FIELD OF INVENTION
[001] The present disclosure relates to the field of cosmetics, in general, and a moisturizing cosmetic in particular. There is provided a moisturizing formulation primarily comprising a combination of caesalpinia spinosa gum and aluminium starch octenylsuccinate, and a process for the preparation of this formulation.
BACKGROUND OF THE INVENTION
[002] Cosmetics constitute a big pie of the fast moving consumer goods (FMCG) segment of products. Skin care creams/lotions; an important subclass of cosmetics, are much in demand because of the protection they offer against harm to the skin caused by various factors like pollution and exposure to sun. Moisturizing cosmetics are a class of cosmetics used for rejuvenating over-dried or dehydrated skin by retaining the inherent moisture. Over-drying and dehydration of the skin is a common problem which may be due to environmental factors, skin conditions, lower concentration water in skin layer and the like. It is known that dehydrated skin is typically linked with poor barrier function thereby reducing protection from environment, microorganisms, toxins, and the like. Further, the dehydrated skin makes the make-up very hard to apply evenly. There are a number of moisturizing formulations available in the market. Most of these moisturizers though, are either day or night moisturizers which are used to provide light or heavy deep moisturization depending upon the requirements, and are generally available as lotions and creams. However, some of the existing formulations suffer from disadvantages such as short-term hydration, oily residue post application, and being abrasive on skin.
[003] There are moisturizing formulations known in the prior art and one such formulation disclosed in US626496 provides an improved skin care composition having enhanced skin hydration, moisturizing, conditioning, and cosmetically acceptable tactile properties. The composition includes skin hydration system comprising glycerine and plant-derived oil, petroleum or mineral oil, a di-lower alkyl
di-higher alkyl ammonium emulsifier, a fatty alcohol, a fatty ester emollient, and
water.
[004] Another moisturizing formulation disclosed in US201440303229 provides a
less irritating skin moisturizing composition comprising at least one natural
moisturizing factor, butyrospermum parkii, at least one silicone, and pantheon,
formulated into a topically applicable, pharmaceutically acceptable medium therefore.
[005] The aforementioned moisturizing formulations disclosed in the prior art suffer
with disadvantages such as short-term hydration, oily residue post application, being
non-gentle on skin, and causing irritation to sensitive skin due to presence of harsh
ingredients.
[006] In view of the aforementioned limitations of the prior art methods, a better
formulation of moisturizing cosmetic is much needed.
SUMMARY OF THE INVENTION
[007] The subject matter described herein is directed towards a moisturizing formulation comprising of cosmetically acceptable excipients and its preparation process.
[008] In an aspect of the present disclosure, there is provided a moisturizing formulation comprising: (a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; and (b) aluminium starch octenylsuccinate, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 — 1:4.
[009] In an aspect of the present disclosure, there is provided a process for the preparation of a moisturizing formulation comprising: (a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; and (b) aluminium starch octenylsuccinate, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; said process comprising the steps of: (a) obtaining caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; (b) obtaining aluminum starch octenylsuccinate; and (c)
contacting caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum starch octenylsuccinate to obtain the formulation.
[0010] These and other features, aspects, and advantages of the present subject matter will be better understood with reference to the following description and appended claims. This summary is provided to introduce a selection of concepts in a simplified form. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter.
DETAILED DESCRIPTION OF THE INVENTION
[0011] The present disclosure relates to a moisturizing formulation comprising of cosmetically acceptable excipients and its preparation process.
[0012] Those skilled in the art will be aware that the present disclosure is subject to variations and modifications other than those specifically described. It is to be understood that the present disclosure includes all such variations and modifications. The disclosure also includes all such steps, features, compositions, and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations of any or more of such steps or features.
Definitions
[0013] For convenience, before further description of the present disclosure, certain
terms employed in the specification, and examples are delineated here. These
definitions should be read in the light of the remainder of the disclosure and
understood as by a person of skill in the art. The terms used herein have the meanings
recognized and known to those of skill in the art, however, for convenience and
completeness, particular terms and their meanings are set forth below.
[0014] The articles "a", "an" and "the" are used to refer to one or to more than one
(i.e., to at least one) of the grammatical object of the article.
