Abstract: ABSTRACT A MILD CLEANSING COMPOSITION The present disclosure describes a mild cleansing composition comprising at least one mild anionic surfactant, at least one alkyl glucoside and at least one betaine. The composition provides oil control without causing dryness and is found to be effective against Propiobacterium acnes.
FIELD OF INVENTION
[001] The present disclosure relates to a cleansing composition in general and in particular to a non-drying cleanser. There is provided a cleansing composition and a process to prepare the aforementioned cleansing composition.
BACKGROUND OF THE INVENTION
[002] Personal cleansing formulations, such as soaps, shower gel, body washes, face washes, cleansing milk, are either soap based or surfactant based. Soap based formulations are known to give quick rinse feel on skin but often result in skin dryness and irritation. Typically, the soap based formulations have a high pH, generally around 9.5-10.5, which can affect skin's natural pH balance and can be irritating to skin. A healthy skin pH balance can be maintained by avoiding harsh soaps. Soaps can be replaced with surfactant based formulations (e.g. sodium/ammonium laureth sulphate based formulation) in order to reduce pH and skin irritation. In order to provide moisturization or achieve non-dry feel, it is found that most of the surfactant based formulations contain oils and silicones as emollients. Still further, few of these formulations are inefficacious in combating post-wash dryness. Another disadvantage of these ingredients is the comedogenicity, which causes blocking of skin pores.
[003] Amongst various cleansing compositions, some are typically used as face-wash which additionally comprise bioactives to act against facial acne. Acne is a common skin condition found predominantly in teenagers, though people of all ages are prone to acne. Acne manifests in different forms on the skin, such as, pimples, pustules, papules, white heads, and black heads. The pathogenesis of acne involves events ranging from excessive sebum production, bacterial colonization, and consequent increased inflammatory response leading to pore blockage, bacterial infection {Propiobacterium acnes), pus formation, post-inflammatory hyperpigmentation. Excessive sebum production further results in an oily skin.
[004] Active research is being carried out in the field of cosmetics, pharmaceuticals, and derma-cosmetics to come up with better solutions for acne management. There are
many products already available in the market which intend to cater to the above-mentioned skin-care needs. However, most available cleansers today have not been able to simultaneously limit dryness and control oiliness.
[005] Accordingly, there remains a need for an improved cleansing composition which provides better oil control, moisturized skin, and at the same time may also be effective against bacterial infections such as acne.
SUMMARY OF THE INVENTION
[006] In an aspect of the present disclosure, there is provided a mild, non-drying cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; and (c) at least one betaine, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[007] In an aspect of the present disclosure, there is provided a process for the preparation of a mild non-drying cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; and (c) at least one betaine, the process including the steps of: (a) obtaining at least one mild anionic surfactant; (b) obtaining at least one alkyl glucoside; (c) obtaining at least one betaine; and (d) contacting the at least one mild anionic surfactant, the at least one alkyl glucoside, and the at least one betaine, to obtain a cleansing composition, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[008] These and other features, aspects, and advantages of the present subject matter will be better understood with reference to the following description and appended claims. This summary is provided to introduce a selection of concepts in a simplified form. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter.
DETAILED DESCRIPTION OF THE INVENTION
[009] Those skilled in the art will be aware that the present disclosure is subject to variations and modifications other than those specifically described. It is to be understood that the present disclosure includes all such variations and modifications. The disclosure also includes all such steps, features, compositions, and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations of any or more of such steps or features.
Definitions
[0010] For convenience, before further description of the present disclosure, certain
terms employed in the specification, and examples are delineated here. These
definitions should be read in the light of the remainder of the disclosure and
understood as by a person of skill in the art. The terms used herein have the meanings
recognized and known to those of skill in the art, however, for convenience and
completeness, particular terms and their meanings are set forth below.
[0011] The articles "a", "an" and "the" are used to refer to one or to more than one
(i.e., to at least one) of the grammatical object of the article.
[0012] The terms "comprise" and "comprising" are used in the inclusive, open sense,
meaning that additional elements may be included. It is not intended to be construed as
"consists of only".
[0013] Throughout this specification, unless the context requires otherwise the word
"comprise", and variations such as "comprises" and "comprising", will be understood
to imply the inclusion of a stated element or step or group of element or steps but not
the exclusion of any other element or step or group of element or steps.
[0014] The term "including" is used to mean "including but not limited to".
"Including" and "including but not limited to" are used interchangeably.
[0015] The term "mildness" refers to the absence of adverse effect such as irritation,
allergic reaction, or sensitization of the skin of the composition on skin when used
over a period of time. Mild anionic surfactants as described herein comprise anionic
surfactants well known in the art as mild anionic surfactants.
[0016] The terms, "anti-microbial" and "anti-bacterial" have been used
interchangeably.
