbal powder composition comprising of a mixture of six native Indian herbs useful for treating asthma or similar airways conditions.
BACKGROUND:
Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath which vary in severity and frequency from person to person. Symptoms may occur several times in a day or week in affected individuals, and for some people become worse during physical activity or at night.
During an asthma attack, the lining of the bronchial tubes swell, causing the airways to narrow and reducing the flow of air into and out of the lungs. Recurrent asthma symptoms frequently cause sleeplessness, daytime fatigue, reduced activity levels and school and work absenteeism. Asthma has a relatively low fatality rate compared to other chronic diseases.
According to World Health Organization (WHO) estimates, 235 million people suffer from asthma. Asthma is the most common chronic disease among children. Asthma is not just a public health problem for high income countries: it occurs in all countries regardless of level of development. Over 80% of asthma deaths occurs in low and lower-middle income countries. Asthma is under-diagnosed and under-treated, creating a substantial burden to individuals and families and possibly restricting individuals' activities for a lifetime.
The fundamental causes of asthma are not completely understood. The strongest risk factors for developing asthma are a combination of genetic predisposition with environmental exposure to inhaled substances and particles that may provoke allergic reactions or irritate the airways, such as:
• indoor allergens (for example house dust mites in bedding, carpets and stuffed furniture, pollution and pet dander)
• outdoor allergens (such as pollens and moulds)
• tobacco smoke
• chemical irritants in the workplace
• air pollution
Other triggers can include cold air, extreme emotional arousal such as anger or fear, and physical exercise. Even certain medications can trigger asthma: aspirin and other non-steroid anti¬inflammatory drugs, and beta-blockers (which are used to treat high blood pressure, heart conditions and migraine).
Urbanization has been associated with an increase in asthma. But the exact nature of this relationship is unclear.
As per the WHO website, although asthma cannot be cured, appropriate management can control the disease and enable people to enjoy good quality of life.
Short-term medications are used to relieve symptoms. People with persistent symptoms must take long-term medication daily to control the underlying inflammation and prevent symptoms and exacerbations.
The past decade has witnessed phenomenal increases in the incidences of asthma, asthma-related deaths, and hospitalization. Existing classes of anti-asthmatic agents offer a limited variety of action that can be combined in a complementary and additive manner. Individual oral agents act only on a part of the pathogenic process of bronchial asthma. Hence, they may not produce any cure and may not prevent all complications of bronchial asthma. In view of this, there remains an unmet need to develop alternative, safe and effective asthma treatments. Although a role of herbal treatment of asthma is uncertain because of lack of well controlled scientific studies, the use of traditional or herbal medicines in the whole world has grown substantially over the last few
decades. Indian herbs and treatments mentioned in ancient Ayurveda, is one of the oldest medical practices in the world and have benefited patients for thousands of years. The combination of herbs is believed to produce synergistic effects and reduce possible side effects.
Accordingly, the development of herbal composition for asthma comprising a limited number of herbal ingredients targeting the treatment of asthma is a desirable and unmet need.
PRIOR ART:
Indian Patent Application No. 401/DEL/2015 relates to a herbal formulation consisting of a mixture of four native Indian herbs useful for lessening or treating asthma or similar conditions. The prior invented medicines especially in the field of ayurvedic, though available in large quantity in the market have not succeeded in giving complete relief to Asthmatic patient. The herbs disclosed in the said application are Cassia fistula Linn. (Aragvadha), Glycyrrhiza glabra Linn (Yasti), Anacyclus pyrethrumDc. (Akarakarabha) andBlepharispersicaBuvm. F. (Utingana). The fruit of Cassia fistula Linn., the roots of Glycyrrhiza glabra Linn and Anacyclus pyrethrum Dc. and the seed of Blepharis persica Burm. F. are taken in percentage of 37.5%, 25%, 18.75% and 18.75%) respectively for the herbal therapy for cure of asthma.
Chinese Patent Application No. 201210024691 .X relates to a medicine for treating bronchitis and bronchial asthma suffered by children aging from three to seven, which is composed of Chinese medicine decoction and acupuncture point injection medicament. The active ingredients of the oral Chinese medicine decoction are composed of various Chinese herbal medicines of roast ephedra, Schisandra chinensis, American ginseng, a Gecko, Zaocys dhumnade, Morinda officinalis, Lumbricus, Semen ginkgo, Semen brassicae, Semen lepidii, Radix pseudostellariae, Ramulus cinnamomi, Radix paeoniae alba, Radix rehmanniae Praeparata, Fructus soraleae, radix Achyranthis bidentatae, Lycium chinense, black ants, Poria cocos, Largehead atractylodes rhizome, Chinese yam, Scorpio, saposhnidoviae Radix, cortex, Magnoliae officinalis, Ganoderma lucidum, blackberry lily, Semen cuscutae, cark plum fruit, roast cortex mori radicis, roast flos farfarae, roast radix stemonae, lily, fried almond, tendril-leaved fritillary bulb and the like. The acupuncture point injection medicament is one of nucleotide and casein, placenta tissue fluid or
astragalus injection. The medicine can treat both principal and secondary aspects of diseases, perform dialectical therapy, increase immunity of the organism and enable the functions of the damaged lungs, spleens, kidneys and hearts to recover, and has the advantages and effects of high curative rate and no relapse.