[0015] The terms "comprise" and "comprising" are used in the inclusive, open sense,
meaning that additional elements may be included. It is not intended to be construed as
"consists of only".
[0016] Throughout this specification, unless the context requires otherwise the word
"comprise", and variations such as "comprises" and "comprising", will be understood
to imply the inclusion of a stated element or step or group of element or steps but not
the exclusion of any other element or step or group of element or steps.
[0017] The term "including" is used to mean "including but not limited to".
"Including" and "including but not limited to" are used interchangeably.
[0018] The term "finished product" refers to a combination of caesalpinia spinosa gum
and hydrolysed caesalpinia spinosa gum, and aluminum starch octenylsuccinate as
disclosed in the present invention.
[0019] Unless defined otherwise, all technical and scientific terms used herein have
the same meaning as commonly understood by one of ordinary skill in the art to which
this disclosure belongs. Although any methods and materials similar or equivalent to
those described herein can be used in the practice or testing of the disclosure, the
preferred methods, and materials are now described. All publications mentioned herein
are incorporated herein by reference.
[0020] The present disclosure is not to be limited in scope by the specific
embodiments described herein, which are intended for the purposes of exemplification
only. Functionally-equivalent products, compositions, and methods are clearly within
the scope of the disclosure, as described herein.
[0021] As discussed above, application of moisturizing cosmetics to dehydrated skin
to increase moisturization is typically practised for protection of skin against drying
up. Though various moisturizing formulations disclosed in the prior art possess
desirable properties like enhanced skin hydration and gentleness on skin, these
formulations suffer with certain disadvantages such as short-term hydration, oily
residue post application, being non-gentle on skin, and causing irritation of skin due to
presence of harsh ingredients. In view of all the problems mentioned above, the
present disclosure provides a formulation comprising a combination of moisturizing agents, to provide a high moisturizing effect.
[0022] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: (a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; and (b) aluminium starch octenylsuccinate, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 — 1:4.
[0023] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate.
[0024] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-P/o with respect to the formulation.
[0025] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1%> with respect to the formulation, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4.
[0026] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1%) with respect to the formulation, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the
range of 1:1.1 - 1:4; further comprising at least one cosmetically acceptable excipient selected from the group consisting of humectants, emollients, silicones, emulsifiers, neutralizing agents, preservatives, antioxidants, polymers, skin soothing agents, chelating agents, fragrances, sunscreens, and combinations thereof. [0027] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one humectant having weight percentage in the range of 1-5% with respect to the formulation.
[0028] In yet another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the humectant is selected from the group consisting of glycerin, propylene glycols, polyols, higher alcohols, and combinations thereof.
[0029] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-P/o with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one humectant having weight percentage in the range of 1-5% with respect to the formulation. [0030] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one emollient having weight percentage in the range of 0.001-10%) with respect to the formulation.
[0031] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the emollient is selected from the group consisting of lanolin, octyldodecanol, hexyl decanol, oleyl alcohol, decyl oleate, isopropyl stearate, isopropyl palmitate, isopropyl myristate, hexyl laureate, glyceryl stearate (and) PEG-100 stearate, dioctyl cyclohexane, PPG-15 stearyl ether,
isohexadecane, stearic acid, cetyl alcohol, caprylic/capric triglyceride, mineral oil, and combinations thereof.
[0032] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1% with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one emollient having weight percentage in the range of 0.001-10% with respect to the formulation. [0033] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one silicone having weight percentage in the range of 5 - 15% with respect to the formulation.
[0034] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the silicone is selected from the group consisting of dimethicone copolyol, dimethylpolysiloxane, diethylpolysiloxane, dimethicone, phenyl dimethicone, dimethiconol, cyclopentasiloxane, dimethicone, Ci-C30 alkyl polysiloxane, cyclopentasiloxane (and) dimethicone crosspolymer, and combinations thereof.
[0035] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and aluminum starch octenyl succinate having weight percentage in the range of 0.5-1%> with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one silicone having weight percentage in the range of 5 - 15% with respect to the formulation.
[0036] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one emulsifier having weight percentage in the range of 0.01-5% with respect to the formulation.