[0017] Unless defined otherwise, all technical and scientific terms used herein have
the same meaning as commonly understood by one of ordinary skill in the art to which
this disclosure belongs. Although any methods and materials similar or equivalent to
those described herein can be used in the practice or testing of the disclosure, the
preferred methods, and materials are now described. All publications mentioned herein
are incorporated herein by reference.
[0018] The present disclosure is not to be limited in scope by the specific
embodiments described herein, which are intended for the purposes of exemplification
only. Functionally-equivalent products, compositions, and methods are clearly within
the scope of the disclosure, as described herein.
[0019] As described above, conventional cleansers available in the market suffer from
certain drawbacks like, inability to strike the right balance between oil-control and
desired level of moisturization. In view of the problems associated with these existing
cleansers, the present invention provides a mild, non-drying non-comedogenic cleanser
which is free of oils and silicone. Further, it provides oil control without drying the
skin and gives good sensorials and feel to skin. The cleansing composition of the
present invention is also found to be effective against propionibacterium acnes (p-
acnes).
[0020] According to the American Academy of Dermatology, a "comedo" is an "acne
lesion", a hard blockage created from an excess of sebum in a pore. This blockage can
lead to whiteheads, blackheads and pimples. The term, "comedogenic" thus refers to
ingredients or products that have a tendency to block pores and promote comedones
(plural of comedo), or acne.
[0021] Oils and waxes such as neem oil, jojoba oil, almond oil, bees wax and the like
are typically added in the cleansers for benefits such as moisturization, non-drying and
post wash sensorials. However, these ingredients block the skin pores and promote
formation of lesions. Accordingly, the present invention avoids such comedogenic
ingredients without affecting desired sensorials such as moisturization and non
dryness.
[0022] In an embodiment of the present disclosure, there is provided a mild cleansing
composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl
' glucoside; and (c) at least one betaine, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0023] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; and (c) at least one betaine, wherein the at least one mild anionic surfactant
to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3 and the at least one mild anionic surfactant to the at least one betaine weight ratio is in the range of 1:0.2-1:2.
[0024] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant selected from the
group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside; and (c) at least one betaine, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0025] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) sodium lauryl sarcosinate; (b) disodium laureth sulfosuccinate; (c) at least one alkyl glucoside; and (d) at least one betaine, wherein sodium lauryl sarcosinate and disodium laureth sulfosuccinate combination to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0026] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; and (c) at least one betaine, wherein the at
least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0027] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) decyl glucoside; (c) lauryl glucoside; and (d) at least one betaine, wherein the at least one mild anionic surfactant to the decyl glucoside and lauryl glucoside combination weight ratio is in the range of 1:0.4-1:3.
[0028] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; and (c) at least one betaine selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0029] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; (c) cocamidopropyl betaine, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0030] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates and combinations thereof; (b) at least one alkyl glucoside selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; and (c) at least one betaine selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0031] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) sodium lauryl sarcosinate; (b) disodium laureth
sulfosuccinate; (c) decyl glucoside; (d) lauryl glucoside; and (e) cocamidopropyl betaine, wherein the sodium lauryl sarcosinate and disodium laureth sulfosuccinate combination to the decyl glucoside and lauryl glucoside combination weight ratio is in the range of 1:0.4-1:3.
[0032] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; and (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0033] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof; and (d) at least one cosmetically acceptable excipient selected
from the group consisting of humectant, emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizer, fragrance, color, bioactive, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4 -1:3.
[0034] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof; and (d) at least one cosmetically acceptable excipient selected from the group consisting of humectant, emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizer, fragrance, color, bioactive, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4 - 1:3. The polymer listed as a part of excipients can be pre-neutralized one or a non-neutralized one.
[0035] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and
combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines,, lauramidopropyl betaine and combinations thereof; (d) at least one humectant having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and selected from the group consisting of glycerin, panthenol, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0036] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one emollient having a weight percentage in the range of 0.001 - 5% with respect to the cleansing composition and selected from the group consisting of tocopheryl acetate, sodium pyrrolidone carboxylic acid (sodium PCA), and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0037] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates,
and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one chelating agent having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0038] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one preservative having a weight percentage in the range of 0.005% - 1% with respect to the composition and selected from the group consisting of paraben, sodium benzoate, phenoxyethanol, methylisothiothiazolinone (and) methylchloroisothiothiazolinone, DMDM hydantoin, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0039] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one antioxidant having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of butylated hydroxytoluene, pentaerythrityl-tetra-di-^-butyl hydroxyhydrocinnamate, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0040] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one photo-stabilizer having a weight percentage
in the range of 0.01% - 1% with respect to the cleansing composition and selected from the group consisting of benzophenone-3, benzophenone-4, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0041] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one emulsifier having a weight percentage in the range of 0.1% - 3% with respect to the cleansing composition and selected from the group consisting of polysorbate-20, Polysorbate-80, PEG 40 castor oil, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0042] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of
1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one polymer/thickener having a weight percentage in the range of 0.1% - 10% with respect to the cleansing composition and selected from the group consisting of carbomer, hydroxypropyl methylcellulose, acrylates, cellulose, cellulose derivatives and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-1:3.