Indian Patent Application No. 1130/MUM/2009 relates to an oral herbal spray for the treatment and maintenance therapy of asthma. The oral herbal spray contains the extract oiAdhatoda vasica Nees., Clerodendrum serratum Linn., Curcuma longa Linn., Solanum xanthocarpum Schrad & Wendl, Piper longum Linn, and one or more pharmaceutical^ acceptable additives. Further the invention also provides the process for preparing the herbal spray.
Korean Patent Application No PCT/KR2005/002873 (publication no. WO/2006/025690) relates to a herb composition for asthma maintenance therapy based on Chungsangboha-tang, which is known to be effective in asthma, capable of reducing the long- term suffering of asthma patients and improving their quality of lives and a manufacturing method thereof. The herbal composition of the present invention is characterized by comprising 5-18 parts by weight of Rehmanniae radix vaporata, 4-14 parts by weight of Dioscoreae radix, 4-14 parts by weight of Corni fructus, 2-9 parts by weight of Pachyma hoelen, 2-9 parts by weight of Moutan radicis cortex, 2-9 parts by weight of Alismatis rhizoma, 2-7 parts by weight of Schizandrae fructus, 2-7 parts by weight of Aspargus cochinchinensis, 2-7 parts by weight of Liriopsis tuber, 2-7 parts by weight of Fritillariae bulbus, 2-7 parts by weight of Trichosantes kirilowii, 2-7 parts by weight of Prunus armeniacae linn, 2-7 parts by weight of Pinelliae rhizoma, 2-7 parts by weight oEAurantii immaturus fructus, 2-7 parts by weight of Platycodi radix, 2-7 parts by weight of Scutellariae radix, 2-7 parts by weight of Coptidis rhizoma and 1-5 parts by weight of Glycyrrhizae radix.
Indian Patent Application No. 1401/CHE/2008 relates to a synergistic polyherbal composition for the treatment of bronchial asthma, said composition comprising:
Achyranthcs aspera: 15.5% -17.5% by wt%; Woodfordiafuriticosal 11.5% -13.6 % by wt%; Solanum xanthocarpum: 0% -13.6% by wt%;
Justicia adhatoda: 11.5 % -13.6 % by wt%; Acacia arabica: 11.5 % -13.6 % by wt%; Zingiber officinalis! .6 % - 4.94% by wt%; Syzygium aromaticum bud: 3.6 % - 4.94 % by wt%; Curcuma longa: 3.6 % - 4.94 % by wt%; Holarrhena antidysentercia 3.6%- 4.94 % by wt%; Enicostemma littorale : 2.22 % - 3.3 % by wt%; Calotropisprocera: 2.22 % - 3.3 % by wt%; f/per longum: 2.22 % - 3.3 by wt%; P/per nigrum: 7.8 - 8.2 % by wt%; Elettaaria Cardamomum: 0.06% - 0.19% by wt%.
Indian Patent Application No. 201721030002 discloses a herbal composition for treatment of digestive system related diseases comprising
\)Foeniculum Vulgar e: 50.47% — 85.43%
2) Trachyspemum Ammi: 29.93% — 9.75%
3) Dolichandrone Falcata: 0.20% — 0.02%
4) Morinda Citrifolia: 0.20% — 0.05%
5) Syzygium Aromaticum: 3.90% —0.75%
6) Piper Nigrum: 3.90% —0.5 0%
7) Cinnamomum Zeylanicum: 3.90% — 1.00% 8] Black Salt: 2.10% - 1.00%
9) Sodium Bicorbonate: 1.50% —0.50%
10) Illilcium Verum: 3.90% — 1.00%
Very important objects of the invention of Indian Patent Application No. 201721030002 are that it controls chronic illnesses like Diabetes Mellitus, Asthma, Hypertension and Arthritis.
There are also various ayurvedic medicines commercially available which are used for the treatment of asthma. Some of the prominent ayurvedic medicines/compositions available in the market are discussed below:
Dabur Shwaasamrit:
Dabur Shwaasamrit is used for asthma and bronchitis. It increases airflow into the lungs, works as an expectorant to help reduce cough, strengthens the respiratory system, reduces breathlessness and helps treat asthma and bronchitis. The herbs used in Dabur Shwaasamrit are Achyranthes Aspera, Elettaria Cardamomum, Clerodendron Serratum, Cinnamomum Tamala, Piper Longum, Justicia Adhatoda, Badi Elaichi and Glycyrrhiza Glabraherbs.
Dabur Agastya Haritaki Avaleha:
Dabur Agastya Haritaki Avaleha is an ayurvedic medicine used for the treatment of asthma and bronchitis, and for treating and providing relief in diseases related to the respiratory system. It is also used for treating allergic respiratory conditions like asthma and chronic bronchitis. The ingredients used for preparing this ayurvedic medicine are Justicia Adhatoda, Badi Elaichi, Glycyrrhiza Glabraherbs, Achyranthes Aspera, Albizia Lebbeck and Piper Longum.
Himalaya Vasaka:
Himalaya Vasaka is pure herb extract of Vasaka (Malabar Nut Tree/Adhatoda zeylanica). It is used for treating cold, cough, whooping-cough, chronic bronchitis, asthma and against allergen-induced bronchial obstruction due to its anti-inflammatory, antitussive and bronchodilatory action.