[0037] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the emulsifier is selected from the group consisting of oxyalkylenated fatty acid esters of polyols, oxyalkylenated fatty acid esters of sorbitan, oxyalkylenated fatty alcohol ethers, alkoxylated/non-alkoxylated sugar esters, cetearyl alcohol (and) ceteareth-20, sorbitan esters, esters of diacids, esters of fatty alcohols, PEG based emulsifiers, polyglyceryl based emulsifiers, and combinations thereof.
[0038] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-P/o with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one emulsifier having weight percentage in the range of 0.01-5% with respect to the formulation. [0039] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one neutralizing agent having weight percentage in the range of 0.005-1%) with respect to the formulation.
[0040] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the neutralizing agent is selected from the group consisting of triethanolamine, potassium hydroxide, sodium hydroxide, and combinations thereof.
[0041] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa
gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1% with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one neutralizing agent having weight percentage in the range of 0.005-1% with respect to the formulation. [0042] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one preservative having weight percentage in the range of 0.001-1% with respect to the formulation.
[0043] In another embodiment of the present disclosure, there is provided a
moisturizing formulation as described herein, wherein the preservative is selected from
the group consisting of methyl paraben, ethyl paraben, propyl paraben,
methylisothiazolinone, butyl paraben, isopropyl paraben, phenoxyethanol, sodium
metabisulfite, methylisothiazolinone (and) phenoxyethanol, sodium benzoate, benzyl
alcohol, ethyl hexyl glycerin, formaldehyde-releasing agents,
alkyltrimethylammonium bromides, haloalkynylcarbamates, and combinations thereof. [0044] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and aluminum starch octenyl succinate having weight percentage in the range of 0.5-1%> with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one preservative having weight percentage in the range of 0.001-1%) with respect to the formulation. [0045] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one antioxidant having weight percentage in the range of 0.1 - 1% with respect to the formulation.
[0046] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the antioxidant is selected from the group consisting of tocopheryl acetate, butylated hydroxytoluene, and combinations thereof.
[0047] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1% with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one antioxidant having weight percentage in the range of 0.1 - 1% with respect to the formulation. [0048] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one polymer having weight percentage in the range of 0.005-2% with respect to the formulation.
[0049] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the polymer is selected from the group consisting of modified starch, cellulose based polymers, carbomer, silicone based polymers, acrylates, guar gum, xanthan gum and combinations thereof. [0050] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and aluminum starch octenyl succinate having weight percentage in the range of 0.5-1%> with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one polymer having weight percentage in the range of 0.005-2%) with respect to the formulation.
[0051] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one skin soothing agent having a weight percentage in the range of 0.05 - 0.5% with respect to the composition.
[0052] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the skin soothing agent is selected from the group consisting of panthenol, dexpanthenol, ethyl panthenol, allantoin, dipotassium glycyrrhizinate, and combinations thereof. [0053] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-P/o with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one skin soothing agent having weight percentage in the range of 0.05 - 0.5% with respect to the formulation. [0054] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the composition further comprises at least one chelating agent having weight percentage of 0.05-0.1%) with respect to the formulation.
[0055] In another embodiment of the present disclosure, there is provided a moisturizing formulation as described herein, wherein the chelating agent is selected from the group consisting of disodium ethylenediaminetetraacetic acid (disodium EDTA), dimercaptosuccinic acid (DMSA), dimercapto-propane sulfonate (DMPS), alpha lipoic acid (ALA), calcium disodium versenate (CaNa2-EDTA), dimercaprol (BAL), etidronic acid, ethyleneglycol tetraacetic acid, ethylenediaminedisuccinic acid, and combinations thereof.
