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A Process For Preparation Of Rabies Vaccine
Abstract: The present invention discloses a novel process of preparation of rabies vaccine. The process includes multiplying Rabies virus on Human diploid cells such as MRC-5. The Human diploid cells were grown on microcarriers and grown cells infected on with rabies virus seed. The multiplication of rabies virus is effected in serum free medium and thus released virus into the medium is harvested and purified by two step column chromatography to effect concentration, purification of virus. The purifies virus suspended in a suitable buffer is then inactivated by beta-propiolactone. The inactivated virus retains antigenic properties for eliciting immune response against rabies virus. This process result in high concentration and purity. The In-process quantification of Virus and antigen are done by analytical gel filtration chromatography.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
17 January 2005
Publication Number
111
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2009-08-25
Renewal Date
Applicants
SERUM INSTITUTE OF INDIA LIMITED
SAROSH BHAVAN,
16-B/1, DR. AMBEDKAR ROAD,
PUNE-411001.
Inventors
1. CYRUS S POONAWALLA
11, GIDNEY PARK,
PUNE 411037.
2. SUBHASH V. KAPRE
GOLDEN BLOSSOM,
FLAT NO.7,
8&9, 3rd FLOOR,
KANCHAN GALLI,
OFF LAW COLLEGE ROAD,
PUNE-411004.
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 46-MUM-2005-POWER OF ATTORNEY (18-08-2008).pdf | 2008-08-18 |
| 2 | 46-MUM-2005-CORRESPONDENCE (18-08-2008).pdf | 2008-08-18 |
| 3 | 46-MUM-2005-POWER OF ATTORNEY(17-12-2008).pdf | 2008-12-17 |
| 4 | 46-MUM-2005-FORM 2(TITLE PAGE)-(17-12-2008).pdf | 2008-12-17 |
| 5 | 46-mum-2005-form 2(17-12-2008).pdf | 2008-12-17 |
| 6 | 46-MUM-2005-DESCRIPTION(COMPLETE)-(17-12-2008).pdf | 2008-12-17 |
| 7 | 46-MUM-2005-CORRESPONDENCE(17-12-2008).pdf | 2008-12-17 |
| 8 | 46-MUM-2005-CLAIMS(MARKED COPY)-(17-12-2008).pdf | 2008-12-17 |
| 9 | 46-MUM-2005-CLAIMS(CANCELLED PAGE)-(17-12-2008).pdf | 2008-12-17 |
| 10 | 46-MUM-2005-CLAIMS(17-12-2008).pdf | 2008-12-17 |
| 11 | 46-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(19-12-2011).pdf | 2011-12-19 |
| 12 | 46-MUM-2005-CORRESPONDENCE-(23-12-2013).pdf | 2013-12-23 |
| 13 | Other Document [04-02-2016(online)].pdf | 2016-02-04 |
| 14 | Form 13 [04-02-2016(online)].pdf | 2016-02-04 |
| 15 | 46-MUM-2005-OTHERS-(05-02-2016).pdf | 2016-02-05 |
| 16 | 46-MUM-2005-GENERAL POWER OF ATTORNEY- (05-02-2016).pdf | 2016-02-05 |
| 17 | 46-MUM-2005-CORRESPONDENCE-(05-02-2016).pdf | 2016-02-05 |
| 18 | Form 27 [16-02-2017(online)].pdf | 2017-02-16 |
| 19 | 46-MUM-2005-RELEVANT DOCUMENTS [22-03-2018(online)].pdf | 2018-03-22 |
| 20 | 46-mum-2005-marked copy(21-4-2009).pdf | 2018-08-09 |
| 21 | 46-mum-2005-form 5(17-1-2005).pdf | 2018-08-09 |
| 22 | 46-mum-2005-form 5(16-1-2006).pdf | 2018-08-09 |