Himalaya Trikatu:
Himalaya Trikatu is an ayurvedic medicinal composition comprising Black Pepper (Piper nigrum), Indian Long Pepper {Piper longum) and the rhizomes of Ginger {Zingiber officinale). The benefits of trikatu are that it stimulates digestion, respiratory support, blood circulation.
Divya Swasari Ras:
Divya Swasari Ras is an ayurvedic composition for the treatment of asthma. The key ingredients of this herbal medicine are Pravala Pishti, Abhraka Bhasma, Mukta-sukti Bhasma, Tankana Bhasma, Sphatika Bhasma, Godanti Bhasma, Kapardaka Bhasma, Shringa Bhasma, Manahsila (pure), root of Akarakarabha, Lavanga (clove), Tvak (cinnamon), pure Vatsanabha, powder of Trikatu (collective name for Shunthi or dry ginger, Pippali or long pepper and Marica or black pepper), Karkata Shringi, Madhu Yasti, fruit of Rudanti.
Baidyanath Kanakasava:
Baidyanath Kanakasava is an ayurvedic composition which is effective in all types of cough. It helps in relieving problems of respiratory system indicated in asthma, cough, chronic respiratory disorders and phthisis. Each 10ml of Baidyanath Kanakasava contains : Dhatura, Vasa each : 63.88mg, Yasti, Pippali, Kantakari, Nagakesara, Sunthi, Bharangi, Talispatra each : 31.944mg, Draksa : 256.111mg, Sarkara ; 1.6g, Madhu : 800mg, Dhataki : 277.777mg, and Asav Base : Q.S
Sapat's Ayusas:
Sapat's Ayusas is another ayurvedic composition marketed in the form of cough drops or syrups. It provides instant relief from throat irritation, cools and soothes the throat, promotes easy breathing, builds immunity, dissolves and expels congealed cough and phlegm. Its ingredients are Adulsa, Kantakari, Haldi, Yashtimadhu and Tulsi.
However, as apparent, none of the prior art documents disclose the invention as disclosed in the following paragraphs.
SUMMARY OF THE INVENTION
The present invention relates to a herbal powder composition for the treatment of asthma comprising:
(a) Tephrosia Purpura (Sarphooka),
(b) Cuscuta Reflexa (Aftimoon Kasoos),
(c) Morinda Citrifolia (Noni),
(d) Terminnalia Arjuna (Arjun Bark),
(e) Piper Longum (Pipal Bari) and
(f) Piper Nigrum (Kali Mirch).
A preferred embodiment of the present invention relates to a composition consisting essentially of:
(a) Tephrosia Purpura (Sarphooka);
(b) Cuscuta Reflexa (Aftimoon Kassos);
(d) Terminnalia Arjuna (Arjuna Bark); and
(e) Piper Longum (Pipal Bari).
Another preferred embodiment of the present invention relates to a composition consisting essentially of:
(a) Tephrosia Purpura (Sarphooka);
(b) Cuscuta Reflexa (Aftimoon Kasoos);
(c) Morinda Citrifolia (Noni); and (e) Piper Longum (Pipal Bari).
An embodiment of the present invention relates to a herbal composition wherein Tephrosia Purpura is in the range of 25 to 60% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Tephrosia Purpura is in the range of 35 to 55% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Tephrosia Purpura is in the range of 40 to 50% by wt.
Another embodiment of the present invention relates to a herbal composition wherein Cuscuta Reflexa is in the range of 1 to 30% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Cuscuta Reflexa is in the range of 5 to 25% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Cuscuta Reflexa is in the range of 8 to 20% by wt.
Another embodiment of the present invention relates to a herbal composition wherein Morinda Citrifolia is in the range of 1 to 30% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Morinda Citrifolia is in the range of 5 to 25% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Morinda Citrifolia is in the range of 8 to 20% by wt.
Yet another embodiment of the present invention relates to a herbal composition wherein Terminnalia Arjuna is in the range of 1 to 30% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Terminnalia Arjuna is in the range of 5 to 25% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Terminnalia Arjuna is in the range of 8 to 20% by wt.
Still another embodiment of the present invention relates to a herbal composition wherein Piper Longum is in the range of 1 to 30% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Piper Longum is in the range of 3 to 25% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Piper Longum is in the range of 5 to 20% by wt.
Another embodiment of the present invention relates to a herbal composition wherein Piper Nigrum is in the range of 1 to 30% by wt.
A preferred embodiment of the above invention relates to a herbal composition wherein Piper Nigrum is in the range of 5 to 25% by wt.
Yet another preferred embodiment of the above invention relates to a herbal composition wherein Piper Nigrum is in the range of 8 to 20% by wt.
Yet another embodiment of the present invention relates to a herbal composition wherein honey, warm water or water at room temperature is employed as a carrier while administering to the subject.
Another embodiment of the present invention relates to a process for the preparation of the composition of the present invention comprising the following steps:
(a) shade drying of Tephrosia Purpura, Cuscuta Reflexa, Morinda Citrifolia, Terminnalia Arjuna, Piper Longum and Piper Nigrum separately;
(b) crushing/grinding the dried parts of Tephrosia Purpura, Cuscuta Reflexa, Morinda Citrifolia, Terminnalia Arjuna, Piper Longum and Piper Nigrum, separately, maintaining the temperature in ambient conditions to a fine powder; and
(c) mixing the dried powders of Tephrosia Purpura, Cuscuta Reflexa, Morinda Citrifolia, Terminnalia Arjuna, Piper Longum and Piper Nigrum in the ratio as mentioned above.