[0056] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: caesalpinia spinosa gum and hydrolysed caesalpinia spinosa
gum having weight percentage in the range of 0.5-2% with respect to the formulation; and aluminum starch octenylsuccinate having weight percentage in the range of 0.5-1% with respect to the formulation, wherein aluminium starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising at least one chelating agent having a weight percentage in the range of 0.05-0.1% with respect to the formulation. [0057] In an embodiment of the present disclosure, there is provided a moisturizing formulation comprising: (a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5-2%) with respect to the formulation; and (b) aluminum starch octenyl succinate having weight percentage in the range of 0.5-1% with respect to the formulation, wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; further comprising: (c) at least one humectant having weight percentage in the range of 1-5% with respect to the formulation; (d) at least one emollient having weight percentage in the range of 0.001-10%) with respect to the formulation; (e) at least one silicone having weight percentage in the range of 5 - 15% with respect to the formulation; (f) at least one emulsifier having weight percentage in the range of 0.01-5% with respect to the formulation; (g) at least one neutralizing agent having weight percentage in the range of 0.005-1%) with respect to the formulation; (h) at least one preservative having weight percentage in the range of 0.001-1%) with respect to the formulation; (i) at least one antioxidant having weight percentage in the range of 0.1 - 1% with respect to the formulation; (j) at least one polymer having weight percentage in the range of 0.005-2%) with respect to the formulation; (k) at least one soothing agent having a weight percentage in the range of 0.05 - 0.5%) with respect to the composition; and (1) at least one chelating agent having a weight percentage in the range of 0.05-0.1%) with respect to the formulation. [0058] In another embodiment of the present disclosure, there is provided a process for the preparation of a moisturizing formulation comprising: (a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; and (b) aluminium starch octenylsuccinate,
wherein aluminium starch octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4; said process comprising the steps of: (a) obtaining caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; (b) obtaining aluminum starch octenyl succinate; and (c) contacting caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum starch octenyl succinate to obtain the formulation.
[0059] In another embodiment of the present disclosure, there is provided a process for the preparation of moisturizing formulation as described herein, said process comprising the steps of: (a) contacting at least one humectant, at least one chelating agent, at least one polymer, and water to obtain an aqueous phase; (b) contacting at least one emollient, and at least one emulsifier to obtain an oil phase; (c) contacting the aqueous phase and the oil phase to obtain an emulsion; (d) contacting the emulsion with at least one neutralizing agent, to obtain a first mixture; (e) contacting the first mixture with aluminum starch octenyl succinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum to obtain a second mixture; and (f) optionally contacting the second mixture with at least one preservative, at least one antioxidant, and at least one fragrance to obtain the formulation.
[0060] In another embodiment of the present disclosure, there is provided a process for the preparation of moisturizing formulation as described herein, the said process comprising the steps of: (a) contacting at least one humectant, at least one chelating agent, at least one polymer, and water and stirring at a speed in the range of 600-900 rpm and a temperature in the range of 75-85 °C to obtain an aqueous phase; (b) contacting at least one emollient, and at least one emulsifier at a temperature in the range of 80-85 °C to obtain an oil phase; (c) contacting the aqueous phase and the oil phase followed by homogenization at a stirring speed in the range of 1500-4000 rpm and a temperature in the range of 70-90 °C to obtain an emulsion; (d) contacting the emulsion with at least one neutralizing agent at a temperature in the range of 40-65 °C to obtain a first mixture; (e) contacting the first mixture with aluminum starch octenylsuccinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum
at stirring speed in the range of 10-50 rpm and a temperature in the range of 35-50 °C to obtain a second mixture; and (f) optionally contacting the second mixture with at least one preservative, at least one antioxidant, and at least one fragrance followed by stirring at a speed in the range of 10-50 rpm and a temperature in the range of 25-40 °C to obtain the formulation.
EXAMPLES
[0061] The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may vary. Example 1: Efficacy Study: Agar Plate Method
[0062] Initial experiments were first carried out to test the effectiveness of formulation comprising caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum starch octenylsuccinate in retaining moisture, vis-a-vis moisture retention achieved using the individual components of the formulation. As a control, placebo was also tested. Base formulation without moisturizing actives/agents was used as a placebo for the purpose of these experiments. Placeboes are substances which are known not exhibit the effect for which they are being tested. Use of a placebo helps establish the fact conclusively that the effect exhibited by the tested substance/formulation being evaluated, is a specific property of that substance/formulation, and that the same property is not possessed by any serendipitously chosen substance/formulation. In context of the present disclosure, the
placebo is known to not exhibit any moisture retention effect. Thus the results obtained using a placebo can be used as a standard against which the results yielded by the formulation of present disclosure can be evaluated. The experiments were carried out using Agar as a substrate. Its weight before and after application of the test substance/formulation/placebo was measured and the difference in final and initial weight was taken as an indication of the extent of moisture loss. The results are summarized in Table 1 below.
