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We claim:A process for making novel pharmaceutical composition, enteric coated tablet of rabeprazole, and a final sustained release blend of Uopride in a capsule, wherein process steps comprising of - coating of rabeprazole sodium, with plurality of alkalizing agent , sieving plurality of diluents, a surface active agent, and a disintegrant through 60 mesh, blending for 5 minutes, dissolving a binder in purified water to make 10% w/v solution and granulating above said blend with said binder to get wet mass, passing said wet mass through mesh no. 8 to get wet granules, air drying, further drying said wet granules at 40° C in a tray drier till the loss on drying of desired value reached at not more than 3.0 % at 70° C, sifting the said dried granules through 20# sieve to get dry pass granules, finally mixing and blending of said dried granules with a disintegrant, a surface active agent and plurality of lubricants to get a lubricated blend, compressing the said lubricated blend into tablets by using compression machine to get core uncoated tablets of rabeprazole, seal coating of said core uncoated tablets of rabeprazole by using a polymer and a plasticizer to get seal coated tablets of rabeprazole, enteric coating of said seal coated tablets of rabeprazole by using enteric coating polymer, a plasticizer, opacifying agent, anti-sticking agent and a coloring agent, in a conventional coating pan to get said enteric coated tablet of rabeprazole,sieving ofltopride hydrochloride along with plurality of polymers, and a diluent through 60# mesh and blending for 5 minutes, dissolving a binder in isopropyl alcohol to make 5 % w/v solution and granulating above blend to get wet mass, sieving said wet mass through 8# mesh to get wet granules, air drying and further drying of said wet granules at 40° C till the loss on drying of desired value reached of not more than 2.5 % at 105° C to get dried granules, sieving said dried granules 20# mesh, finally mixing with plurality of lubricants to get final sustained release blend of Uopride, andfilling of said capsule with said enteric coated tablet of rabeprazole and said final sustained release blend of Uopride by using capsule filling machine equipped with a tablet loader.
Notices, Deadlines & Correspondence
Patent Information
Applicants
ARISTO PHARMACEUTICAL LTD
Inventors
1. MR.MANOHAR ACHARYA
2. MR. MANOJ KUMAR SINGH
3. MR. SURESH KUMAR PASWAN
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 890-mum-2003-correspondence(ipo)-(13-12-2004).pdf | 2004-12-13 |
| 2 | 890-mum-2003-power of attorney(15-9-2004).pdf | 2018-08-09 |
| 3 | 890-mum-2003-form 5(28-9-2004).pdf | 2018-08-09 |
| 4 | 890-mum-2003-form 4(1-9-2004).pdf | 2018-08-09 |
| 5 | 890-mum-2003-form 3(26-8-2003).pdf | 2018-08-09 |
| 6 | 890-mum-2003-form 2(granted)-(1-9-2004).pdf | 2018-08-09 |
| 8 | 890-mum-2003-form 19(3-2-2004).pdf | 2018-08-09 |
| 9 | 890-mum-2003-form 13(4-4-2005).pdf | 2018-08-09 |
| 10 | 890-mum-2003-form 13(15-9-2004).pdf | 2018-08-09 |
| 11 | 890-mum-2003-form 1(2-9-2003).pdf | 2018-08-09 |
| 12 | 890-mum-2003-claims(granted)-(1-9-2004).pdf | 2018-08-09 |
| 14 | 890-mum-2003-cancelled pages(1-9-2004).pdf | 2018-08-09 |