While the whole plant of Tephrosia Purpura is generally used, only the stem and seeds of Cuscuta Reflexa can be used for preparing the powder composition. Further, the bark of Terminnalia Arjuna
is used. Similarly, the fruits oi Morinda Citrifolia, Piper Longum and Piper Nigrum are used in the powder composition.
Drying is normally carried out in shade to avoid degeneration of the active ingredients due to UV light.
Temperature in ambient conditions would mean that no excessive heat should be produced during the crushing process, as excessive heat could affect the properties of the raw materials. Using a mechanized crusher is contemplated where care should be taken so that little or no excessive heat is produced.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to a synergistic composition comprising six ingredients, viz., Tephrosia Purpura (Sarphooka), Cuscuta Reflexa (Aftimoon Kasoos), Morinda Citrifolia (Noni), Terminnalia Arjuna (Arjun Bark), Piper Longum (Pipal Bari) and Piper Nigrum (Kali Mirch) in the particular ratio as provided in the Summary of the Invention.
DESCRIPTION OF PLANTS:
Tephrosia Purpura (Fish Poison, Wild Indigo, Sarphooka)
Tephrosia purpurea is a species of flowering plant in the pea family, Fabaceae, that has a pantropical distribution. It is a common wasteland weed. In many parts it is under cultivation as green manure crop. It is found throughout India and Sri Lanka in poor soils. It is also commonly known as Fish Poison and Wild Lidigo in English, and Sarphooka in Hindi.
Uses:
Tephrosia purpurea is also used traditionally as folk medicine. According to Ayurveda, the plant is anthelmintic, alexiteric, restorative, and antipyretic. It is used in the treatment of leprosy, ulcers,
asthma, and tumors, as well as diseases of the liver, spleen, heart, and blood. A decoction of the roots is given in dyspepsia, diarrhea, rheumatism, asthma and urinary disorders.
Cuscuta Reflexa (Giant Dodder, Swarna Lata, Aftimoon Kasoos)
Cuscuta reflexa, also known as the Giant Dodder, is one of 100-170 species in the genus Cuscuta.
This plant species is common in the Indian Subcontinent. This parasitic plant species is a leafless twined sprawling thin vine that grows over a host plant. This species capable of producing numerous branches which can cover the host plant within a very short period of time and suck life out of the host plant. Flowers are small, bell shaped and white in colour with yellow filaments. Fruits and seeds are produced from the flower.
Uses:
This species is used in producing traditional medicines for the treatment of headache, labour pain, bone fracture, fever, rheumatism etc. This species is used medicinally in Ayurveda, Unani and Sidha.
Morinda Citrifolia (Noni)
Noni is a small evergreen tree in the Pacific Islands, Southeast Asia, Australia, and India that often grows among lava flows. Historically, noni was used to make a red or yellow dye for clothing. It was also used as medicine, usually applied to the skin.
Uses:
People take noni by mouth for colic, convulsions, cough, diabetes, painful urination, stimulating menstrual flow, fever, liver disease, constipation, vaginal discharge during pregnancy, malarial fever, and nausea. It is also used for smallpox, enlarged spleen, swelling, asthma, arthritis and other bone and joint problems, cancer, cataracts, colds, depression, digestive problems, and gastric ulcers. Other uses include high blood pressure, infections, kidney disorders, migraine headache, premenstrual syndrome, stroke, pain, and sedation.
Terminalia Arjuna (Arjun Bark)
Terminalia arjuna, commonly known as arjuna, belongs to the family of Combretaceae. Its bark decoction is being used in the Indian subcontinent for anginal pain, hypertension, congestive heart failure, and dyslipidemia, based on the observations of ancient physicians for centuries.
Uses:
The utility of arjuna in various cardiovascular diseases needs to be studied further. Studies have suggested that the crude drug possesses anti-ischemic, antioxidant, hypolipidemic, and antiatherogenic activities. Its useful phytoconstituents are: Triterpenoids, P-sitosterol, flavonoids, and glycosides. Triterpenoids and flavonoids are considered to be responsible for its beneficial antioxidant cardiovascular properties. The drug has shown promising effect on ischemic cardiomyopathy. It has been found useful in angina pectoris, mild hypertension, and dyslipidemia.
Piper Longum (Pipal Bari):
Long pepper {Piper longum), sometimes called Indian long pepper or pipli, is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. Long pepper has a taste similar to, but hotter than, that of its close relative Piper nigrum - from which black, green and white pepper are obtained.
Uses:
Piper Longum is used for diseases of the respiratory tract (cough, bronchitis, asthma); as sedative (in insomnia and epilepsy); as cholagogue (in obstruction of bile duct and bladder), as emmenagogue, as digestive, appetizer and carminative (in indigestion); as general tonic and haematinic (in anaemia, chronic fevers and for improving intellect). Applied locally on muscular pains and inflammations.