[0043] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of P/o - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one neutralizer having a weight percentage in the range of 0.01 - 3% with respect to the cleansing composition and selected from the group consisting of sodium hydroxide, potassium hydroxide, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0044] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates,
and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; and (d) at least one bioactive having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and selected from the group consisting of allantoin, salicylic acid and derivatives, niacinamide, zinc pyrrolidone carboxylic acid (ZnPCA), lactic acid, benzoyl peroxide, glycolic acid, adapalene, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0045] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; (d) at least one humectant having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and is selected from the group consisting of glycerin, panthenol, sorbitol and combinations thereof; (e) at least one emollient having a weight percentage in the range of 0.001 - 5% with respect to the cleansing composition and selected from the group consisting of tocopheryl acetate, sodium pyrrolidone carboxylic acid (sodium PCA), PEG 40 castor oil, and
combinations thereof; (f) at least one chelating agent having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, and combinations thereof; (g) at least one preservative having a weight percentage in the range of 0.005% - 1% with respect to the composition and selected from the group consisting of paraben, sodium benzoate, phenoxyethanol, methylisothiothiazolinone, methylchloroisothiothiazolinone, DMDM hydantoin, and combinations thereof; (h) at least one antioxidant having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of butylated hydroxytoluene, pentaerythrityl-tetra-di-buty hydroxyhydrocinnamate, and combinations thereof; (i) at least one photo-stabilizer having a weight percentage in the range of 0.01% - 1% with respect to the cleansing composition and selected from the group consisting of benzophenone-3, benzophenone-4, and combinations thereof; (j) at least one emulsifier having a weight percentage in the range of 0.1% - 3% with respect to the cleansing composition and selected from the group consisting of polysorbate-20, PEG 40 castor oil, and combinations thereof; (k) at least one polymer/thickener having a weight percentage in the range of 0.1% - 1% with respect to the cleansing composition and selected from the group consisting of carbomer, hydroxypropyl methylcellulose, acrylates, cellulose, cellulose derivatives, and combinations thereof; (1) at least one neutralizer having a weight percentage in the range of 0.01 - 3% with respect to the cleansing composition and selected from the group consisting of sodium hydroxide, potassium hydroxide, and combinations thereof; and (m) at least one bioactive having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and selected from the group consisting of allantoin, salicylic acid and derivatives, niacinamide, zinc pyrrolidone carboxylic acid (ZnPCA), lactic acid, benzoyl peroxide, glycolic acid, adapalene, and combinations thereof, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0046] In an embodiment of the present disclosure, there is provided a mild cleansing composition comprising: (a) at least one mild anionic surfactant having a weight percentage in the range of 2% - 5% with respect to the cleansing composition and selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates, and combinations thereof; (b) at least one alkyl glucoside having a weight percentage in the range of 2% - 6% with respect to the cleansing composition and selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof; (c) at least one betaine having weight percentage in the range of 1% - 4% with respect to the cleansing composition and selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine, and combinations thereof; (d) at least one humectant having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and is selected from the group consisting of glycerin, panthenol, and combinations thereof; (e) at least one emollient having a weight percentage in the range of 0.001 - 5% with respect to the cleansing composition and selected from the group consisting of tocopheryl acetate, sodium pyrrolidone carboxylic acid (sodium PCA), PEG 40 castor oil, and combinations thereof; (f) at least one chelating agent having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, and combinations thereof; (g) at least one preservative having a weight percentage in the range of 0.005% - 1% with respect to the composition and selected from the group consisting of paraben, sodium benzoate, phenoxyethanol, methylisothiothiazolinone, methylchloroisothiothiazolinone, DMDM hydantoin, and combinations thereof; (h) at least one antioxidant having a weight percentage in the range of 0.01% - 1% with respect to the composition and selected from the group consisting of butylated hydroxytoluene, pentaerythrityl-tetra-di-^-butyl hydroxyhydrocinnamate, and combinations thereof; (i) at least one photo-stabilizer having a weight percentage in the range of 0.01 % - 1% with respect to the cleansing