| 23 | 46-mum-2005-form 3(17-1-2005).pdf | 2018-08-09 |
| 24 | 46-mum-2005-form 2(title page)-(provisional)-(17-1-2005).pdf | 2018-08-09 |
| 25 | 46-mum-2005-form 2(title page)-(granted)-(25-8-2009).pdf | 2018-08-09 |
| 26 | 46-mum-2005-form 2(title page)-(complete)-(21-4-2009).pdf | 2018-08-09 |
| 27 | 46-MUM-2005-FORM 2(TITLE PAGE)-(21-4-2009).pdf | 2018-08-09 |
| 28 | 46-mum-2005-form 2(provisional)-(17-1-2005).pdf | 2018-08-09 |
| 29 | 46-mum-2005-form 2(granted)-(25-8-2009).pdf | 2018-08-09 |
| 30 | 46-mum-2005-form 2(complete)-(21-4-2009).pdf | 2018-08-09 |
| 31 | 46-mum-2005-form 2(21-4-2009).pdf | 2018-08-09 |
| 32 | 46-mum-2005-form 18(10-8-2006).pdf | 2018-08-09 |
| 33 | 46-MUM-2005-FORM 1(21-4-2009).pdf | 2018-08-09 |
| 34 | 46-MUM-2005-FORM 1(17-1-2005).pdf | 2018-08-09 |
| 35 | 46-mum-2005-drawing(granted)-(25-8-2009).pdf | 2018-08-09 |
| 36 | 46-mum-2005-drawing(complete)-(21-4-2009).pdf | 2018-08-09 |
| 37 | 46-MUM-2005-DRAWING(21-4-2009).pdf | 2018-08-09 |
| 38 | 46-MUM-2005-DRAWING(16-1-2006).pdf | 2018-08-09 |
| 39 | 46-mum-2005-description(provisional)-(17-1-2005).pdf | 2018-08-09 |
| 40 | 46-mum-2005-description(granted)-(25-8-2009).pdf | 2018-08-09 |
| 41 | 46-MUM-2005-DESCRIPTION(COMPLETE)-(21-4-2009).pdf | 2018-08-09 |
| 42 | 46-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(17-9-2009).pdf | 2018-08-09 |
| 43 | 46-mum-2005-correspondence(ipo)-(26-8-2009).pdf | 2018-08-09 |
| 44 | 46-MUM-2005-CORRESPONDENCE(21-4-2009).pdf | 2018-08-09 |
| 45 | 46-mum-2005-correspondence(13-4-2009).pdf | 2018-08-09 |
| 46 | 46-mum-2005-correspondence(10-8-2005).pdf | 2018-08-09 |
| 47 | 46-mum-2005-claims(granted)-(25-8-2009).pdf | 2018-08-09 |
| 48 | 46-mum-2005-claims(complete)-(21-4-2009).pdf | 2018-08-09 |
| 49 | 46-MUM-2005-CLAIMS(CANCELLED PAGES)-(21-4-2009).pdf | 2018-08-09 |
| 50 | 46-mum-2005-claims(amanded)-(21-4-2009).pdf | 2018-08-09 |
| 51 | 46-MUM-2005-CLAIMS(21-4-2009).pdf | 2018-08-09 |
| 52 | 46-mum-2005-abstract(provisional)-(17-1-2005).pdf | 2018-08-09 |
| 53 | 46-mum-2005-abstract(granted)-(25-8-2009).pdf | 2018-08-09 |
| 54 | 46-mum-2005-abstract(complete)-(21-4-2009).pdf | 2018-08-09 |
| 55 | 46-MUM-2005-ABSTRACT(21-4-2009).pdf | 2018-08-09 |
| 56 | 46-MUM-2005-ABSTRACT(16-1-2006).pdf | 2018-08-09 |
| 57 | 46-MUM-2005-RELEVANT DOCUMENTS [16-03-2019(online)].pdf | 2019-03-16 |
| 58 | 46-MUM-2005-RELEVANT DOCUMENTS [23-03-2020(online)].pdf | 2020-03-23 |
| 59 | 46-MUM-2005-RELEVANT DOCUMENTS [21-09-2021(online)].pdf | 2021-09-21 |
| 60 | 46-MUM-2005-RELEVANT DOCUMENTS [22-09-2021(online)].pdf | 2021-09-22 |
| 61 | 46-MUM-2005-RELEVANT DOCUMENTS [28-09-2022(online)].pdf | 2022-09-28 |
| 62 | 46-MUM-2005-RELEVANT DOCUMENTS [12-09-2023(online)].pdf | 2023-09-12 |
| 63 | 46-MUM-2005-FORM-27 [10-09-2024(online)].pdf | 2024-09-10 |
| 64 | 46-MUM-2005-FORM-27 [24-09-2025(online)].pdf | 2025-09-24 |