Piper Nigrum (Kali Mirch):
Black pepper (Piper nigrum) is a flowering vine in the family Piperaceae, cultivated for its fruit, known as a peppercorn, which is usually dried and used as a spice and seasoning. When fresh and
fully mature, it is about 5 mm (0.20 in) in diameter and dark red, and contains a single seed, like all drupes. Peppercorns and the ground pepper derived from them may be described simply as pepper, or more precisely as black pepper (cooked and dried unripe fruit), green pepper (dried unripe fruit), or white pepper (ripe fruit seeds).
Uses:
Piper Nigrum is a warm carminative stimulant, producing, when taken into the system, general arterial excitement, but acting with greater proportional energy upon the surfaces with which it is brought more immediately into contact. It is useful in debility of the stomach, and throughout the entire extent of the digestive system exerts a pure stimulant action; and is useful also in fevers where the indications for a stimulant impression exist.
The inventor has surprisingly found that these six native herbs when used together particularly in a well-defined ratio treats asthma significantly, within a period of three to six months. The health condition, age and other concomitant diseases might vary the time required for significant reduction in the symptoms of asthma. Usually, for an otherwise healthy individual, it takes anywhere between three to six months for the significant reduction in the symptoms of asthma.
The composition may be administered with honey, warm or water at room temperature. It may be administered an hour before or after breakfast and half an hour or an hour after dinner. The composition can also be in the form of a capsule or tablet.
The raw materials such as whole plant of Tephrosia Purpura, stem and seeds of Cuscuta Reflexa, bark of Terminnalia Arjuna, fruits oiMorinda Citrifolia, Piper Longum and Piper Nigrum for the present invention are readily and easily available in the market, especially in grocery and Ayurvedic and Unani medicinal shops. However, if the raw ingredients cannot be accessed commercially, the same can also be accessed from farmland or a biological garden. In case the raw materials are not commercially sourced, the raw materials have to be prepared using the specific steps mentioned in the aforementioned process.
Since, the raw ingredients are commercially available and are sourced/bought commercially, no prior approval from National Biological Diversity (NBA) is required particularly in view of section 7 of Biological Diversity Act 2002.
The inventor has not come across a single document which discloses the use of the six herbs or combination of preferred four herbs for the treatment of asthma.
PREPARATION OF THE POWDERS OF THE COMPOSITION:
The respective parts of the six plants Tephrosia Purpura (Sarphooka), Cuscuta Reflexa (Aftimoon Kasoos), Morinda Citrifolia (Noni), Terminnalia Arjuna (Arjun Bark), Piper Longum (Pipal Bari) and Piper Nigrum (Kali Mirch) are bought from the market. Each of the raw ingredients is bought in dried form from regular Ayurvedic and Unani medicinal shops, exemplified by M/s Ram Kishan Raghav Kumar, 67-2, Khari Baoli, Delhi 110 006; M/s Asia Enterprises 6699/1, Khari Baoli, Delhi 110 006; M/s Nidco Pharma, Shop No. 6 & 7, 174 (FF), Gali Abdul Hakim, Tilak Bazar, Khari Baoli, Delhi 110 006. Such materials can be accessed commercially from any shop and are not limited to the shops mentioned above.
Thereafter, Tephrosia Purpura (Sarphooka) is taken in an amount in the range of 25 to 60% by wt., preferably 35 to 55% by wt., more preferably 40 to 50% by wt., Cuscuta Reflexa is taken in the range of 1 to 30% by wt., preferably 5 to 25% by wt., more preferably 8 to 20% by wt., Morinda Citrifolia is taken in the range of 1 to 30% by wt., preferably 5 to 25% by wt., more preferably 8 to 20% by wt., Terminnalia Arjuna is taken in the range of 1 to 30% by wt., preferably 5 to 25% by wt., more preferably 8 to 20% by wt.; Piper Longum is taken in the range of 1 to 30% by wt., preferably 3 to 25% by wt., more preferably 5 to 20% by wt. and Piper Nigrum is taken in the range of 1 to 30% by wt., preferably 5 to 25% by wt., more preferably 8 to 20% by wt.
The present invention comprises of six herbs Tephrosia Purpura, Cuscuta Reflex, Morinda Citrifolia, Terminnalia Arjuna, Piper Longum and Piper Nigrum has been effective in a study with patients having asthma symptoms.
Some of the exemplary herbal compositions are as follows:
a. Herbal composition
Tephrosia Purpura (Sarphooka) - 29.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) -13.00% by wt.
Morinda Citrifolia (Noni) - 17.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 21.00% by wt.
Piper Longum (Pipal Bari) - 8.00% by wt.
Piper Nigrum (Kali Mirch) - 12.00% by wt.
b. Herbal composition
Tephrosia Purpura (Sarphooka) - 34.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 11.00% by wt.
Morinda Citrifolia (Noni) - 17.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 23.00% by wt.
Piper Longum (Pipal Bari) - 7.00% by wt.
Piper Nigrum (Kali Mirch) - 8.00% by wt.
c. Herbal composition
Tephrosia Purpura (Sarphooka) - 39.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 9.00% by wt.
Morinda Citrifolia (Noni) - 19.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 15.00% by wt.
Piper Longum (Pipal Bari) - 12.00% by wt.