composition and selected from the group consisting of benzophenone-3, benzophenone-4, and combinations thereof; (j) at least one emulsifier having a weight percentage in the range of 0.1% - 3% with respect to the cleansing composition and selected from the group consisting of polysorbate-20, PEG-40 castor oil, and combinations thereof; (k) at least one polymer/thickener having a weight percentage in the range of 0.1% - 1% with respect to the cleansing composition and selected from the group consisting of carbomer, hydroxypropyl methylcellulose, acrylates, cellulose, cellulose derivatives, and combinations thereof; (1) at least one neutralizer having a weight percentage in the range of 0.01 - 3% with respect to the cleansing composition and selected from the group consisting of sodium hydroxide, potassium hydroxide, and combinations thereof; and (m) at least one bioactive having a weight percentage in the range of 0.1% - 5% with respect to the cleansing composition and selected from the group consisting of allantoin, salicylic acid and derivatives, niacinamide, zinc pyrrolidone carboxylic acid (ZnPCA), lactic acid, benzoyl peroxide, glycolic acid, adapalene, and combinations thereof; and (n) water having weight percentage as much as is required to make the composition 100%), wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0047] In an embodiment of the present disclosure, there is provided a process for preparation of mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; and (c) at least one betaine, the process including the steps of: (a) obtaining at least one mild anionic surfactant; (b) obtaining at least one alkyl glucoside; (c) obtaining at least one betaine; and (c) contacting the at least one mild anionic surfactant, the at least one alkyl glucoside, and the at least one betaine, to obtain a cleansing composition, wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
[0048] In an embodiment of the present disclosure, there is provided a process for preparation of mild cleansing composition comprising: (a) at least one mild anionic surfactant; (b) at least one alkyl glucoside; (c) at least one betaine; and (d) at least one cosmetically acceptable excipient selected from the group consisting of humectant,
emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizer, fragrance, color, bioactive, and combinations thereof, the process including the steps of: (a) contacting a humectant and water to obtain a premix-1; (b) contacting at least one mild anionic surfactant and premix-1 to obtain a premix-2; (c) contacting at least one alkyl glucoside and premix- 2 to obtain a premix-3; (d) contacting at least one betaine and premix-3 to obtain a premix-4; (e) optionally contacting a bioactive and premix-4 to obtain a premix-5; and (f) optionally contacting at least one cosmetically acceptable excipient selected from the group consisting of emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizers, fragrance, color, and combinations thereof and premix-5 to obtain a cleansing composition.
[0049] In an embodiment of the present disclosure, there is provided a process for preparation of mild cleansing composition including the steps of: (a) contacting a humectant and water to obtain a premix-1 is carried out at a temperature in the range of 20 - 80 °C for a period in the range of 5 - 15 minutes; (b) contacting at least one mild anionic surfactant and premix-1 to obtain a premix-2 is carried out at a temperature in the range of 45 - 80 °C for a period in the range of 5 - 15 minutes; (c) contacting at least one alkyl glucoside and premix- 2 to obtain a premix-3 is carried out at a temperature in the range of 45 - 80 °C for a period in the range of 5 - 15 minutes; (d) contacting at least one betaine and premix-3 to obtain a premix-4 is carried out at a temperature in the range of 45 - 70°C for a period in the range of 5 - 15 minutes; (e) optionally contacting a bioactive and premix-4 to obtain a premix-5 is carried out at a temperature in the range of 45 - 65 °C for a period in the range of 1 -10 minutes; and (f) optionally contacting at least one cosmetically acceptable excipient selected from the group consisting of emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizer, fragrance, color, and combinations thereof, and premix-5 is carried out at a temperature in the range of 40 -55 °C for a period in the range of 10 - 20 minutes to obtain the cleansing composition.
EXAMPLES
[0050] The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may vary.
Example 1
Cleansing compositions with varying quantities of constituents
[0051] Various compositions were prepared by making variations in the weight
percentages of components. These compositions were further assessed for their
performance on various parameters, viz, cleansing capacity, moisturization,
rinseability, lather quantity, lather texture, and anti-bacterial activity with reference to
anti-acne benefits. Table 1 below depicts details of these compositions.
[0052] Table 1 depicts details of three examples (Working examples 1 - 3). All the three examples described in Table 1 had weight percentages of the components in the working ranges which have already been described in the detailed description section. The details of further studies undertaken on these examples can be found in the paragraphs that follow.
[0053] The comparative study with respect to foam amount and foam consistency (foam stability/thickness) was conducted with the help of 30 panellists for the composition of the instant disclosure (Working example 1) and another surfactant based product available in the market (Market product), for comparison purpose. It was found that a significant majority of panellists rated present composition higher for its "foam amount sufficiency and consistency" as compared to Market product. (p<0.05).
[0054] Further, moisturization (non-drying feel) study was conducted on 10 panelists, wherein Working example 1 was compared with Market product. Working example 1 was found to be superior compared to Market product (p=0.006). Similarly, even in terms of other sensorial aspects, like in-use feel on the skin, Working example 1 was found better by the panellists, compared to Market product (p=0.029). Working example 1 fared better compared to Market product in terms of overall likeability too (p=0.015).