As can be seen from the data in Table 1, individually caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum starch octenylsuccinate did not exhibit drastically superior results compared to the placebo. However, the combination
of caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum
starch octenylsuccinate yielded startlingly better results as compared to both, the
placebo as well as the individual components.
[0063] It can be seen from Table 1 that the weight loss difference was observed to be
very less for finished product compared to placebo, and the moisturizing agents
aluminum starch octenyl succinate (0.5%) and caesalpinia spinosa gum (1%) when
used in isolation. The order of hydration was found to be: finished product> with 1%
caesalpinia spinosa >with 0.5% aluminum starch octenyl succinate >Placebo.
[0064] Hence, based on the data in Table 1, it can be concluded that a formulation
comprising aluminum starch octenyl succinate (0.5%) and caesalpinia spinosa gum
(1%>) gives synergistic results when tested for the ability to retain moisture.
Example 2: Effect of variation in weight ratio of aluminum starch
octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa
gum
[0065] Further experiments were carried out to check what range of weight ratios
between aluminium starch octenylsuccinate and caesalpinia spinosa gum and
hydrolysed caesalpinia spinosa gum yielded similar results as the ones obtained for the
formulation described in Table 1. The details of various formulations that were tested
are summarized in Tables 2 and 3 below.
[0066] Formulations described in Table 2 yielded similar results for moisture retention as those for the formulation in Table 1. The detailed results are provided in Tables 4-7. It can be seen from the data contained in Tables 4-7 that all formulations yielded superior results compared to experiments, wherein components of the formulation were used in same amount but individually. Table 3 shows formulations prepared by making further variations in the weight ratios. The differentiating factor though, between formulations of Table 2 and Table 3 is that in Table 3, all formulations have caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum in lower quantities than aluminium starch octenylsuccinate. In case of formulations of Table 3, lump formation was observed in the final formulation, which is undesirable. Thus, based on the data provided in Tables 2 and 3, it was concluded that to obtain formulation which had all other properties sought in a moisturizing formulation, in addition to its moisture retention capacity, weight percentage of caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum had to be higher than that of aluminium starch octenylsuccinate, and the ratio of octenylsuccinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum had to be in the range of 1:1.1 — 1:4.
Example 3: Process for the preparation of formulation:
Step I. In the first step, glycerin, propylene glycol, EDTA, carbomer, acrylates/Cio-C3o alkyl acrylates and xanthan gum were mixed while stirring at 600-900 rpm, with water at a temperature in the range of 75-85 °C to obtain an aqueous phase.
Step II. Capric/caprylic triglyceride, cetyl alcohol, glyceride, cetyl alcohol, glyceryl stearate (and) PEG-100 stearate, polymethylsilsesquioxane, PPG-15 stearyl ether, isopropyl palmitate, and cetearyl alcohol (and) ceteareth-20 were contacted at a temperature in the range of 80-85 °C to obtain an oil phase.
Step III. Further, the oil phase was homogenized with the aqueous phase to obtain an emulsion by stirring at a speed of 2800 rpm. This was followed by addition of triethanolamine to the emulsion.
Step IV. A premix of aluminum starch octenylsuccinate (0.5% - 1.00%) and caesalpinia spinosa gum (0.5%-2.00%) was then added to the emulsion above at a temperature in the range of 42-48 °C, at mixing speed of 20 - 30 rpm.
Step V. Finally, preservatives phenoxyethanol, methylparaben, propyl paraben, methylisothiazolinone (and) phenoxyethanol, butylated hydroxytoluene (BHT) and fragrance were mixed to obtain a smooth cosmetic composition which was free of lumps.
Table 8 below describes the complete formulation along with the acceptable weight percentage ranges for all the components.