Piper Nigrum (Kali Mirch) - 6.00% by wt.
d. Herbal composition
Tephrosia Purpura (Sarphooka) - 58.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 8.00% by wt.
Morinda Citrifolia (Noni) - 12.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 10.00% by wt.
Piper Longum (Pipal Bari) - 5.00% by wt.
Piper Nigrum (Kali Mirch) - 7.00% by wt.
e. Herbal composition
Tephrosia Purpura (Sarphooka) - 60% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 8.00% by wt.
Morinda Citrifolia (Noni) - 6.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 10.00% by wt.
Piper Longum (Pipal Bari) - 5.00% by wt.
Piper Nigrum (Kali Mirch) - 11.00% by wt.
f Herbal composition
Tephrosia Purpura (Sarphooka) - 60.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 8.00% by wt.
Terminnalia Arjuna (Arjuna Bark) - 20.00% by wt.
Piper Longum (Pipal Bari) - 12.00% by wt.
g. Herbal composition
Tephrosia Purpura (Sarphooka) - 57.00% by wt.
Cuscuta Reflexa (Aftimoon Kassos) - 10.00% by wt.
Morinda Citrifolia (Noni) - 21.00% by wt.
Piper Longum (Pipal Bari) - 12.00% by wt.
In case the plants are taken from the farmland, the respective parts of the plants need to be shade
dried before being crushed separately. Once the dried parts of the plants are crushed, the powders
are stored and combined in the proportion as mentioned above as and when required.
WORKING EXAMPLES
The composition prepared in accordance with the disclosure of the present invention should be administered at least once a day.
The invention is further illustrated by way of non-limiting examples. Thus, the following examples should not construe the scope of protection.
Example 1
A person was administered 2 g of the composition (any of composition a., b. c. d. or e.) along with honey, twice a day for a period of three months. The morning dose was administered half an hour before breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Example 2
A person was administered 1 g of the composition (any of composition a., b. c. d. or e.) along with honey, twice a day for a period of five months. The morning dose was administered half an hour before breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Example 3
A person was administered 2 g of the composition (any of composition a., b. c. d. or e.) along with warm water, twice a day for a period of four months. The morning dose was administered half an hour before breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Example 4
A person was administered 1 g of the composition (any of composition a., b. c. d. or e.) along with warm water, twice a day for a period of six months. The morning dose was administered half an hour before breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Example 5
A person was administered 1 g of the composition (composition e.) along with warm water, twice a day for a period of seven months. The morning dose was administered half an hour after breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Example 6
A person was administered 1 g of the composition (composition f) along with warm water, twice a day for a period of seven months. The morning dose was administered half an hour after breakfast and the evening dose an hour after dinner. The person was found to get significant relief from asthma.
Similar tests have been conducted on approximately 300 patients, and all the patients have been found to get significant relief from asthma.
While the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art will appreciate that various modifications and substitutions can be made thereto without departing from the spirit and scope of the invention as set forth in the appended claims.
We Claim:
1. A herbal powder composition for the treatment of asthma comprising:
(a) Tephrosia purpura (Sarphooka),
(b) Cuscuta reflexa (Aftimoon Kasoos),
(c) Morinda citrifolia (Noni),
(d) Terminnalia arjuna (Arjun Bark),
(e) Piper longum (Pipal Bari) and
(f) Piper nigrum (Kali Mirch).
2. The composition as claimed in claim 1 consisting essentially of:
(a) Tephrosia purpura (Sarphooka);
(b) Cuscuta reflexa (Aftimoon Kasoos);
(d) Terminnalia arjuna (Arjuna Bark); and
(e) Piper longum (Pipal Bari).
3. The composition as claimed in claim 1 consisting essentially of:
(a) Tephrosia purpura (Sarphooka);
(b) Cuscuta reflexa (Aftimoon Kasoos);
(c) Morinda citrifolia (Noni); and
(e) Piper longum (Pipal Bari).
4. The composition as claimed in claim 1 wherein Tephrosia purpura is in the range of 25 to 60% by wt.
5. The composition as claimed in claim 1 wherein Tephrosia purpura is in the range of 35 to 55% by wt.
6. The composition as claimed in claim 1 wherein Tephrosia purpura is in the range of 40 to 50% by wt.
7. The composition as claimed in claim 1 wherein Cuscuta reflexa is in the range of 1 to 30% by wt.
8. The composition as claimed in claim 1 wherein Cuscuta reflexa is in the range of 5 to 25% by wt.
9. The composition as claimed in claim 1 wherein Cuscuta reflexa is in the range of 8 to 20% by wt.
10. The composition as claimed in claim 1 wherein Morinda citrifolia is in the range of 1 to 30% by wt.
11. The composition as claimed in claim 1 wherein Morinda citrifolia is in the range of 5 to 25% by wt.
12. The composition as claimed in claim 1 wherein Morinda citrifolia is in the range of 8 to 20% by wt.
13. The composition as claimed in claim 1 wherein Terminnalia arjuna is in the range of 1 to 30% by wt.
14. The composition as claimed in claim 1 wherein Terminnalia arjuna is in the range of 5 to 25% by wt.
15. The composition as claimed in claim 1 wherein Terminnalia arjuna is in the range of 8 to 20% by wt.
16. The composition as claimed in claim 1 wherein Piper longum is in the range of 1 to 30% by wt.
17. The composition as claimed in claim 1 wherein Piper longum is in the range of 3 to 25% by wt.
18. The composition as claimed in claim 1 wherein Piper longum is in the range of 5 to 20% by wt.
19. The composition as claimed in claim 1 wherein Piper nigrum is in the range of 1 to 30% by wt.
20. The composition as claimed in claim 1 wherein Piper nigrum is in the range of 5 to 25% by wt.
21. The composition as claimed in claim 1 wherein Piper nigrum is in the range of 8 to 20% by wt.
22. The composition as claimed in claim 1 wherein honey, warm water or water at room temperature is applied as a carrier while administering to the subject in need.