[0055] With reference to the details mentioned in the preceding paragraph, p < 0.05 implies significance difference at more than 95% accuracy.
The results are tabulated below in Tables 2, 3, and 4
[0056] Table 2 provides panel ratings on a scale of 5, for Working example 1 and the corresponding ratings for a product available in the market (Market product) which was used for comparison purpose. Table 3 details the meanings of these scores. It can be seen from the data in Table 2 that on almost all counts Working example 1 was
rated better by the panel than Market product. In fact, on some of the parameters like amount of lather, foam stability, in-use feel, post-use feel, moisturization, and skin smoothness, Working example 1 outperformed Market product. Overall likeability too was better in case of Working example 1.
[0057] Table 4 below details experiments that were carried out, wherein further variations were made in quantities of various components of the composition.
[0058] Table 4 depicts results that were obtained when compositions containing components in weight percentages outside working ranges were assessed. Columns 3, 4, and 5 of Table 4 represent a working weight percentage value, lower limit of the range and the upper limit of the range respectively, for the corresponding components. Columns 6 and 7 depict results obtained when the said components were used in quantities below and above these ranges respectively.
[0059] It needs to mentioned here that when weight percentage of a certain component (or all components of certain category when more than one component of a certain category constituted the composition) were varied outside working ranges, weight percentages of all other components were maintained in their respective working ranges. For instance, for compositions, wherein mild anionic surfactants were used in weight percentage below or above its specified range, other components like alkyl glucosides and betaines etc. were kept in working ranges. The balance was sought by adjusting the weight percentage of water in the composition which was used quantum satis. Thus, when certain component was in a lower weight percentage, its lack was compensated by a commensurate excess of water and when the component was in a higher weight percentage, weight percentage of water was reduced proportionately.
[0060] As can be seen form the results in Table 4, when mild anionic surfactant was in a lower quantity, cleansing capacity was compromised and when the same component breached upper limit of the range panelists reported dryness of skin post-use. Similarly, when alkyl glucosides were used in lower amounts, foam / lather creaminess was impacted adversely, and when alkyl glucosides were present in higher quantity rinseability suffered. Further, when betaines were used in lower amounts lather volume was found to be reduced and when the same was used in excess, akin to excess alkyl glucosides, composition was difficult to rinse off. When humectants were used in lower quantities, skin dryness post-use was observed and when humectants were used in higher quantities, cleansing was compromised. Further, when quantities of bio-actives were varied on the lower and the higher side, reduced anti-bacterial activity and formulation instability respectively were observed as consequences.
Example 2
Process for the preparation of the composition
[0061] The compositions of the instant disclosure, Working and Non-working alike, were prepared using the following procedure: (a) glycerine was added to water at a temperature of about 70 °C along with for 10 minutes; (b) disodium laureth sulphosuccinate was added to the hot mix at around 70 °C along with stirring for 10 minutes; (c) decyl glucoside was then added at the same temperature as that of the previous step along with stirring for 10 minutes; (d) lauryl glucoside was then added at the same temperature; (e) CAPB was added to the mixture along with stirring for 10 minutes; (e) ZnPCA, niacinamide, allantoin, and salicylic acid were then added with an interval of 5 minutes each, at 60 °C along with stirring for 10 minutes (f) mixture was then cooled down to 40 - 55 °C and then sodium PC A and panthenol were added; (g) mixture was allowed to stir at 40 °C for 15 minutes to obtain the composition.
Example 3
Testing of anti-microbial activity
[0062] The process was carried out in a step-wise manner, the steps being: (a) growing a biofilm; (b) exposing the preformed biofilm to a concentration gradient of antimicrobial agent; (c) washing and refreshing the media; and (d) assay for live cells. The details of the process are as follows.
Growing a biofilm:
a. A culture of the wild-type strain of interest was grown for 24-72 hours
(depending on the culture) in a rich medium at 37 °C under aerobic conditions.
b. The saturated overnight cultures were diluted to Mc Farland BaSC>4 OD of 0.05
in fresh medium for antimicrobial resistance assays. BHTB stimulates the
formation of a robust biofilm.
c. 100 uL of the dilution was added in fresh medium per well in a 96-well
microtiter dish. Since these assays are typically performed in triplicate for each
strain, there should be 66 wells of each strain.
d. The plates were incubated at 37 °C under aerobic conditions for 36 hours for S.
aureus and P. aeruginosa and 72 hours for P. acnes.