Example 4: Panel Study
I) Comparison of present product with placebo
[0067] In addition to the agar plate method for determining moisture retention capacity, panel analysis was also carried out to collect data on how people perceive the formulation in terms of the moisturization it provides. Accordingly, a panel of ten volunteers was constituted. All panellists were asked to use the placebo and report their views on how moisturized their skin felt on application of the placebo. Panellists were provided only the test formulations and were not informed that it was a placebo. Similar procedure was then asked to be carried out using the formulation of the present disclosure. The data are summarized in Table 9 below. It can be inferred from the data that almost all panellists rated the formulation of instant disclosure better than the placebo.
II) Aluminum starch octenylsuccinate alone Vs. caesalpinia spinosa gum alone
Similar panel studies were carried out to find out how the panellists rate the components of formulation when used individually. Accordingly, aluminium starch octenylsuccinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum were subjected individually to panel analysis. The data are summarized in Table 10 below. Panellist's ratings for aluminium starch octenylsuccinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum when applied individually were similar to how they rated the placebo. This makes it amply clear that even in terms of user perception, the formulation was far superior to the individual components.
[0068] The present disclosure thus provides a formulation of a moisturizing cosmetic, comprising of a combination of moisturizing agents to provide a high moisturizing effect. The formulation of present invention scores over the prior art formulations with reference to higher hydration/moisture value.
[0069] Although the subject matter has been described with reference to specific embodiments, this description is not meant to be construed in a limiting sense. Various modifications of the disclosed embodiments, as well as alternate embodiments of the subject matter, will become apparent to persons skilled in the art upon reference to the description of the subject matter. It is therefore contemplated that such modifications can be made without departing from the present subject matter as defined.
I/We Claim:
1. A moisturizing formulation comprising:
a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; and
b) aluminum starch octenyl succinate,
wherein aluminum starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4.
2. The formulation as claimed in claim 1, further comprising at least one cosmetically acceptable excipient selected from the group consisting of humectants, emollients, silicones, emulsifiers, neutralizing agents, preservatives, antioxidants, polymers, skin soothing agents, chelating agents, fragrances, sunscreens, and combinations thereof.
3. The formulation as claimed in claim 2, wherein the humectant has a weight percentage in the range of 1-5 % with respect to the formulation, and the humectant is selected from the group consisting of glycerin, propylene glycols, polyols, higher alcohols, and combinations thereof; emollient has a weight percentage in the range of 0.001-10% with respect to the formulation, and the emollient is selected from the group consisting of lanolin, octyldodecanol, hexyl decanol, oleyl alcohol, decyl oleate, isopropyl stearate, isopropyl palmitate, isopropyl myristate, hexyl laureate, glyceryl stearate (and) PEG-100 stearate, dioctyl cyclohexane, PPG-15 stearyl ether, isohexadecane, stearic acid, cetyl alcohol, caprylic/capric triglyceride, mineral oil, and combinations thereof.
4. The formulation as claimed in claim 2, wherein the silicone has a weight percentage in the range of 5 - 15% with respect to the formulation, and the silicone is selected from the group consisting of dimethicone copolyol, dimethylpolysiloxane, diethylpolysiloxane, dimethicone, phenyl dimethicone, dimethiconol, cyclopentasiloxane, dimethicone, C1-C30 alkyl polysiloxane, cyclopentasiloxane (and) dimethicone crosspolymer, and combinations thereof;
emulsifier has a weight percentage in the range of 0.01-5% with respect to the formulation, and the emulsifier is selected from the group consisting of oxyalkylenated fatty acid esters of polyols, oxyalkylenated fatty acid esters of sorbitan, oxyalkylenated fatty alcohol ethers, alkoxylated/non-alkoxylated sugar esters, cetearyl alcohol (and) ceteareth-20, sorbitan esters, esters of diacids, esters of fatty alcohols, PEG based emulsifiers, polyglyceryl based emulsifiers, and combinations thereof.