23. A process for the preparation of the composition as claimed in claim 1 comprising the following steps:
(a) shade drying of Tephrosia purpura, Cuscuta reflexa, Morinda citrifolia, Terminnalia arjuna, Piper longum and Piper nigrum separately;
(b) crushing/grinding the dried parts of Tephrosia purpura, Cuscuta reflexa, Morinda citrifolia, Terminnalia arjuna, Piper longum and Piper nigrum, separately, maintaining the temperature in ambient conditions to a fine powder; and
(c) mixing the powders so obtained in step (b) of Tephrosia purpura, Cuscuta reflexa, Morinda citrifolia, Terminnalia arjuna, Piper longum and Piper nigrum in the ratio as recited in claims 4 to 21.
| Section | Controller | Decision Date |
|---|---|---|
| # | Name | Date |
|---|---|---|
| 1 | 201911048481-REQUEST FOR CERTIFIED COPY [30-09-2020(online)].pdf | 2020-09-30 |
| 1 | 201911048481-STATEMENT OF UNDERTAKING (FORM 3) [27-11-2019(online)].pdf | 2019-11-27 |
| 2 | 201911048481-STARTUP [27-11-2019(online)].pdf | 2019-11-27 |
| 2 | 201911048481-Written submissions and relevant documents [11-09-2020(online)].pdf | 2020-09-11 |
| 3 | 201911048481-REQUEST FOR EARLY PUBLICATION(FORM-9) [27-11-2019(online)].pdf | 2019-11-27 |
| 3 | 201911048481-Correspondence to notify the Controller [27-08-2020(online)].pdf | 2020-08-27 |
| 4 | 201911048481-US(14)-ExtendedHearingNotice-(HearingDate-28-08-2020).pdf | 2020-07-28 |
| 4 | 201911048481-POWER OF AUTHORITY [27-11-2019(online)].pdf | 2019-11-27 |
| 5 | 201911048481-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [25-07-2020(online)].pdf | 2020-07-25 |
| 5 | 201911048481-FORM28 [27-11-2019(online)].pdf | 2019-11-27 |
| 6 | 201911048481-FORM-9 [27-11-2019(online)].pdf | 2019-11-27 |
| 6 | 201911048481-FORM 13 [17-07-2020(online)].pdf | 2020-07-17 |
| 7 | 201911048481-FORM-26 [17-07-2020(online)].pdf | 2020-07-17 |
| 7 | 201911048481-FORM FOR STARTUP [27-11-2019(online)].pdf | 2019-11-27 |
| 8 | 201911048481-RELEVANT DOCUMENTS [17-07-2020(online)].pdf | 2020-07-17 |
| 8 | 201911048481-FORM FOR SMALL ENTITY(FORM-28) [27-11-2019(online)].pdf | 2019-11-27 |
| 9 | 201911048481-Correspondence-300620.pdf | 2020-07-09 |
| 9 | 201911048481-FORM 18A [27-11-2019(online)].pdf | 2019-11-27 |
| 10 | 201911048481-FORM 1 [27-11-2019(online)].pdf | 2019-11-27 |
| 10 | 201911048481-OTHERS-300620.pdf | 2020-07-09 |
| 11 | 201911048481-FIGURE OF ABSTRACT [27-11-2019(online)].pdf | 2019-11-27 |
| 11 | 202017014539-Correspondence-300620.pdf | 2020-07-09 |
| 12 | 201911048481-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [27-11-2019(online)].pdf | 2019-11-27 |
| 12 | 202017014539-OTHERS-300620-.pdf | 2020-07-09 |
| 13 | 201911048481-EVIDENCE FOR REGISTRATION UNDER SSI [27-11-2019(online)].pdf | 2019-11-27 |
| 13 | 202017014539-OTHERS-300620.pdf | 2020-07-09 |
| 14 | 201911048481-DECLARATION OF INVENTORSHIP (FORM 5) [27-11-2019(online)].pdf | 2019-11-27 |
| 14 | 202017014539-Power of Attorney-300620.pdf | 2020-07-09 |
| 15 | 201911048481-COMPLETE SPECIFICATION [27-11-2019(online)].pdf | 2019-11-27 |
| 15 | 201911048481-US(14)-HearingNotice-(HearingDate-29-07-2020).pdf | 2020-06-29 |
| 16 | 201911048481-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [27-11-2019(online)].pdf | 2019-11-27 |
| 16 | 201911048481-CLAIMS [20-06-2020(online)].pdf | 2020-06-20 |
| 17 | 201911048481-Power of Attorney-121219.pdf | 2019-12-14 |
| 17 | 201911048481-FER_SER_REPLY [20-06-2020(online)].pdf | 2020-06-20 |
| 18 | 201911048481-OTHERS [20-06-2020(online)].pdf | 2020-06-20 |