Exposing the preformed biofilm to a concentration gradient of antimicrobial agent:
a. A 2x dilution series of antimicrobial agent was prepared for 20 wells with the
diluent starting from 50% concentration of antimicrobial agent. Starting
concentration was varied based on the experiment and antimicrobial agent.
b. The spent supernatant was removed (containing planktonic cells) using a
multichannel pipette or vacuum pump.
c. 100 uL of each 2x antimicrobial agent concentration in triplicates for 60 wells
(20 concentrations of antimicrobial agent) was added. 100 uL distilled water
(no antimicrobial agent control-positive growth control) was added to the
remaining 6 wells for each replicate and strain. 100 uL distilled water (no
antimicrobial agent and no bacteria control-negative growth control) was added
to the 6 more wells.
d. The microtiter plate was incubated for 1 hour at 37 °C for antiseptic solutions
and 18 hours at 37 °C for anti-acne formulations. The time of incubation was
adjusted based on the anti-microbial agent tested.
Washing and refreshing the media.
a. The antimicrobial agent was removed and the wells were washed with 100 uL
of distilled water twice.
b. 100 uL of fresh medium was added to all of the wells after washing.
c. The plates were incubated at 37 °C under aerobic conditions for 36 hours for S.
aureus and P. aeruginosa and 72 hours for P. acnes.
Assay for live cells.
a. The media was removed (containing planktonic cells) and the wells were
washed with 100 uL of distilled water once.
b. 20 uL of MTT (0.5% in PBS) was added to the remaining cell suspension in
each well. The well plates were incubated in dark for 5-6 hours at 37 °C. Blue
colored formazan crystals are formed at the bottom of the plate. IOOUL of
DMSO was added to dissolve the crystals. The MBC-B was determined by
identifying the cut-off for bacterial growth, by eye or by using a
spectrophotometer.
Results:
[0063] Working example 1 containing actives was first tested for its antimicrobial activity and similar products available in the market were used as benchmarks. A surfactant based market product (hereinafter Market product 1) and a soap based market product (hereinafter Market product 2) were used for comparison. It was found that all the three samples tested (Working example 1 containing actives and Market products 1 and 2) exhibited around 80% or higher eradication of P.acnes biofilms. Eradication of biofilm at 50% product concentration was higher for working example 1 compared to market products. 88.7% of eradication was observed for the working example 1, whereas soap based market product exhibited 83.5% eradication and the surfactant based market product could yield 83.5 % biofilm eradication.
[0064] When Working example 3 was tested at 50% concentration, a 71.6% eradication of P.acnes biofilms was observed. Similar to some of the examples above, when actives were not part of the composition being tested, the weight percentage was compensated by excess water.
Example 4: Mildness study
[0065] The composition of the present invention (Working example 1) was further
tested for mildness using the zein dissolution test.
[0066] The standard protocol to measure the zein dissolution is as follows: Approximately 250 mg of zein tablet was placed in a tea bag. The tea bag was then placed in a 3% solution of surfactant in a centrifuge tube and shaked at 200 rpm in an orbital shaker for 2 hours at 25 °C. % of weight reduction of the pellet was measured after drying for 48 hours. The details of the test are provided in Table 5 below. The percentage dissolution was calculated using the following formula.
of dissolution = (Amount of zein solubilized / Initial weight of the100 Mildness is measured in terms of % zein dissolution. Lower the zein dissolution, milder the formulation.
The comparative results for mildness in terms of zein value for present composition, a surfactant based formulation and a soap based formulation available in the market, are provided in Table 5 below.
[0067] It is evident from the data in Table 5 that the composition of the present disclosure (Working example 1) performed remarkably well in comparison to other products in the same segment, that are available in the market.
[0068] The present disclosure thus provides a cleansing composition which is mild on skin and provides oil control without causing dryness and imparts good sensorials and is also found to be effective against Propiobacterium acnes.
[0069] Although the subject matter has been described with reference to specific embodiments, this description is not meant to be construed in a limiting sense. Various modifications of the disclosed embodiments, as well as alternate embodiments of the subject matter, will become apparent to persons skilled in the art upon reference to the description of the subject matter. It is therefore contemplated that such modifications can be made without departing from the present subject matter as defined.
I/We Claim:
1. A mild, non-drying cleansing composition comprising:
(a) at least one mild anionic surfactant;
(b) at least one alkyl glucoside; and
(c) at least one betaine,
wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
2. The mild, non-drying cleansing composition as claimed in claim 1, wherein the at least one mild anionic surfactant to the at least one betaine weight ratio is in the range of 1:0.2-1:2.
3. The mild, non-drying cleansing composition as claimed in claim 1, wherein the at least one mild anionic surfactant is selected from the group consisting of sodium lauryl sarcosinate, disodium laureth sulfosuccinate, amphoacetates, alkyl isoethionates, alkyl taurates, cocoyl glutamates and combinations thereof.