5. The formulation as claimed in claim 2, wherein the neutralizing agent has a weight percentage in the range of 0.005-1% with respect to the formulation, and the neutralizing agent is selected from the group consisting of triethanolamine, potassium hydroxide, sodium hydroxide, and combinations thereof; preservative has a weight percentage in the range of 0.001 -1% with respect to the formulation, and the preservative is selected from the group consisting of methyl paraben, ethyl paraben, propyl paraben, methylisothiazolinone, butyl paraben, isopropyl paraben, phenoxyethanol, sodium metabisulfite, methylisothiazolinone (and) phenoxyethanol, sodium benzoate, benzyl alcohol, ethyl hexyl glycerin, formaldehyde-releasing agents, alkyltrimethylammonium bromides, haloalkynylcarbamates, and combinations thereof; antioxidant has a weight percentage in the range of 0.1 - 1% with respect to the formulation, and the antioxidant is selected from the group consisting of tocopheryl acetate, vitamin E, vitamin E derivative, butylated phenol, butylated hydroxytoluene (BHT),- and combinations thereof.
6. The formulation as claimed in claim 2, wherein the polymer has a weight percentage in the range of 0.005 - 2% with respect to the formulation, and the polymer is selected from the group consisting of modified starch, cellulose based polymers, carbomer, silicone based polymers, acrylates, guar gum, xanthan gum and combinations thereof; skin soothing agent has a weight percentage in the range of 0.05 - 0.5% with respect to the formulation, and the skin soothing agent is selected from the group consisting of panthenol,
dexpanthenol, ethyl panthenol, allantoin, dipotassium glycyrrhizinate, and combinations thereof; chelating agent has a weight percentage in the range of 0.05-0.1%, and the chelating agent is selected from the group consisting of disodium ethylenediaminetetraacetic acid (disodium EDTA), dimercaptosuccinic acid (DMSA), dimercapto-propane sulfonate (DMPS), alpha lipoic acid (ALA), calcium disodium versenate (CaNa2-EDTA), dimercaprol (BAL), etidronic acid, ethyl eneglycol tetraacetic acid, ethylenediaminedisuccinic acid, and combinations thereof.
7. A moisturizing formulation comprising:
a) caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum having weight percentage in the range of 0.5 - 2% with respect to the formulation;
b) aluminum starch octenylsuccinate having weight percentage in the range of 0.5 - 1% with respect to the formulation,
wherein aluminum starch octenyl succinate to caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum weight ratio is in the range of 1:1.1 - 1:4.
8. A process for the preparation of formulation as claimed in claim 1, said process comprising the steps of: (a) obtaining caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum; (b) obtaining aluminum starch octenyl succinate; and (c) contacting caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum and aluminum starch octenyl succinate to obtain the formulation.
9. A process for the preparation of formulation as claimed in any of the claims 2 to 7, said process comprising the steps of: (a) contacting at least one humectant, at least one chelating agent, at least one polymer, and water to obtain an aqueous phase; (b) contacting at least one emollient and at least one emulsifier to obtain an oil phase; (c) contacting the aqueous phase and the oil phase to obtain an emulsion; (d) contacting the emulsion with at least one neutralizing agent to obtain a first mixture; (e) contacting the first mixture with aluminum
starch octenyl succinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum to obtain a second mixture; and (f) optionally contacting the second mixture with at least one preservative, at least one antioxidant, and at least one fragrance which has a weight percentage of 0.01-3%, and to obtain the formulation. 10. The process as claimed in claim 9 comprising the steps of: (a) contacting at least one humectant, at least one chelating agent, at least one polymer, and water and stirring at a speed in the range of 600-900 rpm and a temperature in the range of 75-85 °C to obtain an aqueous phase; (b) contacting at least one emollient and at least one emulsifier at a temperature in the range of 80-85 °C to obtain an oil phase; (c) contacting the aqueous phase and the oil phase followed by homogenization at a stirring speed in the range of 1500-4000 rpm and a temperature in the range of 70-90 °C to obtain an emulsion; (d) contacting the emulsion with at least one neutralizing agent at a temperature in the range of 40-65 °C to obtain a first mixture; (e) contacting the first mixture with aluminum starch octenyl succinate and caesalpinia spinosa gum and hydrolysed caesalpinia spinosa gum at stirring speed in the range of 10-200 rpm and a temperature in the range of 35-50 °C to obtain a second mixture; and (f) optionally contacting the second mixture with at least one preservative, at least one antioxidant, and at least one fragrance followed by stirring at a speed in the range of 10-200 rpm and a temperature in the range of 25-40 °C to obtain the formulation.