| 18 | 201911048481-OTHERS-121219.pdf | 2019-12-14 |
| 19 | 201911048481-Correspondence from NBA(03-06-2020).pdf | 2020-06-03 |
| 19 | 201911048481-Correspondence-121219.pdf | 2019-12-14 |
| 20 | 201911048481-FER.pdf | 2020-01-01 |
| 21 | 201911048481-Correspondence from NBA(03-06-2020).pdf | 2020-06-03 |
| 21 | 201911048481-Correspondence-121219.pdf | 2019-12-14 |
| 22 | 201911048481-OTHERS [20-06-2020(online)].pdf | 2020-06-20 |
| 22 | 201911048481-OTHERS-121219.pdf | 2019-12-14 |
| 23 | 201911048481-FER_SER_REPLY [20-06-2020(online)].pdf | 2020-06-20 |
| 23 | 201911048481-Power of Attorney-121219.pdf | 2019-12-14 |
| 24 | 201911048481-CLAIMS [20-06-2020(online)].pdf | 2020-06-20 |
| 24 | 201911048481-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [27-11-2019(online)].pdf | 2019-11-27 |
| 25 | 201911048481-US(14)-HearingNotice-(HearingDate-29-07-2020).pdf | 2020-06-29 |
| 25 | 201911048481-COMPLETE SPECIFICATION [27-11-2019(online)].pdf | 2019-11-27 |
| 26 | 201911048481-DECLARATION OF INVENTORSHIP (FORM 5) [27-11-2019(online)].pdf | 2019-11-27 |
| 26 | 202017014539-Power of Attorney-300620.pdf | 2020-07-09 |
| 27 | 201911048481-EVIDENCE FOR REGISTRATION UNDER SSI [27-11-2019(online)].pdf | 2019-11-27 |
| 27 | 202017014539-OTHERS-300620.pdf | 2020-07-09 |
| 28 | 201911048481-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [27-11-2019(online)].pdf | 2019-11-27 |
| 28 | 202017014539-OTHERS-300620-.pdf | 2020-07-09 |
| 29 | 201911048481-FIGURE OF ABSTRACT [27-11-2019(online)].pdf | 2019-11-27 |
| 29 | 202017014539-Correspondence-300620.pdf | 2020-07-09 |
| 30 | 201911048481-FORM 1 [27-11-2019(online)].pdf | 2019-11-27 |
| 30 | 201911048481-OTHERS-300620.pdf | 2020-07-09 |
| 31 | 201911048481-Correspondence-300620.pdf | 2020-07-09 |
| 31 | 201911048481-FORM 18A [27-11-2019(online)].pdf | 2019-11-27 |
| 32 | 201911048481-FORM FOR SMALL ENTITY(FORM-28) [27-11-2019(online)].pdf | 2019-11-27 |
| 32 | 201911048481-RELEVANT DOCUMENTS [17-07-2020(online)].pdf | 2020-07-17 |
| 33 | 201911048481-FORM FOR STARTUP [27-11-2019(online)].pdf | 2019-11-27 |
| 33 | 201911048481-FORM-26 [17-07-2020(online)].pdf | 2020-07-17 |
| 34 | 201911048481-FORM 13 [17-07-2020(online)].pdf | 2020-07-17 |
| 34 | 201911048481-FORM-9 [27-11-2019(online)].pdf | 2019-11-27 |
| 35 | 201911048481-FORM28 [27-11-2019(online)].pdf | 2019-11-27 |
| 35 | 201911048481-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [25-07-2020(online)].pdf | 2020-07-25 |
| 36 | 201911048481-POWER OF AUTHORITY [27-11-2019(online)].pdf | 2019-11-27 |
| 36 | 201911048481-US(14)-ExtendedHearingNotice-(HearingDate-28-08-2020).pdf | 2020-07-28 |
| 37 | 201911048481-REQUEST FOR EARLY PUBLICATION(FORM-9) [27-11-2019(online)].pdf | 2019-11-27 |
| 37 | 201911048481-Correspondence to notify the Controller [27-08-2020(online)].pdf | 2020-08-27 |
| 38 | 201911048481-Written submissions and relevant documents [11-09-2020(online)].pdf | 2020-09-11 |
| 38 | 201911048481-STARTUP [27-11-2019(online)].pdf | 2019-11-27 |
| 39 | 201911048481-STATEMENT OF UNDERTAKING (FORM 3) [27-11-2019(online)].pdf | 2019-11-27 |
| 39 | 201911048481-REQUEST FOR CERTIFIED COPY [30-09-2020(online)].pdf | 2020-09-30 |
| 1 | searchstrategy_27-12-2019.pdf |
| 1 | tkdL4_27-12-2019.pdf |
| 2 | TKDL1_27-12-2019.pdf |
| 2 | TKDL3_27-12-2019.pdf |
| 3 | TKDL2_27-12-2019.pdf |
| 4 | TKDL1_27-12-2019.pdf |
| 4 | TKDL3_27-12-2019.pdf |
| 5 | searchstrategy_27-12-2019.pdf |
| 5 | tkdL4_27-12-2019.pdf |