4. The mild, non-drying cleansing composition as claimed in claim 3, wherein the at least one mild anionic surfactant is a combination of sodium lauryl sarcosinate, and disodium laureth sulfosuccinate.
5. The mild, non-drying non-oily cleansing composition as claimed in claim 1, wherein the at least one alkyl glucoside is selected from the group consisting of decyl glucoside, myristyl glucoside, lauryl glucoside, and combinations thereof.
6. The mild, non-drying non-oily cleansing composition as claimed in claim 5, wherein the at least one alkyl glucoside is a combination of decyl glucoside and lauryl glucoside.
7. The mild, non-drying non-oily cleansing composition as claimed in claim 1, wherein the at least one betaine is selected from the group consisting of cocamidopropyl betaine, cocobetaines, lauramidopropyl betaine and combinations thereof.
8. The mild, non-drying non-oily cleansing composition as claimed in claim 7, wherein the at least one betaine is cocamidopropyl betaine.
9. The mild, non-drying non-oily cleansing composition as claimed in claim 1, comprising:
(a) at least one mild anionic surfactant having weight percentage in the range of 2%-5% with respect to the cleansing composition;
(b) at least one alkyl glucoside having weight percentage in the range of 2%-6% with respect to the cleansing composition; and
(c) at least one betaine having weight percentage in the range of l%-4% with respect to the cleansing composition,
wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
10. The mild, non-drying non-oily cleansing composition as claimed in claim 1,
comprising:
a. at least one mild anionic surfactant having weight percentage in the
range of 2%-5% with respect to the cleansing composition;
b. at least one alkyl glucoside having weight percentage in the range of
2%-6% with respect to the cleansing composition;
c. at least one betaine having weight percentage in the range of l%-4%
with respect to the cleansing composition; and
d. at least one bioactive having weight percentage in the range of 0.01 to
5%,
wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
11. The mild, non-drying non-oily cleansing composition as claimed in claim 1,
further comprises at least one cosmetically acceptable excipient selected from
the group consisting of humectant, emollient, chelating agent, preservative,
antioxidant, photo-stabilizer, emulsifier, polymer, neutralizer, fragrance, color, and combinations thereof.
12. The mild, non-drying non-oily cleansing composition as claimed in claim 1
wherein pH of said composition is in the range of 5 to 7.5,
13. The mild, non-drying non-oily cleansing composition as claimed in claim 10,
wherein: the humectant has a weight percentage in the range of 0.1 - 5% with
respect to the cleansing composition, and the humectant is selected from the
group consisting of glycerin, panthenol, and combinations thereof; the
emollient has a weight percentage in the range of 0.001% - 5% with respect to
the cleansing composition and the emollient is selected from the group
consisting of tocopheryl acetate, sodium pyrrolidone carboxylic acid (sodium
PC A),, and combinations thereof;; the chelating agent has a weight percentage
in the range of 0.01% - 1% with respect to the cleansing composition, and the
chelating agent is selected from the group consisting of disodium
ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid,
and combinations thereof; the preservative has a weight percentage in the range
of 0.005%) - 1%> with respect to the cleansing composition, and the preservative
is selected from the group consisting of paraben, sodium benzoate,
phenoxyethanol, methylisothiothiazolinone (and)
methylchloroisothiothiazolinone, DMDM hydantoin, and combinations thereof;
the antioxidant has a weight percentage in the range of 0.01%> - 1% with respect
to the cleansing composition, and the antioxidant is selected from the group
consisting of butylated hydroxytoluene, pentaerythrityl-tetra-di-^-butyl
hydroxyhydrocinnamate, and combinations thereof; the photo-stabilizer has a
weight percentage in the range of 0.01%> - 1% with respect to the cleansing
composition, and the photo-stabilizer is selected from the group consisting of
benzophenone-3, benzophenone-4, and combinations thereof; the emulsifier
has a weight percentage in the range of 0.1%> - 3% with respect to the cleansing
composition, and the emulsifier is selected from the group consisting of
polysorbate-20, PEG 40 castor oil, and combinations thereof; the polymer/thickener has a weight percentage in the range of 0.1% - 10% with respect to the cleansing composition, and the polymer/thickener is selected from the group consisting of carbomer, hydroxypropyl methylcellulose, acrylates, cellulose, cellulose derivatives, and combinations thereof; the neutralizer has a weight percentage in the range of 0.01 - 3% with respect to the cleansing composition, and the neutralizer is selected from the group consisting of sodium hydroxide, potassium hydroxide, and combinations thereof; the bioactive has a weight percentage in the range of 0.1 % - 5% with respect to the cleansing composition, and the bioactive is selected from the group consisting of allantoin, salicylic acid and derivatives, niacinamide, zinc pyrrolidone carboxylic acid (ZnPCA), lactic acid, benzoyl peroxide, glycolic acid., adapalene, and combinations thereof.
14. A process for preparation of mild, non-drying non-oily cleansing composition
as claimed in claim 1, the process comprising the steps of:
(a) obtaining at least one mild anionic surfactant;
(b) obtaining at least one alkyl glucoside;
(c) obtaining at least one betaine; and
(d) contacting the at least one mild anionic surfactant, the at least one alkyl glucoside, and the at least one betaine, to obtain a cleansing composition,
wherein the at least one mild anionic surfactant to the at least one alkyl glucoside weight ratio is in the range of 1:0.4-l :3.
15. A process for preparation of preparation of mild, non-drying non-oily cleansing
composition as claimed in any of the claims 1-11, said process comprising the
steps of:
a. contacting a humectant and water to obtain a premix-1;
b. contacting at least one mild anionic surfactant and premix-1 to obtain a
premix-2;
c. contacting at least one alkyl glucoside and premix- 2 to obtain a
premix-3;
d. contacting at least one betaine and premix-3 to obtain a premix-4;
e. optionally contacting a bioactive and premix-4 to obtain a premix-5;
and
f. optionally contacting at least one cosmetically acceptable excipient
selected from the group consisting of emollient, chelating agent,
preservative, antioxidant, photo-stabilizer, emulsifier, polymer,
neutralizers, fragrance, color, and combinations thereof and premix-5 to
obtain a cleansing composition.
16. The process for preparation of preparation of mild, non-drying non-oily cleansing composition, as claimed in claim 13, wherein (a) contacting a humectant and water to obtain a premix-1 is carried out at a temperature in the range of 20-80 °C for a period in the range of 5-15 minutes ; (b) contacting at least one mild anionic surfactant and premix-1 to obtain a premix-2 is carried out at a temperature in the range of 45-80°C for a period in the range of 5-15 minutes ; (c) contacting at least one alkyl glucoside and premix- 2 to obtain a premix-3 is carried out at a temperature in the range of 45-80 °C for a period in the range of 5-15 minutes; (d) contacting at least one betaine and premix-3 to obtain a premix-4 is carried out at a temperature in the range of 45 - 70 °C for a period in the range of 5 - 15 minutes; (e) optionally contacting a bioactive and premix-4 to obtain a premix-5 is carried out at a temperature in the range of 45-65°C for a period in the range of 1-10 minutes ; (f) optionally contacting at least one cosmetically acceptable excipient selected from the group consisting of emollient, chelating agent, preservative, antioxidant, photo-stabilizer, emulsifier, polymer, neutralizers, fragrance, color, and combinations
thereof and premix-5 is carried out at a temperature in the range of 40-55°C for a period in the range of 10-20 minutes to obtain the cleansing composition.
| # | Name | Date |
|---|---|---|
| 1 | Form 5 [28-03-2017(online)].pdf | 2017-03-28 |
| 2 | Form 3 [28-03-2017(online)].pdf | 2017-03-28 |
| 3 | Description(Complete) [28-03-2017(online)].pdf_44.pdf | 2017-03-28 |
| 4 | Description(Complete) [28-03-2017(online)].pdf | 2017-03-28 |
| 5 | PROOF OF RIGHT [06-06-2017(online)].pdf | 2017-06-06 |
| 6 | Form 26 [06-06-2017(online)].pdf | 2017-06-06 |
| 7 | Correspondence by Agent_Power Of Attorney_Proof Of Right_12-06-2017.pdf | 2017-06-12 |
| 8 | 201741011050-FORM 18 [20-02-2021(online)].pdf | 2021-02-20 |
| 9 | 201741011050-Response to office action [08-10-2021(online)].pdf | 2021-10-08 |
| 10 | PROOF OF RIGHT [06-06-2017(online)].pdf | 2017-06-06 |
| 10 | 201741011050-FER.pdf | 2021-10-17 |
| 11 | Description(Complete) [28-03-2017(online)].pdf | 2017-03-28 |
| 11 | 201741011050-FER_SER_REPLY [10-05-2022(online)].pdf | 2022-05-10 |
| 12 | Description(Complete) [28-03-2017(online)].pdf_44.pdf | 2017-03-28 |
| 12 | 201741011050-CLAIMS [10-05-2022(online)].pdf | 2022-05-10 |
| 13 | Form 3 [28-03-2017(online)].pdf | 2017-03-28 |
| 13 | 201741011050-PatentCertificate16-12-2022.pdf | 2022-12-16 |
| 14 | 201741011050-IntimationOfGrant16-12-2022.pdf | 2022-12-16 |
| 14 | Form 5 [28-03-2017(online)].pdf | 2017-03-28 |
| 1 | TPO-2021-03-3011-58-13E_30-03-2021.pdf |
| 2 | IntellectualPropertyIndiaE_30-03-2021.pdf |